John M. Leong Department of Molecular Biology and Microbiology Tufts University School of Medicine Biography Publications Institution JoVE Articles John M. Leong has not added a biography. If you are John M. Leong and would like to personalize this page please email our Author Liaison for assistance. Publications Single Domain Antibodies Against Enteric Pathogen Virulence Factors Are Active As Curli Fiber Fusions on Probiotic E. Coli Nissle 1917 PLoS Pathogens. 09, 2022 | Pubmed ID: 36107831 VlsE, the Nexus for Antigenic Variation of the Lyme Disease Spirochete, Also Mediates Early Bacterial Attachment to the Host Microvasculature Under Shear Force PLoS Pathogens. 05, 2022 | Pubmed ID: 35605029 The Yin and Yang of Pneumolysin During Pneumococcal Infection Frontiers in Immunology. 2022 | Pubmed ID: 35529870 Citrobacter Rodentium(ϕStx2dact), a Murine Infection Model for Enterohemorrhagic Escherichia Coli Current Opinion in Microbiology. 02, 2022 | Pubmed ID: 34929548 Editorial Overview of Pearls Microbiome Series: E Pluribus Unum PLoS Pathogens. 08, 2021 | Pubmed ID: 34464427 Scalable Reporter Assays to Analyze the Regulation of Expression in Shiga Toxin-Producing Enteropathogens Toxins. 07, 2021 | Pubmed ID: 34437405 Host-informed Therapies for the Treatment of Pneumococcal Pneumonia Trends in Molecular Medicine. 10, 2021 | Pubmed ID: 34376327 A Murine Model for Enhancement of Streptococcus Pneumoniae Pathogenicity Upon Viral Infection and Advanced Age Infection and Immunity. 07, 2021 | Pubmed ID: 34031128 Citrobacter Rodentium Lysogenized with a Shiga Toxin-Producing Phage: A Murine Model for Shiga Toxin-Producing E. Coli Infection Methods in Molecular Biology (Clifton, N.J.). 2021 | Pubmed ID: 33704765 Macrophage LC3-associated Phagocytosis is an Immune Defense Against That Diminishes with Host Aging Proceedings of the National Academy of Sciences of the United States of America. 12, 2020 | Pubmed ID: 33376222 Strain-specific Joint Invasion and Colonization by Lyme Disease Spirochetes is Promoted by Outer Surface Protein C PLoS Pathogens. 05, 2020 | Pubmed ID: 32413091 Extracellular Adenosine Enhances the Ability of PMNs to Kill Streptococcus Pneumoniae by Inhibiting IL-10 Production Journal of Leukocyte Biology. 09, 2020 | Pubmed ID: 32017200 Pneumolysin Induces 12-Lipoxygenase-Dependent Neutrophil Migration During Infection Journal of Immunology (Baltimore, Md. : 1950). 01, 2020 | Pubmed ID: 31776202 A1 Adenosine Receptor Signaling Reduces Streptococcus Pneumoniae Adherence to Pulmonary Epithelial Cells by Targeting Expression of Platelet-activating Factor Receptor Cellular Microbiology. 02, 2020 | Pubmed ID: 31709673 Transporters MRP1 and MRP2 Regulate Opposing Inflammatory Signals To Control Transepithelial Neutrophil Migration During Streptococcus Pneumoniae Lung Infection MSphere. 07, 2018 | Pubmed ID: 29976647 Attaching-and-Effacing Pathogens Exploit Junction Regulatory Activities of N-WASP and SNX9 to Disrupt the Intestinal Barrier Cellular and Molecular Gastroenterology and Hepatology. Mar, 2018 | Pubmed ID: 29675452 Nasopharyngeal Exposure to Induces Extended Age-Dependent Protection Against Pulmonary Infection Mediated by Antibodies and CD138 Cells Journal of Immunology (Baltimore, Md. : 1950). 06, 2018 | Pubmed ID: 29661828 Plasticity in Early Immune Evasion Strategies of a Bacterial Pathogen Proceedings of the National Academy of Sciences of the United States of America. 04, 2018 | Pubmed ID: 29610317 Pearls Collections: What We Can Learn About Infectious Disease and Cancer PLoS Pathogens. 03, 2018 | Pubmed ID: 29596508 Correction for Jandhyala Et Al., "Activation of the Classical Mitogen-Activated Protein Kinases Is Part of the Shiga Toxin-Induced Ribotoxic Stress Response and May Contribute to Shiga Toxin-Induced Inflammation" Infection and Immunity. 01, 2018 | Pubmed ID: 29259142 Characterization of Borrelia Burgdorferi Binding to Mammalian Cells and Extracellular Matrix Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29032536 Borrelia Burgdorferi Outer Surface Protein C (OspC) Binds Complement Component C4b and Confers Bloodstream Survival Cellular Microbiology. 12, 2017 | Pubmed ID: 28873507 Cytosolic Phospholipase Aα Promotes Pulmonary Inflammation and Systemic Disease During Streptococcus Pneumoniae Infection Infection and Immunity. 11, 2017 | Pubmed ID: 28808157 Synchronous Disease Kinetics in a Murine Model for Enterohemorrhagic Infection Using Food-Borne Inoculation Frontiers in Cellular and Infection Microbiology. 2016 | Pubmed ID: 27857935 A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response Toxins. 09, 2016 | Pubmed ID: 27598200 Activation of the Classical Mitogen-Activated Protein Kinases Is Part of the Shiga Toxin-Induced Ribotoxic Stress Response and May Contribute to Shiga Toxin-Induced Inflammation Infection and Immunity. 01, 2016 | Pubmed ID: 26483408 Middle Region of the Borrelia Burgdorferi Surface-located Protein 1 (Lmp1) Interacts with Host Chondroitin-6-sulfate and Independently Facilitates Infection Cellular Microbiology. Jan, 2016 | Pubmed ID: 26247174 Extracellular Adenosine Protects Against Streptococcus Pneumoniae Lung Infection by Regulating Pulmonary Neutrophil Recruitment PLoS Pathogens. Aug, 2015 | Pubmed ID: 26313746 Host Cell Heparan Sulfate Glycosaminoglycans Are Ligands for OspF-related Proteins of the Lyme Disease Spirochete Cellular Microbiology. Oct, 2015 | Pubmed ID: 25864455 Integrin Binding by Borrelia Burgdorferi P66 Facilitates Dissemination but is Not Required for Infectivity Cellular Microbiology. Jul, 2015 | Pubmed ID: 25604835 The α-tocopherol Form of Vitamin E Reverses Age-associated Susceptibility to Streptococcus Pneumoniae Lung Infection by Modulating Pulmonary Neutrophil Recruitment Journal of Immunology (Baltimore, Md. : 1950). Feb, 2015 | Pubmed ID: 25512603 Glycosaminoglycan Binding by Borrelia Burgdorferi Adhesin BBK32 Specifically and Uniquely Promotes Joint Colonization Cellular Microbiology. Jun, 2015 | Pubmed ID: 25486989 Effects of Shiga Toxin Type 2 on a Bioengineered Three-dimensional Model of Human Renal Tissue Infection and Immunity. Jan, 2015 | Pubmed ID: 25312954 Strain-specific Variation of the Decorin-binding Adhesin DbpA Influences the Tissue Tropism of the Lyme Disease Spirochete PLoS Pathogens. Jul, 2014 | Pubmed ID: 25079227 Actin Pedestal Formation by Enterohemorrhagic Escherichia Coli Enhances Bacterial Host Cell Attachment and Concomitant Type III Translocation Infection and Immunity. Sep, 2014 | Pubmed ID: 24958711 Identification of Lysine Residues in the Borrelia Burgdorferi DbpA Adhesin Required for Murine Infection Infection and Immunity. Aug, 2014 | Pubmed ID: 24842928 Bacterial RNA:DNA Hybrids Are Activators of the NLRP3 Inflammasome Proceedings of the National Academy of Sciences of the United States of America. May, 2014 | Pubmed ID: 24828532 The Ability of an Attaching and Effacing Pathogen to Trigger Localized Actin Assembly Contributes to Virulence by Promoting Mucosal Attachment Cellular Microbiology. Sep, 2014 | Pubmed ID: 24780054 Shiga Toxin-producing Escherichia Coli O104:H4: an Emerging Pathogen with Enhanced Virulence Infectious Disease Clinics of North America. Sep, 2013 | Pubmed ID: 24011834 A Novel Murine Infection Model for Shiga Toxin-producing Escherichia Coli The Journal of Clinical Investigation. Nov, 2012 | Pubmed ID: 23041631 Enteropathogenic Escherichia Coli and Vaccinia Virus Do Not Require the Family of WASP-interacting Proteins for Pathogen-induced Actin Assembly Infection and Immunity. Dec, 2012 | Pubmed ID: 22966049 TRIF Licenses Caspase-11-dependent NLRP3 Inflammasome Activation by Gram-negative Bacteria Cell. Aug, 2012 | Pubmed ID: 22819539 Membrane-deforming Proteins Play Distinct Roles in Actin Pedestal Biogenesis by Enterohemorrhagic Escherichia Coli The Journal of Biological Chemistry. Jun, 2012 | Pubmed ID: 22544751 Allele- and Tir-independent Functions of Intimin in Diverse Animal Infection Models Frontiers in Microbiology. 2012 | Pubmed ID: 22347213 Enhanced Actin Pedestal Formation by Enterohemorrhagic Escherichia Coli O157:H7 Adapted to the Mammalian Host Frontiers in Microbiology. 2011 | Pubmed ID: 22102844 Calpain Mediates Epithelial Cell Microvillar Effacement by Enterohemorrhagic Escherichia Coli Frontiers in Microbiology. 2011 | Pubmed ID: 22073041 A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness Alexsandra Lenhard*1, Basma H. Joma*2,3, Nalat Siwapornchai2, Anders P. Hakansson4, John M. Leong2,5, Elsa N. Bou Ghanem1 1Department of Microbiology and Immunology, University at Buffalo School of Medicine, 2Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 3Graduate Program in Immunology, Tufts Graduate School of Biomedical Sciences, 4Department of Translational Medicine, Lund University, 5Stuart B. Levy Center for the Integrated Management of Antimicrobial Resistance, Tufts University JoVE 64419 Immunology and Infection
A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness Alexsandra Lenhard*1, Basma H. Joma*2,3, Nalat Siwapornchai2, Anders P. Hakansson4, John M. Leong2,5, Elsa N. Bou Ghanem1 1Department of Microbiology and Immunology, University at Buffalo School of Medicine, 2Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 3Graduate Program in Immunology, Tufts Graduate School of Biomedical Sciences, 4Department of Translational Medicine, Lund University, 5Stuart B. Levy Center for the Integrated Management of Antimicrobial Resistance, Tufts University JoVE 64419 Immunology and Infection
