Junmin Peng Departments of Structural Biology and Developmental Neurobiology St. Jude Children’s Research Hospital Biography Publications Institution JoVE Articles Junmin Peng has not added a biography. If you are Junmin Peng and would like to personalize this page please email our Author Liaison for assistance. Publications JUMPt: Comprehensive Protein Turnover Modeling of In Vivo Pulse SILAC Data by Ordinary Differential Equations Analytical Chemistry. 10, 2021 | Pubmed ID: 34587451 Acute Depletion of CTCF Rewires Genome-wide Chromatin Accessibility Genome Biology. 08, 2021 | Pubmed ID: 34429148 Proteomic Landscape of Alzheimer's Disease: Novel Insights into Pathogenesis and Biomarker Discovery Molecular Neurodegeneration. 08, 2021 | Pubmed ID: 34384464 Global Proteomic Profiling of Pediatric AML: A Pilot Study Cancers. Jun, 2021 | Pubmed ID: 34202615 Network-based Systems Pharmacology Reveals Heterogeneity in LCK and BCL2 Signaling and Therapeutic Sensitivity of T-cell Acute Lymphoblastic Leukemia Nature Cancer. Mar, 2021 | Pubmed ID: 34151288 Structural Analysis of the Full-length Human LRRK2 Cell. Jun, 2021 | Pubmed ID: 34107286 Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators Journal of Medicinal Chemistry. 06, 2021 | Pubmed ID: 34042448 An Age-downregulated Ribosomal RpS28 Protein Variant Regulates the Muscle Proteome G3 (Bethesda, Md.). May, 2021 | Pubmed ID: 33974070 High-Throughput Profiling of Proteome and Posttranslational Modifications by 16-Plex TMT Labeling and Mass Spectrometry Methods in Molecular Biology (Clifton, N.J.). 2021 | Pubmed ID: 33950493 Quantifying Proteome and Protein Modifications in Activated T Cells by Multiplexed Isobaric Labeling Mass Spectrometry Methods in Molecular Biology (Clifton, N.J.). 2021 | Pubmed ID: 33928561 Global Profiling of Lysine Accessibility to Evaluate Protein Structure Changes in Alzheimer's Disease Journal of the American Society for Mass Spectrometry. Apr, 2021 | Pubmed ID: 33683887 Integrative Network Analysis Reveals USP7 Haploinsufficiency Inhibits E-protein Activity in Pediatric T-lineage Acute Lymphoblastic Leukemia (T-ALL) Scientific Reports. Mar, 2021 | Pubmed ID: 33664368 Antagonistic Control of Myofiber Size and Muscle Protein Quality Control by the Ubiquitin Ligase UBR4 During Aging Nature Communications. 03, 2021 | Pubmed ID: 33658508 Deep Profiling of Microgram-Scale Proteome by Tandem Mass Tag Mass Spectrometry Journal of Proteome Research. 01, 2021 | Pubmed ID: 33175545 FBXO11-mediated Proteolysis of BAHD1 Relieves PRC2-dependent Transcriptional Repression in Erythropoiesis Blood. 01, 2021 | Pubmed ID: 33156908 Author Correction: Combinatorial Expression of GPCR Isoforms Affects Signalling and Drug Responses Nature. Dec, 2020 | Pubmed ID: 33244189 Combinatorial Expression of GPCR Isoforms Affects Signalling and Drug Responses Nature. 11, 2020 | Pubmed ID: 33149304 Integrated Analysis of Ultra-deep Proteomes in Cortex, Cerebrospinal Fluid and Serum Reveals a Mitochondrial Signature in Alzheimer's Disease Molecular Neurodegeneration. 07, 2020 | Pubmed ID: 32711556 Toxicoproteomic Profiling of Transgenic Mice Treated with Rifampicin and Isoniazid Cells. Jul, 2020 | Pubmed ID: 32660103 Control of Early B Cell Development by the RNA N-Methyladenosine Methylation Cell Reports. Jun, 2020 | Pubmed ID: 32610122 JUMPm: A Tool for Large-Scale Identification of Metabolites in Untargeted Metabolomics Metabolites. May, 2020 | Pubmed ID: 32408578 Ligand-induced Monoubiquitination of BIK1 Regulates Plant Immunity Nature. 05, 2020 | Pubmed ID: 32404997 27-Plex Tandem Mass Tag Mass Spectrometry for Profiling Brain Proteome in Alzheimer's Disease Analytical Chemistry. 05, 2020 | Pubmed ID: 32343560 Novel Specialized Cell State and Spatial Compartments Within the Germinal Center Nature Immunology. Jun, 2020 | Pubmed ID: 32341509 A Cancer-Specific Ubiquitin Ligase Drives MRNA Alternative Polyadenylation by Ubiquitinating the MRNA 3' End Processing Complex Molecular Cell. 03, 2020 | Pubmed ID: 31980388 An ABC Transporter Drives Medulloblastoma Pathogenesis by Regulating Sonic Hedgehog Signaling Cancer Research. Apr, 2020 | Pubmed ID: 31948942 Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression Neuron. 03, 2020 | Pubmed ID: 31926610 Cerebrospinal Fluid Tau Fragment Correlates with Tau PET: a Candidate Biomarker for Tangle Pathology Brain : a Journal of Neurology. 02, 2020 | Pubmed ID: 31834365 ALS-FTLD-linked Mutations of SQSTM1/p62 Disrupt Selective Autophagy and NFE2L2/NRF2 Anti-oxidative Stress Pathway Autophagy. 05, 2020 | Pubmed ID: 31362587 Systems Immunology: Integrating Multi-omics Data to Infer Regulatory Networks and Hidden Drivers of Immunity Current Opinion in Systems Biology. Jun, 2019 | Pubmed ID: 32789283 Amino Acids License Kinase MTORC1 Activity and Treg Cell Function Via Small G Proteins Rag and Rheb Immunity. 12, 2019 | Pubmed ID: 31668641 Multimodal Imaging of Amyloid Plaques: Fusion of the Single-Probe Mass Spectrometry Image and Fluorescence Microscopy Image Analytical Chemistry. 10, 2019 | Pubmed ID: 31536324 Deep Multiomics Profiling of Brain Tumors Identifies Signaling Networks Downstream of Cancer Driver Genes Nature Communications. 08, 2019 | Pubmed ID: 31420543 A Key Role for the Ubiquitin Ligase UBR4 in Myofiber Hypertrophy in Drosophila and Mice Cell Reports. 07, 2019 | Pubmed ID: 31365869 Akt Phosphorylates NQO1 and Triggers Its Degradation, Abolishing Its Antioxidative Activities in Parkinson's Disease The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 09, 2019 | Pubmed ID: 31358653 Regulation of MAGE-A3/6 by the CRL4-DCAF12 Ubiquitin Ligase and Nutrient Availability EMBO Reports. 07, 2019 | Pubmed ID: 31267705 Circadian Gene Variants and the Skeletal Muscle Circadian Clock Contribute to the Evolutionary Divergence in Longevity Across Populations Genome Research. 08, 2019 | Pubmed ID: 31249065 Kinase Network Dysregulation in a Human Induced Pluripotent Stem Cell Model of DISC1 Schizophrenia Molecular Omics. 06, 2019 | Pubmed ID: 31106784 Corrigendum to "Metabolic Switching in Pluripotent Stem Cells Reorganizes Energy Metabolism and Subcellular Organelles" [379 (2019) 55-64] Experimental Cell Research. Aug, 2019 | Pubmed ID: 31079852 Deep Undepleted Human Serum Proteome Profiling Toward Biomarker Discovery for Alzheimer's Disease Clinical Proteomics. 2019 | Pubmed ID: 31019427 Identification of a Functional Non-coding Variant in the GABA Receptor α2 Subunit of the C57BL/6J Mouse Reference Genome: Major Implications for Neuroscience Research Frontiers in Genetics. 2019 | Pubmed ID: 30984232 ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97 Molecular Cell. 05, 2019 | Pubmed ID: 30979586 Regulation of Gene Expression by MiR-144/451 During Mouse Erythropoiesis Blood. 06, 2019 | Pubmed ID: 30971389 Metabolic Switching in Pluripotent Stem Cells Reorganizes Energy Metabolism and Subcellular Organelles Experimental Cell Research. 06, 2019 | Pubmed ID: 30922922 LKB1 Orchestrates Dendritic Cell Metabolic Quiescence and Anti-tumor Immunity Cell Research. 05, 2019 | Pubmed ID: 30911060 Mutant and Wild-Type Isocitrate Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer Cancer Discovery. 06, 2019 | Pubmed ID: 30862724 Phosphatidic Acid Generated by PLD2 Promotes the Plasma Membrane Recruitment of IQGAP1 and Neointima Formation FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 06, 2019 | Pubmed ID: 30811216 Differentiation of Human Pluripotent Stem Cells into Neurons or Cortical Organoids Requires Transcriptional Co-regulation by UTX and 53BP1 Nature Neuroscience. 03, 2019 | Pubmed ID: 30718900 TET2 Stabilization by 14-3-3 Binding to the Phosphorylated Serine 99 is Deregulated by Mutations in Cancer Cell Research. 03, 2019 | Pubmed ID: 30607016 Deubiquitylase USP9X Maintains Centriolar Satellite Integrity by Stabilizing Pericentriolar Material 1 Protein Journal of Cell Science. 01, 2019 | Pubmed ID: 30584065 Deep Profiling of the Aggregated Proteome in Alzheimer's Disease: From Pathology to Disease Mechanisms Proteomes. Nov, 2018 | Pubmed ID: 30424485 Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R-STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity Immunity. 11, 2018 | Pubmed ID: 30413360 Partial Loss of Psychiatric Risk Gene Mir137 in Mice Causes Repetitive Behavior and Impairs Sociability and Learning Via Increased Pde10a Nature Neuroscience. 12, 2018 | Pubmed ID: 30397325 Identification of Therapeutic Targets in Rhabdomyosarcoma Through Integrated Genomic, Epigenomic, and Proteomic Analyses Cancer Cell. 09, 2018 | Pubmed ID: 30146332 Epidithiodiketopiperazines Inhibit Protein Degradation by Targeting Proteasome Deubiquitinase Rpn11 Cell Chemical Biology. 11, 2018 | Pubmed ID: 30146242 BDNF Inhibits Neurodegenerative Disease-associated Asparaginyl Endopeptidase Activity Via Phosphorylation by AKT JCI Insight. 08, 2018 | Pubmed ID: 30135302 Spectral Library Search Improves Assignment of TMT Labeled MS/MS Spectra Journal of Proteome Research. 09, 2018 | Pubmed ID: 30096983 Reducing Histone Acetylation Rescues Cognitive Deficits in a Mouse Model of Fragile X Syndrome Nature Communications. 06, 2018 | Pubmed ID: 29950602 Quantitative Phosphoproteomic Analysis of the Molecular Substrates of Sleep Need Nature. 06, 2018 | Pubmed ID: 29899451 Isotope Labeling-Assisted Evaluation of Hydrophilic and Hydrophobic Liquid Chromatograph-Mass Spectrometry for Metabolomics Profiling Analytical Chemistry. 07, 2018 | Pubmed ID: 29883117 Hippo/Mst Signalling Couples Metabolic State and Immune Function of CD8α Dendritic Cells Nature. 06, 2018 | Pubmed ID: 29849151 Mutant LRRK2 Mediates Peripheral and Central Immune Responses Leading to Neurodegeneration in Vivo Brain : a Journal of Neurology. 06, 2018 | Pubmed ID: 29800472 Target-Decoy-Based False Discovery Rate Estimation for Large-Scale Metabolite Identification Journal of Proteome Research. 07, 2018 | Pubmed ID: 29790753 CDK2 Inhibitors As Candidate Therapeutics for Cisplatin- and Noise-induced Hearing Loss The Journal of Experimental Medicine. 04, 2018 | Pubmed ID: 29514916 Discrete Roles and Bifurcation of PTEN Signaling and MTORC1-mediated Anabolic Metabolism Underlie IL-7-driven B Lymphopoiesis Science Advances. 01, 2018 | Pubmed ID: 29399633 Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells Developmental Cell. Oct, 2017 | Pubmed ID: 29033361 The Neoepitope Landscape in Pediatric Cancers Genome Medicine. Aug, 2017 | Pubmed ID: 28854978 Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox Cancer Research. Sep, 2017 | Pubmed ID: 28684529 Blocking an N-terminal Acetylation-dependent Protein Interaction Inhibits an E3 Ligase Nature Chemical Biology. Aug, 2017 | Pubmed ID: 28581483 Quantitative Phosphoproteomic Analysis of Brain Tissues Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 28508362 Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation Immunity. Mar, 2017 | Pubmed ID: 28285833 Targeting Human Mas-related G Protein-coupled Receptor X1 to Inhibit Persistent Pain Proceedings of the National Academy of Sciences of the United States of America. Mar, 2017 | Pubmed ID: 28223516 Extensive Peptide Fractionation and Y1 Ion-Based Interference Detection Method for Enabling Accurate Quantification by Isobaric Labeling and Mass Spectrometry Analytical Chemistry. Mar, 2017 | Pubmed ID: 28194965 Deep Profiling of Proteome and Phosphoproteome by Isobaric Labeling, Extensive Liquid Chromatography, and Mass Spectrometry Methods in Enzymology. 2017 | Pubmed ID: 28109439 The C. elegans Taste Receptor Homolog LITE-1 Is a Photoreceptor Cell. 11, 2016 | Pubmed ID: 27863243 C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles Cell. Oct, 2016 | Pubmed ID: 27768896 JUMPg: An Integrative Proteogenomics Pipeline Identifying Unannotated Proteins in Human Brain and Cancer Cells Journal of Proteome Research. Jul, 2016 | Pubmed ID: 27225868 The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis Molecular Cell. May, 2016 | Pubmed ID: 27203176 Enhanced Purification of Ubiquitinated Proteins by Engineered Tandem Hybrid Ubiquitin-binding Domains (ThUBDs) Molecular & Cellular Proteomics : MCP. Apr, 2016 | Pubmed ID: 27037361 SUMO Pathway Modulation of Regulatory Protein Binding at the Ribosomal DNA Locus in Saccharomyces Cerevisiae Genetics. Apr, 2016 | Pubmed ID: 26837752 Joint Mouse-human Phenome-wide Association to Test Gene Function and Disease Risk Nature Communications. Feb, 2016 | Pubmed ID: 26833085 Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination Journal of Molecular Biology. Mar, 2016 | Pubmed ID: 26475525 A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival Molecular & Cellular Proteomics : MCP. Dec, 2015 | Pubmed ID: 26412298 Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia Cancer Cell. Sep, 2015 | Pubmed ID: 26321221 Molecular Characterization of LC3-associated Phagocytosis Reveals Distinct Roles for Rubicon, NOX2 and Autophagy Proteins Nature Cell Biology. Jul, 2015 | Pubmed ID: 26098576 PHD2/3-dependent Hydroxylation Tunes Cardiac Response to β-adrenergic Stress Via Phospholamban The Journal of Clinical Investigation. Jul, 2015 | Pubmed ID: 26075818 Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth Molecular & Cellular Proteomics : MCP. Jul, 2015 | Pubmed ID: 25931508 Quantitative Protein Analysis by Mass Spectrometry Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 25859956 Altered Ubiquitin Causes Perturbed Calcium Homeostasis, Hyperactivation of Calpain, Dysregulated Differentiation, and Cataract Proceedings of the National Academy of Sciences of the United States of America. Jan, 2015 | Pubmed ID: 25583491 Systematic Optimization of Long Gradient Chromatography Mass Spectrometry for Deep Analysis of Brain Proteome Journal of Proteome Research. Feb, 2015 | Pubmed ID: 25455107 Refined Phosphopeptide Enrichment by Phosphate Additive and the Analysis of Human Brain Phosphoproteome Proteomics. Jan, 2015 | Pubmed ID: 25307156 JUMP: a Tag-based Database Search Tool for Peptide Identification with High Sensitivity and Accuracy Molecular & Cellular Proteomics : MCP. Dec, 2014 | Pubmed ID: 25202125 Global Ubiquitination Analysis by SILAC in Mammalian Cells Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 25059610 Integrated Approaches for Analyzing U1-70K Cleavage in Alzheimer's Disease Journal of Proteome Research. Nov, 2014 | Pubmed ID: 24902715 Cell Type-restricted Activity of HnRNPM Promotes Breast Cancer Metastasis Via Regulating Alternative Splicing Genes & Development. Jun, 2014 | Pubmed ID: 24840202 Autoregulation of the 26S Proteasome by in Situ Ubiquitination Molecular Biology of the Cell. Jun, 2014 | Pubmed ID: 24743594 A Nano Ultra-performance Liquid Chromatography-high Resolution Mass Spectrometry Approach for Global Metabolomic Profiling and Case Study on Drug-resistant Multiple Myeloma Analytical Chemistry. Apr, 2014 | Pubmed ID: 24611431 The U4/U6 Recycling Factor SART3 Has Histone Chaperone Activity and Associates with USP15 to Regulate H2B Deubiquitination The Journal of Biological Chemistry. Mar, 2014 | Pubmed ID: 24526689 Identification and Characterization of Phosphorylation Sites Within the Pregnane X Receptor Protein Biochemical Pharmacology. Jan, 2014 | Pubmed ID: 24184507 A Conserved Protein with AN1 Zinc Finger and Ubiquitin-like Domains Modulates Cdc48 (p97) Function in the Ubiquitin-proteasome Pathway The Journal of Biological Chemistry. Nov, 2013 | Pubmed ID: 24121501 U1 Small Nuclear Ribonucleoprotein Complex and RNA Splicing Alterations in Alzheimer's Disease Proceedings of the National Academy of Sciences of the United States of America. Oct, 2013 | Pubmed ID: 24023061 Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity Structure (London, England : 1993). Jul, 2013 | Pubmed ID: 23746807 Proteomic Analysis of Postsynaptic Density in Alzheimer's Disease Clinica Chimica Acta; International Journal of Clinical Chemistry. May, 2013 | Pubmed ID: 23537733 The Cotranslational Function of Ribosome-associated Hsp70 in Eukaryotic Protein Homeostasis Cell. Jan, 2013 | Pubmed ID: 23332755 Sjogren Syndrome Antigen B (SSB)/La Promotes Global MicroRNA Expression by Binding MicroRNA Precursors Through Stem-loop Recognition The Journal of Biological Chemistry. Jan, 2013 | Pubmed ID: 23129761 Regulation of Behavioral Circadian Rhythms and Clock Protein PER1 by the Deubiquitinating Enzyme USP2 Biology Open. Aug, 2012 | Pubmed ID: 23213472 Ubiquitin-specific Protease 9x Deubiquitinates and Stabilizes the Spinal Muscular Atrophy Protein-survival Motor Neuron The Journal of Biological Chemistry. Dec, 2012 | Pubmed ID: 23112048 Synaptic Protein Ubiquitination in Rat Brain Revealed by Antibody-based Ubiquitome Analysis Journal of Proteome Research. Sep, 2012 | Pubmed ID: 22871113 Quantitative Proteomics to Decipher Ubiquitin Signaling Amino Acids. Sep, 2012 | Pubmed ID: 22821265 PHD3-dependent Hydroxylation of HCLK2 Promotes the DNA Damage Response The Journal of Clinical Investigation. Aug, 2012 | Pubmed ID: 22797300 Characterizing Ubiquitination Sites by Peptide-based Immunoaffinity Enrichment Molecular & Cellular Proteomics : MCP. Dec, 2012 | Pubmed ID: 22729469 Analysis of Ubiquitinated Proteome by Quantitative Mass Spectrometry Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22665315 SOX4 Interacts with Plakoglobin in a Wnt3a-dependent Manner in Prostate Cancer Cells BMC Cell Biology. 2011 | Pubmed ID: 22098624 JUMPn：蛋白质共表达聚类和网络分析在蛋白质组学中的简化应用 David Vanderwall1, Poudel Suresh1,2, Yingxue Fu2, Ji-Hoon Cho2, Timothy I. Shaw2,3, Ashutosh Mishra2, Anthony A. High2, Junmin Peng1,2, Yuxin Li1,2 1Departments of Structural Biology and Developmental Neurobiology, St. Jude Children’s Research Hospital, 2Center for Proteomics and Metabolomics, St. Jude Children’s Research Hospital, 3Department of Computational Biology, St. Jude Children’s Research Hospital JoVE 62796 Biochemistry High-throughput and Deep-proteome Profiling by 16-plex Tandem Mass Tag Labeling Coupled with Two-dimensional Chromatography and Mass Spectrometry JoVE 61684 Biology 用等压标记、广泛的液相色谱法、质谱法和软件辅助定量技术进行深层蛋白质组分析 Anthony A. High1, Haiyan Tan1, Vishwajeeth R. Pagala1, Mingming Niu2,3, Ji-Hoon Cho1, Xusheng Wang1, Bing Bai2, Junmin Peng1,2 1St. Jude Proteomics Facility, St. Jude Children's Research Hospital, 2Departments of Structural Biology and Developmental Neurobiology, St. Jude Children's Research Hospital, 3Heilongjiang University of Chinese Medicine JoVE 56474 Biochemistry
JUMPn：蛋白质共表达聚类和网络分析在蛋白质组学中的简化应用 David Vanderwall1, Poudel Suresh1,2, Yingxue Fu2, Ji-Hoon Cho2, Timothy I. Shaw2,3, Ashutosh Mishra2, Anthony A. High2, Junmin Peng1,2, Yuxin Li1,2 1Departments of Structural Biology and Developmental Neurobiology, St. Jude Children’s Research Hospital, 2Center for Proteomics and Metabolomics, St. Jude Children’s Research Hospital, 3Department of Computational Biology, St. Jude Children’s Research Hospital JoVE 62796 Biochemistry
High-throughput and Deep-proteome Profiling by 16-plex Tandem Mass Tag Labeling Coupled with Two-dimensional Chromatography and Mass Spectrometry JoVE 61684 Biology
用等压标记、广泛的液相色谱法、质谱法和软件辅助定量技术进行深层蛋白质组分析 Anthony A. High1, Haiyan Tan1, Vishwajeeth R. Pagala1, Mingming Niu2,3, Ji-Hoon Cho1, Xusheng Wang1, Bing Bai2, Junmin Peng1,2 1St. Jude Proteomics Facility, St. Jude Children's Research Hospital, 2Departments of Structural Biology and Developmental Neurobiology, St. Jude Children's Research Hospital, 3Heilongjiang University of Chinese Medicine JoVE 56474 Biochemistry
