Josephine Hoh Department of Environmental Health Sciences Yale University School of Medicine Biography Publications Institution JoVE Articles Josephine Hoh has not added a biography. If you are Josephine Hoh and would like to personalize this page please email our Author Liaison for assistance. Publications 2016: A 'Mitochondria' Odyssey Trends in Molecular Medicine. Apr, 2016 | Pubmed ID: 27151392 Genetic Risk Score for Essential Hypertension and Risk of Preeclampsia American Journal of Hypertension. Jan, 2016 | Pubmed ID: 26002928 Generation and Characterization of Mice with a Conditional Null Allele of the HtrA4 Gene Molecular Medicine Reports. Nov, 2015 | Pubmed ID: 26353049 Loss of HtrA1-induced Attenuation of TGF-β Signaling in Fibroblasts Might Not Be the Main Mechanism of CARASIL Pathogenesis Proceedings of the National Academy of Sciences of the United States of America. Apr, 2015 | Pubmed ID: 25770224 Postnatal Overexpression of the Human ARMS2 Gene Does Not Induce Abnormalities in Retina and Choroid in Transgenic Mouse Models Investigative Ophthalmology & Visual Science. Feb, 2015 | Pubmed ID: 25717153 Genetic Predisposition to Dyslipidemia and Risk of Preeclampsia American Journal of Hypertension. Jul, 2015 | Pubmed ID: 25523295 Neural-specific Deletion of Htra2 Causes Cerebellar Neurodegeneration and Defective Processing of Mitochondrial OPA1 PloS One. 2014 | Pubmed ID: 25531304 Protoporphyrins Enhance Oligomerization and Enzymatic Activity of HtrA1 Serine Protease PloS One. 2014 | Pubmed ID: 25506911 Scan Statistics in Human Gene Mapping American Journal of Human Genetics. Nov, 2012 | Pubmed ID: 23122592 Stage and Gene Specific Signatures Defined by Histones H3K4me2 and H3K27me3 Accompany Mammalian Retina Maturation in Vivo PloS One. 2012 | Pubmed ID: 23056497 Genome-wide Association Study Identifies a Maternal Copy-number Deletion in PSG11 Enriched Among Preeclampsia Patients BMC Pregnancy and Childbirth. 2012 | Pubmed ID: 22748001 Genetic Signatures of Exceptional Longevity in Humans PloS One. 2012 | Pubmed ID: 22279548 Disease Risk Prediction with Rare and Common Variants BMC Proceedings. 2011 | Pubmed ID: 22373337 A Comparison of Association Methods Correcting for Population Stratification in Case-control Studies Annals of Human Genetics. May, 2011 | Pubmed ID: 21281271 A Pilot Genome-wide Association Study Shows Genomic Variants Enriched in the Non-tumor Cells of Patients with Well-differentiated Neuroendocrine Tumors of the Ileum Endocrine-related Cancer. Feb, 2011 | Pubmed ID: 21139019 PDE11A Associations with Asthma: Results of a Genome-wide Association Scan The Journal of Allergy and Clinical Immunology. Oct, 2010 | Pubmed ID: 20920776 Common Variants Near CAV1 and CAV2 Are Associated with Primary Open-angle Glaucoma Nature Genetics. Oct, 2010 | Pubmed ID: 20835238 Association Between Reduced Copy-number at T-cell Receptor Gamma (TCRgamma) and Childhood Allergic Asthma: A Possible Role for Somatic Mosaicism Mutation Research. Aug, 2010 | Pubmed ID: 20553737 A Genome-wide Association Study on African-ancestry Populations for Asthma The Journal of Allergy and Clinical Immunology. Feb, 2010 | Pubmed ID: 19910028 Detecting Essential and Removable Interactions in Genome-wide Association Studies Statistics and Its Interface. Jan, 2009 | Pubmed ID: 21165165 Common Variants on Chromosome 2 and Risk of Primary Open-angle Glaucoma in the Afro-Caribbean Population of Barbados Proceedings of the National Academy of Sciences of the United States of America. Oct, 2009 | Pubmed ID: 19805132 CCR3: Shedding New Light on a Dark Problem? Journal of Molecular Cell Biology. Oct, 2009 | Pubmed ID: 19684049 Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression: a Meta-analysis JAMA. Jun, 2009 | Pubmed ID: 19531786 Mitochondrial DNA Variants of Respiratory Complex I That Uniquely Characterize Haplogroup T2 Are Associated with Increased Risk of Age-related Macular Degeneration PloS One. 2009 | Pubmed ID: 19434233 Sequence Variants in HTRA1 and LOC387715/ARMS2 and Phenotype and Response to Photodynamic Therapy in Neovascular Age-related Macular Degeneration in Populations from Israel Molecular Vision. 2008 | Pubmed ID: 19065273 Joint Effects of Polymorphisms in the HTRA1, LOC387715/ARMS2, and CFH Genes on AMD in a Caucasian Population Molecular Vision. 2008 | Pubmed ID: 18682806 The NEI/NCBI DbGAP Database: Genotypes and Haplotypes That May Specifically Predispose to Risk of Neovascular Age-related Macular Degeneration BMC Medical Genetics. 2008 | Pubmed ID: 18541031 The Signatures of Autozygosity Among Patients with Colorectal Cancer Cancer Research. Apr, 2008 | Pubmed ID: 18375840 HTRA1 Variants in Exudative Age-related Macular Degeneration and Interactions with Smoking and CFH Investigative Ophthalmology & Visual Science. Jun, 2008 | Pubmed ID: 18316707 Functional and Structural Implications of the Complement Factor H Y402H Polymorphism Associated with Age-related Macular Degeneration Investigative Ophthalmology & Visual Science. May, 2008 | Pubmed ID: 18263814 Further Mapping of 10q26 Supports Strong Association of HTRA1 Polymorphisms with Age-related Macular Degeneration Vision Research. Feb, 2008 | Pubmed ID: 18207215 Linkage Disequilibrium Mapping for Complex Disease Genes Methods in Molecular Biology (Clifton, N.J.). 2007 | Pubmed ID: 17984540 Replicating Genotype-phenotype Associations Nature. Jun, 2007 | Pubmed ID: 17554299 Two Genetic Pathways for Age-related Macular Degeneration Current Opinion in Genetics & Development. Jun, 2007 | Pubmed ID: 17467263 Origin of Dendritic Cells in Peripheral Lymphoid Organs of Mice Nature Immunology. Jun, 2007 | Pubmed ID: 17450143 HTRA1 Promoter Polymorphism Predisposes Japanese to Age-related Macular Degeneration Molecular Vision. 2007 | Pubmed ID: 17438519 Fine-scale Linkage Disequilibrium Mapping of Age-related Macular Degeneration in the Complement Factor H Gene Region The British Journal of Ophthalmology. Jul, 2007 | Pubmed ID: 17314151 A Variant of the HTRA1 Gene Increases Susceptibility to Age-related Macular Degeneration Science (New York, N.Y.). Nov, 2006 | Pubmed ID: 17053109 HTRA1 Promoter Polymorphism in Wet Age-related Macular Degeneration Science (New York, N.Y.). Nov, 2006 | Pubmed ID: 17053108 Systematic Review and Meta-analysis of the Association Between Complement Factor H Y402H Polymorphisms and Age-related Macular Degeneration Human Molecular Genetics. Sep, 2006 | Pubmed ID: 16905558 Association of Angiotensinogen Gene Polymorphisms with Essential Hypertension in African-Americans and Caucasians Human Heredity. 2005 | Pubmed ID: 16210856 Strong Association of the Y402H Variant in Complement Factor H at 1q32 with Susceptibility to Age-related Macular Degeneration American Journal of Human Genetics. Jul, 2005 | Pubmed ID: 15895326 Complement Factor H Polymorphism in Age-related Macular Degeneration Science (New York, N.Y.). Apr, 2005 | Pubmed ID: 15761122 Genetic Dissection of Diseases: Design and Methods Current Opinion in Genetics & Development. Jun, 2004 | Pubmed ID: 15172663 Sum Statistics for the Joint Detection of Multiple Disease Loci in Case-control Association Studies with SNP Markers Genetic Epidemiology. Dec, 2003 | Pubmed ID: 14639704 Mathematical Multi-locus Approaches to Localizing Complex Human Trait Genes Nature Reviews. Genetics. Sep, 2003 | Pubmed ID: 12951571 Set Association Analysis of SNP Case-control and Microarray Data Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 2003 | Pubmed ID: 12935345 Statistical Methods for Analyzing Microarray Feature Data with Replications Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 2003 | Pubmed ID: 12804089 Efficiency of Single-nucleotide Polymorphism Haplotype Estimation from Pooled DNA Proceedings of the National Academy of Sciences of the United States of America. Jun, 2003 | Pubmed ID: 12777616 SNP Haplotype Tagging from DNA Pools of Two Individuals BMC Bioinformatics. Apr, 2003 | Pubmed ID: 12709267 Pharmacogenetic Analysis of Adverse Drug Effect Reveals Genetic Variant for Susceptibility to Liver Toxicity The Pharmacogenomics Journal. 2002 | Pubmed ID: 12439739 A Protein Kinase A-dependent Molecular Switch in Synapsins Regulates Neurite Outgrowth Nature Neuroscience. May, 2002 | Pubmed ID: 11976703 Asthma, Allergy, and Airway Hyperresponsiveness Are Not Linked to the Beta(2)-adrenoceptor Gene Chest. Mar, 2002 | Pubmed ID: 11888952 A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging Victoria L. Patterson*1, Brian S. Thompson*1, Catherine Cherry*1, Shao-bin Wang2, Bo Chen2, Josephine Hoh1,2 1Department of Environmental Health Sciences, Yale University School of Medicine, 2Department of Ophthalmology, Yale University School of Medicine JoVE 54136 Medicine
A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging Victoria L. Patterson*1, Brian S. Thompson*1, Catherine Cherry*1, Shao-bin Wang2, Bo Chen2, Josephine Hoh1,2 1Department of Environmental Health Sciences, Yale University School of Medicine, 2Department of Ophthalmology, Yale University School of Medicine JoVE 54136 Medicine