Junichi Nabekura Division of Homeostatic Development National Institute for Physiological Sciences Biography Publications Institution JoVE Articles Junichi Nabekura has not added a biography. If you are Junichi Nabekura and would like to personalize this page please email our Author Liaison for assistance. Publications Inhibition of Transient Receptor Potential Cation Channel 6 Promotes Capillary Arterialization During Post-ischaemic Blood Flow Recovery British Journal of Pharmacology. Jan, 2023 | Pubmed ID: 36068079 Erratic and Blood Vessel-guided Migration of Astrocyte Progenitors in the Cerebral Cortex Nature Communications. Nov, 2022 | Pubmed ID: 36323680 Controlled Activation of Cortical Astrocytes Modulates Neuropathic Pain-like Behaviour Nature Communications. Jul, 2022 | Pubmed ID: 35835747 Transient Astrocytic MGluR5 Expression Drives Synaptic Plasticity and Subsequent Chronic Pain in Mice The Journal of Experimental Medicine. 04, 2022 | Pubmed ID: 35319723 Synaptic Pruning of Murine Adult-born Neurons by Microglia Depends on Phosphatidylserine The Journal of Experimental Medicine. Apr, 2022 | Pubmed ID: 35297954 Development and Experience-dependent Modulation of the Defensive Behaviors of Mice to Visual Threats The Journal of Physiological Sciences : JPS. Mar, 2022 | Pubmed ID: 35255805 Global Transgenic Upregulation of KCC2 Confers Enhanced Diazepam Efficacy in Treating Sustained Seizures Epilepsia. Jan, 2022 | Pubmed ID: 34791657 Abnormal Ca Signals in Reactive Astrocytes As a Common Cause of Brain Diseases International Journal of Molecular Sciences. Dec, 2021 | Pubmed ID: 35008573 Adenosine A Receptor Down-regulates Metabotropic Glutamate Receptor 5 in Astrocytes During Postnatal Development Glia. 11, 2021 | Pubmed ID: 34339538 Thermosensitive TRPV4 Channels Mediate Temperature-dependent Microglia Movement Proceedings of the National Academy of Sciences of the United States of America. Apr, 2021 | Pubmed ID: 33888579 Reactive Astrocyte-driven Epileptogenesis is Induced by Microglia Initially Activated Following Status Epilepticus JCI Insight. 05, 2021 | Pubmed ID: 33830944 Photoactivatable CaMKII Induces Synaptic Plasticity in Single Synapses Nature Communications. Feb, 2021 | Pubmed ID: 33531495 PEO-CYTOP Fluoropolymer Nanosheets As a Novel Open-Skull Window for Imaging of the Living Mouse Brain IScience. Oct, 2020 | Pubmed ID: 33083745 Histamine Depolarizes Rat Intracardiac Ganglion Neurons Through the Activation of TRPC Non-selective Cation Channels European Journal of Pharmacology. Nov, 2020 | Pubmed ID: 32896550 CMOS-based Bio-image Sensor Spatially Resolves Neural Activity-dependent Proton Dynamics in the Living Brain Nature Communications. Feb, 2020 | Pubmed ID: 32024837 Motor Learning Requires Myelination to Reduce Asynchrony and Spontaneity in Neural Activity Glia. Jan, 2020 | Pubmed ID: 31465122 Dual Microglia Effects on Blood Brain Barrier Permeability Induced by Systemic Inflammation Nature Communications. 12, 2019 | Pubmed ID: 31862977 ShadowR: a Novel Chromoprotein with Reduced Non-specific Binding and Improved Expression in Living Cells Scientific Reports. Aug, 2019 | Pubmed ID: 31427680 In Vivo Two-Photon Imaging of Microglial Synapse Contacts Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 31392692 Physiological Implications of Microglia-Synapse Interactions Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 31392678 Overexpression of Neuronal K-Cl Co-transporter Enhances Dendritic Spine Plasticity and Motor Learning The Journal of Physiological Sciences : JPS. May, 2019 | Pubmed ID: 30758780 PDGFR-β Restores Blood-brain Barrier Functions in a Mouse Model of Focal Cerebral Ischemia Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Aug, 2019 | Pubmed ID: 29629621 Microglia Enhance Synapse Activity to Promote Local Network Synchronization ENeuro. 2018 | Pubmed ID: 30406198 Microglia Mediate Non-cell-autonomous Cell Death of Retinal Ganglion Cells Glia. 11, 2018 | Pubmed ID: 30375063 Cortical Astrocytes Prime the Induction of Spine Plasticity and Mirror Image Pain Pain. Aug, 2018 | Pubmed ID: 29672449 Activity-dependent Functions of Non-electrical Glial Cells Journal of Biochemistry. Jun, 2018 | Pubmed ID: 29447392 The Roles of Cortical Astrocytes in Chronic Pain and Other Brain Pathologies Neuroscience Research. Jan, 2018 | Pubmed ID: 28870605 Author Correction: Reactive Astrocytes Function As Phagocytes After Brain Ischemia Via ABCA1-mediated Pathway Nature Communications. 11, 2017 | Pubmed ID: 29138397 Astrocytes with Previous Chronic Exposure to Amyloid β-peptide Fragment 1-40 Suppress Excitatory Synaptic Transmission Journal of Neurochemistry. 12, 2017 | Pubmed ID: 29076533 Time-controllable Nkcc1 Knockdown Replicates Reversible Hearing Loss in Postnatal Mice Scientific Reports. Oct, 2017 | Pubmed ID: 29051615 Reactive Astrocytes Function As Phagocytes After Brain Ischemia Via ABCA1-mediated Pathway Nature Communications. 06, 2017 | Pubmed ID: 28642575 Astrocyte-mediated Synapse Remodeling in the Pathological Brain Glia. 11, 2017 | Pubmed ID: 28569048 Functional and Structural Plasticity in the Primary Somatosensory Cortex Associated with Chronic Pain Journal of Neurochemistry. May, 2017 | Pubmed ID: 28278355 Activation-Dependent Rapid Postsynaptic Clustering of Glycine Receptors in Mature Spinal Cord Neurons ENeuro. 2017 | Pubmed ID: 28197549 Dual Observation of the ATP-evoked Small GTPase Activation and Ca Transient in Astrocytes Using a Dark Red Fluorescent Protein Scientific Reports. Dec, 2016 | Pubmed ID: 28004840 Microglia Contact Induces Synapse Formation in Developing Somatosensory Cortex Nature Communications. Aug, 2016 | Pubmed ID: 27558646 Microglial Contact Prevents Excess Depolarization and Rescues Neurons from Excitotoxicity ENeuro. 2016 | Pubmed ID: 27390772 Cortical Astrocytes Rewire Somatosensory Cortical Circuits for Peripheral Neuropathic Pain The Journal of Clinical Investigation. May, 2016 | Pubmed ID: 27064281 A Dark Green Fluorescent Protein As an Acceptor for Measurement of Förster Resonance Energy Transfer Scientific Reports. Oct, 2015 | Pubmed ID: 26469148 In Vivo Imaging of Axonal Transport of Mitochondria in the Diseased and Aged Mammalian CNS Proceedings of the National Academy of Sciences of the United States of America. Aug, 2015 | Pubmed ID: 26240337 Noradrenergic Refinement of Glutamatergic Neuronal Circuits in the Lateral Superior Olivary Nucleus Before Hearing Onset Journal of Neurophysiology. Sep, 2015 | Pubmed ID: 26203112 Effect of Rovatirelin, a Novel Thyrotropin-releasing Hormone Analog, on the Central Noradrenergic System European Journal of Pharmacology. Aug, 2015 | Pubmed ID: 26142830 The Role of GABA in the Regulation of GnRH Neurons Frontiers in Neuroscience. 2014 | Pubmed ID: 25506316 Olfactory Plays a Key Role in Spatiotemporal Pathogenesis of Cerebral Malaria Cell Host & Microbe. May, 2014 | Pubmed ID: 24832450 Contribution of Neuronal and Glial Circuit in Intact Hemisphere for Functional Remodeling After Focal Ischemia Neuroscience Research. Jan, 2014 | Pubmed ID: 23896202 [Mechanisms of Neural Circuit Remodeling in the Primary Somatosensory Cortex in Mouse Models of Chronic Pain] Brain and Nerve = Shinkei Kenkyu No Shinpo. Jun, 2013 | Pubmed ID: 23735524 Microglia and Synapse Interactions: Fine Tuning Neural Circuits and Candidate Molecules Frontiers in Cellular Neuroscience. 2013 | Pubmed ID: 23720611 Dynamic Regulation of Glycine-GABA Co-transmission at Spinal Inhibitory Synapses by Neuronal Glutamate Transporter The Journal of Physiology. Aug, 2013 | Pubmed ID: 23690564 Critical Role of the Astrocyte for Functional Remodeling in Contralateral Hemisphere of Somatosensory Cortex After Stroke The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2013 | Pubmed ID: 23486942 Modulation of Diazepam-insensitive GABA(A) Receptors by Micromolar Concentrations of Thyroxine and Related Compounds in Vitro Brain Research. Jan, 2013 | Pubmed ID: 23103412 Enhanced GABAergic Activity in the Mouse Primary Somatosensory Cortex is Insufficient to Alleviate Chronic Pain Behavior with Reduced Expression of Neuronal Potassium-chloride Cotransporter The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2012 | Pubmed ID: 23175811 Synaptic Structure and Function in the Mouse Somatosensory Cortex During Chronic Pain: in Vivo Two-photon Imaging Neural Plasticity. 2012 | Pubmed ID: 22530157 PDGFR-β As a Positive Regulator of Tissue Repair in a Mouse Model of Focal Cerebral Ischemia Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Feb, 2012 | Pubmed ID: 21952111 GABA Regulates the Multidirectional Tangential Migration of GABAergic Interneurons in Living Neonatal Mice PloS One. 2011 | Pubmed ID: 22180776 Phase-specific Plasticity of Synaptic Structures in the Somatosensory Cortex of Living Mice During Neuropathic Pain Molecular Pain. 2011 | Pubmed ID: 22067412 Taltirelin, a Thyrotropin-releasing Hormone Analog, Alleviates Mechanical Allodynia Through Activation of Descending Monoaminergic Neurons in Persistent Inflammatory Pain Brain Research. Sep, 2011 | Pubmed ID: 21872219 Sensory Input Regulates Spatial and Subtype-specific Patterns of Neuronal Turnover in the Adult Olfactory Bulb The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2011 | Pubmed ID: 21832189 Inter-regional Contribution of Enhanced Activity of the Primary Somatosensory Cortex to the Anterior Cingulate Cortex Accelerates Chronic Pain Behavior The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2011 | Pubmed ID: 21613476 Rapid Synaptic Remodeling in the Adult Somatosensory Cortex Following Peripheral Nerve Injury and Its Association with Neuropathic Pain The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2011 | Pubmed ID: 21471384 Depolarizing Shift in the GABA-induced Current Reversal Potential by Lidocaine Hydrochloride Brain Research. Jul, 2010 | Pubmed ID: 20580693 Phospholipase C-related but Catalytically Inactive Protein is Required for Insulin-induced Cell Surface Expression of Gamma-aminobutyric Acid Type A Receptors The Journal of Biological Chemistry. Feb, 2010 | Pubmed ID: 19996098 Excitation of Locus Coeruleus Noradrenergic Neurons by Thyrotropin-releasing Hormone The Journal of Physiology. Dec, 2009 | Pubmed ID: 19840999 Clustering of Neuronal K+-Cl- Cotransporters in Lipid Rafts by Tyrosine Phosphorylation The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19679663 Neuronal Circuit Remodeling in the Contralateral Cortical Hemisphere During Functional Recovery from Cerebral Infarction The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2009 | Pubmed ID: 19675241 Maternal Separation Decreases the Stability of Mushroom Spines in Adult Mice Somatosensory Cortex Brain Research. Oct, 2009 | Pubmed ID: 19651112 Resting Microglia Directly Monitor the Functional State of Synapses in Vivo and Determine the Fate of Ischemic Terminals The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2009 | Pubmed ID: 19339593 Inhibition of Chloride Outward Transport by Gadolinium in Cultured Rat Spinal Cord Neurons Neurotoxicology. Jan, 2009 | Pubmed ID: 19007810 Sustained Depolarizing Shift of the GABA Reversal Potential by Glutamate Receptor Activation in Hippocampal Neurons Neuroscience Research. Dec, 2008 | Pubmed ID: 18840481 Reduction of Metabotropic Glutamate Receptor-mediated Heterosynaptic Inhibition of Developing MNTB-LSO Inhibitory Synapses The European Journal of Neuroscience. Jul, 2007 | Pubmed ID: 17623021 Phospholipase C-related Inactive Protein is Involved in Trafficking of Gamma2 Subunit-containing GABA(A) Receptors to the Cell Surface The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2007 | Pubmed ID: 17301177 Developmental Switch from GABA to Glycine Release in Single Central Synaptic Terminals Nature Neuroscience. Jan, 2004 | Pubmed ID: 14699415 Spatiotemporal Analysis of Microglial Ca2+ Activity at Single-Cell Resolution Hiroshi Horiuchi1,2, Dennis Lawrence Cheung1, Junichi Nabekura1,2 1Division of Homeostatic Development, National Institute for Physiological Sciences, 2Department of Physiological Sciences, SOKENDAI: the Graduate University for Advanced Studies JoVE 64300 Neuroscience
Spatiotemporal Analysis of Microglial Ca2+ Activity at Single-Cell Resolution Hiroshi Horiuchi1,2, Dennis Lawrence Cheung1, Junichi Nabekura1,2 1Division of Homeostatic Development, National Institute for Physiological Sciences, 2Department of Physiological Sciences, SOKENDAI: the Graduate University for Advanced Studies JoVE 64300 Neuroscience
