Kathlyn Laval Department of Molecular Biology Princeton University Biography Publications Institution JoVE Articles Kathlyn Laval Dr. Dr. Kathlyn Laval, a virologist from Pasteur Institute with a PhD in Veterinary Sciences from Ghent University, is currently working as a postdoctoral researcher in the Enquist laboratory at the Department of Molecular Biology, Princeton University. During her postdoctoral research, she developed an animal model to study alphaherpesvirus-induced neuroinflammation. She developed her own research project starting from the writing of several grants (Life Sciences Research Foundation, Multiple Sclerosis and spinal cord injury grants, ...), IACUC protocols and the design of the experiments to the publication of 4 major scientific papers. Her work is funded by National Institute of Neurological Disorders and Stroke (NINDS). Within 7 years of reseach experience, she first-authored 8 publications and co-authored on another 11. As a long-term goal, she aims to continue her work on viral-induced neuroinflammation and neurodegenerative diseases, and ultimately to design innovative therapies. Publications The neuropathic itch caused by Pseudorabies virus infection. Pathogens. 2020 | Pubmed ID: Mouse footpad inoculation model for the study of viral-induced neuroinflammatory responses. J. Vis. Exp. 2020 | Pubmed ID: An alphaherpesvirus exploits antimicrobial defensins to initiate respiratory tract infection. J Virol. 2020 | Pubmed ID: Alphaherpesvirus infection primes DRG neurons to an inflammatory state regulated by TLR2 and IFN type I signaling. PLoS pathogens. 2019 | Pubmed ID: Deoxynivalenol, but not fumonisin B1, aflatoxin B1 or diesel exhaust particles disrupt integrity of the horse’s respiratory epithelium and predispose it for equine herpesvirus type 1 infection. Vet Microbiol. 2019 | Pubmed ID: Beyond gut instinct: metabolic short-chain fatty acids moderate the pathogenesis of alphaherpesviruses. Front Microbiol. 2019 | Pubmed ID: Pollens destroy respiratory epithelial cell anchors and drive alphaherpesvirus infection. Sci Rep. 2019 | Pubmed ID: Unravelling the first key steps in equine herpesvirus type 5 (EHV5) pathogenesis using ex vivo and in vitro equine models. Vet Res. 2019 | Pubmed ID: Equine herpesvirus 1 bridles T-lymphocytes to reach its target organs. J Virol. 2019 | Pubmed ID: Virulent Pseudorabies virus infection induces a specific and lethal inflammatory response in mice. J Virol. 2018 | Pubmed ID: Abortigenic but not neurotropic equine herpes virus type 1 modulates the interferon antiviral defense. Front Cell Infect Microbiol. 2018 | Pubmed ID: Access to a main alphaherpesvirus receptor, located basolaterally in the respiratory epithelium, is masked by intercellular junctions. Nat Sci. Rep. 2017 | Pubmed ID: Replication of neurovirulent EHV-1 in CD172a+ monocytic cells. Comp Immunol Microbiol Infect Dis. 2017 | Pubmed ID: Dual infections of equine herpesvirus 1 and equine arteritis virus in equine respiratory mucosa explants. Virus Res. 2016 | Pubmed ID: Entry of equine herpesvirus type 1 (EHV-1) into CD172a+ cells. J Gen Virol. 2015 | Pubmed ID: Equine herpesvirus type 1 (EHV-1) enhances viral replication in CD172a+ monocytic cells upon adhesion to endothelial cells. J Virol. 2015 | Pubmed ID: Equine herpesvirus type 1 (EHV1) replication is delayed in CD172a+ cells and controlled by histone deacetylases. J Gen Virol. 2015 | Pubmed ID: Pseudorabies virus US3 protein kinase protects infected cells from NK cell-mediated lysis via increased binding of the inhibitory NK cell receptor CD300a. J Virol. 2015 | Pubmed ID: Isolation and characterization of equine nasal mucosal CD172a+cells. Vet Immunol Immunopathol. 2014 | Pubmed ID: Protein B5 is required on extracellular enveloped vaccinia virus for repulsion of superinfecting virions. J Gen Virol. 2012 | Pubmed ID: Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses Kathlyn Laval1, Carola J. Maturana2, Lynn W. Enquist1 1Department of Molecular Biology, Princeton University, 2Princeton Neuroscience Institute, Princeton University JoVE 61121 Immunology and Infection
Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses Kathlyn Laval1, Carola J. Maturana2, Lynn W. Enquist1 1Department of Molecular Biology, Princeton University, 2Princeton Neuroscience Institute, Princeton University JoVE 61121 Immunology and Infection
