K. Sandy Pang

Publications

• Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist
  Journal of Pharmaceutical Sciences. Sep, 2017  |   Pubmed ID: 28479350
• Revisiting the Role of Gut Wall in the Fate of Orally Administered Drugs: Why Now and to What Effect?
  Biopharmaceutics & Drug Disposition. 03, 2017  |   Pubmed ID: 28317174
• Comparing Early Liver Graft Function from Heart Beating and Living-donors: A Pilot Study Aiming to Identify New Biomarkers of Liver Injury
  Biopharmaceutics & Drug Disposition. Jul, 2017  |   Pubmed ID: 28102538
• Unequivocal Evidence Supporting the Segregated Flow Intestinal Model That Discriminates Intestine Versus Liver First-pass Removal with PBPK Modeling
  Biopharmaceutics & Drug Disposition. Apr, 2017  |   Pubmed ID: 27977852
• Physiologically Based Pharmacokinetic Modeling Revealed Minimal Codeine Intestinal Metabolism in First-pass Removal in Rats
  Biopharmaceutics & Drug Disposition. Jan, 2017  |   Pubmed ID: 27925239
• Disrupted Murine Gut-to-Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models
  The Journal of Pharmacology and Experimental Therapeutics. Jan, 2017  |   Pubmed ID: 27789682
• Functional Integrity of the Chimeric (Humanized) Mouse Liver: Enzyme Zonation, Physiologic Spaces, and Hepatic Enzymes and Transporters
  Drug Metabolism and Disposition: the Biological Fate of Chemicals. Sep, 2016  |   Pubmed ID: 27342868
• Metabolite Kinetics: The Segregated Flow Model for Intestinal and Whole Body Physiologically Based Pharmacokinetic Modeling to Describe Intestinal and Hepatic Glucuronidation of Morphine in Rats In Vivo
  Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jul, 2016  |   Pubmed ID: 27098743
• Polymer-lipid Hybrid Nanoparticles Synchronize Pharmacokinetics of Co-encapsulated Doxorubicin-mitomycin C and Enable Their Spatiotemporal Co-delivery and Local Bioavailability in Breast Tumor
  Nanomedicine : Nanotechnology, Biology, and Medicine. Jul, 2016  |   Pubmed ID: 26772427
• Physiologically-Based Pharmacokinetic-Pharmacodynamic Modeling of 1α,25-Dihydroxyvitamin D3 in Mice
  Drug Metabolism and Disposition: the Biological Fate of Chemicals. Feb, 2016  |   Pubmed ID: 26586377
• Response to Letter to the Editor on "fractional Clearance for Verapamil N-demethylation in the Isolated Rat Liver Preparation"
  Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jul, 2015  |   Pubmed ID: 25964425
• PKPD Modelling to Predict Altered Disposition of 1α,25-dihydroxyvitamin D3 in Mice Due to Dose-dependent Regulation of CYP27B1 on Synthesis and CYP24A1 on Degradation
  British Journal of Pharmacology. Jul, 2015  |   Pubmed ID: 25829051
• Pharmacokinetic Modeling of Tranexamic Acid for Patients Undergoing Cardiac Surgery with Normal Renal Function and Model Simulations for Patients with Renal Impairment
  Biopharmaceutics & Drug Disposition. Jul, 2015  |   Pubmed ID: 25704361
• PBPK Modeling to Unravel Nonlinear Pharmacokinetics of Verapamil to Estimate the Fractional Clearance for Verapamil N-demethylation in the Recirculating Rat Liver Preparation
  Drug Metabolism and Disposition: the Biological Fate of Chemicals. Apr, 2015  |   Pubmed ID: 25650380
• Dealing with the Complex Drug-drug Interactions: Towards Mechanistic Models
  Biopharmaceutics & Drug Disposition. Mar, 2015  |   Pubmed ID: 25545151
• Vitamin D Receptor Activation Induces P-glycoprotein and Increases Brain Efflux of Quinidine: an Intracerebral Microdialysis Study in Conscious Rats
  Pharmaceutical Research. Mar, 2015  |   Pubmed ID: 25319098
• Effects of 1α,25-dihydroxyvitamin D3 , the Natural Vitamin D Receptor Ligand, on the Pharmacokinetics of Cefdinir and Cefadroxil, Organic Anion Transporter Substrates, in Rat
  Journal of Pharmaceutical Sciences. Nov, 2014  |   Pubmed ID: 25266751
• 1α,25-Dihydroxyvitamin D3 Reduces Cerebral Amyloid-β Accumulation and Improves Cognition in Mouse Models of Alzheimer's Disease
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2014  |   Pubmed ID: 24849345
• Vitamin D Receptor Activation Down-regulates the Small Heterodimer Partner and Increases CYP7A1 to Lower Cholesterol
  Gastroenterology. Apr, 2014  |   Pubmed ID: 24365583
• Comparative Effects of 1α-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on Transporters and Enzymes in Fxr(+/+) and Fxr(-/-) Mice
  Biopharmaceutics & Drug Disposition. Oct, 2013  |   Pubmed ID: 23897575
• Temporal Changes in Tissue 1α,25-dihydroxyvitamin D3, Vitamin D Receptor Target Genes, and Calcium and PTH Levels After 1,25(OH)2D3 Treatment in Mice
  American Journal of Physiology. Endocrinology and Metabolism. May, 2013  |   Pubmed ID: 23482451
• Why We Need Proper PBPK Models to Examine Intestine and Liver Oral Drug Absorption
  Current Drug Metabolism. Jan, 2013  |   Pubmed ID: 22935069
• 1α,25-Dihydroxyvitamin D3-liganded Vitamin D Receptor Increases Expression and Transport Activity of P-glycoprotein in Isolated Rat Brain Capillaries and Human and Rat Brain Microvessel Endothelial Cells
  Journal of Neurochemistry. Dec, 2012  |   Pubmed ID: 23035695
• Commentary: Theoretical Predictions of Flow Effects on Intestinal and Systemic Availability in Physiologically Based Pharmacokinetic Intestine Models: the Traditional Model, Segregated Flow Model, and QGut Model
  Drug Metabolism and Disposition: the Biological Fate of Chemicals. Oct, 2012  |   Pubmed ID: 22745334
• Effects of 1α,25-dihydroxyvitamin D3 on Transport and Metabolism of Adefovir Dipivoxil and Its Metabolites in Caco-2 Cells
  European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jun, 2012  |   Pubmed ID: 22387228
• Physiologically Based Pharmacokinetic (PBPK) Modeling: It is Here to Stay!
  Biopharmaceutics & Drug Disposition. Mar, 2012  |   Pubmed ID: 22351594
• Utility of a Physiologically-based Pharmacokinetic (PBPK) Modeling Approach to Quantitatively Predict a Complex Drug-drug-disease Interaction Scenario for Rivaroxaban During the Drug Review Process: Implications for Clinical Practice
  Biopharmaceutics & Drug Disposition. Mar, 2012  |   Pubmed ID: 22270945
• Evaluation of Exposure Change of Nonrenally Eliminated Drugs in Patients with Chronic Kidney Disease Using Physiologically Based Pharmacokinetic Modeling and Simulation
  Journal of Clinical Pharmacology. Jan, 2012  |   Pubmed ID: 22232759
• Fraction Absorbed (Fabs ): Different Connotations and Confusion for the Literature?
  Biopharmaceutics & Drug Disposition. 07, 2011  |   Pubmed ID: 21630284
• 1Alpha,25-dihydroxyvitamin D3 Up-regulates P-glycoprotein Via the Vitamin D Receptor and Not Farnesoid X Receptor in Both Fxr(-/-) and Fxr(+/+) Mice and Increased Renal and Brain Efflux of Digoxin in Mice in Vivo
  The Journal of Pharmacology and Experimental Therapeutics. Jun, 2011  |   Pubmed ID: 21421739
• 1α,25-dihydroxyvitamin D3 on Intestinal Transporter Function: Studies with the Rat Everted Intestinal Sac
  Biopharmaceutics & Drug Disposition. Mar, 2011  |   Pubmed ID: 21341280
• Comparative Effects of Doxercalciferol (1α-hydroxyvitamin D₂) Versus Calcitriol (1α,25-dihydroxyvitamin D₃) on the Expression of Transporters and Enzymes in the Rat in Vivo
  Journal of Pharmaceutical Sciences. Apr, 2011  |   Pubmed ID: 20967888
• The Role of Lithocholic Acid in the Regulation of Bile Acid Detoxication, Synthesis, and Transport Proteins in Rat and Human Intestine and Liver Slices
  Toxicology in Vitro : an International Journal Published in Association with BIBRA. Feb, 2011  |   Pubmed ID: 20888898
• PBPK Modeling of Intestinal and Liver Enzymes and Transporters in Drug Absorption and Sequential Metabolism
  Current Drug Metabolism. Nov, 2010  |   Pubmed ID: 21189137
• Physiologically-based Pharmacokinetic Modeling for Absorption, Transport, Metabolism and Excretion
  Journal of Pharmacokinetics and Pharmacodynamics. Dec, 2010  |   Pubmed ID: 21153869
• Interplay of Transporters and Enzymes in the Caco-2 Cell Monolayer: I. Effect of Altered Apical Secretion
  Biopharmaceutics & Drug Disposition. May, 2010  |   Pubmed ID: 20437461
• Physiological Modeling to Understand the Impact of Enzymes and Transporters on Drug and Metabolite Data and Bioavailability Estimates
  Pharmaceutical Research. Jul, 2010  |   Pubmed ID: 20372987
• Interplay of Phase II Enzymes and Transporters in Futile Cycling: Influence of Multidrug Resistance-associated Protein 2-mediated Excretion of Estradiol 17beta-D-glucuronide and Its 3-sulfate Metabolite on Net Sulfation in Perfused TR(-) and Wistar Rat Liver Preparations
  Drug Metabolism and Disposition: the Biological Fate of Chemicals. May, 2010  |   Pubmed ID: 20124397
• Effects of 1alpha,25-dihydroxyvitamin D3 on Transporters and Enzymes of the Rat Intestine and Kidney in Vivo
  Biopharmaceutics & Drug Disposition. Jan, 2010  |   Pubmed ID: 20013813
• Interplay of Transporters and Enzymes in Drug and Metabolite Processing
  Molecular Pharmaceutics. Nov-Dec, 2009  |   Pubmed ID: 19891494
• 1alpha,25-Dihydroxyvitamin D(3) Triggered Vitamin D Receptor and Farnesoid X Receptor-like Effects in Rat Intestine and Liver in Vivo
  Biopharmaceutics & Drug Disposition. Nov, 2009  |   Pubmed ID: 19753549
• Expression and Regulation of the Bile Acid Transporter, OSTalpha-OSTbeta in Rat and Human Intestine and Liver
  Biopharmaceutics & Drug Disposition. Jul, 2009  |   Pubmed ID: 19562681
• Comparison of Effects of VDR Versus PXR, FXR and GR Ligands on the Regulation of CYP3A Isozymes in Rat and Human Intestine and Liver
  European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. May, 2009  |   Pubmed ID: 19429418
• Up-regulation of Transporters and Enzymes by the Vitamin D Receptor Ligands, 1alpha,25-dihydroxyvitamin D3 and Vitamin D Analogs, in the Caco-2 Cell Monolayer
  The Journal of Pharmacology and Experimental Therapeutics. Aug, 2009  |   Pubmed ID: 19414624
• Disparity in Intestine Disposition Between Formed and Preformed Metabolites and Implications: a Theoretical Study
  Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jan, 2009  |   Pubmed ID: 18948379
• Safety Testing of Metabolites: Expectations and Outcomes
  Chemico-biological Interactions. Apr, 2009  |   Pubmed ID: 18926805
• Formed and Preformed Metabolites: Facts and Comparisons
  The Journal of Pharmacy and Pharmacology. Oct, 2008  |   Pubmed ID: 18812018
• The Caco-2 Cell Monolayer: Usefulness and Limitations
  Expert Opinion on Drug Metabolism & Toxicology. Apr, 2008  |   Pubmed ID: 18433344
• A Catenary Model to Study Transport and Conjugation of Baicalein, a Bioactive Flavonoid, in the Caco-2 Cell Monolayer: Demonstration of Substrate Inhibition
  The Journal of Pharmacology and Experimental Therapeutics. Jul, 2008  |   Pubmed ID: 18385448
• Role of Haptoglobin on the Uptake of Native and Beta-chain [trimesoyl-(Lys82)beta-(Lys82)beta] Cross-linked Human Hemoglobins in Isolated Perfused Rat Livers
  Drug Metabolism and Disposition: the Biological Fate of Chemicals. May, 2008  |   Pubmed ID: 18276837
• Permeability, Transport, and Metabolism of Solutes in Caco-2 Cell Monolayers: a Theoretical Study
  Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jan, 2008  |   Pubmed ID: 17932224
• Advanced Pharmacokinetic Models Based on Organ Clearance, Circulatory, and Fractal Concepts
  The AAPS Journal. Jun, 2007  |   Pubmed ID: 17907768
• Transporters, Enzymes, and Enalapril Removal in a Rat (CC531-induced) Liver Metastatic Model
  American Journal of Physiology. Gastrointestinal and Liver Physiology. Nov, 2007  |   Pubmed ID: 17855765
• Increased Estrogen Sulfation of Estradiol 17beta-D-glucuronide in Metastatic Tumor Rat Livers
  The Journal of Pharmacology and Experimental Therapeutics. Nov, 2006  |   Pubmed ID: 16895976
• An Integrated Approach to Model Hepatic Drug Clearance
  European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Nov, 2006  |   Pubmed ID: 16806855
• P-glycoprotein and an Unstirred Water Layer Barring Digoxin Absorption in the Vascularly Perfused Rat Small Intestine Preparation: Induction Studies with Pregnenolone-16alpha-carbonitrile
  Drug Metabolism and Disposition: the Biological Fate of Chemicals. Sep, 2006  |   Pubmed ID: 16751264
• Vectorial Transport of Enalapril by Oatp1a1/Mrp2 and OATP1B1 and OATP1B3/MRP2 in Rat and Human Livers
  The Journal of Pharmacology and Experimental Therapeutics. Jul, 2006  |   Pubmed ID: 16627748
• Transactivation of Rat Apical Sodium-dependent Bile Acid Transporter and Increased Bile Acid Transport by 1alpha,25-dihydroxyvitamin D3 Via the Vitamin D Receptor
  Molecular Pharmacology. Jun, 2006  |   Pubmed ID: 16481392
• Transport is Not Rate-limiting in Morphine Glucuronidation in the Single-pass Perfused Rat Liver Preparation
  The Journal of Pharmacology and Experimental Therapeutics. May, 2006  |   Pubmed ID: 16464965
• Vascular Binding, Blood Flow, Transporter, and Enzyme Interactions on the Processing of Digoxin in Rat Liver
  The Journal of Pharmacology and Experimental Therapeutics. Oct, 2005  |   Pubmed ID: 15994370
• Binding of Acellular, Native and Cross-linked Human Hemoglobins to Haptoglobin: Enhanced Distribution and Clearance in the Rat
  American Journal of Physiology. Gastrointestinal and Liver Physiology. Jun, 2005  |   Pubmed ID: 15890714
• Comparative Pharmacophore Modeling of Organic Anion Transporting Polypeptides: a Meta-analysis of Rat Oatp1a1 and Human OATP1B1
  The Journal of Pharmacology and Experimental Therapeutics. Aug, 2005  |   Pubmed ID: 15845861
• The Roles of Transporters and Enzymes in Hepatic Drug Processing
  Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jan, 2005  |   Pubmed ID: 15466164
• Modeling of Intestinal Drug Absorption: Roles of Transporters and Metabolic Enzymes (for the Gillette Review Series)
  Drug Metabolism and Disposition: the Biological Fate of Chemicals. Dec, 2003  |   Pubmed ID: 14625347
• Influence of P-glycoprotein, Transfer Clearances, and Drug Binding on Intestinal Metabolism in Caco-2 Cell Monolayers or Membrane Preparations: a Theoretical Analysis
  Drug Metabolism and Disposition: the Biological Fate of Chemicals. Oct, 2003  |   Pubmed ID: 12975330
• Substrate Specificities of Rat Oatp1 and Ntcp: Implications for Hepatic Organic Anion Uptake
  American Journal of Physiology. Gastrointestinal and Liver Physiology. Nov, 2003  |   Pubmed ID: 12842829
• Moment Analysis of Metabolic Heterogeneity: Conjugation of Benzoate with Glycine in Rat Liver Studied by Multiple Indicator Dilution Technique
  The Journal of Pharmacology and Experimental Therapeutics. Apr, 2003  |   Pubmed ID: 12649380
• Retention of Transporter Activities in Cryopreserved, Isolated Rat Hepatocytes
  Drug Metabolism and Disposition: the Biological Fate of Chemicals. Apr, 2003  |   Pubmed ID: 12642471
• Segmental Intestinal Transporters and Metabolic Enzymes on Intestinal Drug Absorption
  Drug Metabolism and Disposition: the Biological Fate of Chemicals. Apr, 2003  |   Pubmed ID: 12642462
• Transport of the Sulfated, Amidated Bile Acid, Sulfolithocholyltaurine, into Rat Hepatocytes is Mediated by Oatp1 and Oatp2
  Hepatology (Baltimore, Md.). May, 2002  |   Pubmed ID: 11981753