Judy Lieberman

Publications

• An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MiRNAs and MRNAs It Regulates
  The Journal of Biological Chemistry. Jun, 2015  |   Pubmed ID: 26045559
• Apoptosis Triggers Specific, Rapid, and Global MRNA Decay with 3' Uridylated Intermediates Degraded by DIS3L2
  Cell Reports. May, 2015  |   Pubmed ID: 25959823
• Ex Vivo Cytosolic Delivery of Functional Macromolecules to Immune Cells
  PloS One. 2015  |   Pubmed ID: 25875117
• The Rab2A GTPase Promotes Breast Cancer Stem Cells and Tumorigenesis Via Erk Signaling Activation
  Cell Reports. Apr, 2015  |   Pubmed ID: 25818297
• Harnessing RNA Interference for Therapy: the Silent Treatment
  JAMA. Mar 24-31, 2015  |   Pubmed ID: 25803342
• Dysregulation of MicroRNA Biogenesis and Gene Silencing in Cancer
  Science Signaling. Mar, 2015  |   Pubmed ID: 25783160
• G-quadruplex Structures Contribute to the Neuroprotective Effects of Angiogenin-induced TRNA Fragments
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2014  |   Pubmed ID: 25404306
• MiR-200-containing Extracellular Vesicles Promote Breast Cancer Cell Metastasis
  The Journal of Clinical Investigation. Dec, 2014  |   Pubmed ID: 25401471
• Sequencing of Captive Target Transcripts Identifies the Network of Regulated Genes and Functions of Primate-specific MiR-522
  Cell Reports. Aug, 2014  |   Pubmed ID: 25131211
• Characterization of Dual PTEN and P53-targeting MicroRNAs Identifies MicroRNA-638/Dnm2 As a Two-hit Oncogenic Locus
  Cell Reports. Aug, 2014  |   Pubmed ID: 25088422
• Cytotoxic Cells Kill Intracellular Bacteria Through Granulysin-mediated Delivery of Granzymes
  Cell. Jun, 2014  |   Pubmed ID: 24906149
• Perforin: a Key Pore-forming Protein for Immune Control of Viruses and Cancer
  Sub-cellular Biochemistry. 2014  |   Pubmed ID: 24798013
• Prolyl Isomerase Pin1 Acts Downstream of MiR200c to Promote Cancer Stem-like Cell Traits in Breast Cancer
  Cancer Research. Jul, 2014  |   Pubmed ID: 24786790
• Leukocyte Protease Binding to Nucleic Acids Promotes Nuclear Localization and Cleavage of Nucleic Acid Binding Proteins
  Journal of Immunology (Baltimore, Md. : 1950). Jun, 2014  |   Pubmed ID: 24771851
• Distribution of Immune Cells in the Human Cervix and Implications for HIV Transmission
  American Journal of Reproductive Immunology (New York, N.Y. : 1989). Mar, 2014  |   Pubmed ID: 24410939
• Production of Highly Potent Recombinant SiRNAs in Escherichia Coli
  Nature Protocols. Dec, 2013  |   Pubmed ID: 24177290
• Arf-like GTPase Arl8b Regulates Lytic Granule Polarization and Natural Killer Cell-mediated Cytotoxicity
  Molecular Biology of the Cell. Dec, 2013  |   Pubmed ID: 24088571
• A Genome-wide SiRNA Screen Identifies Proteasome Addiction As a Vulnerability of Basal-like Triple-negative Breast Cancer Cells
  Cancer Cell. Aug, 2013  |   Pubmed ID: 23948298
• Noncoding RNAs and Cancer
  Cell. Mar, 2013  |   Pubmed ID: 23781554
• Durable Knockdown and Protection from HIV Transmission in Humanized Mice Treated with Gel-formulated CD4 Aptamer-siRNA Chimeras
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2013  |   Pubmed ID: 23629001
• Live or Let Die: Posttranscriptional Gene Regulation in Cell Stress and Cell Death
  Immunological Reviews. May, 2013  |   Pubmed ID: 23550650
• Micromanaging Hepatitis C Virus
  The New England Journal of Medicine. May, 2013  |   Pubmed ID: 23534545
• Efficient and Specific Gene Knockdown by Small Interfering RNAs Produced in Bacteria
  Nature Biotechnology. Apr, 2013  |   Pubmed ID: 23475073
• Identification of Regulators of the Innate Immune Response to Cytosolic DNA and Retroviral Infection by an Integrative Approach
  Nature Immunology. Feb, 2013  |   Pubmed ID: 23263557
• SAMHD1 Does It Again, Now in Resting T Cells
  Nature Medicine. Nov, 2012  |   Pubmed ID: 23135508
• Alterations in RNA Processing During Immune-mediated Programmed Cell Death
  Proceedings of the National Academy of Sciences of the United States of America. May, 2012  |   Pubmed ID: 22589304
• Targeted Delivery of PLK1-siRNA by ScFv Suppresses Her2+ Breast Cancer Growth and Metastasis
  Science Translational Medicine. Apr, 2012  |   Pubmed ID: 22517885
• Bone Morphogenetic Protein 4 Promotes Vascular Smooth Muscle Contractility by Activating MicroRNA-21 (miR-21), Which Down-regulates Expression of Family of Dedicator of Cytokinesis (DOCK) Proteins
  The Journal of Biological Chemistry. Feb, 2012  |   Pubmed ID: 22158624
• Capture of MicroRNA-bound MRNAs Identifies the Tumor Suppressor MiR-34a As a Regulator of Growth Factor Signaling
  PLoS Genetics. Nov, 2011  |   Pubmed ID: 22102825
• Coding-independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous MRNAs
  Cell. Oct, 2011  |   Pubmed ID: 22000013
• Conserved Regulation of P53 Network Dosage by MicroRNA-125b Occurs Through Evolving MiRNA-target Gene Pairs
  PLoS Genetics. Sep, 2011  |   Pubmed ID: 21935352
• Prime-boost Vaccination with Heterologous Live Vectors Encoding SIV Gag and Multimeric HIV-1 Gp160 Protein: Efficacy Against Repeated Mucosal R5 Clade C SHIV Challenges
  Vaccine. Aug, 2011  |   Pubmed ID: 21693155
• Perforin Pores in the Endosomal Membrane Trigger the Release of Endocytosed Granzyme B into the Cytosol of Target Cells
  Nature Immunology. Aug, 2011  |   Pubmed ID: 21685908
• Inhibition of HIV Transmission in Human Cervicovaginal Explants and Humanized Mice Using CD4 Aptamer-siRNA Chimeras
  The Journal of Clinical Investigation. Jun, 2011  |   Pubmed ID: 21576818
• HIV DNA is Heavily Uracilated, Which Protects It from Autointegration
  Proceedings of the National Academy of Sciences of the United States of America. May, 2011  |   Pubmed ID: 21576478
• Prior Exposure to an Attenuated Listeria Vaccine Does Not Reduce Immunogenicity: Pre-clinical Assessment of the Efficacy of a Listeria Vaccine in the Induction of Immune Responses Against HIV
  Journal of Immune Based Therapies and Vaccines. 2011  |   Pubmed ID: 21244649
• Gaining a Foothold: How HIV Avoids Innate Immune Recognition
  Current Opinion in Immunology. Feb, 2011  |   Pubmed ID: 21123040
• Promise and Challenge of RNA Interference-based Therapy for Cancer
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Feb, 2011  |   Pubmed ID: 21079135
• Desperately Seeking MicroRNA Targets
  Nature Structural & Molecular Biology. Oct, 2010  |   Pubmed ID: 20924405
• The Cytosolic Exonuclease TREX1 Inhibits the Innate Immune Response to Human Immunodeficiency Virus Type 1
  Nature Immunology. Nov, 2010  |   Pubmed ID: 20871604
• Granzyme A Activates Another Way to Die
  Immunological Reviews. May, 2010  |   Pubmed ID: 20536557
• Anatomy of a Murder: How Cytotoxic T Cells and NK Cells Are Activated, Develop, and Eliminate Their Targets
  Immunological Reviews. May, 2010  |   Pubmed ID: 20536551
• Isolation of Cytotoxic T Cell and NK Granules and Purification of Their Effector Proteins
  Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [et Al.]. Jun, 2010  |   Pubmed ID: 20521234
• Small RNAs Guide Hematopoietic Cell Differentiation and Function
  Journal of Immunology (Baltimore, Md. : 1950). Jun, 2010  |   Pubmed ID: 20483778
• Cleavage of Transaldolase by Granzyme B Causes the Loss of Enzymatic Activity with Retention of Antigenicity for Multiple Sclerosis Patients
  Journal of Immunology (Baltimore, Md. : 1950). Apr, 2010  |   Pubmed ID: 20194725
• Perforin Activates Clathrin- and Dynamin-dependent Endocytosis, Which is Required for Plasma Membrane Repair and Delivery of Granzyme B for Granzyme-mediated Apoptosis
  Blood. Feb, 2010  |   Pubmed ID: 20038786
• Molecular Basis for Antagonism Between PDGF and the TGFbeta Family of Signalling Pathways by Control of MiR-24 Expression
  The EMBO Journal. Feb, 2010  |   Pubmed ID: 20019669
• Micromanaging Cancer
  The New England Journal of Medicine. Oct, 2009  |   Pubmed ID: 19812408
• MiR-200 Enhances Mouse Breast Cancer Cell Colonization to Form Distant Metastases
  PloS One. 2009  |   Pubmed ID: 19787069
• MiR-24 Inhibits Cell Proliferation by Targeting E2F2, MYC, and Other Cell-cycle Genes Via Binding to "seedless" 3'UTR MicroRNA Recognition Elements
  Molecular Cell. Sep, 2009  |   Pubmed ID: 19748357
• MiR-34a Contributes to Megakaryocytic Differentiation of K562 Cells Independently of P53
  Blood. Sep, 2009  |   Pubmed ID: 19584398
• Micromanipulating Cancer: MicroRNA-based Therapeutics?
  RNA Biology. Jul-Aug, 2009  |   Pubmed ID: 19535911
• Numbers Matter: Quantitative and Dynamic Analysis of the Formation of an Immunological Synapse Using Imaging Flow Cytometry
  Journal of Immunological Methods. Aug, 2009  |   Pubmed ID: 19524586
• The Cytotoxic T Lymphocyte Protease Granzyme A Cleaves and Inactivates Poly(adenosine 5'-diphosphate-ribose) Polymerase-1
  Blood. Aug, 2009  |   Pubmed ID: 19506301
• Micromanagers of Immune Cell Fate and Function
  Advances in Immunology. 2009  |   Pubmed ID: 19477322
• Harvard's Women Four Years Later
  Nature Immunology. Jun, 2009  |   Pubmed ID: 19448653
• MiR-24-mediated Downregulation of H2AX Suppresses DNA Repair in Terminally Differentiated Blood Cells
  Nature Structural & Molecular Biology. May, 2009  |   Pubmed ID: 19377482
• The SET Complex Acts As a Barrier to Autointegration of HIV-1
  PLoS Pathogens. Mar, 2009  |   Pubmed ID: 19266025
• Durable Protection from Herpes Simplex Virus-2 Transmission Following Intravaginal Application of SiRNAs Targeting Both a Viral and Host Gene
  Cell Host & Microbe. Jan, 2009  |   Pubmed ID: 19154990
• RIG-ing an Antitumor Response
  Nature Medicine. Nov, 2008  |   Pubmed ID: 18989278
• Identification and Characterization of PWWP Domain Residues Critical for LEDGF/p75 Chromatin Binding and Human Immunodeficiency Virus Type 1 Infectivity
  Journal of Virology. Dec, 2008  |   Pubmed ID: 18799576
• Whither or Wither Microbicides?
  Science (New York, N.Y.). Jul, 2008  |   Pubmed ID: 18653884
• A PP4-phosphatase Complex Dephosphorylates Gamma-H2AX Generated During DNA Replication
  Molecular Cell. Jul, 2008  |   Pubmed ID: 18614045
• Granzyme A Cleaves a Mitochondrial Complex I Protein to Initiate Caspase-independent Cell Death
  Cell. May, 2008  |   Pubmed ID: 18485875
• RNA Interference and Cancer: Endogenous Pathways and Therapeutic Approaches
  Advances in Experimental Medicine and Biology. 2008  |   Pubmed ID: 18437900
• P16(INK4a) Translation Suppressed by MiR-24
  PloS One. 2008  |   Pubmed ID: 18365017
• Death by a Thousand Cuts: Granzyme Pathways of Programmed Cell Death
  Annual Review of Immunology. 2008  |   Pubmed ID: 18304003
• Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen
  Science (New York, N.Y.). Feb, 2008  |   Pubmed ID: 18187620
• Let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells
  Cell. Dec, 2007  |   Pubmed ID: 18083101
• Live Attenuated Listeria Monocytogenes Expressing HIV Gag: Immunogenicity in Rhesus Monkeys
  Vaccine. Oct, 2007  |   Pubmed ID: 17854955
• Mutations in the Gene Encoding the 3'-5' DNA Exonuclease TREX1 Are Associated with Systemic Lupus Erythematosus
  Nature Genetics. Sep, 2007  |   Pubmed ID: 17660818
• Interfering with Disease: a Progress Report on SiRNA-based Therapeutics
  Nature Reviews. Drug Discovery. Jun, 2007  |   Pubmed ID: 17541417
• A Mutation in TREX1 That Impairs Susceptibility to Granzyme A-mediated Cell Death Underlies Familial Chilblain Lupus
  Journal of Molecular Medicine (Berlin, Germany). May, 2007  |   Pubmed ID: 17440703
• Delivering the Kiss of Death: Progress on Understanding How Perforin Works
  Current Opinion in Immunology. Jun, 2007  |   Pubmed ID: 17433871
• Selective Gene Silencing in Activated Leukocytes by Targeting SiRNAs to the Integrin Lymphocyte Function-associated Antigen-1
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2007  |   Pubmed ID: 17360483
• NFAT5 Regulates HIV-1 in Primary Monocytes Via a Highly Conserved Long Terminal Repeat Site
  PLoS Pathogens. Dec, 2006  |   Pubmed ID: 17173480
• Knocking Down Disease with SiRNAs
  Cell. Jul, 2006  |   Pubmed ID: 16873051
• Silencing Viral Infection
  PLoS Medicine. Jul, 2006  |   Pubmed ID: 16848617
• Running Interference: Prospects and Obstacles to Using Small Interfering RNAs As Small Molecule Drugs
  Annual Review of Biomedical Engineering. 2006  |   Pubmed ID: 16834561
• The Exonuclease TREX1 is in the SET Complex and Acts in Concert with NM23-H1 to Degrade DNA During Granzyme A-mediated Cell Death
  Molecular Cell. Jul, 2006  |   Pubmed ID: 16818237
• Determinants of Specific RNA Interference-mediated Silencing of Human Beta-globin Alleles Differing by a Single Nucleotide Polymorphism
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2006  |   Pubmed ID: 16585504
• Granzyme A, Which Causes Single-stranded DNA Damage, Targets the Double-strand Break Repair Protein Ku70
  EMBO Reports. Apr, 2006  |   Pubmed ID: 16440001
• An SiRNA-based Microbicide Protects Mice from Lethal Herpes Simplex Virus 2 Infection
  Nature. Jan, 2006  |   Pubmed ID: 16306938
• A Phosphatase Complex That Dephosphorylates GammaH2AX Regulates DNA Damage Checkpoint Recovery
  Nature. Jan, 2006  |   Pubmed ID: 16299494
• Your Health in the 21st Century. Silencing Bad Genes
  Newsweek. 2005  |   Pubmed ID: 16375146
• Gamma-H2AX Dephosphorylation by Protein Phosphatase 2A Facilitates DNA Double-strand Break Repair
  Molecular Cell. Dec, 2005  |   Pubmed ID: 16310392
• Perforin Triggers a Plasma Membrane-repair Response That Facilitates CTL Induction of Apoptosis
  Immunity. Sep, 2005  |   Pubmed ID: 16169498
• Listeria-infected Myeloid Dendritic Cells Produce IFN-beta, Priming T Cell Activation
  Journal of Immunology (Baltimore, Md. : 1950). Jul, 2005  |   Pubmed ID: 15972676
• Vaccinia Virus Induces Strong Immunoregulatory Cytokine Production in Healthy Human Epidermal Keratinocytes: a Novel Strategy for Immune Evasion
  Journal of Virology. Jun, 2005  |   Pubmed ID: 15919891
• Antibody Mediated in Vivo Delivery of Small Interfering RNAs Via Cell-surface Receptors
  Nature Biotechnology. Jun, 2005  |   Pubmed ID: 15908939
• Granzyme B Binds to Target Cells Mostly by Charge and Must Be Added at the Same Time As Perforin to Trigger Apoptosis
  Journal of Immunology (Baltimore, Md. : 1950). May, 2005  |   Pubmed ID: 15843543
• Lentiviral Delivery of Short Hairpin RNAs Protects CD4 T Cells from Multiple Clades and Primary Isolates of HIV
  Blood. Aug, 2005  |   Pubmed ID: 15831707
• Granzyme A Induces Caspase-independent Mitochondrial Damage, a Required First Step for Apoptosis
  Immunity. Mar, 2005  |   Pubmed ID: 15780992
• The Prospect of Silencing Disease Using RNA Interference
  JAMA. Mar, 2005  |   Pubmed ID: 15769970
• Adenovirus Protein VII Functions Throughout Early Phase and Interacts with Cellular Proteins SET and Pp32
  Journal of Virology. Feb, 2005  |   Pubmed ID: 15681448
• The Silent Revolution: RNA Interference As Basic Biology, Research Tool, and Therapeutic
  Annual Review of Medicine. 2005  |   Pubmed ID: 15660519
• Cross-clade CD8 T-cell Responses to HIV(IIIB) and Chinese B' and C/B' Viruses in North American and Chinese HIV-seropositive Donors
  Journal of Acquired Immune Deficiency Syndromes (1999). Dec, 2004  |   Pubmed ID: 15602120
• Small Interfering RNA Targeting Fas Protects Mice Against Renal Ischemia-reperfusion Injury
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2004  |   Pubmed ID: 15466709
• Increased Expression of the Natural Killer Cell Inhibitory Receptor CD85j/ILT2 on Antigen-specific Effector CD8 T Cells and Its Impact on CD8 T-cell Function
  Immunology. Aug, 2004  |   Pubmed ID: 15270723
• Tracking the Killers: How Should We Measure CD8 T Cells in HIV Infection?
  AIDS (London, England). Jul, 2004  |   Pubmed ID: 15238766
• Proliferation Responses to HIVp24 During Antiretroviral Therapy Do Not Reflect Improved Immune Phenotype or Function
  AIDS (London, England). Mar, 2004  |   Pubmed ID: 15090765
• Public Health. A Sound Rationale Needed for Phase III HIV-1 Vaccine Trials
  Science (New York, N.Y.). Jan, 2004  |   Pubmed ID: 14726576
• Mapping Cross-clade HIV-1 Vaccine Epitopes Using a Bioinformatics Approach
  Vaccine. Oct, 2003  |   Pubmed ID: 14505932
• Nuclear War: the Granzyme A-bomb
  Current Opinion in Immunology. Oct, 2003  |   Pubmed ID: 14499264
• Interfering with Disease: Opportunities and Roadblocks to Harnessing RNA Interference
  Trends in Molecular Medicine. Sep, 2003  |   Pubmed ID: 13129706
• Sustained Small Interfering RNA-mediated Human Immunodeficiency Virus Type 1 Inhibition in Primary Macrophages
  Journal of Virology. Jul, 2003  |   Pubmed ID: 12805416
• The ABCs of Granule-mediated Cytotoxicity: New Weapons in the Arsenal
  Nature Reviews. Immunology. May, 2003  |   Pubmed ID: 12766758
• A Fragment of Anthrax Lethal Factor Delivers Proteins to the Cytosol Without Requiring Protective Antigen
  Proceedings of the National Academy of Sciences of the United States of America. May, 2003  |   Pubmed ID: 12740437
• The Gp49B1 Inhibitory Receptor Regulates the IFN-gamma Responses of T Cells and NK Cells
  Journal of Immunology (Baltimore, Md. : 1950). Apr, 2003  |   Pubmed ID: 12682239
• Tumor Suppressor NM23-H1 is a Granzyme A-activated DNase During CTL-mediated Apoptosis, and the Nucleosome Assembly Protein SET is Its Inhibitor
  Cell. Mar, 2003  |   Pubmed ID: 12628186
• RNA Interference Targeting Fas Protects Mice from Fulminant Hepatitis
  Nature Medicine. Mar, 2003  |   Pubmed ID: 12579197
• Cleaving the Oxidative Repair Protein Ape1 Enhances Cell Death Mediated by Granzyme A
  Nature Immunology. Feb, 2003  |   Pubmed ID: 12524539
• HIV-1 Antiviral Activity of Recombinant Natural Killer Cell Enhancing Factors, NKEF-A and NKEF-B, Members of the Peroxiredoxin Family
  The Journal of Biological Chemistry. Jan, 2003  |   Pubmed ID: 12421812
• Most Antiviral CD8 T Cells During Chronic Viral Infection Do Not Express High Levels of Perforin and Are Not Directly Cytotoxic
  Blood. Jan, 2003  |   Pubmed ID: 12393740
• The Functional CD8 T Cell Response to HIV Becomes Type-specific in Progressive Disease
  The Journal of Clinical Investigation. Nov, 2002  |   Pubmed ID: 12417573
• Defying Death--HIV Mutation to Evade Cytotoxic T Lymphocytes
  The New England Journal of Medicine. Oct, 2002  |   Pubmed ID: 12374884
• Avoiding the Kiss of Death: How HIV and Other Chronic Viruses Survive
  Current Opinion in Immunology. Aug, 2002  |   Pubmed ID: 12088683
• SiRNA-directed Inhibition of HIV-1 Infection
  Nature Medicine. Jul, 2002  |   Pubmed ID: 12042777
• Engineered Listeria Monocytogenes As an AIDS Vaccine
  Vaccine. May, 2002  |   Pubmed ID: 11983264
• HMG2 Interacts with the Nucleosome Assembly Protein SET and is a Target of the Cytotoxic T-lymphocyte Protease Granzyme A
  Molecular and Cellular Biology. Apr, 2002  |   Pubmed ID: 11909973