John S. Condeelis Cancer Dormancy and Tumor Microenvironment Institute Albert Einstein College of Medicine/Montefiore Medical Center Biography Publications Institution JoVE Articles John S. Condeelis has not added a biography. If you are John S. Condeelis and would like to personalize this page please email our Author Liaison for assistance. Publications Racial Disparity in Tumor Microenvironment and Distant Recurrence in Residual Breast Cancer After Neoadjuvant Chemotherapy NPJ Breast Cancer. Jun, 2023 | Pubmed ID: 37311792 Macrophages Promote Tumor Cell Extravasation Across an Endothelial Barrier Through Thin Membranous Connections Cancers. Mar, 2023 | Pubmed ID: 37046751 Cooperative NF-κB and Notch1 Signaling Promotes Macrophage-mediated MenaINV Expression in Breast Cancer Breast Cancer Research : BCR. Apr, 2023 | Pubmed ID: 37024946 Intravital Imaging to Study Cancer Progression and Metastasis Nature Reviews. Cancer. Jan, 2023 | Pubmed ID: 36385560 Interleukin 4 Controls the Pro-Tumoral Role of Macrophages in Mammary Cancer Pulmonary Metastasis in Mice Cancers. Sep, 2022 | Pubmed ID: 36077870 Assessment of MRI to Estimate Metastatic Dissemination Risk and Prometastatic Effects of Chemotherapy NPJ Breast Cancer. Sep, 2022 | Pubmed ID: 36056005 Racial Disparity in Distant Recurrence-free Survival in Patients with Localized Breast Cancer: A Pooled Analysis of National Surgical Adjuvant Breast and Bowel Project Trials Cancer. Jul, 2022 | Pubmed ID: 35578919 Combining TMEM Doorway Score and Mena Score Improves the Prediction of Distant Recurrence Risk in HR+/HER2- Breast Cancer Patients Cancers. Apr, 2022 | Pubmed ID: 35565297 Primary Tumor Associated Macrophages Activate Programs of Invasion and Dormancy in Disseminating Tumor Cells Nature Communications. Feb, 2022 | Pubmed ID: 35110548 Validation of an Automated Quantitative Digital Pathology Approach for Scoring TMEM, a Prognostic Biomarker for Metastasis Cancers. Mar, 2020 | Pubmed ID: 32244564 Black Race and Distant Recurrence After Neoadjuvant or Adjuvant Chemotherapy in Breast Cancer Clinical & Experimental Metastasis. 10, 2018 | Pubmed ID: 30136072 Signatures of Breast Cancer Metastasis at a Glance Journal of Cell Science. May, 2016 | Pubmed ID: 27084578 GPCR Signaling Mediates Tumor Metastasis Via PI3Kβ Cancer Research. May, 2016 | Pubmed ID: 27013201 3-D Individual Cell Based Computational Modeling of Tumor Cell-macrophage Paracrine Signaling Mediated by EGF and CSF-1 Gradients Integrative Biology : Quantitative Biosciences from Nano to Macro. Jan, 2016 | Pubmed ID: 26686751 Characterization of the Expression of the Pro-metastatic Mena(INV) Isoform During Breast Tumor Progression Clinical & Experimental Metastasis. Mar, 2016 | Pubmed ID: 26680363 PTP1B-dependent Regulation of Receptor Tyrosine Kinase Signaling by the Actin-binding Protein Mena Molecular Biology of the Cell. Nov, 2015 | Pubmed ID: 26337385 Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA Cancer Discovery. Sep, 2015 | Pubmed ID: 26269515 Menacalc, a Quantitative Method of Metastasis Assessment, As a Prognostic Marker for Axillary Node-negative Breast Cancer BMC Cancer. 2015 | Pubmed ID: 26112005 Invasive Breast Carcinoma Cells from Patients Exhibit MenaINV- and Macrophage-dependent Transendothelial Migration Science Signaling. Nov, 2014 | Pubmed ID: 25429076 An in Vitro One-dimensional Assay to Study Growth Factor-regulated Tumor Cell-macrophage Interaction Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 24908299 Metastatic Cells: Moving Onco-targets Oncotarget. Jun, 2014 | Pubmed ID: 24907202 Tumor Microenvironment of Metastasis and Risk of Distant Metastasis of Breast Cancer Journal of the National Cancer Institute. Aug, 2014 | Pubmed ID: 24895374 Invadopodia in Context Cell Adhesion & Migration. 2014 | Pubmed ID: 24713806 Spatial Regulation of Tumor Cell Protrusions by RhoC Cell Adhesion & Migration. 2014 | Pubmed ID: 24642482 Filamin A Interacting Protein 1-like Inhibits WNT Signaling and MMP Expression to Suppress Cancer Cell Invasion and Metastasis International Journal of Cancer. Jul, 2014 | Pubmed ID: 24327474 Intravital Multiphoton Imaging Reveals Multicellular Streaming As a Crucial Component of in Vivo Cell Migration in Human Breast Tumors Intravital. Apr, 2013 | Pubmed ID: 25013744 Wiskott-Aldrich Syndrome Protein Regulates Leukocyte-dependent Breast Cancer Metastasis Cell Reports. Aug, 2013 | Pubmed ID: 23911287 Dysregulation of PAD4-mediated Citrullination of Nuclear GSK3β Activates TGF-β Signaling and Induces Epithelial-to-mesenchymal Transition in Breast Cancer Cells Proceedings of the National Academy of Sciences of the United States of America. Jul, 2013 | Pubmed ID: 23818587 Development Path and Current Status of the NANIVID: a New Device for Cancer Cell Studies Journal of Micro/nanolithography, MEMS, and MOEMS : JM3. Mar, 2012 | Pubmed ID: 25419258 Reconstitution of in Vivo Macrophage-tumor Cell Pairing and Streaming Motility on One-dimensional Micro-patterned Substrates Intravital. Jul, 2012 | Pubmed ID: 24634804 Selective Gene-expression Profiling of Migratory Tumor Cells in Vivo Predicts Clinical Outcome in Breast Cancer Patients Breast Cancer Research : BCR. 2012 | Pubmed ID: 23113900 Quantitative Assessment of Invasive Mena Isoforms (Menacalc) As an Independent Prognostic Marker in Breast Cancer Breast Cancer Research : BCR. 2012 | Pubmed ID: 22971274 A FRET-facilitated Photoswitching Using an Orange Fluorescent Protein with the Fast Photoconversion Kinetics Journal of the American Chemical Society. Sep, 2012 | Pubmed ID: 22900938 Three-dimensional Microfluidic Model for Tumor Cell Intravasation and Endothelial Barrier Function Proceedings of the National Academy of Sciences of the United States of America. Aug, 2012 | Pubmed ID: 22869695 Correlated Immunohistochemical and Cytological Assays for the Prediction of Hematogenous Dissemination of Breast Cancer The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Jan, 2012 | Pubmed ID: 22215635 Opposing Roles of CXCR4 and CXCR7 in Breast Cancer Metastasis Breast Cancer Research : BCR. Dec, 2011 | Pubmed ID: 22152016 An EMT-driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype PLoS Genetics. Aug, 2011 | Pubmed ID: 21876675 A Photoswitchable Orange-to-far-red Fluorescent Protein, PSmOrange Nature Methods. Sep, 2011 | Pubmed ID: 21804536 Chemotaxis in Cancer Nature Reviews. Cancer. Aug, 2011 | Pubmed ID: 21779009 Mena Invasive (MenaINV) Promotes Multicellular Streaming Motility and Transendothelial Migration in a Mouse Model of Breast Cancer Journal of Cell Science. Jul, 2011 | Pubmed ID: 21670198 Mena Invasive (Mena(INV)) and Mena11a Isoforms Play Distinct Roles in Breast Cancer Cell Cohesion and Association with TMEM Clinical & Experimental Metastasis. Aug, 2011 | Pubmed ID: 21484349 Mena Deficiency Delays Tumor Progression and Decreases Metastasis in Polyoma Middle-T Transgenic Mouse Mammary Tumors Breast Cancer Research : BCR. 2010 | Pubmed ID: 21108830 A New Chemotaxis Device for Cell Migration Studies Integrative Biology : Quantitative Biosciences from Nano to Macro. Nov, 2010 | Pubmed ID: 20938544 AACR Special Conference on Epithelial-mesenchymal Transition and Cancer Progression and Treatment Cancer Research. Oct, 2010 | Pubmed ID: 20823151 Gene Expression Analysis of Macrophages That Facilitate Tumor Invasion Supports a Role for Wnt-signaling in Mediating Their Activity in Primary Mammary Tumors Journal of Immunology (Baltimore, Md. : 1950). Jan, 2010 | Pubmed ID: 20018620 Invasion of Human Breast Cancer Cells in Vivo Requires Both Paracrine and Autocrine Loops Involving the Colony-stimulating Factor-1 Receptor Cancer Research. Dec, 2009 | Pubmed ID: 19934330 Differential Enhancement of Breast Cancer Cell Motility and Metastasis by Helical and Kinase Domain Mutations of Class IA Phosphoinositide 3-kinase Cancer Research. Dec, 2009 | Pubmed ID: 19903845 Tumor Microenvironment of Metastasis in Human Breast Carcinoma: a Potential Prognostic Marker Linked to Hematogenous Dissemination Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2009 | Pubmed ID: 19318480 Identification of Invasion Specific Splice Variants of the Cytoskeletal Protein Mena Present in Mammary Tumor Cells During Invasion in Vivo Clinical & Experimental Metastasis. 2009 | Pubmed ID: 18985426 A Mena Invasion Isoform Potentiates EGF-induced Carcinoma Cell Invasion and Metastasis Developmental Cell. Dec, 2008 | Pubmed ID: 19081071 Mechanisms and Cellular Roles of Local Protein Synthesis in Mammalian Cells Current Opinion in Cell Biology. Apr, 2008 | Pubmed ID: 18378131 RhoA/ROCK-mediated Switching Between Cdc42- and Rac1-dependent Protrusion in MTLn3 Carcinoma Cells Experimental Cell Research. Apr, 2008 | Pubmed ID: 18316075 Imaging Real-time Gene Expression in Living Systems with Single-transcript Resolution: Construct Design and Imaging System Setup CSH Protocols. 2007 | Pubmed ID: 21356986 Imaging Real-Time Gene Expression in Living Systems with Single-Transcript Resolution: Single MRNA Particle Tracking with ImageJ-Based Analysis CSH Protocols. 2007 | Pubmed ID: 21356980 Imaging Real-time Gene Expression in Living Systems with Single-transcript Resolution: Image Analysis of Single MRNA Transcripts CSH Protocols. 2007 | Pubmed ID: 21356979 Imaging Real-time Gene Expression in Living Yeast CSH Protocols. 2007 | Pubmed ID: 21356978 Imaging Real-time Gene Expression in Mammalian Cells with Single-transcript Resolution CSH Protocols. 2007 | Pubmed ID: 21356977 EGF-induced PIP2 Hydrolysis Releases and Activates Cofilin Locally in Carcinoma Cells The Journal of Cell Biology. Dec, 2007 | Pubmed ID: 18086920 ZBP1 Enhances Cell Polarity and Reduces Chemotaxis Journal of Cell Science. Sep, 2007 | Pubmed ID: 17878234 Cdc42 is Required for EGF-stimulated Protrusion and Motility in MTLn3 Carcinoma Cells Journal of Cell Science. Oct, 2007 | Pubmed ID: 17855387 The Distinct Roles of Ras and Rac in PI 3-kinase-dependent Protrusion During EGF-stimulated Cell Migration Journal of Cell Science. Sep, 2007 | Pubmed ID: 17698922 Coordinated Regulation of Pathways for Enhanced Cell Motility and Chemotaxis is Conserved in Rat and Mouse Mammary Tumors Cancer Research. Apr, 2007 | Pubmed ID: 17440055 Molecular Cloning of HMena (ENAH) and Its Splice Variant HMena+11a: Epidermal Growth Factor Increases Their Expression and Stimulates HMena+11a Phosphorylation in Breast Cancer Cell Lines Cancer Research. Mar, 2007 | Pubmed ID: 17363586 ROCK- and Myosin-dependent Matrix Deformation Enables Protease-independent Tumor-cell Invasion in Vivo Current Biology : CB. Aug, 2006 | Pubmed ID: 16890527 Initiation of Cofilin Activity in Response to EGF is Uncoupled from Cofilin Phosphorylation and Dephosphorylation in Carcinoma Cells Journal of Cell Science. Jul, 2006 | Pubmed ID: 16803871 The Activity Status of Cofilin is Directly Related to Invasion, Intravasation, and Metastasis of Mammary Tumors The Journal of Cell Biology. May, 2006 | Pubmed ID: 16651380 Macrophages Promote the Invasion of Breast Carcinoma Cells Via a Colony-stimulating Factor-1/epidermal Growth Factor Paracrine Loop Cancer Research. Jun, 2005 | Pubmed ID: 15958574 Tumor Cells Caught in the Act of Invading: Their Strategy for Enhanced Cell Motility Trends in Cell Biology. Mar, 2005 | Pubmed ID: 15752977 Identification and Testing of a Gene Expression Signature of Invasive Carcinoma Cells Within Primary Mammary Tumors Cancer Research. Dec, 2004 | Pubmed ID: 15574765 Breast Cancer Cells Isolated by Chemotaxis from Primary Tumors Show Increased Survival and Resistance to Chemotherapy Cancer Research. Nov, 2004 | Pubmed ID: 15520165 Over-expression of the P110beta but Not P110alpha Isoform of PI 3-kinase Inhibits Motility in Breast Cancer Cells Cell Motility and the Cytoskeleton. Nov, 2004 | Pubmed ID: 15468162 Cofilin Promotes Actin Polymerization and Defines the Direction of Cell Motility Science (New York, N.Y.). Apr, 2004 | Pubmed ID: 15118165 Gene Expression Analysis on Small Numbers of Invasive Cells Collected by Chemotaxis from Primary Mammary Tumors of the Mouse BMC Biotechnology. Aug, 2003 | Pubmed ID: 12914671 GFP Expression in the Mammary Gland for Imaging of Mammary Tumor Cells in Transgenic Mice Cancer Research. Dec, 2002 | Pubmed ID: 12499251 Single Cell Behavior in Metastatic Primary Mammary Tumors Correlated with Gene Expression Patterns Revealed by Molecular Profiling Cancer Research. Nov, 2002 | Pubmed ID: 12414658 A New Strategy for Caging Proteins Regulated by Kinases Journal of the American Chemical Society. Mar, 2002 | Pubmed ID: 11890784 Author Spotlight: Decoding Metastasis-to-Metastasis Seeding Using a New In Vivo Technique for Tracking Breast Cancer Spread (Video) | JoVE Madeline Friedman-DeLuca1,2, Prachiben P. Patel1,2, Burcu Karadal-Ferrena1,2, Nicole D. Barth1,2, Camille L. Duran1,2, Xianjun Ye1,2,3, Michael Papanicolaou2,4, John S. Condeelis2,3,4,5,6,7, Maja H. Oktay1,2,3,5,6,7, Lucia Borriello*1,2,8, David Entenberg*1,2,3,5,6 1Department of Pathology, Albert Einstein College of Medicine/Montefiore Medical Center, 2Cancer Dormancy and Tumor Microenvironment Institute, Albert Einstein College of Medicine/Montefiore Medical Center, 3Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine/Montefiore Medical Center, 4Department of Cell Biology, Albert Einstein College of Medicine/Montefiore Medical Center, 5Montefiore Einstein Cancer Center, Albert Einstein College of Medicine/Montefiore Medical Center, 6Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine/Montefiore Medical Center, 7Department of Surgery, Albert Einstein College of Medicine/Montefiore Medical Center, 8Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Fox Chase Cancer Center JoVE 65732 Cancer Research De longo prazo de alta resolução Intravital Microscopia no pulmão com um vácuo estabilizado Janela de imagem Carolina Rodriguez-Tirado1, Takanori Kitamura5, Yu Kato1,2, Jeffery W. Pollard1,2,5, John S. Condeelis3,4, David Entenberg3,4 1Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 2Department of Obstetrics/Gynecology and Woman’s Health, Albert Einstein College of Medicine, 3Department of Anatomy & Structural Biology, Albert Einstein College of Medicine, 4Gruss-Lipper Biophotonics Center Integrated Imaging Program, Albert Einstein College of Medicine, 5Medical Research Council Centre for Reproductive Health, Queen’s Medical Research Institute, University of Edinburgh Cancer Research Estendida Time-lapse Imagem intravital do Real-time multicelular Dynamics no microambiente tumoral Allison S. Harney1,2,3,4, Yarong Wang1,3, John S. Condeelis1,3,4, David Entenberg1,3,4 1Department of Anatomy & Structural Biology, Albert Einstein College of Medicine, 2Department of Radiology, Albert Einstein College of Medicine, 3Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, 4Integrated Imaging Program, Albert Einstein College of Medicine JoVE 54042 Medicine
Author Spotlight: Decoding Metastasis-to-Metastasis Seeding Using a New In Vivo Technique for Tracking Breast Cancer Spread (Video) | JoVE Madeline Friedman-DeLuca1,2, Prachiben P. Patel1,2, Burcu Karadal-Ferrena1,2, Nicole D. Barth1,2, Camille L. Duran1,2, Xianjun Ye1,2,3, Michael Papanicolaou2,4, John S. Condeelis2,3,4,5,6,7, Maja H. Oktay1,2,3,5,6,7, Lucia Borriello*1,2,8, David Entenberg*1,2,3,5,6 1Department of Pathology, Albert Einstein College of Medicine/Montefiore Medical Center, 2Cancer Dormancy and Tumor Microenvironment Institute, Albert Einstein College of Medicine/Montefiore Medical Center, 3Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine/Montefiore Medical Center, 4Department of Cell Biology, Albert Einstein College of Medicine/Montefiore Medical Center, 5Montefiore Einstein Cancer Center, Albert Einstein College of Medicine/Montefiore Medical Center, 6Integrated Imaging Program for Cancer Research, Albert Einstein College of Medicine/Montefiore Medical Center, 7Department of Surgery, Albert Einstein College of Medicine/Montefiore Medical Center, 8Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Fox Chase Cancer Center JoVE 65732 Cancer Research
De longo prazo de alta resolução Intravital Microscopia no pulmão com um vácuo estabilizado Janela de imagem Carolina Rodriguez-Tirado1, Takanori Kitamura5, Yu Kato1,2, Jeffery W. Pollard1,2,5, John S. Condeelis3,4, David Entenberg3,4 1Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 2Department of Obstetrics/Gynecology and Woman’s Health, Albert Einstein College of Medicine, 3Department of Anatomy & Structural Biology, Albert Einstein College of Medicine, 4Gruss-Lipper Biophotonics Center Integrated Imaging Program, Albert Einstein College of Medicine, 5Medical Research Council Centre for Reproductive Health, Queen’s Medical Research Institute, University of Edinburgh Cancer Research
Estendida Time-lapse Imagem intravital do Real-time multicelular Dynamics no microambiente tumoral Allison S. Harney1,2,3,4, Yarong Wang1,3, John S. Condeelis1,3,4, David Entenberg1,3,4 1Department of Anatomy & Structural Biology, Albert Einstein College of Medicine, 2Department of Radiology, Albert Einstein College of Medicine, 3Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, 4Integrated Imaging Program, Albert Einstein College of Medicine JoVE 54042 Medicine
