Karen Mossman

Publications

• Danger, Diversity and Priming in Innate Antiviral Immunity
  Cytokine & Growth Factor Reviews. Jul, 2014  |   Pubmed ID: 25081316
• Type-I Interferon Signaling Through ISGF3 Complex is Required for Sustained Rip3 Activation and Necroptosis in Macrophages
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2014  |   Pubmed ID: 25049377
• Extracellular DsRNA: Its Function and Mechanism of Cellular Uptake
  Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research. Jun, 2014  |   Pubmed ID: 24905198
• Novel Roles of Cytoplasmic ICP0: Proteasome-independent Functions of the RING Finger Are Required to Block Interferon-stimulated Gene Production but Not to Promote Viral Replication
  Journal of Virology. Jul, 2014  |   Pubmed ID: 24807717
• Permissiveness of Human Cancer Cells to Oncolytic Bovine Herpesvirus 1 is Mediated in Part by KRAS Activity
  Journal of Virology. Jun, 2014  |   Pubmed ID: 24696490
• Immunogenic HSV-mediated Oncolysis Shapes the Antitumor Immune Response and Contributes to Therapeutic Efficacy
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2014  |   Pubmed ID: 24343053
• Oncolytic Virotherapy and Immunogenic Cancer Cell Death: Sharpening the Sword for Improved Cancer Treatment Strategies
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2014  |   Pubmed ID: 24048442
• Combining Oncolytic HSV-1 with Immunogenic Cell Death-inducing Drug Mitoxantrone Breaks Cancer Immune Tolerance and Improves Therapeutic Efficacy
  Cancer Immunology Research. Nov, 2013  |   Pubmed ID: 24777969
• Rewiring Cancer Cell Death to Enhance Oncolytic Viro-immunotherapy
  Oncoimmunology. Dec, 2013  |   Pubmed ID: 24498567
• HIV-1 Gp120 Induces TLR2- and TLR4-mediated Innate Immune Activation in Human Female Genital Epithelium
  Journal of Immunology (Baltimore, Md. : 1950). Oct, 2013  |   Pubmed ID: 24043886
• Novel Paradigms of Innate Immune Sensing of Viral Infections
  Cytokine. Sep, 2013  |   Pubmed ID: 23800788
• Proinflammatory Cytokines and Chemokines - but Not Interferon-β - Produced in Response to HSV-2 in Primary Human Genital Epithelial Cells Are Associated with Viral Replication and the Presence of the Virion Host Shutoff Protein
  American Journal of Reproductive Immunology (New York, N.Y. : 1989). Sep, 2013  |   Pubmed ID: 23621693
• The Herpes Simplex Virus 1-encoded Envelope Glycoprotein B Activates NF-κB Through the Toll-like Receptor 2 and MyD88/TRAF6-dependent Signaling Pathway
  PloS One. 2013  |   Pubmed ID: 23382920
• MARCO is Required for TLR2- and Nod2-mediated Responses to Streptococcus Pneumoniae and Clearance of Pneumococcal Colonization in the Murine Nasopharynx
  Journal of Immunology (Baltimore, Md. : 1950). Jan, 2013  |   Pubmed ID: 23197261
• Recent Advances in Understanding Viral Evasion of Type I Interferon
  Immunology. Mar, 2013  |   Pubmed ID: 23173987
• Comparative Functional Evaluation of Immunocompetent Mouse Breast Cancer Models Established from PyMT-tumors Using Small Animal PET with [(18)F]FDG and [(18)F]FLT
  American Journal of Nuclear Medicine and Molecular Imaging. 2012  |   Pubmed ID: 23133804
• Encefalite Di Anti-NMDA Receptor. La Malattia, La Diagnosi Ed Il Immunobiology
  Autoimmunity Reviews. Mar, 2012  |   Pubmed ID: 22440397
• The Nitric Oxide Pathway Provides Innate Antiviral Protection in Conjunction with the Type I Interferon Pathway in Fibroblasts
  PloS One. 2012  |   Pubmed ID: 22363706
• Herpes Simplex Virus 1 Tegument Protein US11 Downmodulates the RLR Signaling Pathway Via Direct Interaction with RIG-I and MDA-5
  Journal of Virology. Apr, 2012  |   Pubmed ID: 22301138
• Methods Related to Molecular Virology
  Methods (San Diego, Calif.). Oct, 2011  |   Pubmed ID: 22050902
• Varicella-zoster Virus Immediate-early Protein ORF61 Abrogates the IRF3-mediated Innate Immune Response Through Degradation of Activated IRF3
  Journal of Virology. Nov, 2011  |   Pubmed ID: 21835786
• Membrane Perturbation Elicits an IRF3-dependent, Interferon-independent Antiviral Response
  Journal of Virology. Oct, 2011  |   Pubmed ID: 21813605
• Retroviral Expression of MIR2 Decreases Both Surface MHC Class I and the Alloimmune CTL Response
  Journal of Tissue Engineering and Regenerative Medicine. Jul, 2011  |   Pubmed ID: 21695793
• A Critical Role for IL-15 in TLR-mediated Innate Antiviral Immunity Against Genital HSV-2 Infection
  Immunology and Cell Biology. Aug, 2011  |   Pubmed ID: 21339766
• IL 15 E Il Tipo L'interferone Sono Necessari Per L'attivazione Delle Cellule NK Tumoricidal Dalle Cellule Dendritiche Infettate Da Virus
  Cancer Research. Apr, 2011  |   Pubmed ID: 21307131
• L'immunità Adattativa Antivirale è Un Fattore Determinante Del Successo Terapeutico Dell'oncolytic Virotherapy
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2011  |   Pubmed ID: 21119618
• Treating Viral Exacerbations of Chronic Obstructive Pulmonary Disease: Insights from a Mouse Model of Cigarette Smoke and H1N1 Influenza Infection
  PloS One. 2010  |   Pubmed ID: 20967263
• Replication of Subgenomic Hepatitis C Virus Replicons in Mouse Fibroblasts is Facilitated by Deletion of Interferon Regulatory Factor 3 and Expression of Liver-specific MicroRNA 122
  Journal of Virology. Sep, 2010  |   Pubmed ID: 20592082
• Recognition of Virus Infection and Innate Host Responses to Viral Gene Therapy Vectors
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Aug, 2010  |   Pubmed ID: 20551916
• Cellular Localization of the Herpes Simplex Virus ICP0 Protein Dictates Its Ability to Block IRF3-mediated Innate Immune Responses
  PloS One. 2010  |   Pubmed ID: 20454685
• An Accessory to the 'Trinity': SR-As Are Essential Pathogen Sensors of Extracellular DsRNA, Mediating Entry and Leading to Subsequent Type I IFN Responses
  PLoS Pathogens. Mar, 2010  |   Pubmed ID: 20360967
• Innate and Adaptive Immune Responses to Herpes Simplex Virus
  Viruses. Dec, 2009  |   Pubmed ID: 21994578
• Long Double-stranded RNA Induces an Antiviral Response Independent of IFN Regulatory Factor 3, IFN-beta Promoter Stimulator 1, and IFN
  Journal of Immunology (Baltimore, Md. : 1950). Nov, 2009  |   Pubmed ID: 19864603
• Mechanisms Employed by Herpes Simplex Virus 1 to Inhibit the Interferon Response
  Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research. Sep, 2009  |   Pubmed ID: 19694546
• Exposure to Cigarette Smoke Suppresses IL-15 Generation and Its Regulatory NK Cell Functions in Poly I:C-augmented Human PBMCs
  Molecular Immunology. Sep, 2009  |   Pubmed ID: 19592095
• Cell Fusion-induced Activation of Interferon-stimulated Genes is Not Required for Restriction of a Herpes Simplex Virus VP16/ICP0 Mutant in Heterokarya Formed Between Permissive and Restrictive Cells
  Journal of Virology. Sep, 2009  |   Pubmed ID: 19535444
• Differential Modification of Interferon Regulatory Factor 3 Following Virus Particle Entry
  Journal of Virology. May, 2009  |   Pubmed ID: 19211751
• Characterization of the Interferon Regulatory Factor 3-mediated Antiviral Response in a Cell Line Deficient for IFN Production
  Molecular Immunology. Jan, 2009  |   Pubmed ID: 19038458
• Cigarette Smoke Attenuation of Poly I:C-induced Innate Antiviral Responses in Human PBMC is Mainly Due to Inhibition of IFN-beta Production
  Molecular Immunology. Feb, 2009  |   Pubmed ID: 18930547
• FimH Adhesin of Type 1 Fimbriae is a Potent Inducer of Innate Antimicrobial Responses Which Requires TLR4 and Type 1 Interferon Signalling
  PLoS Pathogens. Dec, 2008  |   Pubmed ID: 19057665
• Cutting Edge: FimH Adhesin of Type 1 Fimbriae is a Novel TLR4 Ligand
  Journal of Immunology (Baltimore, Md. : 1950). Nov, 2008  |   Pubmed ID: 18981086
• Restoration of Vitamin C Synthesis in Transgenic Gulo-/- Mice by Helper-dependent Adenovirus-based Expression of Gulonolactone Oxidase
  Human Gene Therapy. Dec, 2008  |   Pubmed ID: 18764764
• Cigarette Smoke Suppresses Type I Interferon-mediated Antiviral Immunity in Lung Fibroblast and Epithelial Cells
  Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research. Mar, 2008  |   Pubmed ID: 18338949
• Impairment of Human NK Cell Cytotoxic Activity and Cytokine Release by Cigarette Smoke
  Journal of Leukocyte Biology. Mar, 2008  |   Pubmed ID: 18055568
• Presentazione Dell'antigene Di Fatto Rilasciato Dalle Cellule Dendritiche Del Peptide-pulsato Non è Soppressa Dalla Presenza Di CTL Attivo
  Journal of Immunology (Baltimore, Md. : 1950). Oct, 2007  |   Pubmed ID: 17911587
• Distinct Functional Motifs Within the IL-17 Receptor Regulate Signal Transduction and Target Gene Expression
  Proceedings of the National Academy of Sciences of the United States of America. May, 2007  |   Pubmed ID: 17456598
• La Risposta Di IFN-indipendente All'ingresso Di Particelle Di Virus Fornisce Una Prima Linea Di Difesa Antivirale Che è Indipendente Da TLR E Retinoic Acid Inducible Gene I
  Journal of Immunology (Baltimore, Md. : 1950). Dec, 2006  |   Pubmed ID: 17114474
• Induction of Innate Immunity Against Herpes Simplex Virus Type 2 Infection Via Local Delivery of Toll-like Receptor Ligands Correlates with Beta Interferon Production
  Journal of Virology. Oct, 2006  |   Pubmed ID: 17005672
• Identification of a Novel Pathway Essential for the Immediate-early, Interferon-independent Antiviral Response to Enveloped Virions
  Journal of Virology. Jan, 2006  |   Pubmed ID: 16352547
• ICP0 Prevents RNase L-independent RRNA Cleavage in Herpes Simplex Virus Type 1-infected Cells
  Journal of Virology. Jan, 2006  |   Pubmed ID: 16352546
• Functional Inaccessibility of Quiescent Herpes Simplex Virus Genomes
  Virology Journal. 2005  |   Pubmed ID: 16300675
• The Role of ICP0-Null HSV-1 and Interferon Signaling Defects in the Effective Treatment of Breast Adenocarcinoma
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2005  |   Pubmed ID: 16140040
• Herpesviruses and the Innate Immune Response
  Viral Immunology. 2005  |   Pubmed ID: 16035939
• Analysis of Anti-interferon Properties of the Herpes Simplex Virus Type I ICP0 Protein
  Methods in Molecular Medicine. 2005  |   Pubmed ID: 16000863
• Innate Cellular Response to Virus Particle Entry Requires IRF3 but Not Virus Replication
  Journal of Virology. Feb, 2004  |   Pubmed ID: 14747536
• The Herpes Simplex Virus ICP0 RING Finger Domain Inhibits IRF3- and IRF7-mediated Activation of Interferon-stimulated Genes
  Journal of Virology. Feb, 2004  |   Pubmed ID: 14747533
• Activation and Inhibition of Virus and Interferon: the Herpesvirus Story
  Viral Immunology. 2002  |   Pubmed ID: 11952145
• Herpes Simplex Virus ICP0 and ICP34.5 Counteract Distinct Interferon-induced Barriers to Virus Replication
  Journal of Virology. Feb, 2002  |   Pubmed ID: 11799195