Articles by Joshua Bush in JoVE
फेज प्रदर्शित लाइब्रेरी से पेप्टाइड्स mesenchymal कोशिकाओं में जीन अभिव्यक्ति न्यूनाधिक और Unicortical अस्थि दोष में अस्थिजनन शक्ति Gary Balian1, Gina Beck1, Vedavathi Madhu1, Robert Sikes2, Quanjun Cui3, Haixiang Liang1, Joshua Bush1 1Orthopaedics Research, University of Virginia, 2Biological Sciences, University of Delaware, 3Orthopaedic Surgery, University of Virginia एक फेज प्रदर्शन पुस्तकालय के लिए पेप्टाइड दृश्यों लक्ष्य हड्डी है कि की पहचान करने के लिए इस्तेमाल किया गया था. उद्देश्य mesenchymal सेल भेदभाव पर इन पेप्टाइड्स के प्रभाव की जांच और हड्डी पुनर्जनन पर उनके प्रभाव को निर्धारित किया गया था.
Other articles by Joshua Bush on PubMed
Improved Bio-implant Using Ultrafast Laser Induced Self-assembled Nanotexture in Titanium Journal of Biomedical Materials Research. Part B, Applied Biomaterials. May, 2011 | Pubmed ID: 21394901 The most successful metal implant materials currently have relatively smooth surfaces on the micron size scale, with most failures occurring after only 10 years. To move beyond this limiting time scale, texturing methods have been developed to modify the metal surface to enhance integration of the implant directly with surrounding bone. A flexible single-step ultrafast-laser texturing process has been developed that results in a surface texture that exhibits micron scale peaks and troughs with superimposed submicron and nano-scale features. The textured titanium samples remain completely hydrophilic with no measurable contact angle even after several weeks in normal atmosphere. An increase in mesenchymal stem cell number is observed over that on an untreated control titanium surface. Extensive formation of cellular bridges by stromal cells between pillars shows the favorable response of differentiated cells to the surface and the promotion of their attachment. Expression of the alkaline phosphatase and osteocalcin genes in human bone marrow cells were seen to increase on the textured surface. The development of this single-step method for creating micron, submicron, and nano-scale surface texture directly on metals makes a significant contribution to the goal of improving the integration and life span of joint replacement implants.