Katherine M. Kocan Department of Veterinary Pathobiology, Center for Veterinary Health Sciences Oklahoma State University Biography Publications Institution JoVE Articles Katherine M. Kocan has not added a biography. If you are Katherine M. Kocan and would like to personalize this page please email our Author Liaison for assistance. Publications Targeting Arthropod Subolesin/akirin for the Development of a Universal Vaccine for Control of Vector Infestations and Pathogen Transmission Veterinary Parasitology. Sep, 2011 | Pubmed ID: 21561715 The Relevance of Tick Bites to the Production of IgE Antibodies to the Mammalian Oligosaccharide Galactose-α-1,3-galactose The Journal of Allergy and Clinical Immunology. May, 2011 | Pubmed ID: 21453959 Control of Rhipicephalus (Boophilus) Microplus Infestations by the Combination of Subolesin Vaccination and Tick Autocidal Control After Subolesin Gene Knockdown in Ticks Fed on Cattle Vaccine. Mar, 2011 | Pubmed ID: 21288805 Expression of Heat Shock and Other Stress Response Proteins in Ticks and Cultured Tick Cells in Response to Anaplasma Spp. Infection and Heat Shock International Journal of Proteomics. 2010 | Pubmed ID: 22084679 Characterization of Pathogen-specific Expression of Host Immune Response Genes in Anaplasma and Mycobacterium Species Infected Ruminants Comparative Immunology, Microbiology and Infectious Diseases. Dec, 2010 | Pubmed ID: 20952064 Characterization of Anaplasma Phagocytophilum and A. Ovis Infection in a Naturally Infected Sheep Flock with Poor Health Condition Tropical Animal Health and Production. Oct, 2010 | Pubmed ID: 20405320 Differential Expression of Genes in Salivary Glands of Male Rhipicephalus (Boophilus)microplus in Response to Infection with Anaplasma Marginale BMC Genomics. 2010 | Pubmed ID: 20298599 Subolesin Expression in Response to Pathogen Infection in Ticks BMC Immunology. 2010 | Pubmed ID: 20170494 Identification of Protective Antigens by RNA Interference for Control of the Lone Star Tick, Amblyomma Americanum Vaccine. Feb, 2010 | Pubmed ID: 20018267 Functional Genomics and Evolution of Tick-Anaplasma Interactions and Vaccine Development Veterinary Parasitology. Feb, 2010 | Pubmed ID: 19819630 The Natural History of Anaplasma Marginale Veterinary Parasitology. Feb, 2010 | Pubmed ID: 19811876 Phylogeographic Analysis Reveals Association of Tick-borne Pathogen, Anaplasma Marginale, MSP1a Sequences with Ecological Traits Affecting Tick Vector Performance BMC Biology. 2009 | Pubmed ID: 19723295 Anaplasma Phagocytophilum and Anaplasma Marginale Elicit Different Gene Expression Responses in Cultured Tick Cells Comparative and Functional Genomics. 2009 | Pubmed ID: 19636428 Light and Transmission Electron Microscopic Characteristics of a Novel Hepatozoon Spp. in Naturally Infected Cotton Rats (Sigmodon Hispidus) Parasitology Research. Oct, 2009 | Pubmed ID: 19629526 Silencing of Genes Involved in Anaplasma Marginale-tick Interactions Affects the Pathogen Developmental Cycle in Dermacentor Variabilis BMC Developmental Biology. 2009 | Pubmed ID: 19607704 Characterization of Possible Correlates of Protective Response Against Brucella Ovis Infection in Rams Immunized with the B. Melitensis Rev 1 Vaccine Vaccine. May, 2009 | Pubmed ID: 19428917 Genetic Diversity of Anaplasma Marginale in Argentina Veterinary Parasitology. May, 2009 | Pubmed ID: 19285808 Conservation and Immunogenicity of the Mosquito Ortholog of the Tick-protective Antigen, Subolesin Parasitology Research. Jul, 2009 | Pubmed ID: 19229557 Transmission of Cytauxzoon Felis to a Domestic Cat by Amblyomma Americanum Veterinary Parasitology. Apr, 2009 | Pubmed ID: 19168288 Gene Expression Profiles of European Wild Boar Naturally Infected with Mycobacterium Bovis Veterinary Immunology and Immunopathology. May, 2009 | Pubmed ID: 19131115 Differential Expression of Inflammatory and Immune Response Genes in Rams Experimentally Infected with a Rough Virulent Strain of Brucella Ovis Veterinary Immunology and Immunopathology. Feb, 2009 | Pubmed ID: 19056128 Ultrastructural and Fluorochromatic Changes of Anaplasma Marginale Exposed to Oxytetracycline, Imidocarb and Enrofloxacin in Short-term Erythrocyte Cultures Veterinary Microbiology. Apr, 2009 | Pubmed ID: 19054634 Tick Subolesin is an Ortholog of the Akirins Described in Insects and Vertebrates Developmental and Comparative Immunology. Apr, 2009 | Pubmed ID: 19041667 Inoculation of White-tailed Deer (Odocoileus Virginianus) with Ap-V1 Or NY-18 Strains of Anaplasma Phagocytophilum and Microscopic Demonstration of Ap-V1 In Ixodes Scapularis Adults That Acquired Infection from Deer As Nymphs Vector Borne and Zoonotic Diseases (Larchmont, N.Y.). Oct, 2009 | Pubmed ID: 18973438 The Impact of RNA Interference of the Subolesin and Voraxin Genes in Male Amblyomma Hebraeum (Acari: Ixodidae) on Female Engorgement and Oviposition Experimental & Applied Acarology. Jan, 2009 | Pubmed ID: 18830675 Defining the Role of Subolesin in Tick Cell Culture by Use of RNA Interference Annals of the New York Academy of Sciences. Dec, 2008 | Pubmed ID: 19120170 Differential Expression of the Tick Protective Antigen Subolesin in Anaplasma Marginale- and A. Phagocytophilum-infected Host Cells Annals of the New York Academy of Sciences. Dec, 2008 | Pubmed ID: 19120168 Evidence of the Role of Tick Subolesin in Gene Expression BMC Genomics. 2008 | Pubmed ID: 18673577 Differential Expression of Inflammatory and Immune Response Genes in Sheep Infected with Anaplasma Phagocytophilum Veterinary Immunology and Immunopathology. Nov, 2008 | Pubmed ID: 18640728 Observations on Antricola Ticks: Small Nymphs Feed on Mammalian Hosts and Have a Salivary Gland Structure Similar to Ixodid Ticks The Journal of Parasitology. Aug, 2008 | Pubmed ID: 18576742 Silencing Expression of the Defensin, Varisin, in Male Dermacentor Variabilis by RNA Interference Results in Reduced Anaplasma Marginale Infections Experimental & Applied Acarology. Dec, 2008 | Pubmed ID: 18523848 Advances Toward Understanding the Molecular Biology of the Anaplasma-tick Interface Frontiers in Bioscience : a Journal and Virtual Library. 2008 | Pubmed ID: 18508714 Targeting the Tick-pathogen Interface for Novel Control Strategies Frontiers in Bioscience : a Journal and Virtual Library. 2008 | Pubmed ID: 18508707 Overview: Ticks As Vectors of Pathogens That Cause Disease in Humans and Animals Frontiers in Bioscience : a Journal and Virtual Library. 2008 | Pubmed ID: 18508706 Expression of Perilipin in Human Promyelocytic Cells in Response to Anaplasma Phagocytophilum Infection Results in Modified Lipid Metabolism Journal of Medical Microbiology. Feb, 2008 | Pubmed ID: 18201980 Differential Expression of Inflammatory and Immune Response Genes in Mesenteric Lymph Nodes of Iberian Red Deer (Cervus Elaphus Hispanicus) Naturally Infected with Mycobacterium Bovis Developmental and Comparative Immunology. 2008 | Pubmed ID: 17604102 Serologic and Molecular Characterization of Tickborne Pathogens in Lions (Panthera Leo) from the Fasano Safari Park, Italy Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians. Dec, 2007 | Pubmed ID: 18229868 Experimental Transmission of Anaplasma Marginale by Male Dermacentor Reticulatus BMC Veterinary Research. 2007 | Pubmed ID: 18053123 Functional Genomic Studies of Tick Cells in Response to Infection with the Cattle Pathogen, Anaplasma Marginale Genomics. Dec, 2007 | Pubmed ID: 17964755 Movement of Rhipicephalus Sanguineus Adults Between Co-housed Dogs During Active Feeding Veterinary Parasitology. Nov, 2007 | Pubmed ID: 17904292 Sp110 Transcription is Induced and Required by Anaplasma Phagocytophilum for Infection of Human Promyelocytic Cells BMC Infectious Diseases. 2007 | Pubmed ID: 17883869 A Ten-year Review of Commercial Vaccine Performance for Control of Tick Infestations on Cattle Animal Health Research Reviews / Conference of Research Workers in Animal Diseases. Jun, 2007 | Pubmed ID: 17692140 Comparison of the Complement Fixation Test and Competitive ELISA for Serodiagnosis of Anaplasma Marginale Infection in Experimentally Infected Steers American Journal of Veterinary Research. Aug, 2007 | Pubmed ID: 17669027 RNA Interference for the Study and Genetic Manipulation of Ticks Trends in Parasitology. Sep, 2007 | Pubmed ID: 17656154 Transovarial Silencing of the Subolesin Gene in Three-host Ixodid Tick Species After Injection of Replete Females with Subolesin DsRNA Parasitology Research. May, 2007 | Pubmed ID: 17372765 Gene Silencing of the Tick Protective Antigens, Bm86, Bm91 and Subolesin, in the One-host Tick Boophilus Microplus by RNA Interference International Journal for Parasitology. May, 2007 | Pubmed ID: 17196597 Proteomic and Transcriptomic Analyses of Differential Stress/inflammatory Responses in Mandibular Lymph Nodes and Oropharyngeal Tonsils of European Wild Boars Naturally Infected with Mycobacterium Bovis Proteomics. Jan, 2007 | Pubmed ID: 17163576 Analysis of World Strains of Anaplasma Marginale Using Major Surface Protein 1a Repeat Sequences Veterinary Microbiology. Jan, 2007 | Pubmed ID: 17084044 Sequence Analysis of the Msp4 Gene of Anaplasma Ovis Strains Veterinary Microbiology. Jan, 2007 | Pubmed ID: 17052866 Comparison of the Efficacy of Enrofloxacin, Imidocarb, and Oxytetracycline for Clearance of Persistent Anaplasma Marginale Infections in Cattle Veterinary Therapeutics : Research in Applied Veterinary Medicine. 2006 | Pubmed ID: 17216590 Anaplasmosis: Focusing on Host-vector-pathogen Interactions for Vaccine Development Annals of the New York Academy of Sciences. Oct, 2006 | Pubmed ID: 17114750 Molecular Epidemiology of Human and Bovine Anaplasmosis in Southern Europe Annals of the New York Academy of Sciences. Oct, 2006 | Pubmed ID: 17114686 Tick Control: Further Thoughts on a Research Agenda Trends in Parasitology. Dec, 2006 | Pubmed ID: 17005451 Molecular Characterization of Anaplasma Platys Strains from Dogs in Sicily, Italy BMC Veterinary Research. 2006 | Pubmed ID: 16872489 Genetic Characterization of Anaplasma Ovis Strains from Bighorn Sheep in Montana Journal of Wildlife Diseases. Apr, 2006 | Pubmed ID: 16870861 Reduction of Tick Infections with Anaplasma Marginale and A. Phagocytophilum by Targeting the Tick Protective Antigen Subolesin Parasitology Research. Dec, 2006 | Pubmed ID: 16816958 Characterization of Selected Genes Upregulated in Non-tuberculous European Wild Boar As Possible Correlates of Resistance to Mycobacterium Bovis Infection Veterinary Microbiology. Aug, 2006 | Pubmed ID: 16672181 Autocidal Control of Ticks by Silencing of a Single Gene by RNA Interference Biochemical and Biophysical Research Communications. May, 2006 | Pubmed ID: 16630571 The Tick Protective Antigen, 4D8, is a Conserved Protein Involved in Modulation of Tick Blood Ingestion and Reproduction Vaccine. May, 2006 | Pubmed ID: 16580098 Synergistic Effect of Silencing the Expression of Tick Protective Antigens 4D8 and Rs86 in Rhipicephalus Sanguineus by RNA Interference Parasitology Research. Jul, 2006 | Pubmed ID: 16518610 Genes Differentially Expressed in Oropharyngeal Tonsils and Mandibular Lymph Nodes of Tuberculous and Nontuberculous European Wild Boars Naturally Exposed to Mycobacterium Bovis FEMS Immunology and Medical Microbiology. Mar, 2006 | Pubmed ID: 16487312 Potential Vertebrate Reservoir Hosts and Invertebrate Vectors of Anaplasma Marginale and A. Phagocytophilum in Central Spain Vector Borne and Zoonotic Diseases (Larchmont, N.Y.). 2005 | Pubmed ID: 16417435 Capillary Tube Feeding System for Studying Tick-pathogen Interactions of Dermacentor Variabilis (Acari: Ixodidae) and Anaplasma Marginale (Rickettsiales: Anaplasmataceae) Journal of Medical Entomology. Sep, 2005 | Pubmed ID: 16366000 Genetic Diversity of Anaplasma Species Major Surface Proteins and Implications for Anaplasmosis Serodiagnosis and Vaccine Development Animal Health Research Reviews / Conference of Research Workers in Animal Diseases. Jun, 2005 | Pubmed ID: 16164010 Vaccination with Recombinant Tick Antigens for the Control of Ixodes Scapularis Adult Infestations Vaccine. Nov, 2005 | Pubmed ID: 16153760 Serologic and Molecular Characterization of Anaplasma Species Infection in Farm Animals and Ticks from Sicily Veterinary Parasitology. Nov, 2005 | Pubmed ID: 16043300 Characterization of Three Ixodes Scapularis CDNAs Protective Against Tick Infestations Vaccine. Aug, 2005 | Pubmed ID: 16005748 BptA (bbe16) is Essential for the Persistence of the Lyme Disease Spirochete, Borrelia Burgdorferi, in Its Natural Tick Vector Proceedings of the National Academy of Sciences of the United States of America. May, 2005 | Pubmed ID: 15860579 RNA Interference Screening in Ticks for Identification of Protective Antigens Parasitology Research. Jun, 2005 | Pubmed ID: 15824899 Seroprevalence of Anaplasmosis Among Cattle in Switzerland in 1998 and 2003: No Evidence of an Emerging Disease Veterinary Microbiology. Apr, 2005 | Pubmed ID: 15795079 Gene Expression Profiling of Human Promyelocytic Cells in Response to Infection with Anaplasma Phagocytophilum Cellular Microbiology. Apr, 2005 | Pubmed ID: 15760455 Sequence Analysis of the Msp4 Gene of Anaplasma Phagocytophilum Strains Journal of Clinical Microbiology. Mar, 2005 | Pubmed ID: 15750101 Comparison of Three Oxytetracycline Regimes for the Treatment of Persistent Anaplasma Marginale Infections in Beef Cattle Veterinary Parasitology. Jan, 2005 | Pubmed ID: 15675047 Characterization of Genetic Diversity in Dermacentor Andersoni (Acari: Ixodidae) with Body Size and Weight Polymorphism Experimental Parasitology. Jan, 2005 | Pubmed ID: 15639135 Recent Studies on the Characterization of Anaplasma Marginale Isolated from North American Bison Annals of the New York Academy of Sciences. Oct, 2004 | Pubmed ID: 15604478 Identification of a Novel Anaplasma Marginale Appendage-associated Protein That Localizes with Actin Filaments During Intraerythrocytic Infection Infection and Immunity. Dec, 2004 | Pubmed ID: 15557651 Concurrent Infections with Vector-borne Pathogens Associated with Fatal Hemolytic Anemia in a Cattle Herd in Switzerland Journal of Clinical Microbiology. Aug, 2004 | Pubmed ID: 15297529 Anaplasma Infection in Free-ranging Iberian Red Deer in the Region of Castilla-La Mancha, Spain Veterinary Microbiology. Jun, 2004 | Pubmed ID: 15145495 Genetic Diversity and Molecular Phylogeny of Anaplasma Marginale Isolates from Minas Gerais, Brazil Veterinary Parasitology. May, 2004 | Pubmed ID: 15135871 Glycosylation of Anaplasma Marginale Major Surface Protein 1a and Its Putative Role in Adhesion to Tick Cells Infection and Immunity. May, 2004 | Pubmed ID: 15102815 Adhesion of Outer Membrane Proteins Containing Tandem Repeats of Anaplasma and Ehrlichia Species (Rickettsiales: Anaplasmataceae) to Tick Cells Veterinary Microbiology. Mar, 2004 | Pubmed ID: 15036540 Differential Expression of the Msp1alpha Gene of Anaplasma Marginale Occurs in Bovine Erythrocytes and Tick Cells Veterinary Microbiology. Mar, 2004 | Pubmed ID: 15036535 Mapping of B-cell Epitopes in the N-terminal Repeated Peptides of Anaplasma Marginale Major Surface Protein 1a and Characterization of the Humoral Immune Response of Cattle Immunized with Recombinant and Whole Organism Antigens Veterinary Immunology and Immunopathology. Apr, 2004 | Pubmed ID: 15010223 Advances in the Identification and Characterization of Protective Antigens for Recombinant Vaccines Against Tick Infestations Expert Review of Vaccines. Aug, 2003 | Pubmed ID: 14711342 Antigens and Alternatives for Control of Anaplasma Marginale Infection in Cattle Clinical Microbiology Reviews. Oct, 2003 | Pubmed ID: 14557295 Characterization of Anaplasma Marginale Isolated from North American Bison Applied and Environmental Microbiology. Aug, 2003 | Pubmed ID: 12902301 Anaplasma Marginale Msp1alpha Genotypes Evolved Under Positive Selection Pressure but Are Not Markers for Geographic Isolates Journal of Clinical Microbiology. Apr, 2003 | Pubmed ID: 12682152 Co-feeding Studies of Ticks Infected with Anaplasma Marginale Veterinary Parasitology. Mar, 2003 | Pubmed ID: 12623209 Identification of Protective Antigens for the Control of Ixodes Scapularis Infestations Using CDNA Expression Library Immunization Vaccine. Mar, 2003 | Pubmed ID: 12615446 Antibodies to Anaplasma Marginale Major Surface Proteins 1a and 1b Inhibit Infectivity for Cultured Tick Cells Veterinary Parasitology. Feb, 2003 | Pubmed ID: 12531299 Infection Exclusion of the Rickettsial Pathogen Anaplasma Marginale in the Tick Vector Dermacentor Variabilis Clinical and Diagnostic Laboratory Immunology. Jan, 2003 | Pubmed ID: 12522060 Characterization of the Functional Domain of Major Surface Protein 1a Involved in Adhesion of the Rickettsia Anaplasma Marginale to Host Cells Veterinary Microbiology. Feb, 2003 | Pubmed ID: 12458174 Adaptations of the Tick-borne Pathogen, Anaplasma Marginale, for Survival in Cattle and Ticks Experimental & Applied Acarology. 2002 | Pubmed ID: 14570114 Applications of a Cell Culture System for Studying the Interaction of Anaplasma Marginale with Tick Cells Animal Health Research Reviews / Conference of Research Workers in Animal Diseases. Dec, 2002 | Pubmed ID: 12665106 Vaccination of Cattle with Anaplasma Marginale Derived from Tick Cell Culture and Bovine Erythrocytes Followed by Challenge-exposure with Infected Ticks Veterinary Microbiology. Oct, 2002 | Pubmed ID: 12243900 Phylogeography of New World Isolates of Anaplasma Marginale Based on Major Surface Protein Sequences Veterinary Microbiology. Sep, 2002 | Pubmed ID: 12151201 Effect of Tetracycline on Development of Anaplasma Marginale in Cultured Ixodes Scapularis Cells Veterinary Parasitology. Jul, 2002 | Pubmed ID: 12072219 Infection of Tick Cells and Bovine Erythrocytes with One Genotype of the Intracellular Ehrlichia Anaplasma Marginale Excludes Infection with Other Genotypes Clinical and Diagnostic Laboratory Immunology. May, 2002 | Pubmed ID: 11986275 Conservation of Major Surface Protein 1 Genes of Anaplasma Marginale During Cyclic Transmission Between Ticks and Cattle Gene. Jan, 2002 | Pubmed ID: 11814681 RNA Interference in Ticks Katherine M. Kocan1, Edmour Blouin1, José de la Fuente1,2 1Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, 2(CSIC-UCLM-JCCM), Instituto de Investigación en Recursos Cinegéticos IREC JoVE 2474 Immunology and Infection
RNA Interference in Ticks Katherine M. Kocan1, Edmour Blouin1, José de la Fuente1,2 1Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, 2(CSIC-UCLM-JCCM), Instituto de Investigación en Recursos Cinegéticos IREC JoVE 2474 Immunology and Infection