Karen M. Vasquez Division of Pharmacology and Toxicology, College of Pharmacy The University of Texas at Austin Biography Publications Institution JoVE Articles Karen M. Vasquez has not added a biography. If you are Karen M. Vasquez and would like to personalize this page please email our Author Liaison for assistance. Publications Detection of Cis- and Trans-acting Factors in DNA Structure-Induced Genetic Instability Using In Silico and Cellular Approaches Frontiers in Genetics. 2016 | Pubmed ID: 27532010 Translocation and Deletion Breakpoints in Cancer Genomes Are Associated with Potential Non-B DNA-forming Sequences Nucleic Acids Research. Jul, 2016 | Pubmed ID: 27084947 HMGB1 Interacts with XPA to Facilitate the Processing of DNA Interstrand Crosslinks in Human Cells Nucleic Acids Research. Feb, 2016 | Pubmed ID: 26578599 New Perspectives on DNA and RNA Triplexes As Effectors of Biological Activity PLoS Genetics. Dec, 2015 | Pubmed ID: 26700634 Long Non-coding RNA: A New Paradigm for Lung Cancer Molecular Carcinogenesis. Nov, 2015 | Pubmed ID: 26332907 Erratum To: The Somatic Autosomal Mutation Matrix in Cancer Genomes Human Genetics. Aug, 2015 | Pubmed ID: 26071096 The Somatic Autosomal Mutation Matrix in Cancer Genomes Human Genetics. Aug, 2015 | Pubmed ID: 26001532 Local DNA Dynamics Shape Mutational Patterns of Mononucleotide Repeats in Human Genomes Nucleic Acids Research. May, 2015 | Pubmed ID: 25897114 Short Inverted Repeats Are Hotspots for Genetic Instability: Relevance to Cancer Genomes Cell Reports. Mar, 2015 | Pubmed ID: 25772355 Impact of Alternative DNA Structures on DNA Damage, DNA Repair, and Genetic Instability DNA Repair. Jul, 2014 | Pubmed ID: 24767258 Mechanisms of Base Substitution Mutagenesis in Cancer Genomes Genes. Mar, 2014 | Pubmed ID: 24705290 Triplex-forming Oligonucleotides Targeting C-MYC Potentiate the Anti-tumor Activity of Gemcitabine in a Mouse Model of Human Cancer Molecular Carcinogenesis. Sep, 2014 | Pubmed ID: 23681918 Guanine Holes Are Prominent Targets for Mutation in Cancer and Inherited Disease PLoS Genetics. 2013 | Pubmed ID: 24086153 DHX9 Helicase is Involved in Preventing Genomic Instability Induced by Alternatively Structured DNA in Human Cells Nucleic Acids Research. Dec, 2013 | Pubmed ID: 24049074 Methods to Detect Replication-dependent and Replication-independent DNA Structure-induced Genetic Instability Methods (San Diego, Calif.). Nov, 2013 | Pubmed ID: 23954565 DNA Structure Matters Genome Medicine. 2013 | Pubmed ID: 23796271 FANCM and FAAP24 Maintain Genome Stability Via Cooperative As Well As Unique Functions Molecular Cell. Mar, 2013 | Pubmed ID: 23333308 The Yin and Yang of Repair Mechanisms in DNA Structure-induced Genetic Instability Mutation Research. Mar-Apr, 2013 | Pubmed ID: 23219604 Direct and Inverted Repeats Elicit Genetic Instability by Both Exploiting and Eluding DNA Double-strand Break Repair Systems in Mycobacteria PloS One. 2012 | Pubmed ID: 23251422 2,6-Dithiopurine, a Nucleophilic Scavenger, Protects Against Mutagenesis in Mouse Skin Treated in Vivo with 2-(chloroethyl) Ethyl Sulfide, a Mustard Gas Analog Toxicology and Applied Pharmacology. Sep, 2012 | Pubmed ID: 22732900 On the Sequence-directed Nature of Human Gene Mutation: the Role of Genomic Architecture and the Local DNA Sequence Environment in Mediating Gene Mutations Underlying Human Inherited Disease Human Mutation. Oct, 2011 | Pubmed ID: 21853507 Triplex Technology in Studies of DNA Damage, DNA Repair, and Mutagenesis Biochimie. Aug, 2011 | Pubmed ID: 21501652 Non-B DNA-forming Sequences and WRN Deficiency Independently Increase the Frequency of Base Substitution in Human Cells The Journal of Biological Chemistry. Mar, 2011 | Pubmed ID: 21285356 Human DHX9 Helicase Unwinds Triple-helical DNA Structures Biochemistry. Aug, 2010 | Pubmed ID: 20669935 DNA Interstrand Crosslinks: Repair, Cell Signaling, and Therapeutic Implications Environmental and Molecular Mutagenesis. Jul, 2010 | Pubmed ID: 20577999 Pathways for Double-strand Break Repair in Genetically Unstable Z-DNA-forming Sequences Journal of Molecular Biology. May, 2010 | Pubmed ID: 20347845 Targeting and Processing of Site-specific DNA Interstrand Crosslinks Environmental and Molecular Mutagenesis. Jul, 2010 | Pubmed ID: 20196133 2,6-Dithiopurine Blocks Toxicity and Mutagenesis in Human Skin Cells Exposed to Sulfur Mustard Analogues, 2-chloroethyl Ethyl Sulfide and 2-chloroethyl Methyl Sulfide Chemical Research in Toxicology. Mar, 2010 | Pubmed ID: 20050631 Non-B DNA Structure-induced Genetic Instability and Evolution Cellular and Molecular Life Sciences : CMLS. Jan, 2010 | Pubmed ID: 19727556 Targeted Gene Conversion Induced by Triplex-directed Psoralen Interstrand Crosslinks in Mammalian Cells Nucleic Acids Research. Oct, 2009 | Pubmed ID: 19726585 Cruciform-forming Inverted Repeats Appear to Have Mediated Many of the Microinversions That Distinguish the Human and Chimpanzee Genomes Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 2009 | Pubmed ID: 19475482 Mismatch Repair and Nucleotide Excision Repair Proteins Cooperate in the Recognition of DNA Interstrand Crosslinks Nucleic Acids Research. Jul, 2009 | Pubmed ID: 19468048 Human HMGB1 Directly Facilitates Interactions Between Nucleotide Excision Repair Proteins on Triplex-directed Psoralen Interstrand Crosslinks DNA Repair. Jul, 2009 | Pubmed ID: 19446504 HMGB1: the Jack-of-all-trades Protein is a Master DNA Repair Mechanic Molecular Carcinogenesis. Jul, 2009 | Pubmed ID: 19360789 Intrinsic Genomic Instability from Naturally Occurring DNA Structures: An Introduction to the Special Issue Molecular Carcinogenesis. Apr, 2009 | Pubmed ID: 19306307 Methods to Determine DNA Structural Alterations and Genetic Instability Methods (San Diego, Calif.). May, 2009 | Pubmed ID: 19245837 Models for Chromosomal Replication-independent Non-B DNA Structure-induced Genetic Instability Molecular Carcinogenesis. Apr, 2009 | Pubmed ID: 19123200 Role of TLS DNA Polymerases Eta and Kappa in Processing Naturally Occurring Structured DNA in Human Cells Molecular Carcinogenesis. Apr, 2009 | Pubmed ID: 19117014 DNA Structure-induced Genomic Instability in Vivo Journal of the National Cancer Institute. Dec, 2008 | Pubmed ID: 19066276 Efficient Processing of TFO-directed Psoralen DNA Interstrand Crosslinks by the UvrABC Nuclease Nucleic Acids Research. Dec, 2008 | Pubmed ID: 18996898 Human MLH1 Protein Participates in Genomic Damage Checkpoint Signaling in Response to DNA Interstrand Crosslinks, While MSH2 Functions in DNA Repair PLoS Genetics. Sep, 2008 | Pubmed ID: 18787700 High Mobility Group Protein B1 Enhances DNA Repair and Chromatin Modification After DNA Damage Proceedings of the National Academy of Sciences of the United States of America. Jul, 2008 | Pubmed ID: 18650382 Processing of Triplex-directed Psoralen DNA Interstrand Crosslinks by Recombination Mechanisms Nucleic Acids Research. Aug, 2008 | Pubmed ID: 18628293 Targeted Generation of DNA Strand Breaks Using Pyrene-conjugated Triplex-forming Oligonucleotides Biochemistry. Jun, 2008 | Pubmed ID: 18473480 Inhibitory Effect of a Short Z-DNA Forming Sequence on Transcription Elongation by T7 RNA Polymerase Nucleic Acids Research. Jun, 2008 | Pubmed ID: 18400779 DNA Triple Helices: Biological Consequences and Therapeutic Potential Biochimie. Aug, 2008 | Pubmed ID: 18331847 A Triplex-forming Sequence from the Human C-MYC Promoter Interferes with DNA Transcription The Journal of Biological Chemistry. Nov, 2007 | Pubmed ID: 17785457 Z-DNA, an Active Element in the Genome Frontiers in Bioscience : a Journal and Virtual Library. May, 2007 | Pubmed ID: 17485386 Therapeutic Effect of Rapamycin on Gallbladder Cancer in a Transgenic Mouse Model Cancer Research. Apr, 2007 | Pubmed ID: 17440093 High-affinity Triplex-forming Oligonucleotide Target Sequences in Mammalian Genomes Molecular Carcinogenesis. Jan, 2007 | Pubmed ID: 17013831 A Web-based Search Engine for Triplex-forming Oligonucleotide Target Sequences Oligonucleotides. 2006 | Pubmed ID: 16764543 Targeting Oncogenes to Improve Breast Cancer Chemotherapy Cancer Research. Apr, 2006 | Pubmed ID: 16618728 Non-B DNA Structure-induced Genetic Instability Mutation Research. Jun, 2006 | Pubmed ID: 16516932 Z-DNA-forming Sequences Generate Large-scale Deletions in Mammalian Cells Proceedings of the National Academy of Sciences of the United States of America. Feb, 2006 | Pubmed ID: 16473937 Repair of Genome Destabilizing Lesions Radiation Research. Oct, 2005 | Pubmed ID: 16187737 Human XPC-hHR23B Interacts with XPA-RPA in the Recognition of Triplex-directed Psoralen DNA Interstrand Crosslinks Nucleic Acids Research. 2005 | Pubmed ID: 15914671 Mismatch Repair Participates in Error-free Processing of DNA Interstrand Crosslinks in Human Cells EMBO Reports. Jun, 2005 | Pubmed ID: 15891767 Interplay Between Human High Mobility Group Protein 1 and Replication Protein A on Psoralen-cross-linked DNA Biochemistry. Mar, 2005 | Pubmed ID: 15766246 Naturally Occurring H-DNA-forming Sequences Are Mutagenic in Mammalian Cells Proceedings of the National Academy of Sciences of the United States of America. Sep, 2004 | Pubmed ID: 15342911 Mutation Frequencies in Murine Keratinocytes As a Function of Carcinogenic Status Molecular Carcinogenesis. Jun, 2004 | Pubmed ID: 15170817 Critical DNA Damage Recognition Functions of XPC-hHR23B and XPA-RPA in Nucleotide Excision Repair Molecular Carcinogenesis. Sep, 2003 | Pubmed ID: 12949838 Site-directed Recombination Via Bifunctional PNA-DNA Conjugates Proceedings of the National Academy of Sciences of the United States of America. Dec, 2002 | Pubmed ID: 12461167 Triplex-forming Oligonucleotides: Principles and Applications Quarterly Reviews of Biophysics. Feb, 2002 | Pubmed ID: 11997982 Human XPA and RPA DNA Repair Proteins Participate in Specific Recognition of Triplex-induced Helical Distortions Proceedings of the National Academy of Sciences of the United States of America. Apr, 2002 | Pubmed ID: 11972036 Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks Anirban Mukherjee1, Karen M. Vasquez1 1Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin JoVE 54678 Genetics
Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks Anirban Mukherjee1, Karen M. Vasquez1 1Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin JoVE 54678 Genetics