Keith Baar Department of Neurobiology, Physiology, and Behavior University of California, Davis Biography Publications Institution JoVE Articles Keith Baar has not added a biography. If you are Keith Baar and would like to personalize this page please email our Author Liaison for assistance. Publications Adaptations to Endurance and Strength Training Cold Spring Harbor Perspectives in Medicine. May, 2017 | Pubmed ID: 28490537 DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline That Occurs During Aging Cell Metabolism. May, 2017 | Pubmed ID: 28467930 Muscle-specific and Age-related Changes in Protein Synthesis and Protein Degradation in Response to Hindlimb Unloading in Rats Journal of Applied Physiology (Bethesda, Md. : 1985). May, 2017 | Pubmed ID: 28336537 Minimizing Injury and Maximizing Return to Play: Lessons from Engineered Ligaments Sports Medicine (Auckland, N.Z.). Mar, 2017 | Pubmed ID: 28332110 Vitamin C-enriched Gelatin Supplementation Before Intermittent Activity Augments Collagen Synthesis The American Journal of Clinical Nutrition. Jan, 2017 | Pubmed ID: 27852613 Age-related Differences in Dystrophin: Impact on Force Transfer Proteins, Membrane Integrity, and Neuromuscular Junction Stability The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. May, 2017 | Pubmed ID: 27382038 Factors That Affect Tissue-Engineered Skeletal Muscle Function and Physiology Cells, Tissues, Organs. 2016 | Pubmed ID: 27825147 Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation Cell Reports. Sep, 2016 | Pubmed ID: 27626651 Age-related Deficits in Skeletal Muscle Recovery Following Disuse Are Associated with Neuromuscular Junction Instability and ER Stress, Not Impaired Protein Synthesis Aging. Jan, 2016 | Pubmed ID: 26826670 Contribution of Mechanical Unloading to Trabecular Bone Loss Following Non-invasive Knee Injury in Mice Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Oct, 2016 | Pubmed ID: 26826014 Acute Resistance Exercise Activates Rapamycin-sensitive and -insensitive Mechanisms That Control Translational Activity and Capacity in Skeletal Muscle The Journal of Physiology. Jan, 2016 | Pubmed ID: 26548696 Utilizing Small Nutrient Compounds As Enhancers of Exercise-induced Mitochondrial Biogenesis Frontiers in Physiology. 2015 | Pubmed ID: 26578969 Bias is Stagnating Physiology The Physiologist. Mar, 2015 | Pubmed ID: 26390773 The Exercise-induced Biochemical Milieu Enhances Collagen Content and Tensile Strength of Engineered Ligaments The Journal of Physiology. Oct, 2015 | Pubmed ID: 26282066 Rapamycin Does Not Prevent Increases in Myofibrillar or Mitochondrial Protein Synthesis Following Endurance Exercise The Journal of Physiology. Sep, 2015 | Pubmed ID: 26227152 Neuromuscular Junction Formation in Tissue-Engineered Skeletal Muscle Augments Contractile Function and Improves Cytoskeletal Organization Tissue Engineering. Part A. Oct, 2015 | Pubmed ID: 26166548 Estrogen Inhibits Lysyl Oxidase and Decreases Mechanical Function in Engineered Ligaments Journal of Applied Physiology (Bethesda, Md. : 1985). May, 2015 | Pubmed ID: 25979936 Effects of Aging, Exercise, and Disease on Force Transfer in Skeletal Muscle American Journal of Physiology. Endocrinology and Metabolism. Jul, 2015 | Pubmed ID: 25968577 Role of Contraction Duration in Inducing Fast-to-slow Contractile and Metabolic Protein and Functional Changes in Engineered Muscle Journal of Cellular Physiology. Oct, 2015 | Pubmed ID: 25857846 The Molecular Basis for Load-induced Skeletal Muscle Hypertrophy Calcified Tissue International. Mar, 2015 | Pubmed ID: 25359125 Glucose Concentration and Streptomycin Alter in Vitro Muscle Function and Metabolism Journal of Cellular Physiology. Jun, 2015 | Pubmed ID: 25358470 Contractile and Metabolic Properties of Engineered Skeletal Muscle Derived from Slow and Fast Phenotype Mouse Muscle Journal of Cellular Physiology. Aug, 2015 | Pubmed ID: 25335966 Streptomycin Decreases the Functional Shift to a Slow Phenotype Induced by Electrical Stimulation in Engineered Muscle Tissue Engineering. Part A. Mar, 2015 | Pubmed ID: 25333771 Pharmacology of Manipulating Lean Body Mass Clinical and Experimental Pharmacology & Physiology. Jan, 2015 | Pubmed ID: 25311629 Nutritional Strategies to Support Concurrent Training European Journal of Sport Science. 2015 | Pubmed ID: 25159707 Using Molecular Biology to Maximize Concurrent Training Sports Medicine (Auckland, N.Z.). Nov, 2014 | Pubmed ID: 25355186 MTOR and the Health Benefits of Exercise Seminars in Cell & Developmental Biology. Dec, 2014 | Pubmed ID: 25218794 The Effect of Serum Origin on Tissue Engineered Skeletal Muscle Function Journal of Cellular Biochemistry. Dec, 2014 | Pubmed ID: 25146978 Molecular Brakes Regulating MTORC1 Activation in Skeletal Muscle Following Synergist Ablation American Journal of Physiology. Endocrinology and Metabolism. Aug, 2014 | Pubmed ID: 24961241 Nutrition and the Adaptation to Endurance Training Sports Medicine (Auckland, N.Z.). May, 2014 | Pubmed ID: 24791912 Compensatory Regulation of HDAC5 in Muscle Maintains Metabolic Adaptive Responses and Metabolism in Response to Energetic Stress FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2014 | Pubmed ID: 24732133 Novel Sorafenib-based Structural Analogues: In-vitro Anticancer Evaluation of T-MTUCB and T-AUCMB Anti-cancer Drugs. Apr, 2014 | Pubmed ID: 24525589 Maintenance of Muscle Mass and Load-induced Growth in Muscle RING Finger 1 Null Mice with Age Aging Cell. Feb, 2014 | Pubmed ID: 23941502 Glycogen Content Regulates Peroxisome Proliferator Activated Receptor-∂ (PPAR-∂) Activity in Rat Skeletal Muscle PloS One. 2013 | Pubmed ID: 24146969 May the Force Move You: TSC-ing the Mechanical Activation of MTOR The Journal of Physiology. Sep, 2013 | Pubmed ID: 24037132 The Role of Amino Acids in Skeletal Muscle Adaptation to Exercise Nestle Nutrition Institute Workshop Series. 2013 | Pubmed ID: 23899757 Inhibition of Myostatin Signaling Through Notch Activation Following Acute Resistance Exercise PloS One. 2013 | Pubmed ID: 23844238 Factors Affecting the Structure and Maturation of Human Tissue Engineered Skeletal Muscle Biomaterials. Jul, 2013 | Pubmed ID: 23643182 Endurance Training in Mice Increases the Unfolded Protein Response Induced by a High-fat Diet Journal of Physiology and Biochemistry. Jun, 2013 | Pubmed ID: 23011781 Is Irisin a Human Exercise Gene? Nature. Aug, 2012 | Pubmed ID: 22932392 The Effect of Growth Factors on Both Collagen Synthesis and Tensile Strength of Engineered Human Ligaments Biomaterials. Sep, 2012 | Pubmed ID: 22698725 Supplementation of a Suboptimal Protein Dose with Leucine or Essential Amino Acids: Effects on Myofibrillar Protein Synthesis at Rest and Following Resistance Exercise in Men The Journal of Physiology. Jun, 2012 | Pubmed ID: 22451437 Fine-tuning Metabolism--how Products of Contraction Regulate Skeletal Muscle Adaptation American Journal of Physiology. Endocrinology and Metabolism. Jun, 2012 | Pubmed ID: 22436694 More Than a Store: Regulatory Roles for Glycogen in Skeletal Muscle Adaptation to Exercise American Journal of Physiology. Endocrinology and Metabolism. Jun, 2012 | Pubmed ID: 22395109 Resveratrol Ameliorates Aging-related Metabolic Phenotypes by Inhibiting CAMP Phosphodiesterases Cell. Feb, 2012 | Pubmed ID: 22304913 Analysis of Skeletal Muscle Hypertrophy in Models of Increased Loading Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22130839 Defined Electrical Stimulation Emphasizing Excitability for the Development and Testing of Engineered Skeletal Muscle Tissue Engineering. Part C, Methods. May, 2012 | Pubmed ID: 22092374 Optimizing an Intermittent Stretch Paradigm Using ERK1/2 Phosphorylation Results in Increased Collagen Synthesis in Engineered Ligaments Tissue Engineering. Part A. Feb, 2012 | Pubmed ID: 21902469 Altering Endogenous Carbohydrate Availability to Support Training Adaptations Nestle Nutrition Institute Workshop Series. 2011 | Pubmed ID: 22301834 Sirt1 Enhances Skeletal Muscle Insulin Sensitivity in Mice During Caloric Restriction The Journal of Clinical Investigation. Nov, 2011 | Pubmed ID: 21985785 The PGC-1α-related Coactivator Promotes Mitochondrial and Myogenic Adaptations in C2C12 Myotubes American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Oct, 2011 | Pubmed ID: 21795630 Sirtuin 1 (SIRT1) Deacetylase Activity is Not Required for Mitochondrial Biogenesis or Peroxisome Proliferator-activated Receptor-gamma Coactivator-1alpha (PGC-1alpha) Deacetylation Following Endurance Exercise The Journal of Biological Chemistry. Sep, 2011 | Pubmed ID: 21757760 The Influence of Carbohydrate-protein Co-ingestion Following Endurance Exercise on Myofibrillar and Mitochondrial Protein Synthesis The Journal of Physiology. Aug, 2011 | Pubmed ID: 21746787 Beneficial Effects of Resistance Exercise on Glycemic Control Are Not Further Improved by Protein Ingestion PloS One. 2011 | Pubmed ID: 21701685 ER Stress Induces Anabolic Resistance in Muscle Cells Through PKB-induced Blockade of MTORC1 PloS One. 2011 | Pubmed ID: 21698202 Regulation of Contractility and Metabolic Signaling by the β2-adrenergic Receptor in Rat Ventricular Muscle Life Sciences. May, 2011 | Pubmed ID: 21466811 Understanding the Regulation of Muscle Plasticity Journal of Applied Physiology (Bethesda, Md. : 1985). Jan, 2011 | Pubmed ID: 21088204 Signals Mediating Skeletal Muscle Remodeling by Resistance Exercise: PI3-kinase Independent Activation of MTORC1 Journal of Applied Physiology (Bethesda, Md. : 1985). Feb, 2011 | Pubmed ID: 21071597 A Limited Role for PI(3,4,5)P3 Regulation in Controlling Skeletal Muscle Mass in Response to Resistance Exercise PloS One. Jul, 2010 | Pubmed ID: 20661274 Engineering an in Vitro Model of a Functional Ligament from Bone to Bone Tissue Engineering. Part A. Nov, 2010 | Pubmed ID: 20593972 Comments on Point:Counterpoint: IGF Is/is Not the Major Physiological Regulator of Muscle Mass. Irrelevant Growth Factor-I Journal of Applied Physiology (Bethesda, Md. : 1985). Jun, 2010 | Pubmed ID: 20527696 Prolonged Activation of S6K1 Does Not Suppress IRS or PI-3 Kinase Signaling During Muscle Cell Differentiation BMC Cell Biology. May, 2010 | Pubmed ID: 20507574 The Unfolded Protein Response is Activated in Skeletal Muscle by High-fat Feeding: Potential Role in the Downregulation of Protein Synthesis American Journal of Physiology. Endocrinology and Metabolism. Nov, 2010 | Pubmed ID: 20501874 Factors Affecting the Longevity and Strength in an in Vitro Model of the Bone-ligament Interface Annals of Biomedical Engineering. Jun, 2010 | Pubmed ID: 20431953 Pyruvate Suppresses PGC1alpha Expression and Substrate Utilization Despite Increased Respiratory Chain Content in C2C12 Myotubes American Journal of Physiology. Cell Physiology. Aug, 2010 | Pubmed ID: 20410436 The Initiation of Embryonic-like Collagen Fibrillogenesis by Adult Human Tendon Fibroblasts when Cultured Under Tension Biomaterials. Jun, 2010 | Pubmed ID: 20356622 Training with Low Muscle Glycogen Enhances Fat Metabolism in Well-trained Cyclists Medicine and Science in Sports and Exercise. Nov, 2010 | Pubmed ID: 20351596 A Novel Bioreactor for Stimulating Skeletal Muscle in Vitro Tissue Engineering. Part C, Methods. Aug, 2010 | Pubmed ID: 19807268 The Signaling Underlying FITness Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme. Jun, 2009 | Pubmed ID: 19448707 The Training Stimulus Experienced by the Leg Muscles During Cycling in Humans Experimental Physiology. Jun, 2009 | Pubmed ID: 19218358 Regulating Fibrinolysis to Engineer Skeletal Muscle from the C2C12 Cell Line Tissue Engineering. Part C, Methods. Sep, 2009 | Pubmed ID: 19191517 MVps34 is Activated Following High-resistance Contractions The Journal of Physiology. Jan, 2009 | Pubmed ID: 19015198 Engineering the Bone-ligament Interface Using Polyethylene Glycol Diacrylate Incorporated with Hydroxyapatite Tissue Engineering. Part A. Jun, 2009 | Pubmed ID: 18991487 Small Molecules Can Have Big Effects on Endurance Nature Chemical Biology. Oct, 2008 | Pubmed ID: 18800044 Tension is Required for Fibripositor Formation Matrix Biology : Journal of the International Society for Matrix Biology. May, 2008 | Pubmed ID: 18262777 Normal Hypertrophy Accompanied by Phosphoryation and Activation of AMP-activated Protein Kinase Alpha1 Following Overload in LKB1 Knockout Mice The Journal of Physiology. Mar, 2008 | Pubmed ID: 18202101 Muscle Growth: No IGFs, Ands, or Buts The Journal of Physiology. Jan, 2008 | Pubmed ID: 18167368 Engineered Muscle: a Tool for Studying Muscle Physiology and Function Exercise and Sport Sciences Reviews. Oct, 2007 | Pubmed ID: 17921787 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside Acutely Stimulates Skeletal Muscle 2-deoxyglucose Uptake in Healthy Men Diabetes. Aug, 2007 | Pubmed ID: 17513706 Tendon Mechanics: the Argument Heats Up Journal of Applied Physiology (Bethesda, Md. : 1985). Aug, 2007 | Pubmed ID: 17446408 Myogenic Gene Expression Signature Establishes That Brown and White Adipocytes Originate from Distinct Cell Lineages Proceedings of the National Academy of Sciences of the United States of America. Mar, 2007 | Pubmed ID: 17360536 Denervation Does Not Change the Ratio of Collagen I and Collagen III MRNA in the Extracellular Matrix of Muscle American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Feb, 2007 | Pubmed ID: 17008458 Resistance Exercise, Muscle Loading/unloading and the Control of Muscle Mass Essays in Biochemistry. 2006 | Pubmed ID: 17144880 Training for Endurance and Strength: Lessons from Cell Signaling Medicine and Science in Sports and Exercise. Nov, 2006 | Pubmed ID: 17095927 To Perform Your Best: Work Hard Not Long The Journal of Physiology. Sep, 2006 | Pubmed ID: 16873398 Activation of Akt As a Potential Mediator of Adaptations That Reduce Muscle Injury Medicine and Science in Sports and Exercise. Jun, 2006 | Pubmed ID: 16775545 Regional Variation of Tibialis Anterior Tendon Mechanics is Lost Following Denervation Journal of Applied Physiology (Bethesda, Md. : 1985). Oct, 2006 | Pubmed ID: 16728516 Cultured Slow Vs. Fast Skeletal Muscle Cells Differ in Physiology and Responsiveness to Stimulation American Journal of Physiology. Cell Physiology. Jul, 2006 | Pubmed ID: 16436474 New Dimensions in Tissue Engineering: Possible Models for Human Physiology Experimental Physiology. Nov, 2005 | Pubmed ID: 16091402 Development of a Three-dimensional Physiological Model of the Internal Anal Sphincter Bioengineered in Vitro from Isolated Smooth Muscle Cells American Journal of Physiology. Gastrointestinal and Liver Physiology. Aug, 2005 | Pubmed ID: 15774939 Self-organization of Rat Cardiac Cells into Contractile 3-D Cardiac Tissue FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2005 | Pubmed ID: 15574489 Rapid Formation of Functional Muscle in Vitro Using Fibrin Gels Journal of Applied Physiology (Bethesda, Md. : 1985). Feb, 2005 | Pubmed ID: 15475606 Involvement of PPAR Gamma Co-activator-1, Nuclear Respiratory Factors 1 and 2, and PPAR Alpha in the Adaptive Response to Endurance Exercise The Proceedings of the Nutrition Society. May, 2004 | Pubmed ID: 15294042 Engineering of Functional Tendon Tissue Engineering. May-Jun, 2004 | Pubmed ID: 15265292 Skeletal Muscle Overexpression of Nuclear Respiratory Factor 1 Increases Glucose Transport Capacity FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Sep, 2003 | Pubmed ID: 12958173 Exercise Induces an Increase in Muscle UCP3 As a Component of the Increase in Mitochondrial Biogenesis American Journal of Physiology. Endocrinology and Metabolism. Jan, 2003 | Pubmed ID: 12388129 Adaptations of Skeletal Muscle to Exercise: Rapid Increase in the Transcriptional Coactivator PGC-1 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2002 | Pubmed ID: 12468452 Response of Rat Muscle to Acute Resistance Exercise Defined by Transcriptional and Translational Profiling The Journal of Physiology. Nov, 2002 | Pubmed ID: 12433947 Tratamento de estruturas ligamentares com soro condicionado por exercício: um modelo de engenharia de tecido translacional Ann Lee-Barthel1, Keith Baar1,2, Daniel W. D. West1,3 1Department of Neurobiology, Physiology, and Behavior, University of California, Davis, 2Department of Physiology and Membrane Biology, University of California, Davis, 3Faculty of Kinesiology and Physical Education, University of Toronto JoVE 55339 Bioengineering
Tratamento de estruturas ligamentares com soro condicionado por exercício: um modelo de engenharia de tecido translacional Ann Lee-Barthel1, Keith Baar1,2, Daniel W. D. West1,3 1Department of Neurobiology, Physiology, and Behavior, University of California, Davis, 2Department of Physiology and Membrane Biology, University of California, Davis, 3Faculty of Kinesiology and Physical Education, University of Toronto JoVE 55339 Bioengineering