Juan Iovanna

Publications

• PML Hyposumoylation is Responsible for the Resistance of Pancreatic Cancer
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2019  |   Pubmed ID: 31557059
• Designing and Repurposing Drugs to Target Intrinsically Disordered Proteins for Cancer Treatment: Using NUPR1 As a Paradigm
  Molecular & Cellular Oncology. 2019  |   Pubmed ID: 31528692
• Emerging Epigenomic Landscapes of Pancreatic Cancer in the Era of Precision Medicine
  Nature Communications. Aug, 2019  |   Pubmed ID: 31462645
• Dynamics of the Intrinsically Disordered Protein NUPR1 in Isolation and in Its Fuzzy Complexes with DNA and Prothymosin α
  Biochimica Et Biophysica Acta. Proteins and Proteomics. Nov, 2019  |   Pubmed ID: 31325636
• Flavonoid-alkylphospholipid Conjugates Elicit Dual Inhibition of Cancer Cell Growth and Lipid Accumulation
  Chemical Communications (Cambridge, England). Aug, 2019  |   Pubmed ID: 31270526
• Pancreatic Cancer Organoids for Determining Sensitivity to Bromodomain and Extra-Terminal Inhibitors (BETi)
  Frontiers in Oncology. 2019  |   Pubmed ID: 31231611
• Can the Plasma PD-1 Levels Predict the Presence and Efficiency of Tumor-infiltrating Lymphocytes in Patients with Metastatic Melanoma?
  Therapeutic Advances in Medical Oncology. 2019  |   Pubmed ID: 31205506
• Dendrimers As Competitors of Protein-Protein Interactions of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1
  Biomacromolecules. Jul, 2019  |   Pubmed ID: 31181156
• Aurora Kinase B-phosphorylated HP1α Functions in Chromosomal Instability
  Cell Cycle (Georgetown, Tex.). Jun, 2019  |   Pubmed ID: 31130069
• Pancreatic Cancer Heterogeneity Can Be Explained Beyond the Genome
  Frontiers in Oncology. 2019  |   Pubmed ID: 31024848
• Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas Upon Combined Inhibition of EGFR and C-RAF
  Cancer Cell. Apr, 2019  |   Pubmed ID: 30975481
• Ligand-based Design Identifies a Potent NUPR1 Inhibitor Exerting Anticancer Activity Via Necroptosis
  The Journal of Clinical Investigation. 03, 2019  |   Pubmed ID: 30920390
• Prognostic Significance of Circulating PD-1, PD-L1, Pan-BTN3As, BTN3A1 and BTLA in Patients with Pancreatic Adenocarcinoma
  Oncoimmunology. 2019  |   Pubmed ID: 30906655
• Pancreatic Cancer Chemo-resistance is Driven by Tumor Phenotype Rather Than Tumor Genotype
  Heliyon. Dec, 2018  |   Pubmed ID: 30582059
• Ribonuclease MCPiP1 Contributes to the Loss of Micro-RNA-200 Family Members in Pancreatic Cancer Cells
  Oncotarget. Nov, 2018  |   Pubmed ID: 30542509
• Inactivation of NUPR1 Promotes Cell Death by Coupling ER-stress Responses with Necrosis
  Scientific Reports. 11, 2018  |   Pubmed ID: 30451898
• Self-assembling Supramolecular Dendrimer Nanosystem for PET Imaging of Tumors
  Proceedings of the National Academy of Sciences of the United States of America. 11, 2018  |   Pubmed ID: 30348798
• Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway
  Scientific Reports. 10, 2018  |   Pubmed ID: 30305677
• Chloroquine Plays a Cell-dependent Role in the Response to Treatment of Pancreatic Adenocarcinoma
  Oncotarget. Jul, 2018  |   Pubmed ID: 30112111
• Epigenetics of Gastrointestinal Diseases: Notes from a Workshop
  Epigenetics. 2018  |   Pubmed ID: 30056798
• α-lipoic Acid Reduces Postreperfusion Syndrome in Human Liver Transplantation - a Pilot Study
  Transplant International : Official Journal of the European Society for Organ Transplantation. 12, 2018  |   Pubmed ID: 29974521
• The Chromatin Nuclear Protein NUPR1L is Intrinsically Disordered and Binds to the Same Proteins As Its Paralogue
  The Biochemical Journal. 07, 2018  |   Pubmed ID: 29925531
• [Multi-omic Approaches Reveal New Therapeutic Targets for the Treatment of Pancreatic Cancer]
  Medecine Sciences : M/S. May, 2018  |   Pubmed ID: 29900832
• Pancreatic Ductal Adenocarcinoma: A Strong Imbalance of Good and Bad Immunological Cops in the Tumor Microenvironment
  Frontiers in Immunology. 2018  |   Pubmed ID: 29868007
• E2F Signature is Predictive for the Pancreatic Adenocarcinoma Clinical Outcome and Sensitivity to E2F Inhibitors, but Not for the Response to Cytotoxic-based Treatments
  Scientific Reports. 05, 2018  |   Pubmed ID: 29844366
• Distinct Epigenetic Landscapes Underlie the Pathobiology of Pancreatic Cancer Subtypes
  Nature Communications. 05, 2018  |   Pubmed ID: 29773832
• Optimization of a Bioluminescence Resonance Energy Transfer-Based Assay for Screening of Trypanosoma Cruzi Protein/Protein Interaction Inhibitors
  Molecular Biotechnology. May, 2018  |   Pubmed ID: 29600316
• Amphipathic Helical Peptides Hamper Protein-protein Interactions of the Intrinsically Disordered Chromatin Nuclear Protein 1 (NUPR1)
  Biochimica Et Biophysica Acta. General Subjects. 06, 2018  |   Pubmed ID: 29530795
• Cadherin-1 and Cadherin-3 Cooperation Determines the Aggressiveness of Pancreatic Ductal Adenocarcinoma
  British Journal of Cancer. 02, 2018  |   Pubmed ID: 29161242
• Prevalence of Microsatellite Instability in Intraductal Papillary Mucinous Neoplasms of the Pancreas
  Gastroenterology. 03, 2018  |   Pubmed ID: 29158190
• BTN3A is a Prognosis Marker and a Promising Target for Vγ9Vδ2 T Cells Based-immunotherapy in Pancreatic Ductal Adenocarcinoma (PDAC)
  Oncoimmunology. 2017  |   Pubmed ID: 29296524
• Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts
  Cell Reports. Nov, 2017  |   Pubmed ID: 29186684
• Factors Released by the Tumor Far Microenvironment Are Decisive for Pancreatic Adenocarcinoma Development and Progression
  Oncoimmunology. 2017  |   Pubmed ID: 29147622
• Speeding Towards Individualized Treatment for Pancreatic Cancer by Taking an Alternative Road
  Cancer Letters. 12, 2017  |   Pubmed ID: 28947138
• Collagen-derived Proline Promotes Pancreatic Ductal Adenocarcinoma Cell Survival Under Nutrient Limited Conditions
  Nature Communications. 07, 2017  |   Pubmed ID: 28685754
• REG3β Modifies Cell Tumor Function by Impairing Extracellular Vesicle Uptake
  Scientific Reports. 06, 2017  |   Pubmed ID: 28600520
• Combined AURKA and H3K9 Methyltransferase Targeting Inhibits Cell Growth By Inducing Mitotic Catastrophe
  Molecular Cancer Research : MCR. 08, 2017  |   Pubmed ID: 28442587
• [Autophagy Contributes to the Initiation of Pancreatic Cancer]
  Medecine Sciences : M/S. Mar, 2017  |   Pubmed ID: 28367822
• Gene Expression Profiling of Patient-derived Pancreatic Cancer Xenografts Predicts Sensitivity to the BET Bromodomain Inhibitor JQ1: Implications for Individualized Medicine Efforts
  EMBO Molecular Medicine. 04, 2017  |   Pubmed ID: 28275007
• Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma
  Scientific Reports. 01, 2017  |   Pubmed ID: 28054562
• GATA6 Regulates EMT and Tumour Dissemination, and is a Marker of Response to Adjuvant Chemotherapy in Pancreatic Cancer
  Gut. 09, 2017  |   Pubmed ID: 27325420
• Autophagy Induced During Pancreatitis Promotes -Dependent Transformation in the Pancreas
  Frontiers in Oncology. 2016  |   Pubmed ID: 27833900
• Stratification and Therapeutic Potential of PML in Metastatic Breast Cancer
  Nature Communications. 08, 2016  |   Pubmed ID: 27553708
• A Pancreatic Ductal Adenocarcinoma Subpopulation is Sensitive to FK866, an Inhibitor of NAMPT
  Oncotarget. Aug, 2016  |   Pubmed ID: 27462772
• The Promise of Epigenomic Therapeutics in Pancreatic Cancer
  Epigenomics. 06, 2016  |   Pubmed ID: 27337224
• Determinants of the PKa Values of Ionizable Residues in an Intrinsically Disordered Protein
  Archives of Biochemistry and Biophysics. 05, 2016  |   Pubmed ID: 27046343
• REG3β Plays a Key Role in IL17RA Protumoral Effect-Response
  Cancer Research. 04, 2016  |   Pubmed ID: 26992425
• α-Lipoic Acid Protects Against Ischemia-Reperfusion Injury in Simultaneous Kidney-Pancreas Transplantation
  Transplantation. Apr, 2016  |   Pubmed ID: 26502371
• Response to "Is the Reg3α (HIP/PAP) Protein Really an Obesogenic Factor?"
  Journal of Cellular Physiology. Jan, 2016  |   Pubmed ID: 26280560
• Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation
  Scientific Reports. Nov, 2015  |   Pubmed ID: 26617245
• A Mycobacterium Tuberculosis Dormancy Antigen Differentiates Latently Infected Bacillus Calmette-Guérin-vaccinated Individuals
  EBioMedicine. Aug, 2015  |   Pubmed ID: 26425695
• IL17 Functions Through the Novel REG3β-JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer
  Cancer Research. Nov, 2015  |   Pubmed ID: 26404002
• Targeting CD44 As a Novel Therapeutic Approach for Treating Pancreatic Cancer Recurrence
  Oncoscience. 2015  |   Pubmed ID: 26244163
• IER3 in Pancreatic Carcinogenesis
  Oncotarget. Jun, 2015  |   Pubmed ID: 26158545
• The Aurora A-HP1γ Pathway Regulates Gene Expression and Mitosis in Cells from the Sperm Lineage
  BMC Developmental Biology. May, 2015  |   Pubmed ID: 26021315
• Functional Characterization of Nupr1L, A Novel P53-Regulated Isoform of the High-Mobility Group (HMG)-Related Protumoral Protein Nupr1
  Journal of Cellular Physiology. Dec, 2015  |   Pubmed ID: 25899918
• Defects in Mitophagy Promote Redox-driven Metabolic Syndrome in the Absence of TP53INP1
  EMBO Molecular Medicine. Jun, 2015  |   Pubmed ID: 25828351
• Deciphering the Cellular Source of Tumor Relapse Identifies CD44 As a Major Therapeutic Target in Pancreatic Adenocarcinoma
  Oncotarget. Apr, 2015  |   Pubmed ID: 25797268
• Transcriptomic Analysis Predicts Survival and Sensitivity to Anticancer Drugs of Patients with a Pancreatic Adenocarcinoma
  The American Journal of Pathology. Apr, 2015  |   Pubmed ID: 25765988
• Methodological Aspects of the Molecular and Histological Study of Prostate Cancer: Focus on PTEN
  Methods (San Diego, Calif.). May, 2015  |   Pubmed ID: 25697760
• The Thymus-specific Serine Protease TSSP/PRSS16 is Crucial for the Antitumoral Role of CD4(+) T Cells
  Cell Reports. Jan, 2015  |   Pubmed ID: 25543139
• A Subgroup of Pancreatic Adenocarcinoma is Sensitive to the 5-aza-dC DNA Methyltransferase Inhibitor
  Oncotarget. Jan, 2015  |   Pubmed ID: 25481873
• P8 Deficiency Increases Cellular ROS and Induces HO-1
  Archives of Biochemistry and Biophysics. Jan, 2015  |   Pubmed ID: 25475530
• Redox-sensitive TP53INP1 SUMOylation As an Oxidative Stress Sensor to Activate TP53
  Molecular & Cellular Oncology. Jul-Sep, 2014  |   Pubmed ID: 27308354
• Pancreatitis Promotes Oncogenic Kras(G12D)-induced Pancreatic Transformation Through Activation of Nupr1
  Molecular & Cellular Oncology. 2014  |   Pubmed ID: 27308320
• Further Characterization of HDAC and SIRT Gene Expression Patterns in Pancreatic Cancer and Their Relation to Disease Outcome
  PloS One. 2014  |   Pubmed ID: 25275504
• Pancreatic Cancer-induced Cachexia is Jak2-dependent in Mice
  Journal of Cellular Physiology. Oct, 2014  |   Pubmed ID: 24648112
• Oligomerization and Phosphorylation Dependent Regulation of ArgBP2 Adaptive Capabilities and Associated Functions
  PloS One. 2014  |   Pubmed ID: 24475245
• Pancreatitis-associated Protein Does Not Predict Disease Relapse in Inflammatory Bowel Disease Patients
  PloS One. 2014  |   Pubmed ID: 24416322
• Genetic Inactivation of Nupr1 Acts As a Dominant Suppressor Event in a Two-hit Model of Pancreatic Carcinogenesis
  Gut. Jun, 2014  |   Pubmed ID: 24026351
• PAP/HIP Protein is an Obesogenic Factor
  Journal of Cellular Physiology. Feb, 2014  |   Pubmed ID: 23881718
• Development of an ELISA Detecting Tumor Protein 53-Induced Nuclear Protein 1 in Serum of Prostate Cancer Patients
  Results in Immunology. 2013  |   Pubmed ID: 24600558
• Nuclear Protein 1 Promotes Pancreatic Cancer Development and Protects Cells from Stress by Inhibiting Apoptosis
  The Journal of Clinical Investigation. Jun, 2012  |   Pubmed ID: 22565310