Joseph A. Trapani

Publications

• TRAIL(+) NK Cells Control CD4(+) T Cell Responses During Chronic Viral Infection to Limit Autoimmunity
  Immunity. Oct, 2014  |   Pubmed ID: 25367576
• A Method for Detecting Intracellular Perforin in Mouse Lymphocytes
  Journal of Immunology (Baltimore, Md. : 1950). Dec, 2014  |   Pubmed ID: 25348626
• Granzyme H is a Novel Protease Expressed by Human Mast Cells
  International Archives of Allergy and Immunology. 2014  |   Pubmed ID: 25342632
• The Perforin Pore Facilitates the Delivery of Cationic Cargos
  The Journal of Biological Chemistry. Mar, 2014  |   Pubmed ID: 24558045
• B-CLL Cells Acquire APC- and CTL-like Phenotypic Characteristics After Stimulation with CpG ODN and IL-21
  International Immunology. Jul, 2014  |   Pubmed ID: 24497611
• Perforinopathy: a Spectrum of Human Immune Disease Caused by Defective Perforin Delivery or Function
  Frontiers in Immunology. 2013  |   Pubmed ID: 24376445
• Exploration of a Series of 5-arylidene-2-thioxoimidazolidin-4-ones As Inhibitors of the Cytolytic Protein Perforin
  Journal of Medicinal Chemistry. Dec, 2013  |   Pubmed ID: 24195776
• Defining the Interaction of Perforin with Calcium and the Phospholipid Membrane
  The Biochemical Journal. Dec, 2013  |   Pubmed ID: 24070258
• Rapid and Unidirectional Perforin Pore Delivery at the Cytotoxic Immune Synapse
  Journal of Immunology (Baltimore, Md. : 1950). Sep, 2013  |   Pubmed ID: 23885110
• Persistence and Efficacy of Second Generation CAR T Cell Against the LeY Antigen in Acute Myeloid Leukemia
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2013  |   Pubmed ID: 23831595
• Human Perforin Mutations and Susceptibility to Multiple Primary Cancers
  Oncoimmunology. Apr, 2013  |   Pubmed ID: 23734337
• Cloning and Characterising an Unusual Perforin from Chicken (Gallus Gallus)
  Developmental and Comparative Immunology. Oct, 2013  |   Pubmed ID: 23680640
• Perforin Forms Transient Pores on the Target Cell Plasma Membrane to Facilitate Rapid Access of Granzymes During Killer Cell Attack
  Blood. Apr, 2013  |   Pubmed ID: 23377437
• Surprisingly Variable "dangers, Toils, and Snares" Faced by Humans and Mice
  Blood. Jan, 2013  |   Pubmed ID: 23349371
• Granzyme B is Dispensable in the Development of Diabetes in Non-obese Diabetic Mice
  PloS One. 2012  |   Pubmed ID: 22792290
• A Novel Role for Granzymes in Anti-tumor Immunity
  Oncoimmunology. Mar, 2012  |   Pubmed ID: 22720248
• Protecting a Serial Killer: Pathways for Perforin Trafficking and Self-defence Ensure Sequential Target Cell Death
  Trends in Immunology. Aug, 2012  |   Pubmed ID: 22608996
• Perforin Evolved from a Gene Duplication of MPEG1, Followed by a Complex Pattern of Gene Gain and Loss Within Euteleostomi
  BMC Evolutionary Biology. 2012  |   Pubmed ID: 22551122
• Activated Mouse B Cells Lack Expression of Granzyme B
  Journal of Immunology (Baltimore, Md. : 1950). Apr, 2012  |   Pubmed ID: 22427643
• Inhibition of the Pore-forming Protein Perforin by a Series of Aryl-substituted Isobenzofuran-1(3H)-ones
  Bioorganic & Medicinal Chemistry. Feb, 2012  |   Pubmed ID: 22244072
• Fatal Immune Dysregulation Due to a Gain of Glycosylation Mutation in Lymphocyte Perforin
  Blood. Feb, 2012  |   Pubmed ID: 22186995
• A Critical Role for Granzymes in Antigen Cross-presentation Through Regulating Phagocytosis of Killed Tumor Cells
  Journal of Immunology (Baltimore, Md. : 1950). Aug, 2011  |   Pubmed ID: 21709155
• Inhibition of the Cellular Function of Perforin by 1-amino-2,4-dicyanopyrido[1,2-a]benzimidazoles
  Bioorganic & Medicinal Chemistry. Jul, 2011  |   Pubmed ID: 21664824
• Protection from Endogenous Perforin: Glycans and the C Terminus Regulate Exocytic Trafficking in Cytotoxic Lymphocytes
  Immunity. Jun, 2011  |   Pubmed ID: 21658975
• Homeostatic Defects in Interleukin 18-deficient Mice Contribute to Protection Against the Lethal Effects of Endotoxin
  Immunology and Cell Biology. Aug, 2011  |   Pubmed ID: 21263463
• The Immunostimulatory Effect of Lenalidomide on NK-cell Function is Profoundly Inhibited by Concurrent Dexamethasone Therapy
  Blood. Feb, 2011  |   Pubmed ID: 20978269
• Cathepsin C Limits Acute Viral Infection Independently of NK Cell and CD8+ T-cell Cytolytic Function
  Immunology and Cell Biology. May, 2011  |   Pubmed ID: 20975734
• Tumor Ablation by Gene-modified T Cells in the Absence of Autoimmunity
  Cancer Research. Dec, 2010  |   Pubmed ID: 21098715
• The Structural Basis for Membrane Binding and Pore Formation by Lymphocyte Perforin
  Nature. Nov, 2010  |   Pubmed ID: 21037563
• Proteases in Lymphocyte Killer Function: Redundancy, Polymorphism and Questions Remaining
  Biological Chemistry. Aug, 2010  |   Pubmed ID: 20731542
• A Role for Granzyme M in TLR4-driven Inflammation and Endotoxicosis
  Journal of Immunology (Baltimore, Md. : 1950). Aug, 2010  |   Pubmed ID: 20585036
• Functional Dissection of the Granzyme Family: Cell Death and Inflammation
  Immunological Reviews. May, 2010  |   Pubmed ID: 20536556
• Perforin: Structure, Function, and Role in Human Immunopathology
  Immunological Reviews. May, 2010  |   Pubmed ID: 20536554
• Human and Mouse Perforin Are Processed in Part Through Cleavage by the Lysosomal Cysteine Proteinase Cathepsin L
  Immunology. Oct, 2010  |   Pubmed ID: 20497254
• Functional Crosstalk Between Type I and II Interferon Through the Regulated Expression of STAT1
  PLoS Biology. 2010  |   Pubmed ID: 20436908
• Cathepsin H is an Additional Convertase of Pro-granzyme B
  The Journal of Biological Chemistry. Jul, 2010  |   Pubmed ID: 20435891
• Incentives: Encouraging Adventurous Ideas
  Science (New York, N.Y.). Jan, 2010  |   Pubmed ID: 20056875
• The Battlefield of Perforin/granzyme Cell Death Pathways
  Journal of Leukocyte Biology. Feb, 2010  |   Pubmed ID: 19915166
• Endolysosomal Proteases and Their Inhibitors in Immunity
  Nature Reviews. Immunology. Dec, 2009  |   Pubmed ID: 19935806
• Proteolytic Activation of the Cytotoxic Phenotype During Human NK Cell Development
  Journal of Immunology (Baltimore, Md. : 1950). Jul, 2009  |   Pubmed ID: 19570824
• Cutting Edge: Rapid and Efficient in Vivo Cytotoxicity by Cytotoxic T Cells is Independent of Granzymes A and B
  Journal of Immunology (Baltimore, Md. : 1950). Jul, 2009  |   Pubmed ID: 19525394
• Temperature Sensitivity of Human Perforin Mutants Unmasks Subtotal Loss of Cytotoxicity, Delayed FHL, and a Predisposition to Cancer
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2009  |   Pubmed ID: 19487666
• The Molecular Basis for Perforin Oligomerization and Transmembrane Pore Assembly
  Immunity. May, 2009  |   Pubmed ID: 19446473
• The Lewis-Y Carbohydrate Antigen is Expressed by Many Human Tumors and Can Serve As a Target for Genetically Redirected T Cells Despite the Presence of Soluble Antigen in Serum
  Journal of Immunotherapy (Hagerstown, Md. : 1997). Apr, 2009  |   Pubmed ID: 19242371
• Perforin-mediated Suppression of B-cell Lymphoma
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2009  |   Pubmed ID: 19196996
• Dihydrofuro[3,4-c]pyridinones As Inhibitors of the Cytolytic Effects of the Pore-forming Glycoprotein Perforin
  Journal of Medicinal Chemistry. Dec, 2008  |   Pubmed ID: 19007200
• A Renaissance in Understanding the Multiple and Diverse Functions of Granzymes?
  Immunity. Nov, 2008  |   Pubmed ID: 19006688
• Granzyme K Expressing Cytotoxic T Lymphocytes Protects Against Influenza Virus in Granzyme AB-/- Mice
  Viral Immunology. Sep, 2008  |   Pubmed ID: 18788942
• The MACPF/CDC Family of Pore-forming Toxins
  Cellular Microbiology. Sep, 2008  |   Pubmed ID: 18564372
• The Role of P202 in Regulating Hematopoietic Cell Proliferation and Differentiation
  Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research. Jan, 2008  |   Pubmed ID: 18370867
• Measuring Cell Death Mediated by Cytotoxic Lymphocytes or Their Granule Effector Molecules
  Methods (San Diego, Calif.). Mar, 2008  |   Pubmed ID: 18314055
• Cloning and Characterisation of Ifi206: a New Murine HIN-200 Family Member
  Journal of Cellular Biochemistry. Mar, 2008  |   Pubmed ID: 17786933
• Sustained Antigen-specific Antitumor Recall Response Mediated by Gene-modified CD4+ T Helper-1 and CD8+ T Cells
  Cancer Research. Dec, 2007  |   Pubmed ID: 18056471
• H is for Helper: Granzyme H Helps Granzyme B Kill Adenovirus-infected Cells
  Trends in Immunology. Sep, 2007  |   Pubmed ID: 17766182
• A Common Fold Mediates Vertebrate Defense and Bacterial Attack
  Science (New York, N.Y.). Sep, 2007  |   Pubmed ID: 17717151
• Infective, Neoplastic, and Homeostatic Sequelae of the Loss of Perforin Function in Humans
  Advances in Experimental Medicine and Biology. 2007  |   Pubmed ID: 17713010
• The Granzyme B Gene is Highly Polymorphic in Wild Mice but Essentially Invariant in Common Inbred Laboratory Strains
  Tissue Antigens. Sep, 2007  |   Pubmed ID: 17661907
• Perforin Activity and Immune Homeostasis: the Common A91V Polymorphism in Perforin Results in Both Presynaptic and Postsynaptic Defects in Function
  Blood. Aug, 2007  |   Pubmed ID: 17475905
• The Complex Issue of Regulating Perforin Expression
  Trends in Immunology. Jun, 2007  |   Pubmed ID: 17466595
• Apoptosis Induced by the Lymphocyte Effector Molecule Perforin
  Current Opinion in Immunology. Jun, 2007  |   Pubmed ID: 17442557
• Residual Active Granzyme B in Cathepsin C-null Lymphocytes is Sufficient for Perforin-dependent Target Cell Apoptosis
  The Journal of Cell Biology. Feb, 2007  |   Pubmed ID: 17283185
• A Novel C-Jun-dependent Signal Transduction Pathway Necessary for the Transcriptional Activation of Interferon Gamma Response Genes
  The Journal of Biological Chemistry. Jan, 2007  |   Pubmed ID: 17105733
• Perforin-mediated Target-cell Death and Immune Homeostasis
  Nature Reviews. Immunology. Dec, 2006  |   Pubmed ID: 17124515
• Ligation of the Cell Surface Receptor, CD46, Alters T Cell Polarity and Response to Antigen Presentation
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2006  |   Pubmed ID: 17116876
• The Major Human and Mouse Granzymes Are Structurally and Functionally Divergent
  The Journal of Cell Biology. Nov, 2006  |   Pubmed ID: 17116752
• Cytotoxic T-cells from T-cell Receptor Transgenic NOD8.3 Mice Destroy Beta-cells Via the Perforin and Fas Pathways
  Diabetes. Sep, 2006  |   Pubmed ID: 16936188
• Cytotoxic T Lymphocytes from Cathepsin B-deficient Mice Survive Normally in Vitro and in Vivo After Encountering and Killing Target Cells
  The Journal of Biological Chemistry. Oct, 2006  |   Pubmed ID: 16914553
• Granzyme B-mediated Death of Pancreatic Beta-cells Requires the Proapoptotic BH3-only Molecule Bid
  Diabetes. Aug, 2006  |   Pubmed ID: 16873683
• Cytotoxic T Lymphocyte-induced Killing in the Absence of Granzymes A and B is Unique and Distinct from Both Apoptosis and Perforin-dependent Lysis
  The Journal of Cell Biology. Apr, 2006  |   Pubmed ID: 16606695
• Perforin and Fas Induced by IFNgamma and TNFalpha Mediate Beta Cell Death by OT-I CTL
  International Immunology. Jun, 2006  |   Pubmed ID: 16574667
• A Critical Role for Granzyme B, in Addition to Perforin and TNFalpha, in Alloreactive CTL-induced Mouse Pancreatic Beta Cell Death
  Transplantation. Jan, 2006  |   Pubmed ID: 16436955
• Role of Bid-induced Mitochondrial Outer Membrane Permeabilization in Granzyme B-induced Apoptosis
  Immunology and Cell Biology. Feb, 2006  |   Pubmed ID: 16405654
• Addressing the Mysteries of Perforin Function
  Immunology and Cell Biology. Feb, 2006  |   Pubmed ID: 16405653
• Report on Apoptosis and Immunity, 31 May-3 June 2005, Palm Cove, Queensland, Australia
  Immunology and Cell Biology. Feb, 2006  |   Pubmed ID: 16405648
• Adoptive Transfer of T Cells Modified with a Humanized Chimeric Receptor Gene Inhibits Growth of Lewis-Y-expressing Tumors in Mice
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2005  |   Pubmed ID: 16365285
• The Dual Adverse Effects of TGF-beta Secretion on Tumor Progression
  Cancer Cell. Nov, 2005  |   Pubmed ID: 16286241
• Cationic Sites on Granzyme B Contribute to Cytotoxicity by Promoting Its Uptake into Target Cells
  Molecular and Cellular Biology. Sep, 2005  |   Pubmed ID: 16107729
• Adoptive Transfer of Gene-engineered CD4+ Helper T Cells Induces Potent Primary and Secondary Tumor Rejection
  Blood. Nov, 2005  |   Pubmed ID: 16030195
• Extracellular Matrix Remodeling by Human Granzyme B Via Cleavage of Vitronectin, Fibronectin, and Laminin
  The Journal of Biological Chemistry. Jun, 2005  |   Pubmed ID: 15843372
• Interaction of the Nuclear Localizing Cytolytic Granule Serine Protease Granzyme B with Importin Alpha or Beta: Modulation by the Serpin Inhibitor PI-9
  Journal of Cellular Biochemistry. Jun, 2005  |   Pubmed ID: 15791691
• A Functional Analysis of the Putative Polymorphisms A91V and N252S and 22 Missense Perforin Mutations Associated with Familial Hemophagocytic Lymphohistiocytosis
  Blood. Jun, 2005  |   Pubmed ID: 15755897
• Biochemical and Growth Regulatory Activities of the HIN-200 Family Member and Putative Tumor Suppressor Protein, AIM2
  Biochemical and Biophysical Research Communications. Jan, 2005  |   Pubmed ID: 15582594
• Calcium-dependent Plasma Membrane Binding and Cell Lysis by Perforin Are Mediated Through Its C2 Domain: A Critical Role for Aspartate Residues 429, 435, 483, and 485 but Not 491
  The Journal of Biological Chemistry. Mar, 2005  |   Pubmed ID: 15576364
• A Central Role for Bid in Granzyme B-induced Apoptosis
  The Journal of Biological Chemistry. Feb, 2005  |   Pubmed ID: 15574417
• The Functional Basis for Hemophagocytic Lymphohistiocytosis in a Patient with Co-inherited Missense Mutations in the Perforin (PFN1) Gene
  The Journal of Experimental Medicine. Sep, 2004  |   Pubmed ID: 15365097
• Cytotoxic Lymphocytes; Instigators of Dramatic Target Cell Death
  Biochemical Pharmacology. Sep, 2004  |   Pubmed ID: 15313398
• Gene-engineered T Cells As a Superior Adjuvant Therapy for Metastatic Cancer
  Journal of Immunology (Baltimore, Md. : 1950). Aug, 2004  |   Pubmed ID: 15265951
• Cytotoxic Activity of the Lymphocyte Toxin Granzyme B
  Microbes and Infection / Institut Pasteur. Jul, 2004  |   Pubmed ID: 15207822
• Assaying Cytochrome C Translocation During Apoptosis
  Methods in Molecular Biology (Clifton, N.J.). 2004  |   Pubmed ID: 15173625
• Discordant Regulation of Granzyme H and Granzyme B Expression in Human Lymphocytes
  The Journal of Biological Chemistry. Jun, 2004  |   Pubmed ID: 15069086
• A Functional Role for CD28 Costimulation in Tumor Recognition by Single-chain Receptor-modified T Cells
  Cancer Gene Therapy. May, 2004  |   Pubmed ID: 15060573
• Granzyme M Mediates a Novel Form of Perforin-dependent Cell Death
  The Journal of Biological Chemistry. May, 2004  |   Pubmed ID: 15028722
• Granzyme B Encoded by the Commonly Occurring Human RAH Allele Retains Pro-apoptotic Activity
  The Journal of Biological Chemistry. Apr, 2004  |   Pubmed ID: 14752093
• HScrib is a Functional Homologue of the Drosophila Tumour Suppressor Scribble
  Oncogene. Dec, 2003  |   Pubmed ID: 14681682
• Granzyme B: Pro-apoptotic, Antiviral and Antitumor Functions
  Current Opinion in Immunology. Oct, 2003  |   Pubmed ID: 14499262
• Novel Mechanisms of Apoptosis Induced by Histone Deacetylase Inhibitors
  Cancer Research. Aug, 2003  |   Pubmed ID: 12907619
• Cutting Edge: Granzymes A and B Are Not Essential for Perforin-mediated Tumor Rejection
  Journal of Immunology (Baltimore, Md. : 1950). Jul, 2003  |   Pubmed ID: 12847210
• Purification of Natural Killer Cell Cytotoxic Granules for Assaying Target Cell Apoptosis
  Journal of Immunological Methods. May, 2003  |   Pubmed ID: 12738359
• Caspase Activation by Granzyme B is Indirect, and Caspase Autoprocessing Requires the Release of Proapoptotic Mitochondrial Factors
  Immunity. Mar, 2003  |   Pubmed ID: 12648450
• Expression of IFI 16 in Epithelial Cells and Lymphoid Tissues
  Histochemistry and Cell Biology. Jan, 2003  |   Pubmed ID: 12548405
• A Clathrin/dynamin- and Mannose-6-phosphate Receptor-independent Pathway for Granzyme B-induced Cell Death
  The Journal of Cell Biology. Jan, 2003  |   Pubmed ID: 12538642
• Rejection of Syngeneic Colon Carcinoma by CTLs Expressing Single-chain Antibody Receptors Codelivering CD28 Costimulation
  Journal of Immunology (Baltimore, Md. : 1950). Nov, 2002  |   Pubmed ID: 12421958
• Single-chain Antigen Recognition Receptors That Costimulate Potent Rejection of Established Experimental Tumors
  Blood. Nov, 2002  |   Pubmed ID: 12384413
• Functional Significance of the Perforin/granzyme Cell Death Pathway
  Nature Reviews. Immunology. Oct, 2002  |   Pubmed ID: 12360212
• Tumor-mediated Apoptosis of Cancer-specific T Lymphocytes--reversing the "kiss of Death"?
  Cancer Cell. Sep, 2002  |   Pubmed ID: 12242147
• Suppression of Lymphoma and Epithelial Malignancies Effected by Interferon Gamma
  The Journal of Experimental Medicine. Jul, 2002  |   Pubmed ID: 12093877
• Functional Role of Phosphatidylinositol 3-kinase in Direct Tumor Lysis by Human Natural Killer Cells
  Immunobiology. Mar, 2002  |   Pubmed ID: 11999346
• Cytotoxic Cell Granule-mediated Apoptosis: Perforin Delivers Granzyme B-serglycin Complexes into Target Cells Without Plasma Membrane Pore Formation
  Immunity. Mar, 2002  |   Pubmed ID: 11911826