John C. Bell

Publications

• Electrochemical Differentiation of Epitope-Specific Aptamers
  Analytical Chemistry. Feb, 2012  |   Pubmed ID: 22324738
• Aptamer-Based Viability Impedimetric Sensor for Viruses
  Analytical Chemistry. Feb, 2012  |   Pubmed ID: 22303883
• ORFV: A Novel Oncolytic and Immune Stimulating Parapoxvirus Therapeutic
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2012  |   Pubmed ID: 22273579
• Electrochemical Sensing of Aptamer-facilitated Virus Immunoshielding
  Analytical Chemistry. Feb, 2012  |   Pubmed ID: 22242920
• Oncolytic Viruses: Smart Therapeutics for Smart Cancers
  Future Oncology (London, England). Jan, 2012  |   Pubmed ID: 22149027
• The Oncolytic Poxvirus JX-594 Selectively Replicates in and Destroys Cancer Cells Driven by Genetic Pathways Commonly Activated in Cancers
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2011  |   Pubmed ID: 22186794
• Sensitivity of Cervical Carcinoma Cells to Vesicular Stomatitis Virus-induced Oncolysis: Potential Role of Human Papilloma Virus Infection
  International Journal of Cancer. Journal International Du Cancer. Dec, 2011  |   Pubmed ID: 22173567
• Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-γ-mediated Disinhibition
  Cell. Dec, 2011  |   Pubmed ID: 22153080
• Interfering with Tumor Pathways That Augment Viral Oncolysis
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2011  |   Pubmed ID: 22134743
• A Selectable and Excisable Marker System for the Rapid Creation of Recombinant Poxviruses
  PloS One. 2011  |   Pubmed ID: 21931792
• Intravenous Delivery of a Multi-mechanistic Cancer-targeted Oncolytic Poxvirus in Humans
  Nature. Sep, 2011  |   Pubmed ID: 21886163
• A Mechanistic Proof-of-concept Clinical Trial with JX-594, a Targeted Multi-mechanistic Oncolytic Poxvirus, in Patients with Metastatic Melanoma
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2011  |   Pubmed ID: 21772252
• Targeted and Armed Oncolytic Poxviruses for Cancer: The Lead Example of JX-594
  Current Pharmaceutical Biotechnology. Jul, 2011  |   Pubmed ID: 21740365
• Viral Quantitative Capillary Electrophoresis for Counting Intact Viruses
  Analytical Chemistry. Jul, 2011  |   Pubmed ID: 21599011
• Chromosomal Position Effects Are Linked to Sir2-mediated Variation in Transcriptional Burst Size
  Biophysical Journal. May, 2011  |   Pubmed ID: 21575565
• Thunder and Lightning: Immunotherapy and Oncolytic Viruses Collide
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2011  |   Pubmed ID: 21505424
• Sequential Therapy with JX-594, a Targeted Oncolytic Poxvirus, Followed by Sorafenib in Hepatocellular Carcinoma: Preclinical and Clinical Demonstration of Combination Efficacy
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2011  |   Pubmed ID: 21427706
• Targeting Tumor Vasculature with an Oncolytic Virus
  Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2011  |   Pubmed ID: 21364541
• Enhancement of Vaccinia Virus Based Oncolysis with Histone Deacetylase Inhibitors
  PloS One. 2010  |   Pubmed ID: 21283510
• Efficacy and Safety/toxicity Study of Recombinant Vaccinia Virus JX-594 in Two Immunocompetent Animal Models of Glioma
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2010  |   Pubmed ID: 20808290
• Oncolytic Targeting of Renal Cell Carcinoma Via Encephalomyocarditis Virus
  EMBO Molecular Medicine. Jul, 2010  |   Pubmed ID: 20623734
• Identification of Genetically Modified Maraba Virus As an Oncolytic Rhabdovirus
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Aug, 2010  |   Pubmed ID: 20551913
• Navigating the Clinical Development Landscape for Oncolytic Viruses and Other Cancer Therapeutics: No Shortcuts on the Road to Approval
  Cytokine & Growth Factor Reviews. Apr-Jun, 2010  |   Pubmed ID: 20472490
• A High-throughput Pharmacoviral Approach Identifies Novel Oncolytic Virus Sensitizers
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2010  |   Pubmed ID: 20389287
• Double Trouble for Tumours: Exploiting the Tumour Microenvironment to Enhance Anticancer Effect of Oncolytic Viruses
  Cytokine & Growth Factor Reviews. Apr-Jun, 2010  |   Pubmed ID: 20338801
• Synergistic Interaction Between Oncolytic Viruses Augments Tumor Killing
  Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2010  |   Pubmed ID: 20234341
• United Virus: the Oncolytic Tag-team Against Cancer!
  Cytokine & Growth Factor Reviews. Apr-Jun, 2010  |   Pubmed ID: 20227326
• Novel Oncolytic Viruses: Riding High on the Next Wave?
  Cytokine & Growth Factor Reviews. Apr-Jun, 2010  |   Pubmed ID: 20219409
• Potent Oncolytic Activity of Raccoonpox Virus in the Absence of Natural Pathogenicity
  Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2010  |   Pubmed ID: 20160706
• Vesicular Stomatitis Virus Oncolysis is Potentiated by Impairing MTORC1-dependent Type I IFN Production
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2010  |   Pubmed ID: 20080710
• Intravenously Administered Alphavirus Vector VA7 Eradicates Orthotopic Human Glioma Xenografts in Nude Mice
  PloS One. 2010  |   Pubmed ID: 20066051
• Intelligent Design: Combination Therapy with Oncolytic Viruses
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2010  |   Pubmed ID: 20029399
• Down-regulation of Type I Interferon Receptor Sensitizes Bladder Cancer Cells to Vesicular Stomatitis Virus-induced Cell Death
  International Journal of Cancer. Journal International Du Cancer. Aug, 2010  |   Pubmed ID: 19957332
• Antiangiogenic Arming of an Oncolytic Vaccinia Virus Enhances Antitumor Efficacy in Renal Cell Cancer Models
  Journal of Virology. Jan, 2010  |   Pubmed ID: 19906926
• Efficacy of Systemically Administered Oncolytic Vaccinia Virotherapy for Malignant Gliomas is Enhanced by Combination Therapy with Rapamycin or Cyclophosphamide
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2009  |   Pubmed ID: 19351762
• Diplomatic Immunity: Turning a Foe into an Ally
  Current Opinion in Molecular Therapeutics. Feb, 2009  |   Pubmed ID: 19169955
• The P14 FAST Protein of Reptilian Reovirus Increases Vesicular Stomatitis Virus Neuropathogenesis
  Journal of Virology. Jan, 2009  |   Pubmed ID: 18971262
• MicroRNAs Fine-tune Oncolytic Viruses
  Nature Biotechnology. Dec, 2008  |   Pubmed ID: 19060871
• Chemical Targeting of the Innate Antiviral Response by Histone Deacetylase Inhibitors Renders Refractory Cancers Sensitive to Viral Oncolysis
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2008  |   Pubmed ID: 18815361
• Development of Targeted Oncolytic Virotherapeutics Through Translational Research
  Expert Opinion on Biological Therapy. Sep, 2008  |   Pubmed ID: 18694356
• Efficacy of Systemically Administered Mutant Vesicular Stomatitis Virus (VSVDelta51) Combined with Radiation for Nasopharyngeal Carcinoma
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2008  |   Pubmed ID: 18676763
• A Let-7 MicroRNA-sensitive Vesicular Stomatitis Virus Demonstrates Tumor-specific Replication
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Aug, 2008  |   Pubmed ID: 18560417
• Oncolytic Vesicular Stomatitis Viruses Are Potent Agents for Intravesical Treatment of High-risk Bladder Cancer
  Cancer Research. Jun, 2008  |   Pubmed ID: 18559493
• Translation of Targeted Oncolytic Virotherapeutics from the Lab into the Clinic, and Back Again: a High-value Iterative Loop
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2008  |   Pubmed ID: 18500240
• Use of a Targeted Oncolytic Poxvirus, JX-594, in Patients with Refractory Primary or Metastatic Liver Cancer: a Phase I Trial
  The Lancet Oncology. Jun, 2008  |   Pubmed ID: 18495536
• Complex Rearrangement of Chromosomes 19, 21, and 22 in Ewing Sarcoma Involving a Novel Reciprocal Inversion-insertion Mechanism of EWS-ERG Fusion Gene Formation: a Case Analysis and Literature Review
  Cancer Genetics and Cytogenetics. Mar, 2008  |   Pubmed ID: 18295659
• Oncolytic Efficacy of Recombinant Vesicular Stomatitis Virus and Myxoma Virus in Experimental Models of Rhabdoid Tumors
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2008  |   Pubmed ID: 18281557
• Translational Control of the Innate Immune Response Through IRF-7
  Nature. Mar, 2008  |   Pubmed ID: 18272964
• Innate Immunity, Tumor Microenvironment and Oncolytic Virus Therapy: Friends or Foes?
  Current Opinion in Molecular Therapeutics. Feb, 2008  |   Pubmed ID: 18228179
• Matrix Protein Mediated Shutdown of Host Cell Metabolism Limits Vesicular Stomatitis Virus-induced Interferon-alpha Responses to Plasmacytoid Dendritic Cells
  Immunobiology. 2007  |   Pubmed ID: 18086387
• Intercellular Trafficking of VP22, a Herpes Simplex Virus Type 1 Tegument Protein
  Iranian Biomedical Journal. Jan, 2007  |   Pubmed ID: 18051705
• Targeted Inflammation During Oncolytic Virus Therapy Severely Compromises Tumor Blood Flow
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2007  |   Pubmed ID: 17579581
• Radioiodide Imaging and Radiovirotherapy of Multiple Myeloma Using VSV(Delta51)-NIS, an Attenuated Vesicular Stomatitis Virus Encoding the Sodium Iodide Symporter Gene
  Blood. Oct, 2007  |   Pubmed ID: 17515401
• Oncolytic Viruses: What's Next?
  Current Cancer Drug Targets. Mar, 2007  |   Pubmed ID: 17346103
• Cell-based Delivery of Oncolytic Viruses: a New Strategic Alliance for a Biological Strike Against Cancer
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2007  |   Pubmed ID: 17264852
• Carrier Cell-based Delivery of an Oncolytic Virus Circumvents Antiviral Immunity
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2007  |   Pubmed ID: 17164783
• Novel Therapeutic Target: the PERKs of Inhibiting the Integrated Stress Response
  Cell Cycle (Georgetown, Tex.). Dec, 2006  |   Pubmed ID: 17218786
• Effects of Intravenously Administered Recombinant Vesicular Stomatitis Virus (VSV(deltaM51)) on Multifocal and Invasive Gliomas
  Journal of the National Cancer Institute. Nov, 2006  |   Pubmed ID: 17077357
• Matrix Protein of Vesicular Stomatitis Virus Harbours a Cryptic Mitochondrial-targeting Motif
  The Journal of General Virology. Nov, 2006  |   Pubmed ID: 17030873
• Perk-dependent Translational Regulation Promotes Tumor Cell Adaptation and Angiogenesis in Response to Hypoxic Stress
  Molecular and Cellular Biology. Dec, 2006  |   Pubmed ID: 17030613
• A Phase 1 Clinical Study of Intravenous Administration of PV701, an Oncolytic Virus, Using Two-step Desensitization
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2006  |   Pubmed ID: 16638865
• Internal Ribosome Entry Site-mediated Translation of Apaf-1, but Not XIAP, is Regulated During UV-induced Cell Death
  The Journal of Biological Chemistry. Jun, 2006  |   Pubmed ID: 16595687
• Recent Progress in the Battle Between Oncolytic Viruses and Tumours
  Nature Reviews. Cancer. Dec, 2005  |   Pubmed ID: 16294217
• Internal Translation Initiation Mediated by the Angiogenic Factor Tie2
  The Journal of Biological Chemistry. Jun, 2005  |   Pubmed ID: 15802272
• Resistance to Vesicular Stomatitis Virus Infection Requires a Functional Cross Talk Between the Eukaryotic Translation Initiation Factor 2alpha Kinases PERK and PKR
  Journal of Virology. Dec, 2004  |   Pubmed ID: 15542627
• Vesicular Stomatitis Virus: a Potential Therapeutic Virus for the Treatment of Hematologic Malignancy
  Human Gene Therapy. Sep, 2004  |   Pubmed ID: 15353037
• Activating Transcription Factor 4 is Translationally Regulated by Hypoxic Stress
  Molecular and Cellular Biology. Sep, 2004  |   Pubmed ID: 15314157
• Vesicular Stomatitis Virus: Re-inventing the Bullet
  Trends in Molecular Medicine. May, 2004  |   Pubmed ID: 15121047
• VSV Strains with Defects in Their Ability to Shutdown Innate Immunity Are Potent Systemic Anti-cancer Agents
  Cancer Cell. Oct, 2003  |   Pubmed ID: 14585354
• Getting Oncolytic Virus Therapies off the Ground
  Cancer Cell. Jul, 2003  |   Pubmed ID: 12892708
• CHD1 Associates with NCoR and Histone Deacetylase As Well As with RNA Splicing Proteins
  Biochemical and Biophysical Research Communications. Aug, 2003  |   Pubmed ID: 12890497
• An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress
  Molecular Cell. Mar, 2003  |   Pubmed ID: 12667446