Karen S. Wilcox

Publications

• Spontaneous Recurrent Seizures in an Intra-amygdala Kainate Microinjection Model of Temporal Lobe Epilepsy Are Differentially Sensitive to Antiseizure Drugs
  Experimental Neurology. 03, 2022  |   Pubmed ID: 34922908
• Screening of Prototype Antiseizure and Anti-inflammatory Compounds in the Theiler's Murine Encephalomyelitis Virus Model of Epilepsy
  Epilepsia Open. 03, 2022  |   Pubmed ID: 34668659
• Inflammation Unleashed in Viral-Induced Epileptogenesis
  Epilepsy Currents. Nov-Dec, 2021  |   Pubmed ID: 34924851
• Development of an Antiepileptogenesis Drug Screening Platform: Effects of Everolimus and Phenobarbital
  Epilepsia. 07, 2021  |   Pubmed ID: 34080183
• Antiepileptogenesis and Disease Modification: Progress, Challenges, and the Path Forward-Report of the Preclinical Working Group of the 2018 NINDS-sponsored Antiepileptogenesis and Disease Modification Workshop
  Epilepsia Open. 06, 2021  |   Pubmed ID: 34033232
• Development of an Antiseizure Drug Screening Platform for Dravet Syndrome at the NINDS Contract Site for the Epilepsy Therapy Screening Program
  Epilepsia. 07, 2021  |   Pubmed ID: 34002394
• Response: Usefulness of the Post-kainate Spontaneous Recurrent Seizure Model for Screening for Antiseizure and for Neuroprotective Effects
  Epilepsia. 05, 2021  |   Pubmed ID: 33778946
• Identification of Clinically Relevant Biomarkers of Epileptogenesis - a Strategic Roadmap
  Nature Reviews. Neurology. 04, 2021  |   Pubmed ID: 33594276
• Reactivity and Increased Proliferation of NG2 Cells Following Central Nervous System Infection with Theiler's Murine Encephalomyelitis Virus
  Journal of Neuroinflammation. Dec, 2020  |   Pubmed ID: 33272299
• Accurate Detection of Spontaneous Seizures Using a Generalized Linear Model with External Validation
  Epilepsia. 09, 2020  |   Pubmed ID: 32761902
• Evaluation of Subchronic Administration of Antiseizure Drugs in Spontaneously Seizing Rats
  Epilepsia. 06, 2020  |   Pubmed ID: 32420627
• Discovery of the First Vitamin K Analogue As a Potential Treatment of Pharmacoresistant Seizures
  Journal of Medicinal Chemistry. 06, 2020  |   Pubmed ID: 32390424
• Ultrastructural and Functional Changes at the Tripartite Synapse During Epileptogenesis in a Model of Temporal Lobe Epilepsy
  Experimental Neurology. 04, 2020  |   Pubmed ID: 31935368
• The Current Approach of the Epilepsy Therapy Screening Program Contract Site for Identifying Improved Therapies for the Treatment of Pharmacoresistant Seizures in Epilepsy
  Neuropharmacology. 04, 2020  |   Pubmed ID: 31790717
• Evaluation of Antiseizure Drug Efficacy and Tolerability in the Rat Lamotrigine-resistant Amygdala Kindling Model
  Epilepsia Open. Sep, 2019  |   Pubmed ID: 31440726
• Cannabidiol Reduces Seizures Following CNS Infection with Theiler's Murine Encephalomyelitis Virus
  Epilepsia Open. Sep, 2019  |   Pubmed ID: 31440724
• Genetic and Pharmacological Manipulation of Glial Glutamate Transporters Does Not Alter Infection-induced Seizure Activity
  Experimental Neurology. 08, 2019  |   Pubmed ID: 31022385
• Conditional Knock-out of MGluR5 from Astrocytes During Epilepsy Development Impairs High-Frequency Glutamate Uptake
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 01, 2019  |   Pubmed ID: 30504280
• Recurrent Epileptiform Discharges in the Medial Entorhinal Cortex of Kainate-treated Rats Are Differentially Sensitive to Antiseizure Drugs
  Epilepsia. 11, 2018  |   Pubmed ID: 30328622
• Epilepsy As a Network Disorder (2): What Can We Learn from Other Network Disorders Such As Dementia and Schizophrenia, and What Are the Implications for Translational Research?
  Epilepsy & Behavior : E&B. 01, 2018  |   Pubmed ID: 29097123
• Novel Targets for Developing Antiseizure And, Potentially, Antiepileptogenic Drugs
  Epilepsy Currents. Sep-Oct, 2017  |   Pubmed ID: 29225544
• Corneal Kindled C57BL/6 Mice Exhibit Saturated Dentate Gyrus Long-term Potentiation and Associated Memory Deficits in the Absence of Overt Neuron Loss
  Neurobiology of Disease. Sep, 2017  |   Pubmed ID: 28624414
• Preclinical Comparison of Mechanistically Different Antiseizure, Antinociceptive, And/or Antidepressant Drugs in a Battery of Rodent Models of Nociceptive and Neuropathic Pain
  Neurochemical Research. Jul, 2017  |   Pubmed ID: 28508174
• Hippocampal TNFα Signaling Contributes to Seizure Generation in an Infection-Induced Mouse Model of Limbic Epilepsy
  ENeuro. Mar-Apr, 2017  |   Pubmed ID: 28497109
• Evaluation of Cannabidiol in Animal Seizure Models by the Epilepsy Therapy Screening Program (ETSP)
  Neurochemical Research. Jul, 2017  |   Pubmed ID: 28478594
• Development and Pharmacologic Characterization of the Rat 6 Hz Model of Partial Seizures
  Epilepsia. 06, 2017  |   Pubmed ID: 28449218
• Validation of a Preclinical Drug Screening Platform for Pharmacoresistant Epilepsy
  Neurochemical Research. Jul, 2017  |   Pubmed ID: 28303498
• Acute Treatment with Minocycline, but Not Valproic Acid, Improves Long-term Behavioral Outcomes in the Theiler's Virus Model of Temporal Lobe Epilepsy
  Epilepsia. 12, 2016  |   Pubmed ID: 27739576
• NBQX, a Highly Selective Competitive Antagonist of AMPA and KA Ionotropic Glutamate Receptors, Increases Seizures and Mortality Following Picornavirus Infection
  Experimental Neurology. 06, 2016  |   Pubmed ID: 27072529
• Neuronal Injury, Gliosis, and Glial Proliferation in Two Models of Temporal Lobe Epilepsy
  Journal of Neuropathology and Experimental Neurology. Apr, 2016  |   Pubmed ID: 26945036
• Repeated Low-dose Kainate Administration in C57BL/6J Mice Produces Temporal Lobe Epilepsy Pathology but Infrequent Spontaneous Seizures
  Experimental Neurology. May, 2016  |   Pubmed ID: 26896834
• Altered Structure and Function of Astrocytes Following Status Epilepticus
  Epilepsy & Behavior : E&B. Aug, 2015  |   Pubmed ID: 26219575
• Oxidative Stress in Murine Theiler's Virus-induced Temporal Lobe Epilepsy
  Experimental Neurology. Sep, 2015  |   Pubmed ID: 26079647
• Imaging Activity in Astrocytes and Neurons with Genetically Encoded Calcium Indicators Following in Utero Electroporation
  Frontiers in Molecular Neuroscience. 2015  |   Pubmed ID: 25926768
• Evaluating an Etiologically Relevant Platform for Therapy Development for Temporal Lobe Epilepsy: Effects of Carbamazepine and Valproic Acid on Acute Seizures and Chronic Behavioral Comorbidities in the Theiler's Murine Encephalomyelitis Virus Mouse Model
  The Journal of Pharmacology and Experimental Therapeutics. May, 2015  |   Pubmed ID: 25755209
• Imaging Activity in Neurons and Glia with a Polr2a-based and Cre-dependent GCaMP5G-IRES-tdTomato Reporter Mouse
  Neuron. Sep, 2014  |   Pubmed ID: 25155958
• The Challenge and Promise of Anti-epileptic Therapy Development in Animal Models
  The Lancet. Neurology. Sep, 2014  |   Pubmed ID: 25127174
• Does Brain Inflammation Mediate Pathological Outcomes in Epilepsy?
  Advances in Experimental Medicine and Biology. 2014  |   Pubmed ID: 25012376
• Antiseizure Drugs Differentially Modulate θ-burst Induced Long-term Potentiation in C57BL/6 Mice
  Epilepsia. Feb, 2014  |   Pubmed ID: 24447124
• Impaired Cognitive Ability and Anxiety-like Behavior Following Acute Seizures in the Theiler's Virus Model of Temporal Lobe Epilepsy
  Neurobiology of Disease. Apr, 2014  |   Pubmed ID: 24412221
• Novel, Broad-spectrum Anticonvulsants Containing a Sulfamide Group: Pharmacological Properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112)
  Journal of Medicinal Chemistry. Nov, 2013  |   Pubmed ID: 24205976
• The Expression of Kainate Receptor Subunits in Hippocampal Astrocytes After Experimentally Induced Status Epilepticus
  Journal of Neuropathology and Experimental Neurology. Oct, 2013  |   Pubmed ID: 24042195
• Issues Related to Development of New Antiseizure Treatments
  Epilepsia. Aug, 2013  |   Pubmed ID: 23909851
• Rapid Loss of Efficacy to the Antiseizure Drugs Lamotrigine and Carbamazepine: a Novel Experimental Model of Pharmacoresistant Epilepsy
  Epilepsia. Jul, 2013  |   Pubmed ID: 23750799
• The Activity Within the CA3 Excitatory Network During Theiler's Virus Encephalitis is Distinct from That Observed During Chronic Epilepsy
  Journal of Neurovirology. Feb, 2012  |   Pubmed ID: 22328242
• A New Derivative of Valproic Acid Amide Possesses a Broad-spectrum Antiseizure Profile and Unique Activity Against Status Epilepticus and Organophosphate Neuronal Damage
  Epilepsia. Jan, 2012  |   Pubmed ID: 22150444
• Altered Learning and Arc-regulated Consolidation of Learning in Striatum by Methamphetamine-induced Neurotoxicity
  Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Mar, 2012  |   Pubmed ID: 22071872
• Once Initiated, Viral Encephalitis-induced Seizures Are Consistent No Matter the Treatment or Lack of Interleukin-6
  Journal of Neurovirology. Oct, 2011  |   Pubmed ID: 21833798
• Lack of Correlation of Central Nervous System Inflammation and Neuropathology with the Development of Seizures Following Acute Virus Infection
  Journal of Virology. Aug, 2011  |   Pubmed ID: 21680509
• CAMP-dependent Protein Kinase A Activity Modulates Topiramate Potentiation of GABA(A) Receptors
  Epilepsy Research. Sep, 2011  |   Pubmed ID: 21665439
• Interleukin-6, Produced by Resident Cells of the Central Nervous System and Infiltrating Cells, Contributes to the Development of Seizures Following Viral Infection
  Journal of Virology. Jul, 2011  |   Pubmed ID: 21543484
• Topiramate Modulation of β(1)- and β(3)-homomeric GABA(A) Receptors
  Pharmacological Research. Jul, 2011  |   Pubmed ID: 21421049
• CGX-1007 Prevents Excitotoxic Cell Death Via Actions at Multiple Types of NMDA Receptors
  Neurotoxicology. Aug, 2011  |   Pubmed ID: 21396956
• Development of Postinfection Epilepsy After Theiler's Virus Infection of C57BL/6 Mice
  Journal of Neuropathology and Experimental Neurology. Dec, 2010  |   Pubmed ID: 21107134
• Role for Complement in the Development of Seizures Following Acute Viral Infection
  Journal of Virology. Jul, 2010  |   Pubmed ID: 20427530
• Theiler's Virus Infection Chronically Alters Seizure Susceptibility
  Epilepsia. Aug, 2010  |   Pubmed ID: 20002148
• Innate but Not Adaptive Immune Responses Contribute to Behavioral Seizures Following Viral Infection
  Epilepsia. Mar, 2010  |   Pubmed ID: 19845729
• Electroconvulsive Seizure Thresholds and Kindling Acquisition Rates Are Altered in Mouse Models of Human KCNQ2 and KCNQ3 Mutations for Benign Familial Neonatal Convulsions
  Epilepsia. Jul, 2009  |   Pubmed ID: 19453707
• Differences in Excitatory Transmission Between Thalamic and Cortical Afferents to Single Spiny Efferent Neurons of Rat Dorsal Striatum
  The European Journal of Neuroscience. Nov, 2008  |   Pubmed ID: 19046385
• Mouse Models of Human KCNQ2 and KCNQ3 Mutations for Benign Familial Neonatal Convulsions Show Seizures and Neuronal Plasticity Without Synaptic Reorganization
  The Journal of Physiology. Jul, 2008  |   Pubmed ID: 18483067
• Seizures Following Picornavirus Infection
  Epilepsia. Jun, 2008  |   Pubmed ID: 18325012
• Inhibition of the Betaine-GABA Transporter (mGAT2/BGT-1) Modulates Spontaneous Electrographic Bursting in the Medial Entorhinal Cortex (mEC)
  Epilepsy Research. Mar, 2008  |   Pubmed ID: 18262393
• Mechanisms of Action of Antiepileptic Drugs
  International Review of Neurobiology. 2007  |   Pubmed ID: 17433919
• Phenytoin- and Carbamazepine-resistant Spontaneous Bursting in Rat Entorhinal Cortex is Blocked by Retigabine in Vitro
  Epilepsy Research. May, 2007  |   Pubmed ID: 17395429
• Differential Contribution of Kainate Receptors to Excitatory Postsynaptic Currents in Superficial Layer Neurons of the Rat Medial Entorhinal Cortex
  Neuroscience. May, 2007  |   Pubmed ID: 17395391
• Discovery of Antiepileptic Drugs
  Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Jan, 2007  |   Pubmed ID: 17199014
• A Rat Brain Slice Preparation for Characterizing Both Thalamostriatal and Corticostriatal Afferents
  Journal of Neuroscience Methods. Jan, 2007  |   Pubmed ID: 16899300
• Felbamate is a Subunit Selective Modulator of Recombinant Gamma-aminobutyric Acid Type A Receptors Expressed in Xenopus Oocytes
  European Journal of Pharmacology. Dec, 2006  |   Pubmed ID: 17056029
• Effect of Conantokin G on NMDA Receptor-mediated Spontaneous EPSCs in Cultured Cortical Neurons
  Journal of Neurophysiology. Sep, 2006  |   Pubmed ID: 16760339
• Subunit Selectivity of Topiramate Modulation of Heteromeric GABA(A) Receptors
  Neuropharmacology. Jun, 2006  |   Pubmed ID: 16490221
• A Spontaneous Mutation Involving Kcnq2 (Kv7.2) Reduces M-current Density and Spike Frequency Adaptation in Mouse CA1 Neurons
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2006  |   Pubmed ID: 16481438
• Mice Carrying the Szt1 Mutation Exhibit Increased Seizure Susceptibility and Altered Sensitivity to Compounds Acting at the M-channel
  Epilepsia. Sep, 2004  |   Pubmed ID: 15329063
• The Effect of CGX-1007 and CI-1041, Novel NMDA Receptor Antagonists, on NMDA Receptor-mediated EPSCs
  Epilepsy Research. Mar, 2004  |   Pubmed ID: 15135163
• Characterization of the Anticonvulsant Profile and Enantioselective Pharmacokinetics of the Chiral Valproylamide Propylisopropyl Acetamide in Rodents
  British Journal of Pharmacology. Feb, 2003  |   Pubmed ID: 12598414
• Evidence for Functionally Distinct Synaptic NMDA Receptors in Ventromedial Versus Dorsolateral Striatum
  Journal of Neurophysiology. Jan, 2003  |   Pubmed ID: 12522160
• Effects of the Anticonvulsant Retigabine on Cultured Cortical Neurons: Changes in Electroresponsive Properties and Synaptic Transmission
  Molecular Pharmacology. Apr, 2002  |   Pubmed ID: 11901232