Joan Mecsas

Publications

• Unraveling Neutrophil- Interactions During Tissue Infection
  F1000Research. 2019  |   Pubmed ID: 31327994
• Detection of Cells Translocated with Yersinia Yops in Infected Tissues Using β-Lactamase Fusions
  Methods in Molecular Biology (Clifton, N.J.). 2019  |   Pubmed ID: 31177435
• Amino Acid Biosynthetic Pathways Are Required for Growth in Immunocompromised Lungs and Are Druggable Targets During Infection
  Antimicrobial Agents and Chemotherapy. May, 2019  |   Pubmed ID: 31109974
• New Age Strategies To Reconstruct Mucosal Tissue Colonization and Growth in Cell Culture Systems
  Microbiology Spectrum. 03, 2019  |   Pubmed ID: 30848233
• Promises and Challenges of the Type Three Secretion System Injectisome As an Antivirulence Target
  EcoSal Plus. 02, 2019  |   Pubmed ID: 30706846
• Pre-colonization with the Commensal Fungus Candida Albicans Reduces Murine Susceptibility to Clostridium Difficile Infection
  Gut Microbes. 11, 2018  |   Pubmed ID: 29667487
• Editorial Overview: Host-pathogen Interactions Shaped Through Evolutionary and Regulatory Processes
  Current Opinion in Microbiology. 02, 2018  |   Pubmed ID: 29559085
• A 3D Intestinal Tissue Model Supports Clostridioides Difficile Germination, Colonization, Toxin Production and Epithelial Damage
  Anaerobe. Apr, 2018  |   Pubmed ID: 29462695
• Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance
  Frontiers in Cellular and Infection Microbiology. 2017  |   Pubmed ID: 28890882
• Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-β Synthesis Induced by Lipopolysaccharide
  Journal of Immunology (Baltimore, Md. : 1950). 06, 2017  |   Pubmed ID: 28461567
• The Yersinia Pestis Effector YopM Inhibits Pyrin Inflammasome Activation
  PLoS Pathogens. Dec, 2016  |   Pubmed ID: 27911947
• Fis Is Essential for Yersinia Pseudotuberculosis Virulence and Protects Against Reactive Oxygen Species Produced by Phagocytic Cells During Infection
  PLoS Pathogens. Sep, 2016  |   Pubmed ID: 27689357
• Inhibition of the Injectisome and Flagellar Type III Secretion Systems by INP1855 Impairs Pseudomonas Aeruginosa Pathogenicity and Inflammasome Activation
  The Journal of Infectious Diseases. 10, 2016  |   Pubmed ID: 27412581
• Klebsiella Pneumoniae: Going on the Offense with a Strong Defense
  Microbiology and Molecular Biology Reviews : MMBR. 09, 2016  |   Pubmed ID: 27307579
• Beyond Antibiotics: New Therapeutic Approaches for Bacterial Infections
  Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. 07, 2016  |   Pubmed ID: 27025826
• Bacterial Secretion Systems: An Overview
  Microbiology Spectrum. Feb, 2016  |   Pubmed ID: 26999395
• A Single Bacterial Immune Evasion Strategy Dismantles Both MyD88 and TRIF Signaling Pathways Downstream of TLR4
  Cell Host & Microbe. Dec, 2015  |   Pubmed ID: 26651944
• Robust Bioengineered 3D Functional Human Intestinal Epithelium
  Scientific Reports. 2015  |   Pubmed ID: 26374193
• Intestinal Alkaline Phosphatase Deficiency Leads to Lipopolysaccharide Desensitization and Faster Weight Gain
  Infection and Immunity. Jan, 2015  |   Pubmed ID: 25348635
• Mutations in the Pseudomonas Aeruginosa Needle Protein Gene PscF Confer Resistance to Phenoxyacetamide Inhibitors of the Type III Secretion System
  Antimicrobial Agents and Chemotherapy. 2014  |   Pubmed ID: 24468789
• Yersinia Pseudotuberculosis Uses Ail and YadA to Circumvent Neutrophils by Directing Yop Translocation During Lung Infection
  Cellular Microbiology. Feb, 2014  |   Pubmed ID: 24119087
• Identifying Yersinia YopH-targeted Signal Transduction Pathways That Impair Neutrophil Responses During in Vivo Murine Infection
  Cell Host & Microbe. Sep, 2013  |   Pubmed ID: 24034616
• Adhesins and Host Serum Factors Drive Yop Translocation by Yersinia into Professional Phagocytes During Animal Infection
  PLoS Pathogens. 2013  |   Pubmed ID: 23818844
• A Mutant with Aberrant Extracellular LcrV-YscF Interactions Fails to Form Pores and Translocate Yop Effector Proteins but Retains the Ability to Trigger Yop Secretion in Response to Host Cell Contact
  Journal of Bacteriology. May, 2013  |   Pubmed ID: 23475976
• Identification of MrtAB, an ABC Transporter Specifically Required for Yersinia Pseudotuberculosis to Colonize the Mesenteric Lymph Nodes
  PLoS Pathogens. 2012  |   Pubmed ID: 22876175
• The NLRP12 Inflammasome Recognizes Yersinia Pestis
  Immunity. Jul, 2012  |   Pubmed ID: 22840842
• Yersinia Pestis AcrAB-TolC in Antibiotic Resistance and Virulence
  Antimicrobial Agents and Chemotherapy. Feb, 2012  |   Pubmed ID: 22083483
• Development of a Vaccinia Virus Based Reservoir-targeted Vaccine Against Yersinia Pestis
  Vaccine. Nov, 2010  |   Pubmed ID: 20875494
• Small Molecule Inhibitors of LcrF, a Yersinia Pseudotuberculosis Transcription Factor, Attenuate Virulence and Limit Infection in a Murine Pneumonia Model
  Infection and Immunity. Nov, 2010  |   Pubmed ID: 20823209
• Identification and Characterization of Small-molecule Inhibitors of Yop Translocation in Yersinia Pseudotuberculosis
  Antimicrobial Agents and Chemotherapy. Aug, 2010  |   Pubmed ID: 20498321
• The C-terminal Tail of Yersinia Pseudotuberculosis YopM is Critical for Interacting with RSK1 and for Virulence
  Infection and Immunity. Jun, 2010  |   Pubmed ID: 20368345
• A Dominant-negative Needle Mutant Blocks Type III Secretion of Early but Not Late Substrates in Yersinia
  Molecular Microbiology. Apr, 2010  |   Pubmed ID: 20199604
• ROS-inhibitory Activity of YopE is Required for Full Virulence of Yersinia in Mice
  Cellular Microbiology. Jul, 2010  |   Pubmed ID: 20148901
• The Presence of Professional Phagocytes Dictates the Number of Host Cells Targeted for Yop Translocation During Infection
  Cellular Microbiology. Aug, 2010  |   Pubmed ID: 20148898
• Effect of MarA-like Proteins on Antibiotic Resistance and Virulence in Yersinia Pestis
  Infection and Immunity. Jan, 2010  |   Pubmed ID: 19841071
• CD8(+) T Cells Restrict Yersinia Pseudotuberculosis Infection: Bypass of Anti-phagocytosis by Targeting Antigen-presenting Cells
  PLoS Pathogens. Sep, 2009  |   Pubmed ID: 19730693
• Effect of Age on Susceptibility to Salmonella Typhimurium Infection in C57BL/6 Mice
  Journal of Medical Microbiology. Dec, 2009  |   Pubmed ID: 19729455
• Self-regulation of Candida Albicans Population Size During GI Colonization
  PLoS Pathogens. Dec, 2007  |   Pubmed ID: 18069889
• Oral Inoculation with Type III Secretion Mutants of Yersinia Pseudotuberculosis Provides Protection from Oral, Intraperitoneal, or Intranasal Challenge with Virulent Yersinia
  Vaccine. Feb, 2007  |   Pubmed ID: 17194509
• Intranasal Inoculation of Mice with Yersinia Pseudotuberculosis Causes a Lethal Lung Infection That is Dependent on Yersinia Outer Proteins and PhoP
  Infection and Immunity. Jan, 2007  |   Pubmed ID: 17074849
• Mutations in the Yersinia Pseudotuberculosis Type III Secretion System Needle Protein, YscF, That Specifically Abrogate Effector Translocation into Host Cells
  Journal of Bacteriology. Jan, 2007  |   Pubmed ID: 17071752
• Yersinia Has a Tropism for B and T Cell Zones of Lymph Nodes That is Independent of the Type III Secretion System
  PLoS Pathogens. Sep, 2006  |   Pubmed ID: 16948531
• A Non-invasive Quantitative Assay to Measure Murine Intestinal Inflammation Using the Neutrophil Marker Lactoferrin
  Journal of Immunological Methods. Jun, 2006  |   Pubmed ID: 16806255
• Yersinia Pseudotuberculosis Disseminates Directly from a Replicating Bacterial Pool in the Intestine
  The Journal of Experimental Medicine. Jun, 2006  |   Pubmed ID: 16754724
• The Proinflammatory Response Induced by Wild-type Yersinia Pseudotuberculosis Infection Inhibits Survival of Yop Mutants in the Gastrointestinal Tract and Peyer's Patches
  Infection and Immunity. Mar, 2006  |   Pubmed ID: 16495522
• Requirement of the Yersinia Pseudotuberculosis Effectors YopH and YopE in Colonization and Persistence in Intestinal and Lymph Tissues
  Infection and Immunity. Aug, 2003  |   Pubmed ID: 12874339
• Use of Signature-tagged Mutagenesis in Pathogenesis Studies
  Current Opinion in Microbiology. Feb, 2002  |   Pubmed ID: 11834366
• Identification of Attenuated Yersinia Pseudotuberculosis Strains and Characterization of an Orogastric Infection in BALB/c Mice on Day 5 Postinfection by Signature-tagged Mutagenesis
  Infection and Immunity. May, 2001  |   Pubmed ID: 11292689