John C. Schimenti

Publications

• The DNA Damage Checkpoint Eliminates Mouse Oocytes with Chromosome Synapsis Failure
  Molecular Cell. Sep, 2017  |   Pubmed ID: 28844861
• Pharmacological Inhibition of the DNA Damage Checkpoint Prevents Radiation-Induced Oocyte Death
  Genetics. 08, 2017  |   Pubmed ID: 28576861
• Repair of Meiotic DNA Breaks and Homolog Pairing in Mouse Meiosis Requires a Minichromosome Maintenance (MCM) Paralog
  Genetics. 02, 2017  |   Pubmed ID: 27986806
• The Chromatin Remodeling Component Arid1a Is a Suppressor of Spontaneous Mammary Tumors in Mice
  Genetics. 08, 2016  |   Pubmed ID: 27280691
• L. C. Dunn and Donald Charles on Quantitative Traits in the Mouse
  Genetics. Mar, 2016  |   Pubmed ID: 26953264
• Transcriptional Profiling of Cortical Versus Cancellous Bone from Mechanically-loaded Murine Tibiae Reveals Differential Gene Expression
  Bone. May, 2016  |   Pubmed ID: 26876048
• Chronic DNA Replication Stress Reduces Replicative Lifespan of Cells by TRP53-Dependent, MicroRNA-Assisted MCM2-7 Downregulation
  PLoS Genetics. Jan, 2016  |   Pubmed ID: 26765334
• MCM9 Deficiency Delays Primordial Germ Cell Proliferation Independent of the ATM Pathway
  Genesis (New York, N.Y. : 2000). Nov, 2015  |   Pubmed ID: 26388201
• The Genetics of Human Infertility by Functional Interrogation of SNPs in Mice
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2015  |   Pubmed ID: 26240362
• Mechanism and Regulation of Rapid Telomere Prophase Movements in Mouse Meiotic Chromosomes
  Cell Reports. Apr, 2015  |   Pubmed ID: 25892231
• Effects of Deletion of ERα in Osteoblast-Lineage Cells on Bone Mass and Adaptation to Mechanical Loading Differ in Female and Male Mice
  Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Aug, 2015  |   Pubmed ID: 25707500
• Mouse BRWD1 is Critical for Spermatid Postmeiotic Transcription and Female Meiotic Chromosome Stability
  The Journal of Cell Biology. Jan, 2015  |   Pubmed ID: 25547156
• A Mouse Geneticist's Practical Guide to CRISPR Applications
  Genetics. Jan, 2015  |   Pubmed ID: 25271304
• A Method for Isolating High Quality RNA from Mouse Cortical and Cancellous Bone
  Bone. Nov, 2014  |   Pubmed ID: 25073031
• Hypersensitivity of Primordial Germ Cells to Compromised Replication-associated DNA Repair Involves ATM-p53-p21 Signaling
  PLoS Genetics. Jul, 2014  |   Pubmed ID: 25010009
• Applying "gold Standards" to In-vitro-derived Germ Cells
  Cell. Jun, 2014  |   Pubmed ID: 24906145
• Induced Pluripotent Stem Cells Have Similar Immunogenic and More Potent Immunomodulatory Properties Compared with Bone Marrow-derived Stromal Cells in Vitro
  Regenerative Medicine. 2014  |   Pubmed ID: 24773530
• MiR-34 Cooperates with P53 in Suppression of Prostate Cancer by Joint Regulation of Stem Cell Compartment
  Cell Reports. Mar, 2014  |   Pubmed ID: 24630988
• STAG3 is a Strong Candidate Gene for Male Infertility
  Human Molecular Genetics. Jul, 2014  |   Pubmed ID: 24608227
• Reversal of Female Infertility by Chk2 Ablation Reveals the Oocyte DNA Damage Checkpoint Pathway
  Science (New York, N.Y.). Jan, 2014  |   Pubmed ID: 24482479
• IQ Motif-containing G (Iqcg) is Required for Mouse Spermiogenesis
  G3 (Bethesda, Md.). Feb, 2014  |   Pubmed ID: 24362311
• Female Mice Lacking Estrogen Receptor-alpha in Osteoblasts Have Compromised Bone Mass and Strength
  Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Feb, 2014  |   Pubmed ID: 24038209
• Role of DNA Damage Response Pathways in Preventing Carcinogenesis Caused by Intrinsic Replication Stress
  Oncogene. Jul, 2014  |   Pubmed ID: 23975433
• AKAP9 is Essential for Spermatogenesis and Sertoli Cell Maturation in Mice
  Genetics. Jun, 2013  |   Pubmed ID: 23608191
• An Ancient Transcription Factor Initiates the Burst of PiRNA Production During Early Meiosis in Mouse Testes
  Molecular Cell. Apr, 2013  |   Pubmed ID: 23523368
• The MCM8-MCM9 Complex Promotes RAD51 Recruitment at DNA Damage Sites to Facilitate Homologous Recombination
  Molecular and Cellular Biology. Apr, 2013  |   Pubmed ID: 23401855
• Interallelic and Intergenic Incompatibilities of the Prdm9 (Hst1) Gene in Mouse Hybrid Sterility
  PLoS Genetics. 2012  |   Pubmed ID: 23133405
• Meiosis Arrest Female 1 (MARF1) Has Nuage-like Function in Mammalian Oocytes
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2012  |   Pubmed ID: 23090997
• Tissue-specific Functional Networks for Prioritizing Phenotype and Disease Genes
  PLoS Computational Biology. 2012  |   Pubmed ID: 23028291
• Using Genetic Networks and Homology to Understand the Evolution of Phenotypic Traits
  Current Genomics. Mar, 2012  |   Pubmed ID: 22942677
• Genetics of Meiosis and Recombination in Mice
  International Review of Cell and Molecular Biology. 2012  |   Pubmed ID: 22878107
• Genetic Background Affects Induced Pluripotent Stem Cell Generation
  Stem Cell Research & Therapy. Aug, 2012  |   Pubmed ID: 22862934
• Comparative Oncogenomics Implicates the Neurofibromin 1 Gene (NF1) As a Breast Cancer Driver
  Genetics. Oct, 2012  |   Pubmed ID: 22851646
• MARF1 Regulates Essential Oogenic Processes in Mice
  Science (New York, N.Y.). Mar, 2012  |   Pubmed ID: 22442484
• Post-transcriptional Homeostasis and Regulation of MCM2-7 in Mammalian Cells
  Nucleic Acids Research. Jun, 2012  |   Pubmed ID: 22362746
• MCM4 Mutation Causes Adrenal Failure, Short Stature, and Natural Killer Cell Deficiency in Humans
  The Journal of Clinical Investigation. Mar, 2012  |   Pubmed ID: 22354170
• Phosphorylation of Chromosome Core Components May Serve As Axis Marks for the Status of Chromosomal Events During Mammalian Meiosis
  PLoS Genetics. Feb, 2012  |   Pubmed ID: 22346761
• Spata22, a Novel Vertebrate-specific Gene, is Required for Meiotic Progress in Mouse Germ Cells
  Biology of Reproduction. Feb, 2012  |   Pubmed ID: 22011390
• Haploid Embryonic Stem Cells and the Dominance of Recessive Traits
  Cell Stem Cell. Dec, 2011  |   Pubmed ID: 22136917
• Minichromosome Maintenance Helicase Paralog MCM9 is Dispensible for DNA Replication but Functions in Germ-line Stem Cells and Tumor Suppression
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2011  |   Pubmed ID: 21987787
• Genetic Evidence That Synaptonemal Complex Axial Elements Govern Recombination Pathway Choice in Mice
  Genetics. Sep, 2011  |   Pubmed ID: 21750255
• A-MYB (MYBL1) Transcription Factor is a Master Regulator of Male Meiosis
  Development (Cambridge, England). Aug, 2011  |   Pubmed ID: 21750041
• A Reduction of Licensed Origins Reveals Strain-specific Replication Dynamics in Mice
  Mammalian Genome : Official Journal of the International Mammalian Genome Society. Oct, 2011  |   Pubmed ID: 21611832
• Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, As an E3 SUMO Ligase
  Genes. Dec, 2010  |   Pubmed ID: 21779533
• High Resolution Mapping and Positional Cloning of ENU-induced Mutations in the Rw Region of Mouse Chromosome 5
  BMC Genetics. Nov, 2010  |   Pubmed ID: 21118569
• Incremental Genetic Perturbations to MCM2-7 Expression and Subcellular Distribution Reveal Exquisite Sensitivity of Mice to DNA Replication Stress
  PLoS Genetics. Sep, 2010  |   Pubmed ID: 20838603
• The Full-length Isoform of the Mouse Pleckstrin Homology Domain-interacting Protein (PHIP) is Required for Postnatal Growth
  FEBS Letters. Sep, 2010  |   Pubmed ID: 20816727
• PDCD2 is Essential for Inner Cell Mass Development and Embryonic Stem Cell Maintenance
  Developmental Biology. Nov, 2010  |   Pubmed ID: 20813103
• An Allele Separating Skeletal Patterning and Spermatogonial Renewal Functions of PLZF
  BMC Developmental Biology. Mar, 2010  |   Pubmed ID: 20338044
• Deficiency of Suppressor Enhancer Lin12 1 Like (SEL1L) in Mice Leads to Systemic Endoplasmic Reticulum Stress and Embryonic Lethality
  The Journal of Biological Chemistry. Apr, 2010  |   Pubmed ID: 20197277
• SEL1L Deficiency Impairs Growth and Differentiation of Pancreatic Epithelial Cells
  BMC Developmental Biology. Feb, 2010  |   Pubmed ID: 20170518
• Aneuploidy and Improved Growth Are Coincident but Not Causal in a Yeast Cancer Model
  PLoS Biology. Jul, 2009  |   Pubmed ID: 19636358
• Mouse H6 Homeobox 1 (Hmx1) Mutations Cause Cranial Abnormalities and Reduced Body Mass
  BMC Developmental Biology. Apr, 2009  |   Pubmed ID: 19379485
• Development and Use of DNA Archives at Veterinary Teaching Hospitals to Investigate the Genetic Basis of Disease in Dogs
  Journal of the American Veterinary Medical Association. Jan, 2009  |   Pubmed ID: 19119968
• The Dual Bromodomain and WD Repeat-containing Mouse Protein BRWD1 is Required for Normal Spermiogenesis and the Oocyte-embryo Transition
  Developmental Biology. May, 2008  |   Pubmed ID: 18353305
• Mutation in Mouse Hei10, an E3 Ubiquitin Ligase, Disrupts Meiotic Crossing Over
  PLoS Genetics. Aug, 2007  |   Pubmed ID: 17784788
• Mouse Pachytene Checkpoint 2 (trip13) is Required for Completing Meiotic Recombination but Not Synapsis
  PLoS Genetics. Aug, 2007  |   Pubmed ID: 17696610
• Different Regulatory Systems Operate in the Midpiece and Principal Piece of the Mammalian Sperm Flagellum
  Society of Reproduction and Fertility Supplement. 2007  |   Pubmed ID: 17644973
• A Dominant, Recombination-defective Allele of Dmc1 Causing Male-specific Sterility
  PLoS Biology. May, 2007  |   Pubmed ID: 17425408
• Mutation of a Ubiquitously Expressed Mouse Transmembrane Protein (Tapt1) Causes Specific Skeletal Homeotic Transformations
  Genetics. Feb, 2007  |   Pubmed ID: 17151244
• The Translesion DNA Polymerase Theta Plays a Dominant Role in Immunoglobulin Gene Somatic Hypermutation
  The EMBO Journal. Nov, 2005  |   Pubmed ID: 16222339
• Random Mutagenesis of Proximal Mouse Chromosome 5 Uncovers Predominantly Embryonic Lethal Mutations
  Genome Research. Aug, 2005  |   Pubmed ID: 16024820
• The Mouse Genomic Instability Mutation Chaos1 is an Allele of Polq That Exhibits Genetic Interaction with Atm
  Molecular and Cellular Biology. Dec, 2004  |   Pubmed ID: 15542845