Jonathan W. Astin Department of Molecular Medicine and Pathology The University of Auckland Biography Publications Institution JoVE Articles Jonathan W. Astin My research focuses on understanding how vascular development is regulated. My research utilises the zebrafish model of vertebrate development which has transgenic tools that allow us to visualise the developing lymphatic and blood vessels. We couple high-resolution in vivo imaging with both forward and reverse genetics, to uncover how blood and lymphatic vessels form in the developing embryo. Publications Zebrafish Facial Lymphatics Develop Through Sequential Addition of Venous and Non-venous Progenitors EMBO Reports. May, 2019 | Pubmed ID: 30877134 Liposome-Mediated Drug Delivery in Larval Zebrafish to Manipulate Macrophage Function Zebrafish. Apr, 2019 | Pubmed ID: 30724716 Macrophages Enhance Vegfa-driven Angiogenesis in an Embryonic Zebrafish Tumour Xenograft Model Disease Models & Mechanisms. 11, 2018 | Pubmed ID: 30396905 Characterization of Zebrafish Facial Lymphatics Methods in Molecular Biology (Clifton, N.J.). Month, 2018 | Pubmed ID: 30242753 Blocking Fatty Acid-fueled MROS Production Within Macrophages Alleviates Acute Gouty Inflammation The Journal of Clinical Investigation. May, 2018 | Pubmed ID: 29584621 The Innate Immune Cell Response to Bacterial Infection in Larval Zebrafish is Light-regulated Scientific Reports. 10, 2017 | Pubmed ID: 28978916 Lymphatics, Cancer and Zebrafish Advances in Experimental Medicine and Biology. Month, 2016 | Pubmed ID: 27165355 A Zebrafish Model of Inflammatory Lymphangiogenesis Biology Open. Sep, 2015 | Pubmed ID: 26369931 Mafba is a Downstream Transcriptional Effector of Vegfc Signaling Essential for Embryonic Lymphangiogenesis in Zebrafish Genes & Development. Aug, 2015 | Pubmed ID: 26253536 An Inducible Transgene Reports Activation of Macrophages in Live Zebrafish Larvae Developmental and Comparative Immunology. Nov, 2015 | Pubmed ID: 26123890 An in Vivo Antilymphatic Screen in Zebrafish Identifies Novel Inhibitors of Mammalian Lymphangiogenesis and Lymphatic-mediated Metastasis Molecular Cancer Therapeutics. Oct, 2014 | Pubmed ID: 25053822 Vegfd Can Compensate for Loss of Vegfc in Zebrafish Facial Lymphatic Sprouting Development (Cambridge, England). Jul, 2014 | Pubmed ID: 24903752 Pkd1 Regulates Lymphatic Vascular Morphogenesis During Development Cell Reports. May, 2014 | Pubmed ID: 24767999 Immunoresponsive Gene 1 Augments Bactericidal Activity of Macrophage-lineage Cells by Regulating β-oxidation-dependent Mitochondrial ROS Production Cell Metabolism. Aug, 2013 | Pubmed ID: 23931757 Lyve1 Expression Reveals Novel Lymphatic Vessels and New Mechanisms for Lymphatic Vessel Development in Zebrafish Development (Cambridge, England). Jul, 2012 | Pubmed ID: 22627281 DMXAA (Vadimezan, ASA404) is a Multi-kinase Inhibitor Targeting VEGFR2 in Particular Clinical Science (London, England : 1979). May, 2012 | Pubmed ID: 22142330 Imaging in vivo e quantitazione dell'ospite risposta angiogenica in Xenogrfts tumore zebrati Denver D. Britto1, Christopher J. Hall1, Jonathan W. Astin1 1Department of Molecular Medicine and Pathology, School of Medical Sciences, University of Auckland JoVE 59849 Cancer Research
Imaging in vivo e quantitazione dell'ospite risposta angiogenica in Xenogrfts tumore zebrati Denver D. Britto1, Christopher J. Hall1, Jonathan W. Astin1 1Department of Molecular Medicine and Pathology, School of Medical Sciences, University of Auckland JoVE 59849 Cancer Research
