John Arcaroli

Publications

• Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2
  Journal of the National Cancer Institute. Jan, 2017  |   Pubmed ID: 27634934
• Antitumor Activity of the Aurora a Selective Kinase Inhibitor, Alisertib, Against Preclinical Models of Colorectal Cancer
  Oncotarget. Jul, 2016  |   Pubmed ID: 27385211
• The Novel Tankyrase Inhibitor (AZ1366) Enhances Irinotecan Activity in Tumors That Exhibit Elevated Tankyrase and Irinotecan Resistance
  Oncotarget. May, 2016  |   Pubmed ID: 27070088
• Aldehyde Dehydrogenase 1B1 As a Modulator of Pancreatic Adenocarcinoma
  Pancreas. Jan, 2016  |   Pubmed ID: 26566217
• A NOTCH1 Gene Copy Number Gain is a Prognostic Indicator of Worse Survival and a Predictive Biomarker to a Notch1 Targeting Antibody in Colorectal Cancer
  International Journal of Cancer. Jan, 2016  |   Pubmed ID: 26152787
• Antitumor Activity of a Potent MEK Inhibitor, TAK-733, Against Colorectal Cancer Cell Lines and Patient Derived Xenografts
  Oncotarget. Oct, 2015  |   Pubmed ID: 26439693
• Targeting the WNT Signaling Pathway in Cancer Therapeutics
  The Oncologist. Oct, 2015  |   Pubmed ID: 26306903
• Combined Inhibition of MEK and Aurora A Kinase in KRAS/PIK3CA Double-mutant Colorectal Cancer Models
  Frontiers in Pharmacology. 2015  |   Pubmed ID: 26136684
• ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/β-Catenin, Notch and PI3K/Akt Signaling Pathways
  PloS One. 2015  |   Pubmed ID: 25950950
• Potent Antitumor Activity of Cabozantinib, a C-MET and VEGFR2 Inhibitor, in a Colorectal Cancer Patient-derived Tumor Explant Model
  International Journal of Cancer. Apr, 2015  |   Pubmed ID: 25242168
• Dual Pharmacological Targeting of the MAP Kinase and PI3K/mTOR Pathway in Preclinical Models of Colorectal Cancer
  PloS One. 2014  |   Pubmed ID: 25401499
• An Improved High Yield Total Synthesis and Cytotoxicity Study of the Marine Alkaloid Neoamphimedine: an ATP-competitive Inhibitor of Topoisomerase IIα and Potent Anticancer Agent
  Marine Drugs. Sep, 2014  |   Pubmed ID: 25244109
• A Phase II Study of the Gamma Secretase Inhibitor RO4929097 in Patients with Previously Treated Metastatic Pancreatic Adenocarcinoma
  Investigational New Drugs. Aug, 2014  |   Pubmed ID: 24668033
• Hsa-miR29b, a Critical Downstream Target of Non-canonical Wnt Signaling, Plays an Anti-proliferative Role in Non-small Cell Lung Cancer Cells Via Targeting MDM2 Expression
  Biology Open. Jul, 2013  |   Pubmed ID: 23862015
• Rational Combination of a MEK Inhibitor, Selumetinib, and the Wnt/calcium Pathway Modulator, Cyclosporin A, in Preclinical Models of Colorectal Cancer
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2013  |   Pubmed ID: 23757356
• A Patient Tumor Transplant Model of Squamous Cell Cancer Identifies PI3K Inhibitors As Candidate Therapeutics in Defined Molecular Bins
  Molecular Oncology. Aug, 2013  |   Pubmed ID: 23607916
• Association of the Epithelial-to-mesenchymal Transition Phenotype with Responsiveness to the P21-activated Kinase Inhibitor, PF-3758309, in Colon Cancer Models
  Frontiers in Pharmacology. 2013  |   Pubmed ID: 23543898
• Phase I Pharmacokinetic and Pharmacodynamic Study of Cetuximab, Irinotecan and Sorafenib in Advanced Colorectal Cancer
  Investigational New Drugs. Apr, 2013  |   Pubmed ID: 22615057
• Biomarker-driven Trial in Metastatic Pancreas Cancer: Feasibility in a Multicenter Study of Saracatinib, an Oral Src Inhibitor, in Previously Treated Pancreatic Cancer
  Cancer Medicine. Oct, 2012  |   Pubmed ID: 23342270
• Stromal Cell-derived Factor 1α Mediates Resistance to MTOR-directed Therapy in Pancreatic Cancer
  Neoplasia (New York, N.Y.). Aug, 2012  |   Pubmed ID: 22952422
• Common PIK3CA Mutants and a Novel 3' UTR Mutation Are Associated with Increased Sensitivity to Saracatinib
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2012  |   Pubmed ID: 22553375
• ALDH+ Tumor-initiating Cells Exhibiting Gain in NOTCH1 Gene Copy Number Have Enhanced Regrowth Sensitivity to a γ-secretase Inhibitor and Irinotecan in Colorectal Cancer
  Molecular Oncology. Jun, 2012  |   Pubmed ID: 22521243
• Patient-derived Tumour Xenografts As Models for Oncology Drug Development
  Nature Reviews. Clinical Oncology. Jun, 2012  |   Pubmed ID: 22508028
• Similarity-based Multimarker Association Tests for Continuous Traits
  Annals of Human Genetics. May, 2012  |   Pubmed ID: 22497480
• Preclinical Activity of the Rational Combination of Selumetinib (AZD6244) in Combination with Vorinostat in KRAS-mutant Colorectal Cancer Models
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2012  |   Pubmed ID: 22173548
• Association Between IL-32 Genotypes and Outcome in Infection-associated Acute Lung Injury
  Critical Care (London, England). 2011  |   Pubmed ID: 21649914
• Identification of Predictive Markers of Response to the MEK1/2 Inhibitor Selumetinib (AZD6244) in K-ras-mutated Colorectal Cancer
  Molecular Cancer Therapeutics. Dec, 2010  |   Pubmed ID: 20923857
• Gene Array and Fluorescence in Situ Hybridization Biomarkers of Activity of Saracatinib (AZD0530), a Src Inhibitor, in a Preclinical Model of Colorectal Cancer
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2010  |   Pubmed ID: 20682712
• Extracellular Superoxide Dismutase Haplotypes Are Associated with Acute Lung Injury and Mortality
  American Journal of Respiratory and Critical Care Medicine. Jan, 2009  |   Pubmed ID: 18948423
• Association Between Urokinase Haplotypes and Outcome from Infection-associated Acute Lung Injury
  Intensive Care Medicine. Feb, 2008  |   Pubmed ID: 17994220
• HMGB1 and LPS Induce Distinct Patterns of Gene Expression and Activation in Neutrophils from Patients with Sepsis-induced Acute Lung Injury
  Intensive Care Medicine. Oct, 2007  |   Pubmed ID: 17581740
• Variant IRAK-1 Haplotype is Associated with Increased Nuclear Factor-kappaB Activation and Worse Outcomes in Sepsis
  American Journal of Respiratory and Critical Care Medicine. Jun, 2006  |   Pubmed ID: 16528020
• Genetic Polymorphisms and Sepsis
  Shock (Augusta, Ga.). Oct, 2005  |   Pubmed ID: 16205313
• Hemorrhage-induced Acute Lung Injury is TLR-4 Dependent
  American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Sep, 2004  |   Pubmed ID: 15072965
• Modulation of Bone Marrow-derived Neutrophil Signaling by H2O2: Disparate Effects on Kinases, NF-kappaB, and Cytokine Expression
  American Journal of Physiology. Cell Physiology. Mar, 2004  |   Pubmed ID: 14656721
• Urokinase-type Plasminogen Activator Potentiates Lipopolysaccharide-induced Neutrophil Activation
  Journal of Immunology (Baltimore, Md. : 1950). Jun, 2003  |   Pubmed ID: 12759445
• Early Alterations in Neutrophil Activation Are Associated with Outcome in Acute Lung Injury
  American Journal of Respiratory and Critical Care Medicine. Jun, 2003  |   Pubmed ID: 12626346
• Activation of Gene Expression in Human Neutrophils by High Mobility Group Box 1 Protein
  American Journal of Physiology. Cell Physiology. Apr, 2003  |   Pubmed ID: 12620891
• Evidence for Extracellular Superoxide Dismutase As a Mediator of Hemorrhage-induced Lung Injury
  American Journal of Physiology. Lung Cellular and Molecular Physiology. Apr, 2003  |   Pubmed ID: 12618426
• Involvement of Phosphatidylinositol 3-kinase Gamma in Neutrophil Apoptosis
  Cellular Signalling. Feb, 2003  |   Pubmed ID: 12464394
• Effects of Catecholamines on Kinase Activation in Lung Neutrophils After Hemorrhage or Endotoxemia
  Journal of Leukocyte Biology. Sep, 2002  |   Pubmed ID: 12223526
• Lipopolysaccharide-induced Neutrophil Gene Expression Under in Vivo or in Vitro Conditions
  Chest. Mar, 2002  |   Pubmed ID: 11893694