Keigi Fujiwara

Publications

• STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity
  Arteriosclerosis, Thrombosis, and Vascular Biology. May, 2017  |   Pubmed ID: 28302626
• Coordination of Cellular Localization-Dependent Effects of Sumoylation in Regulating Cardiovascular and Neurological Diseases
  Advances in Experimental Medicine and Biology. 2017  |   Pubmed ID: 28197922
• Sub-cellular Localization Specific SUMOylation in the Heart
  Biochimica Et Biophysica Acta. Jan, 2017  |   Pubmed ID: 28130202
• Flow Signaling and Atherosclerosis
  Cellular and Molecular Life Sciences : CMLS. May, 2017  |   Pubmed ID: 28039525
• PECAM1 Regulates Flow-mediated Gab1 Tyrosine Phosphorylation and Signaling
  Cellular Signalling. Mar, 2016  |   Pubmed ID: 26706435
• Mechanosignaling in the Vasculature: Emerging Concepts in Sensing, Transduction and Physiological Responses
  American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2015  |   Pubmed ID: 25862828
• Mitochondrial Dynamics Regulate Neointima Formation
  Cardiovascular Research. May, 2015  |   Pubmed ID: 25800033
• Disturbed Flow-activated P90RSK Kinase Accelerates Atherosclerosis by Inhibiting SENP2 Function
  The Journal of Clinical Investigation. Mar, 2015  |   Pubmed ID: 25689261
• Identification of Activators of ERK5 Transcriptional Activity by High-throughput Screening and the Role of Endothelial ERK5 in Vasoprotective Effects Induced by Statins and Antimalarial Agents
  Journal of Immunology (Baltimore, Md. : 1950). Oct, 2014  |   Pubmed ID: 25187658
• ERK5 Activation in Macrophages Promotes Efferocytosis and Inhibits Atherosclerosis
  Circulation. Jul, 2014  |   Pubmed ID: 25001623
• Intima Modifier Locus 2 Controls Endothelial Cell Activation and Vascular Permeability
  Physiological Genomics. Sep, 2014  |   Pubmed ID: 24986958
• Shear Stress and Atherosclerosis
  Molecules and Cells. Jun, 2014  |   Pubmed ID: 24781409
• De-SUMOylation Enzyme of Sentrin/SUMO-specific Protease 2 Regulates Disturbed Flow-induced SUMOylation of ERK5 and P53 That Leads to Endothelial Dysfunction and Atherosclerosis
  Circulation Research. Mar, 2013  |   Pubmed ID: 23381569
• A Crucial Role for P90RSK-mediated Reduction of ERK5 Transcriptional Activity in Endothelial Dysfunction and Atherosclerosis
  Circulation. Jan, 2013  |   Pubmed ID: 23243209
• Phosphorylation of Protein Inhibitor of Activated STAT1 (PIAS1) by MAPK-activated Protein Kinase-2 Inhibits Endothelial Inflammation Via Increasing Both PIAS1 Transrepression and SUMO E3 Ligase Activity
  Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2013  |   Pubmed ID: 23202365
• P62 Binding to Protein Kinase C ζ Regulates Tumor Necrosis Factor α-induced Apoptotic Pathway in Endothelial Cells
  Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2012  |   Pubmed ID: 23023376
• Reactive Oxygen Species, SUMOylation, and Endothelial Inflammation
  International Journal of Inflammation. 2012  |   Pubmed ID: 22991685
• Glucagon-like Peptide-1 and Its Cardiovascular Effects
  Current Atherosclerosis Reports. Oct, 2012  |   Pubmed ID: 22878937
• Thioredoxin Interacting Protein Promotes Endothelial Cell Inflammation in Response to Disturbed Flow by Increasing Leukocyte Adhesion and Repressing Kruppel-like Factor 2
  Circulation Research. Feb, 2012  |   Pubmed ID: 22267843
• P90RSK Targets the ERK5-CHIP Ubiquitin E3 Ligase Activity in Diabetic Hearts and Promotes Cardiac Apoptosis and Dysfunction
  Circulation Research. Feb, 2012  |   Pubmed ID: 22267842
• Disturbed-flow-mediated Vascular Reactive Oxygen Species Induce Endothelial Dysfunction
  Circulation Journal : Official Journal of the Japanese Circulation Society. 2011  |   Pubmed ID: 22076424
• Cyclic Nucleotide Phosphodiesterase 1A: a Key Regulator of Cardiac Fibroblast Activation and Extracellular Matrix Remodeling in the Heart
  Basic Research in Cardiology. Nov, 2011  |   Pubmed ID: 22012077
• PKCζ Mediates Disturbed Flow-induced Endothelial Apoptosis Via P53 SUMOylation
  The Journal of Cell Biology. May, 2011  |   Pubmed ID: 21624955
• MK2 SUMOylation Regulates Actin Filament Remodeling and Subsequent Migration in Endothelial Cells by Inhibiting MK2 Kinase and HSP27 Phosphorylation
  Blood. Feb, 2011  |   Pubmed ID: 21131586
• PKCzeta Decreases ENOS Protein Stability Via Inhibitory Phosphorylation of ERK5
  Blood. Sep, 2010  |   Pubmed ID: 20538799
• Collagen I Matrix Turnover is Regulated by Fibronectin Polymerization
  American Journal of Physiology. Cell Physiology. May, 2010  |   Pubmed ID: 20107040
• Physiologic Stress-mediated Signaling in the Endothelium
  Methods in Enzymology. 2008  |   Pubmed ID: 18772009
• Mechanotransduction in an Extracted Cell Model: Fyn Drives Stretch- and Flow-elicited PECAM-1 Phosphorylation
  The Journal of Cell Biology. Aug, 2008  |   Pubmed ID: 18710921
• Phosphorylation and Localization of Protein-zero Related (PZR) in Cultured Endothelial Cells
  Endothelium : Journal of Endothelial Cell Research. May-Jun, 2008  |   Pubmed ID: 18568953
• ECM Remodeling in Hypertensive Heart Disease
  The Journal of Clinical Investigation. Mar, 2007  |   Pubmed ID: 17332884
• Down-regulation of ERK but Not MEK Phosphorylation in Cultured Endothelial Cells by Repeated Changes in Cyclic Stretch
  Cardiovascular Research. Mar, 2007  |   Pubmed ID: 17289004
• Serum Response Factor: Master Regulator of the Actin Cytoskeleton and Contractile Apparatus
  American Journal of Physiology. Cell Physiology. Jan, 2007  |   Pubmed ID: 16928770
• Endothelial Cell-cell Adhesion and Mechanosignal Transduction
  Endothelium : Journal of Endothelial Cell Research. Jan-Feb, 2004  |   Pubmed ID: 15203879
• Mechanical Stresses Keep Endothelial Cells Healthy: Beneficial Effects of a Physiological Level of Cyclic Stretch on Endothelial Barrier Function
  American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2003  |   Pubmed ID: 12959924
• Evidence for a Role of Platelet Endothelial Cell Adhesion Molecule-1 in Endothelial Cell Mechanosignal Transduction: is It a Mechanoresponsive Molecule?
  The Journal of Cell Biology. Aug, 2002  |   Pubmed ID: 12177047
• Vascular Endothelial Cells That Express Dystroglycan Are Involved in Angiogenesis
  Journal of Cell Science. Apr, 2002  |   Pubmed ID: 11896196