Karl Broich Federal Institute for Drugs and Medical Devices (BfArM) Biography Publications Institution JoVE Articles Karl Broich has not added a biography. If you are Karl Broich and would like to personalize this page please email our Author Liaison for assistance. Publications Motor Cortex Theta and Gamma Architecture in Young Adult APPswePS1dE9 Alzheimer Mice PloS One. 2017 | Pubmed ID: 28072877 Review: Cav2.3 R-type Voltage-Gated Ca(2+) Channels - Functional Implications in Convulsive and Non-convulsive Seizure Activity The Open Neurology Journal. 2016 | Pubmed ID: 27843503 Gender-Specific Hippocampal Dysrhythmia and Aberrant Hippocampal and Cortical Excitability in the APPswePS1dE9 Model of Alzheimer's Disease Neural Plasticity. 2016 | Pubmed ID: 27840743 [Improving Drug Licensing for Children and Adolescents : Position Paper from the More Medicines For Minors Symposion 8 June 2015 in Bonn] Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz. Dec, 2016 | Pubmed ID: 27778087 The New EU Regulation on in Vitro Diagnostics: Potential Issues at the Interface of Medicines and Companion Diagnostics Biomarkers in Medicine. Dec, 2016 | Pubmed ID: 27661101 Regular Benzodiazepine and Z-Substance Use and Risk of Dementia: An Analysis of German Claims Data Journal of Alzheimer's Disease : JAD. Sep, 2016 | Pubmed ID: 27567804 The Regulator's Perspective: How Should New Therapies and Follow-on Products for MS Be Clinically Evaluated in the Future? Multiple Sclerosis (Houndmills, Basingstoke, England). Aug, 2016 | Pubmed ID: 27465615 Sampling Rate, Signal Bandwidth and Related Pitfalls in EEG Analysis Journal of Neuroscience Methods. Aug, 2016 | Pubmed ID: 27172844 Drug Regulation and Pricing--Can Regulators Influence Affordability? The New England Journal of Medicine. May, 2016 | Pubmed ID: 27168431 Preclinical Alzheimer's Disease: Definition, Natural History, and Diagnostic Criteria Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Mar, 2016 | Pubmed ID: 27012484 Association of Proton Pump Inhibitors With Risk of Dementia: A Pharmacoepidemiological Claims Data Analysis JAMA Neurology. Apr, 2016 | Pubmed ID: 26882076 EEG Radiotelemetry in Small Laboratory Rodents: A Powerful State-of-the Art Approach in Neuropsychiatric, Neurodegenerative, and Epilepsy Research Neural Plasticity. 2016 | Pubmed ID: 26819775 Identification and Validation of Biomarkers for Autism Spectrum Disorders Nature Reviews. Drug Discovery. Jan, 2016 | Pubmed ID: 26718285 Evolving Evidence for the Value of Neuroimaging Methods and Biological Markers in Subjects Categorized with Subjective Cognitive Decline Journal of Alzheimer's Disease : JAD. Sep, 2015 | Pubmed ID: 26402088 Altered Theta Oscillations and Aberrant Cortical Excitatory Activity in the 5XFAD Model of Alzheimer's Disease Neural Plasticity. 2015 | Pubmed ID: 25922768 Limited Effects of an EIF2αS51A Allele on Neurological Impairments in the 5xFAD Mouse Model of Alzheimer's Disease Neural Plasticity. 2015 | Pubmed ID: 25883808 The European Medicines Agency's Strategies to Meet the Challenges of Alzheimer Disease Nature Reviews. Drug Discovery. Apr, 2015 | Pubmed ID: 25829266 Advances in the Therapy of Alzheimer's Disease: Targeting Amyloid Beta and Tau and Perspectives for the Future Expert Review of Neurotherapeutics. Jan, 2015 | Pubmed ID: 25537424 Risk of Dementia in Elderly Patients with the Use of Proton Pump Inhibitors European Archives of Psychiatry and Clinical Neuroscience. Aug, 2015 | Pubmed ID: 25341874 Taking Stock: A Multistakeholder Perspective on Improving the Delivery of Care and the Development of Treatments for Alzheimer's Disease Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Apr, 2015 | Pubmed ID: 24751826 [Safety of Medical Devices] Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz. Dec, 2014 | Pubmed ID: 25394355 Addressing the Regulatory and Scientific Challenges in Multiple Sclerosis--a Statement from the EU Regulators Multiple Sclerosis (Houndmills, Basingstoke, England). Sep, 2014 | Pubmed ID: 25160121 The CaV2.3 R-type Voltage-gated Ca2+ Channel in Mouse Sleep Architecture Sleep. May, 2014 | Pubmed ID: 24790266 Florbetapir (18F) for Brain Amyloid Positron Emission Tomography: Highlights on the European Marketing Approval Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Oct, 2014 | Pubmed ID: 24418060 Perspective on Future Role of Biological Markers in Clinical Therapy Trials of Alzheimer's Disease: a Long-range Point of View Beyond 2020 Biochemical Pharmacology. Apr, 2014 | Pubmed ID: 24275164 [Personalised Medicine] Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz. Nov, 2013 | Pubmed ID: 24170074 Designing Drug Trials for Alzheimer's Disease: What We Have Learned from the Release of the Phase III Antibody Trials: a Report from the EU/US/CTAD Task Force Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Jul, 2013 | Pubmed ID: 23809364 [Cancer: Is It Really So Different? Particularities of Oncologic Drugs from the Perspective of the Pharmaceutical Regulatory Agency] Zeitschrift Für Evidenz, Fortbildung Und Qualität Im Gesundheitswesen. 2013 | Pubmed ID: 23663906 DSM-5 and Clinical Trials in Psychiatry: Challenges to Come? Nature Reviews. Drug Discovery. Aug, 2012 | Pubmed ID: 22850770 Voltage-gated Ca(2+) Channel Mediated Ca(2+) Influx in Epileptogenesis Advances in Experimental Medicine and Biology. 2012 | Pubmed ID: 22453990 Biomarker Candidates of Neurodegeneration in Parkinson's Disease for the Evaluation of Disease-modifying Therapeutics Journal of Neural Transmission (Vienna, Austria : 1996). Jan, 2012 | Pubmed ID: 21755462 Burnout: a Fashionable Diagnosis Deutsches Ärzteblatt International. Nov, 2011 | Pubmed ID: 22163259 Biomarkers in Clinical Trials for Neurodegenerative Diseases: Regulatory Perspectives and Requirements Progress in Neurobiology. Dec, 2011 | Pubmed ID: 21945642 使用抗胆碱能药物和老年痴呆症风险： 痴呆症预防的目标。 European Archives of Psychiatry and Clinical Neuroscience. Nov, 2010 | Pubmed ID: 20960005 Suicidality and Risk of Suicide--definition, Drug Safety Concerns, and a Necessary Target for Drug Development: a Consensus Statement The Journal of Clinical Psychiatry. Aug, 2010 | Pubmed ID: 20797373 Suicidality and Risk of Suicide--definition, Drug Safety Concerns, and a Necessary Target for Drug Development: a Brief Report The Journal of Clinical Psychiatry. Aug, 2010 | Pubmed ID: 20673551 Biomarkers for Alzheimer's Disease: Academic, Industry and Regulatory Perspectives Nature Reviews. Drug Discovery. Jul, 2010 | Pubmed ID: 20592748 Principle Standards and Problems Regarding Proof of Efficacy in Clinical Psychopharmacology European Archives of Psychiatry and Clinical Neuroscience. Feb, 2010 | Pubmed ID: 19888620 Use of Drugs with Anticholinergic Effect and Impact on Cognition in Parkinson's Disease: a Cohort Study Journal of Neurology, Neurosurgery, and Psychiatry. Feb, 2010 | Pubmed ID: 19770163 Biological Markers for Early Detection and Pharmacological Treatment of Alzheimer's Disease Dialogues in Clinical Neuroscience. 2009 | Pubmed ID: 19585950 Committee for Medicinal Products for Human Use (CHMP) Assessment on Efficacy of Antidepressants European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. May, 2009 | Pubmed ID: 19269795 Outcome Measures in Clinical Trials on Medicinal Products for the Treatment of Dementia: a European Regulatory Perspective International Psychogeriatrics / IPA. Jun, 2007 | Pubmed ID: 17433121 Clinical Practice with Anti-dementia Drugs: a Consensus Statement from British Association for Psychopharmacology Journal of Psychopharmacology (Oxford, England). Nov, 2006 | Pubmed ID: 17060346 Selective COX-2 Inhibitors and Risk of Thromboembolic Events - Regulatory Aspects Thrombosis and Haemostasis. Oct, 2006 | Pubmed ID: 17003918 Mild Cognitive Impairment Lancet (London, England). Apr, 2006 | Pubmed ID: 16631882 Do Recent Efficacy Data on the Drug Treatment of Acute Bipolar Depression Support the Position That Drugs Other Than Antidepressants Are the Treatment of Choice? A Conceptual Review European Archives of Psychiatry and Clinical Neuroscience. Feb, 2006 | Pubmed ID: 16078087 Changes in Regional Cerebral Blood Flow by Therapeutic Vagus Nerve Stimulation in Depression: an Exploratory Approach Psychiatry Research. Aug, 2005 | Pubmed ID: 16043331 Regulatory Issues in Vascular Dementia: a European Perspective International Psychogeriatrics / IPA. 2003 | Pubmed ID: 16191258 Placebo-controlled Studies in Depression: Necessary, Ethical and Feasible European Archives of Psychiatry and Clinical Neuroscience. Feb, 2003 | Pubmed ID: 12664309 脑干中的数据采集与分析 在小鼠中引发响应音频测量 Andreas Lundt1,2, Julien Soos1, Christina Henseler1, Muhammad Imran Arshaad1, Ralf Müller3, Dan Ehninger4, Jürgen Hescheler5, Agapios Sachinidis5, Karl Broich6, Carola Wormuth1,7, Anna Papazoglou1, Marco Weiergräber1 1Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices, 2KBRwyle GmbH, 3Cognitive Neurophysiology, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Cologne, 4Molecular and Cellular Cognition, German Center for Neurodegenerative Diseases (DZNE), 5Institute of Neurophysiology, Faculty of Medicine, University of Cologne, 6Federal Institute for Drugs and Medical Devices (BfArM), 7Thescon GmbH JoVE 59200 Neuroscience 高度组织的Theta振荡在鼠脑的自动检测 Ralf Müller1, Anna Papazoglou2, Julien Soos2, Andreas Lundt2, Carola Wormuth2, Christina Henseler2, Dan Ehninger3, Karl Broich4, Marco Weiergräber2 1Department of Psychiatry and Psychotherapy, University of Cologne, 2Department of Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices, 3Molecular and Cellular Cognition Lab, German Center for Neurodegenerative Diseases, 4Federal Institute for Drugs and Medical Devices Behavior 非约束脑电遥测：硬膜外和脑深部脑电立体定位放置电极 Anna Papazoglou1, Andreas Lundt1, Carola Wormuth1, Dan Ehninger2, Christina Henseler1, Julien Soós1, Karl Broich1, Marco Weiergräber1 1Department of Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM), 2Molecular and Cellular Cognition Lab, German Center for Neurodegenerative Diseases (Deutsches Zentrum für Neurodegenerative Erkrankungen, DZNE) JoVE 54216 Neuroscience
脑干中的数据采集与分析 在小鼠中引发响应音频测量 Andreas Lundt1,2, Julien Soos1, Christina Henseler1, Muhammad Imran Arshaad1, Ralf Müller3, Dan Ehninger4, Jürgen Hescheler5, Agapios Sachinidis5, Karl Broich6, Carola Wormuth1,7, Anna Papazoglou1, Marco Weiergräber1 1Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices, 2KBRwyle GmbH, 3Cognitive Neurophysiology, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Cologne, 4Molecular and Cellular Cognition, German Center for Neurodegenerative Diseases (DZNE), 5Institute of Neurophysiology, Faculty of Medicine, University of Cologne, 6Federal Institute for Drugs and Medical Devices (BfArM), 7Thescon GmbH JoVE 59200 Neuroscience
高度组织的Theta振荡在鼠脑的自动检测 Ralf Müller1, Anna Papazoglou2, Julien Soos2, Andreas Lundt2, Carola Wormuth2, Christina Henseler2, Dan Ehninger3, Karl Broich4, Marco Weiergräber2 1Department of Psychiatry and Psychotherapy, University of Cologne, 2Department of Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices, 3Molecular and Cellular Cognition Lab, German Center for Neurodegenerative Diseases, 4Federal Institute for Drugs and Medical Devices Behavior
非约束脑电遥测：硬膜外和脑深部脑电立体定位放置电极 Anna Papazoglou1, Andreas Lundt1, Carola Wormuth1, Dan Ehninger2, Christina Henseler1, Julien Soós1, Karl Broich1, Marco Weiergräber1 1Department of Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM), 2Molecular and Cellular Cognition Lab, German Center for Neurodegenerative Diseases (Deutsches Zentrum für Neurodegenerative Erkrankungen, DZNE) JoVE 54216 Neuroscience
