In JoVE (1)
Articles by Kathleen LaSance in JoVE
In Vivo Optical Imaging of Brain Tumors and Arthritis Using Fluorescent SapC-DOPS Nanovesicles Zhengtao Chu1,2, Kathleen LaSance3, Victor Blanco1, Chang-Hyuk Kwon5,6, Balveen Kaur5,6, Malinda Frederick4, Sherry Thornton4, Lisa Lemen3, Xiaoyang Qi1,2 1Division of Hematology-Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, 2Division of Human Genetics, University of Cincinnati College of Medicine, 3Department of Radiology, University of Cincinnati College of Medicine, 4Division of Rheumatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 5Solid Tumor Biology Program, James Comprehensive Cancer Center, The Ohio State University Medical Center, 6Department of Neurological Surgery, James Comprehensive Cancer Center, The Ohio State University Medical Center We describe a multi-angle rotational optical imaging (MAROI) system for in vivo quantitation of a fluorescent marker delivered by saposin C (SapC)-dioleoylphosphatidylserine (DOPS) nanovesicles. Employing mouse models of cancer and arthritis, we demonstrate how the MAROI signal curve analysis can be used for the precise mapping and biological characterization of disease processes.
Other articles by Kathleen LaSance on PubMed
Molecular Strategy to Reduce in Vivo Collagen Barrier Promotes Entry of NCX1 Positive Inducible Pluripotent Stem Cells (iPSC(NCX¹⁺)) into Ischemic (or Injured) Myocardium PloS One. 2013 | Pubmed ID: 23990893 The purpose of this study was to assess the effect of collagen composition on engraftment of progenitor cells within infarcted myocardium.
Ocular Delivery of PRNA Nanoparticles: Distribution and Clearance After Subconjunctival Injection Pharmaceutical Research. Apr, 2014 | Pubmed ID: 24297069 RNA nanoparticles derived from the three-way junction (3WJ) of the pRNA of bacteriophage phi29 DNA packaging motor were previously found to be thermodynamically stable. As the nanoparticles could have potential in ocular drug delivery, the objectives in the present study were to investigate the distribution of pRNA nanoparticles after subconjunctival injection and examine the feasibility to deliver the nanoparticles to the cells of cornea and retina.