Juan Carlos Zapata

School of Medicine-University of Maryland.

University of Maryland

Juan Carlos Zapata
Research Associate

My main research interest is in virus-host interactions using animal models, genomic profiling, and basic molecular virology. I focused not only on host responses but also on changes that occur in the viral population in order to describe virus-host coevolution. I identified mutations in the arenavirus nucleocapsid protein (NP) that are likely to impact viral pathogenesis and the induction of protective immunity. During my postdoctoral training, I worked in detecting and characterizing HIV viral factors related with latency in the reservoir cells and in implanting patient-derived ATL cells into NSG mice to study cancer pathogenesis and treatment options. Currently, I am using humanized animal models to study infectious diseases (HIV, HTLV, HBV, HCV, and Dengue), human cancers and graft vs host disease (GvHD). I have also detected and characterized a CD8+ T cell sub-population, in humanized mice, that correlated with HIV protection in human beings.

Publications

मानवीकृत इम्यूनोडेफिजेंट माउस मॉडल में क्रोनिक, एक्यूट और रीएक्टिवेटेड एचआईवी संक्रमण

1Institute of Human Virology, School of Medicine, University of Maryland, 2Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia

JoVE 60315

 Immunology and Infection