Johan van der Vlag Radboud Institute for Molecular Life Sciences, Department of Nephrology Radboud University Medical Center Biography Publications Institution JoVE Articles Johan van der Vlag has not added a biography. If you are Johan van der Vlag and would like to personalize this page please email our Author Liaison for assistance. Publications Inhibition of MTOR Delayed but Could Not Prevent Experimental Collapsing Focal Segmental Glomerulosclerosis Scientific Reports. May, 2020 | Pubmed ID: 32444668 Heparanase in Kidney Disease Advances in Experimental Medicine and Biology. 2020 | Pubmed ID: 32274730 Angiotensin-neprilysin Inhibition Confers Renoprotection in Rats with Diabetes and Hypertension by Limiting Podocyte Injury Journal of Hypertension. Apr, 2020 | Pubmed ID: 31790054 Novel Parietal Epithelial Cell Subpopulations Contribute to Focal Segmental Glomerulosclerosis and Glomerular Tip Lesions Kidney International. 07, 2019 | Pubmed ID: 31029503 C3 Glomerulopathy - Understanding a Rare Complement-driven Renal Disease Nature Reviews. Nephrology. 03, 2019 | Pubmed ID: 30692664 To NET or Not to NET:current Opinions and State of the Science Regarding the Formation of Neutrophil Extracellular Traps Cell Death and Differentiation. 03, 2019 | Pubmed ID: 30622307 Vascular Bioengineering of Scaffolds Derived from Human Discarded Transplant Kidneys Using Human Pluripotent Stem Cell-derived Endothelium American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 05, 2019 | Pubmed ID: 30506641 Cleaved N-terminal Histone Tails Distinguish Between NADPH Oxidase (NOX)-dependent and NOX-independent Pathways of Neutrophil Extracellular Trap Formation Annals of the Rheumatic Diseases. 12, 2018 | Pubmed ID: 30120096 Alternative Pathway Is Essential for Glomerular Complement Activation and Proteinuria in a Mouse Model of Membranous Nephropathy Frontiers in Immunology. 2018 | Pubmed ID: 29988342 The Calcium-Dependent Protease Calpain-1 Links TRPC6 Activity to Podocyte Injury Journal of the American Society of Nephrology : JASN. 08, 2018 | Pubmed ID: 29954830 Sialic Acid Blockade Suppresses Tumor Growth by Enhancing T-cell-Mediated Tumor Immunity Cancer Research. 07, 2018 | Pubmed ID: 29703719 Interleukin-6 is Essential for Glomerular Immunoglobulin A Deposition and the Development of Renal Pathology in Cd37-deficient mice Kidney International. 06, 2018 | Pubmed ID: 29551516 IL-1β Promotes a New Function of DNase I As a Transcription Factor for the Fas Receptor Gene Frontiers in Cell and Developmental Biology. 2018 | Pubmed ID: 29468159 A Novel Choroidal Endothelial Cell Line Has a Decreased Affinity for the Age-Related Macular Degeneration-Associated Complement Factor H Variant 402H Investigative Ophthalmology & Visual Science. 02, 2018 | Pubmed ID: 29392318 Complement Factor H Protects Mice from Ischemic Acute Kidney Injury but is Not Critical for Controlling Complement Activation by Glomerular IgM European Journal of Immunology. 05, 2018 | Pubmed ID: 29389016 CD44 is Required for the Pathogenesis of Experimental Crescentic Glomerulonephritis and Collapsing Focal Segmental Glomerulosclerosis Kidney International. 03, 2018 | Pubmed ID: 29276101 Lithium Reduces Blood Glucose Levels, but Aggravates Albuminuria in BTBR-ob/ob Mice PloS One. 2017 | Pubmed ID: 29244860 Acetylated Histones in Apoptotic Microparticles Drive the Formation of Neutrophil Extracellular Traps in Active Lupus Nephritis Frontiers in Immunology. 2017 | Pubmed ID: 28959262 Systemic Monocyte Chemotactic Protein-1 Inhibition Modifies Renal Macrophages and Restores Glomerular Endothelial Glycocalyx and Barrier Function in Diabetic Nephropathy The American Journal of Pathology. Nov, 2017 | Pubmed ID: 28837800 Leukocyte Bim Deficiency Does Not Impact Atherogenesis in Ldlrmice, Despite a Pronounced Induction of Autoimmune Inflammation Scientific Reports. Jun, 2017 | Pubmed ID: 28596542 Neutrophil Extracellular Traps Drive Endothelial-to-Mesenchymal Transition Arteriosclerosis, Thrombosis, and Vascular Biology. 07, 2017 | Pubmed ID: 28495931 Cracking the Pathogenesis of Cocaine-induced Vasculitis Rheumatology (Oxford, England). 04, 2017 | Pubmed ID: 28339525 Human Alpha-1-Antitrypsin (hAAT) Therapy Reduces Renal Dysfunction and Acute Tubular Necrosis in a Murine Model of Bilateral Kidney Ischemia-reperfusion Injury PloS One. 2017 | Pubmed ID: 28235038 Heparanase: Roles in Cell Survival, Extracellular Matrix Remodelling and the Development of Kidney Disease Nature Reviews. Nephrology. Apr, 2017 | Pubmed ID: 28163306 Direct Observation of Enhanced Nitric Oxide in a Murine Model of Diabetic Nephropathy PloS One. 2017 | Pubmed ID: 28103268 Sildenafil Prevents Podocyte Injury PPAR--Mediated TRPC6 Inhibition Journal of the American Society of Nephrology : JASN. May, 2017 | Pubmed ID: 27895156 Blood-borne Phagocytes Internalize Urate Microaggregates and Prevent Intravascular NETosis by Urate Crystals Scientific Reports. 12, 2016 | Pubmed ID: 27917897 RNA Contaminates Glycosaminoglycans Extracted from Cells and Tissues PloS One. 2016 | Pubmed ID: 27898729 Neutrophils Discriminate Between Lipopolysaccharides of Different Bacterial Sources and Selectively Release Neutrophil Extracellular Traps Frontiers in Immunology. 2016 | Pubmed ID: 27867387 Autoantibodies Against Modified Histone Peptides in SLE Patients Are Associated with Disease Activity and Lupus Nephritis PloS One. 2016 | Pubmed ID: 27780265 Cathepsin L is Crucial for the Development of Early Experimental Diabetic Nephropathy Kidney International. Nov, 2016 | Pubmed ID: 27575559 Endothelial Nitric Oxide Synthase Prevents Heparanase Induction and the Development of Proteinuria PloS One. 2016 | Pubmed ID: 27505185 Atrasentan Reduces Albuminuria by Restoring the Glomerular Endothelial Glycocalyx Barrier in Diabetic Nephropathy Diabetes. Aug, 2016 | Pubmed ID: 27207530 Endothelin-1 Induces Proteinuria by Heparanase-Mediated Disruption of the Glomerular Glycocalyx Journal of the American Society of Nephrology : JASN. Dec, 2016 | Pubmed ID: 27026367 Heparanase Is Essential for the Development of Acute Experimental Glomerulonephritis The American Journal of Pathology. Apr, 2016 | Pubmed ID: 26873445 1,25-Vitamin D3 Deficiency Induces Albuminuria The American Journal of Pathology. Apr, 2016 | Pubmed ID: 26851346 Mutations in Complement Factor H Impair Alternative Pathway Regulation on Mouse Glomerular Endothelial Cells in Vitro The Journal of Biological Chemistry. Mar, 2016 | Pubmed ID: 26728463 Circulating Apoptotic Microparticles in Systemic Lupus Erythematosus Patients Drive the Activation of Dendritic Cell Subsets and Prime Neutrophils for NETosis Arthritis & Rheumatology (Hoboken, N.J.). Feb, 2016 | Pubmed ID: 26360137 Disturbed T Cell Signaling and Altered Th17 and Regulatory T Cell Subsets in the Pathogenesis of Systemic Lupus Erythematosus Frontiers in Immunology. 2015 | Pubmed ID: 26648939 Reactivity in ELISA with DNA-loaded Nucleosomes in Patients with Proliferative Lupus Nephritis Molecular Immunology. Nov, 2015 | Pubmed ID: 26597199 Differential Expression of Specific Dermatan Sulfate Domains in Renal Pathology PloS One. 2015 | Pubmed ID: 26322947 Increased Expression of Lysosome Membrane Protein 2 in Glomeruli of Patients with Idiopathic Membranous Nephropathy Proteomics. Nov, 2015 | Pubmed ID: 26304790 Vitamin D Attenuates Proteinuria by Inhibition of Heparanase Expression in the Podocyte The Journal of Pathology. Dec, 2015 | Pubmed ID: 26202309 Enhanced Activation of Dendritic Cells by Autologous Apoptotic Microvesicles in MRL/lpr Mice Arthritis Research & Therapy. Apr, 2015 | Pubmed ID: 25886192 A Microscopic View on the Renal Endothelial Glycocalyx American Journal of Physiology. Renal Physiology. May, 2015 | Pubmed ID: 25673809 The Role of Heparan Sulfate As Determining Pathogenic Factor in Complement Factor H-associated Diseases Molecular Immunology. Feb, 2015 | Pubmed ID: 25246018 TRPC6 Single Nucleotide Polymorphisms and Progression of Idiopathic Membranous Nephropathy PloS One. 2014 | Pubmed ID: 25019165 Breaking Immunological Tolerance in Systemic Lupus Erythematosus Frontiers in Immunology. 2014 | Pubmed ID: 24782867 Glucose Specifically Regulates TRPC6 Expression in the Podocyte in an AngII-dependent Manner The American Journal of Pathology. Jun, 2014 | Pubmed ID: 24731445 Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation Jennifer Eymael1, Laura Miesen1, Fieke Mooren1, Jitske Jansen1,2, Jack Wetzels3, Johan van der Vlag4, Bart Smeets1 1Radboud Institute for Molecular Life Sciences, Department of Pathology, Radboud University Medical Center, 2Radboud Institute for Molecular Life Sciences, Amalia Children's Hospital, Department of Paediatric Nephrology, Radboud University Medical Center, 3Radboud Institute for Health Sciences, Department of Nephrology, Radboud University Medical Center, 4Radboud Institute for Molecular Life Sciences, Department of Nephrology, Radboud University Medical Center JoVE 60324 Biology
Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation Jennifer Eymael1, Laura Miesen1, Fieke Mooren1, Jitske Jansen1,2, Jack Wetzels3, Johan van der Vlag4, Bart Smeets1 1Radboud Institute for Molecular Life Sciences, Department of Pathology, Radboud University Medical Center, 2Radboud Institute for Molecular Life Sciences, Amalia Children's Hospital, Department of Paediatric Nephrology, Radboud University Medical Center, 3Radboud Institute for Health Sciences, Department of Nephrology, Radboud University Medical Center, 4Radboud Institute for Molecular Life Sciences, Department of Nephrology, Radboud University Medical Center JoVE 60324 Biology
