K. George Chandy Lee Kong Chian School of Medicine Nanyang Technological University Biography Publications Institution JoVE Articles K. George Chandy has not added a biography. If you are K. George Chandy and would like to personalize this page please email our Author Liaison for assistance. Publications Peptide Blockers of Kv1.3 Channels in T Cells As Therapeutics for Autoimmune Disease Current Opinion in Chemical Biology. Apr, 2017 | Pubmed ID: 28412597 Tissue Resident Memory T Cells in the Human Conjunctiva and Immune Signatures in Human Dry Eye Disease Scientific Reports. Mar, 2017 | Pubmed ID: 28345628 International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels Pharmacological Reviews. Jan, 2017 | Pubmed ID: 28267675 Immunology: Channelling Potassium to Fight Cancer Nature. 09, 2016 | Pubmed ID: 27626384 Kv1.3 Channel-blocking Immunomodulatory Peptides from Parasitic Worms: Implications for Autoimmune Diseases FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2014 | Pubmed ID: 24891519 Blockade of Kv1.3 Channels Ameliorates Radiation-induced Brain Injury Neuro-oncology. Apr, 2014 | Pubmed ID: 24305723 Shaker-related Potassium Channels in the Central Medial Nucleus of the Thalamus Are Important Molecular Targets for Arousal Suppression by Volatile General Anesthetics The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2013 | Pubmed ID: 24107962 Selective Kv1.3 Channel Blocker As Therapeutic for Obesity and Insulin Resistance Proceedings of the National Academy of Sciences of the United States of America. Jun, 2013 | Pubmed ID: 23729813 Intracellular Trafficking of the KV1.3 Potassium Channel is Regulated by the Prodomain of a Matrix Metalloprotease The Journal of Biological Chemistry. Mar, 2013 | Pubmed ID: 23300077 Modulation of Voltage-gated K+ Channels by the Sodium Channel β1 Subunit Proceedings of the National Academy of Sciences of the United States of America. Nov, 2012 | Pubmed ID: 23090990 Durable Pharmacological Responses from the Peptide Drug ShK-186, a Specific Kv1.3 Channel Inhibitor That Suppresses T Cell Mediators of Autoimmune Disease The Journal of Pharmacology and Experimental Therapeutics. May, 2012 | Pubmed ID: 22637724 Kv1.3 Deletion Biases T Cells Toward an Immunoregulatory Phenotype and Renders Mice Resistant to Autoimmune Encephalomyelitis Journal of Immunology (Baltimore, Md. : 1950). Jun, 2012 | Pubmed ID: 22581856 Inhibitors of Mitochondrial Kv1.3 Channels Induce Bax/Bak-independent Death of Cancer Cells EMBO Molecular Medicine. Jul, 2012 | Pubmed ID: 22496117 Development of a Sea Anemone Toxin As an Immunomodulator for Therapy of Autoimmune Diseases Toxicon : Official Journal of the International Society on Toxinology. Aug, 2011 | Pubmed ID: 21867724 Therapeutic Potential of Peptide Toxins That Target Ion Channels Inflammation & Allergy Drug Targets. Oct, 2011 | Pubmed ID: 21745182 18F-Fallypride PET of Pancreatic Islets: in Vitro and in Vivo Rodent Studies Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Jul, 2011 | Pubmed ID: 21680697 Genetics and the Environment Converge to Dysregulate N-glycosylation in Multiple Sclerosis Nature Communications. 2011 | Pubmed ID: 21629267 Potassium Channel Modulation by a Toxin Domain in Matrix Metalloprotease 23 The Journal of Biological Chemistry. Mar, 2010 | Pubmed ID: 19965868 The Functional Network of Ion Channels in T Lymphocytes Immunological Reviews. Sep, 2009 | Pubmed ID: 19754890 Kv1.3 Potassium Channels As a Therapeutic Target in Multiple Sclerosis Expert Opinion on Therapeutic Targets. Aug, 2009 | Pubmed ID: 19538097 Imaging of Effector Memory T Cells During a Delayed-type Hypersensitivity Reaction and Suppression by Kv1.3 Channel Block Immunity. Oct, 2008 | Pubmed ID: 18835197 The Intermediate-conductance Calcium-activated Potassium Channel KCa3.1 Contributes to Atherogenesis in Mice and Humans The Journal of Clinical Investigation. Sep, 2008 | Pubmed ID: 18688283 The D-diastereomer of ShK Toxin Selectively Blocks Voltage-gated K+ Channels and Inhibits T Lymphocyte Proliferation The Journal of Biological Chemistry. Jan, 2008 | Pubmed ID: 17984097 Kv1.3 Channels Are a Therapeutic Target for T Cell-mediated Autoimmune Diseases Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17088564 International Union of Pharmacology. LIII. Nomenclature and Molecular Relationships of Voltage-gated Potassium Channels Pharmacological Reviews. Dec, 2005 | Pubmed ID: 16382104 International Union of Pharmacology. LII. Nomenclature and Molecular Relationships of Calcium-activated Potassium Channels Pharmacological Reviews. Dec, 2005 | Pubmed ID: 16382103 Potassium Channels, Memory T Cells, and Multiple Sclerosis The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. Dec, 2005 | Pubmed ID: 16282596 The Voltage-gated Potassium Channel Kv1.3 is Highly Expressed on Inflammatory Infiltrates in Multiple Sclerosis Brain Proceedings of the National Academy of Sciences of the United States of America. Aug, 2005 | Pubmed ID: 16043714 Targeting Effector Memory T Cells with a Selective Peptide Inhibitor of Kv1.3 Channels for Therapy of Autoimmune Diseases Molecular Pharmacology. Apr, 2005 | Pubmed ID: 15665253 K+ Channel Expression During B Cell Differentiation: Implications for Immunomodulation and Autoimmunity Journal of Immunology (Baltimore, Md. : 1950). Jul, 2004 | Pubmed ID: 15240664 Kv1.3-blocking 5-phenylalkoxypsoralens: a New Class of Immunomodulators Molecular Pharmacology. Jun, 2004 | Pubmed ID: 15155830 K+ Channels As Targets for Specific Immunomodulation Trends in Pharmacological Sciences. May, 2004 | Pubmed ID: 15120495 SKCa Channels Mediate the Medium but Not the Slow Calcium-activated Afterhyperpolarization in Cortical Neurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2004 | Pubmed ID: 15071101 Enhanced Neuronal Excitability in the Absence of Neurodegeneration Induces Cerebellar Ataxia The Journal of Clinical Investigation. Feb, 2004 | Pubmed ID: 14966567 SK3-1C, a Dominant-negative Suppressor of SKCa and IKCa Channels The Journal of Biological Chemistry. Feb, 2004 | Pubmed ID: 14638680 International Union of Pharmacology. XLI. Compendium of Voltage-gated Ion Channels: Potassium Channels Pharmacological Reviews. Dec, 2003 | Pubmed ID: 14657415 Potassium Channels As Therapeutic Targets for Autoimmune Disorders Current Opinion in Drug Discovery & Development. Sep, 2003 | Pubmed ID: 14579513 Blockade of the Intermediate-conductance Calcium-activated Potassium Channel As a New Therapeutic Strategy for Restenosis Circulation. Sep, 2003 | Pubmed ID: 12939222 The Voltage-gated Kv1.3 K(+) Channel in Effector Memory T Cells As New Target for MS The Journal of Clinical Investigation. Jun, 2003 | Pubmed ID: 12782673 A Novel Fluorescent Toxin to Detect and Investigate Kv1.3 Channel Up-regulation in Chronically Activated T Lymphocytes The Journal of Biological Chemistry. Mar, 2003 | Pubmed ID: 12511563 Mutating a Critical Lysine in ShK Toxin Alters Its Binding Configuration in the Pore-vestibule Region of the Voltage-gated Potassium Channel, Kv1.3 Biochemistry. Oct, 2002 | Pubmed ID: 12356296 Characterisation of the Human Voltage-gated Potassium Channel Gene, KCNA7, a Candidate Gene for Inherited Cardiac Disorders, and Its Exclusion As Cause of Progressive Familial Heart Block I (PFHBI) European Journal of Human Genetics : EJHG. Jan, 2002 | Pubmed ID: 11896454 Modulation of Mouse Paneth Cell Alpha-defensin Secretion by MIKCa1, a Ca2+-activated, Intermediate Conductance Potassium Channel The Journal of Biological Chemistry. Feb, 2002 | Pubmed ID: 11724775 Uma maneira não invasiva de isolar e células de fenótipo da Conjuntiva Tanima Bose1, Aihua Hou2, Ryan Lee2, Louis Tong2,3,4,5, K. George Chandy1 1Lee Kong Chian School of Medicine, Nanyang Technological University, 2Singapore Eye Research Institute, 3Singapore National Eye Center, 4Duke-NUS Medical School, 5Yong Loo Lin School of Medicine JoVE 55591 Immunology and Infection Um modelo crônico de Rato de olho seco autoimune com aumento de células de memória E Effect no tecido do globo ocular Aihua Hou1,2, Tanima Bose3, K. George Chandy3, Louis Tong1,2,4,5 1Singapore Eye Research Insitute, A Member of SingHealth, 2DUKE-National University of Singapore Medical School, 3Lee Kong Chian School of Medicine, Nanyang Technological University, 4Singapore National Eye Center, 5Yong Loo Lin School of Medicine, National University of Singapore JoVE 55592 Immunology and Infection As células de memória efetoras T imagem no ouvido após a indução de DTH Adoptive Melanie P. Matheu1, Christine Beeton1, Ian Parker2, K. George Chandy1, Michael D. Cahalan1 1Department of Physiology and Biophysics, University of California, Irvine (UCI), 2Department of Neurobiology and Behavior, University of California, Irvine (UCI) JoVE 907 Biology Isolamento de células mononucleares do Sistema Nervoso Central de ratos com EAE Christine Beeton1, K. George Chandy1 1Department of Physiology and Biophysics, University of California, Irvine (UCI) JoVE 527 Biology Preparando-se Fator de Crescimento de Células T esplenócitos Rat Christine Beeton1, K. George Chandy1 1Department of Physiology and Biophysics, University of California, Irvine (UCI) JoVE 402 Biology Imuno-histoquímica: Seções de parafina Usando o Kit de Vectastain ABC Vector Labs Victor Chi1, K. George Chandy1 1Department of Physiology and Biophysics, University of California, Irvine (UCI) JoVE 308 Biology Indução e Monitoramento de hipersensibilidade tardia-Type Adoptive em Ratos Christine Beeton1, K. George Chandy1 1Department of Physiology and Biophysics, University of California, Irvine (UCI) JoVE 325 Biology Enriquecimento das células NK do sangue humano com o Kit RosetteSep de StemCell Technologies Christine Beeton1, K. George Chandy1 1Department of Physiology and Biophysics, University of California, Irvine (UCI) JoVE 326 Biology Desenho de sangue de ratos através da veia safena e por punção cardíaca Christine Beeton1, Adriana Garcia1, K. George Chandy1 1Department of Physiology and Biophysics, University of California, Irvine (UCI) JoVE 266 Biology Indução e Monitoramento de hipersensibilidade do tipo retardada Ativa (DTH) em ratos Christine Beeton1, K. George Chandy1 1Department of Physiology and Biophysics, University of California, Irvine (UCI) JoVE 237 Biology Indução e pontuação clínica de doenças crônico-recidivante encefalomielite autoimune experimental Christine Beeton1, Adriana Garcia1, K. George Chandy1 1Department of Physiology and Biophysics, University of California, Irvine (UCI) JoVE 224 Biology Rato de isolamento de células Adrenal Cromafim Aaron Kolski-Andreaco1, Haijiang Cai2,3, D. Spencer Currle4, K. George Chandy1, Robert H. Chow2,3 1Department of Physiology and Biophysics, University of California, Irvine (UCI), 2Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, 3Zilkha Neurogenetic Institute, University of Southern California, Keck School of Medicine, 4Department of Developmental and Cell Biology, University of California, Irvine (UCI) JoVE 129 Biology
Uma maneira não invasiva de isolar e células de fenótipo da Conjuntiva Tanima Bose1, Aihua Hou2, Ryan Lee2, Louis Tong2,3,4,5, K. George Chandy1 1Lee Kong Chian School of Medicine, Nanyang Technological University, 2Singapore Eye Research Institute, 3Singapore National Eye Center, 4Duke-NUS Medical School, 5Yong Loo Lin School of Medicine JoVE 55591 Immunology and Infection
Um modelo crônico de Rato de olho seco autoimune com aumento de células de memória E Effect no tecido do globo ocular Aihua Hou1,2, Tanima Bose3, K. George Chandy3, Louis Tong1,2,4,5 1Singapore Eye Research Insitute, A Member of SingHealth, 2DUKE-National University of Singapore Medical School, 3Lee Kong Chian School of Medicine, Nanyang Technological University, 4Singapore National Eye Center, 5Yong Loo Lin School of Medicine, National University of Singapore JoVE 55592 Immunology and Infection
As células de memória efetoras T imagem no ouvido após a indução de DTH Adoptive Melanie P. Matheu1, Christine Beeton1, Ian Parker2, K. George Chandy1, Michael D. Cahalan1 1Department of Physiology and Biophysics, University of California, Irvine (UCI), 2Department of Neurobiology and Behavior, University of California, Irvine (UCI) JoVE 907 Biology
Isolamento de células mononucleares do Sistema Nervoso Central de ratos com EAE Christine Beeton1, K. George Chandy1 1Department of Physiology and Biophysics, University of California, Irvine (UCI) JoVE 527 Biology
Preparando-se Fator de Crescimento de Células T esplenócitos Rat Christine Beeton1, K. George Chandy1 1Department of Physiology and Biophysics, University of California, Irvine (UCI) JoVE 402 Biology
Imuno-histoquímica: Seções de parafina Usando o Kit de Vectastain ABC Vector Labs Victor Chi1, K. George Chandy1 1Department of Physiology and Biophysics, University of California, Irvine (UCI) JoVE 308 Biology
Indução e Monitoramento de hipersensibilidade tardia-Type Adoptive em Ratos Christine Beeton1, K. George Chandy1 1Department of Physiology and Biophysics, University of California, Irvine (UCI) JoVE 325 Biology
Enriquecimento das células NK do sangue humano com o Kit RosetteSep de StemCell Technologies Christine Beeton1, K. George Chandy1 1Department of Physiology and Biophysics, University of California, Irvine (UCI) JoVE 326 Biology
Desenho de sangue de ratos através da veia safena e por punção cardíaca Christine Beeton1, Adriana Garcia1, K. George Chandy1 1Department of Physiology and Biophysics, University of California, Irvine (UCI) JoVE 266 Biology
Indução e Monitoramento de hipersensibilidade do tipo retardada Ativa (DTH) em ratos Christine Beeton1, K. George Chandy1 1Department of Physiology and Biophysics, University of California, Irvine (UCI) JoVE 237 Biology
Indução e pontuação clínica de doenças crônico-recidivante encefalomielite autoimune experimental Christine Beeton1, Adriana Garcia1, K. George Chandy1 1Department of Physiology and Biophysics, University of California, Irvine (UCI) JoVE 224 Biology
Rato de isolamento de células Adrenal Cromafim Aaron Kolski-Andreaco1, Haijiang Cai2,3, D. Spencer Currle4, K. George Chandy1, Robert H. Chow2,3 1Department of Physiology and Biophysics, University of California, Irvine (UCI), 2Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, 3Zilkha Neurogenetic Institute, University of Southern California, Keck School of Medicine, 4Department of Developmental and Cell Biology, University of California, Irvine (UCI) JoVE 129 Biology
