Other Publications (1)
Articles by Joseph Larkin III in JoVE
Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes Simone K. Bedoya*1, Tenisha D. Wilson*1, Erin L. Collins1, Kenneth Lau1, Joseph Larkin III1 1Department of Microbiology and Cell Science, The University of Florida With effector functions distinct from other T cell subsets, Th17 cells have been centrally implicated in inflammatory autoimmunity. This in vitro Th17 differentiation protocol provides a means to determine whether naïve CD4+ T lymphocytes can differentiate into Th17 cells, and to further examine their role in autoimmunity and host response.
Other articles by Joseph Larkin III on PubMed
Therapeutic Targeting of STAT Pathways in CNS Autoimmune Diseases JAK-STAT. Jan, 2013 | Pubmed ID: 24058800 Signal transducers and activators of transcription (STATs) transduce extracellular signals that regulate the initiation, duration and intensity of immune responses. However, unbridled activation of STATs by pro-inflammatory cytokines or growth factors contributes to pathogenic autoimmunity. In this review, we briefly discuss STAT pathways that promote the development and expansion of T cells that mediate two CNS inflammatory diseases, multiple sclerosis (MS) and uveitis. Particular focus is on animal models of MS and uveitis and new approaches to the treatment of CNS autoimmune diseases based on therapeutic targeting of Th17 cells and STAT pathways.