Keiyo Takubo Department of Stem Cell Biology, Research Institute National Center for Global Health and Medicine Biography Publications Institution JoVE Articles Keiyo Takubo has not added a biography. If you are Keiyo Takubo and would like to personalize this page please email our Author Liaison for assistance. Publications Characterization of Genetically Modified Mice for Phosphoglycerate Mutase, a Vitally-essential Enzyme in Glycolysis PloS One. 2021 | Pubmed ID: 33914812 P38α Plays Differential Roles in Hematopoietic Stem Cell Activity Dependent on Aging Contexts The Journal of Biological Chemistry. Mar, 2021 | Pubmed ID: 33745970 OGT Regulates Hematopoietic Stem Cell Maintenance Via PINK1-Dependent Mitophagy Cell Reports. Jan, 2021 | Pubmed ID: 33406421 UTX Maintains the Functional Integrity of the Murine Hematopoietic System by Globally Regulating Aging-associated Genes Blood. Feb, 2021 | Pubmed ID: 33174606 Detection of Residual Disease in Chronic Myeloid Leukemia Utilizing Genomic Next Generation Sequencing Reveals Persistence of Differentiated Ph B Cells but Not Bone Marrow Stem/progenitors Leukemia & Lymphoma. 03, 2021 | Pubmed ID: 33106061 Protocol for the Maintenance of Quiescent Murine Hematopoietic Stem Cells STAR Protocols. Sep, 2020 | Pubmed ID: 33111112 Short-chain Fatty Acids Bind to Apoptosis-associated Speck-like Protein to Activate Inflammasome Complex to Prevent Salmonella Infection PLoS Biology. 09, 2020 | Pubmed ID: 32991574 Phosphoglycerate Mutase Cooperates with Chk1 Kinase to Regulate Glycolysis IScience. Jul, 2020 | Pubmed ID: 32634742 Identification and Local Manipulation of Bone Marrow Vasculature During Intravital Imaging Scientific Reports. 04, 2020 | Pubmed ID: 32286470 Discrimination of Dormant and Active Hematopoietic Stem Cells by G Marker Reveals Dormancy Regulation by Cytoplasmic Calcium Cell Reports. 12, 2019 | Pubmed ID: 31851939 Type I Interferon Delivery by IPSC-Derived Myeloid Cells Elicits Antitumor Immunity Via XCR1 Dendritic Cells Cell Reports. 10, 2019 | Pubmed ID: 31577946 Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses Cell. 08, 2019 | Pubmed ID: 31442401 Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo Cell Reports. 07, 2019 | Pubmed ID: 31269436 ATP Turnover and Glucose Dependency in Hematopoietic Stem/progenitor Cells Are Increased by Proliferation and Differentiation Biochemical and Biophysical Research Communications. 06, 2019 | Pubmed ID: 31030941 Potential Involvement of Semaphorin 3A in Maintaining Intervertebral Disc Tissue Homeostasis Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 04, 2019 | Pubmed ID: 30816586 Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. 10, 2018 | Pubmed ID: 29893999 Hematopoietic Insults Damage Bone Marrow Niche by Activating P53 in Vascular Endothelial Cells Experimental Hematology. 07, 2018 | Pubmed ID: 29709619 Gold-nanofève Surface-enhanced Raman Spectroscopy Visualizes Hypotaurine As a Robust Anti-oxidant Consumed in Cancer Survival Nature Communications. 04, 2018 | Pubmed ID: 29674746 Abnormal Hematopoiesis and Hematopoietic Stem Cell Niche [Rinsho Ketsueki] The Japanese Journal of Clinical Hematology. 2017 | Pubmed ID: 28978823 Lysophosphatidic Acid Acyltransferase 3 Tunes the Membrane Status of Germ Cells by Incorporating Docosahexaenoic Acid During Spermatogenesis The Journal of Biological Chemistry. 07, 2017 | Pubmed ID: 28578315 Metabolic Regulation of Hematopoietic and Leukemic Stem/progenitor Cells Under Homeostatic and Stress Conditions International Journal of Hematology. Jul, 2017 | Pubmed ID: 28540498 [Stress Response Mechanism in Hematopoietic Stem Cells.] Clinical Calcium. 2017 | Pubmed ID: 28536320 Acquired Expression of in Mice Induces Dysplastic Myelopoiesis Mimicking Chronic Myelomonocytic Leukemia Blood. 04, 2017 | Pubmed ID: 28209720 Maintenance of the Functional Integrity of Mouse Hematopoiesis by EED and Promotion of Leukemogenesis by EED Haploinsufficiency Scientific Reports. 07, 2016 | Pubmed ID: 27432459 P38α Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress Cell Stem Cell. 08, 2016 | Pubmed ID: 27345838 Setdb1 Maintains Hematopoietic Stem and Progenitor Cells by Restricting the Ectopic Activation of Nonhematopoietic Genes Blood. 08, 2016 | Pubmed ID: 27301860 Chordoma-derived Cell Line U-CH1-N Recapitulates the Biological Properties of Notochordal Nucleus Pulposus Cells Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 08, 2016 | Pubmed ID: 27248133 Loss of Folliculin Disrupts Hematopoietic Stem Cell Quiescence and Homeostasis Resulting in Bone Marrow Failure Stem Cells (Dayton, Ohio). Apr, 2016 | Pubmed ID: 27095138 Angiopoietin-like Protein 2 Is a Multistep Regulator of Inflammatory Neovascularization in a Murine Model of Age-related Macular Degeneration The Journal of Biological Chemistry. Apr, 2016 | Pubmed ID: 26839315 How Hematopoietic Stem/progenitors and Their Niche Sense and Respond To infectious Stress Experimental Hematology. Feb, 2016 | Pubmed ID: 26646990 Hypoxia Regulates the Hematopoietic Stem Cell Niche Pflugers Archiv : European Journal of Physiology. Jan, 2016 | Pubmed ID: 26490456 CLEC-2 in Megakaryocytes is Critical for Maintenance of Hematopoietic Stem Cells in the Bone Marrow The Journal of Experimental Medicine. Nov, 2015 | Pubmed ID: 26552707 Excessive Reactive Oxygen Species Are Therapeutic Targets for Intervertebral Disc Degeneration Arthritis Research & Therapy. Nov, 2015 | Pubmed ID: 26542776 [Metabolic Regulation of Stem Cells] [Rinsho Ketsueki] The Japanese Journal of Clinical Hematology. Oct, 2015 | Pubmed ID: 26458425 ADAM12 and ADAM17 Are Essential Molecules for Hypoxia-induced Impairment of Neural Vascular Barrier Function Scientific Reports. Aug, 2015 | Pubmed ID: 26242473 Integrative Analysis of the Acquisition of Pluripotency in PGCs Reveals the Mutually Exclusive Roles of Blimp-1 and AKT Signaling Stem Cell Reports. Jul, 2015 | Pubmed ID: 26050930 Bacterial C-di-GMP Affects Hematopoietic Stem/progenitors and Their Niches Through STING Cell Reports. Apr, 2015 | Pubmed ID: 25843711 Regulation of Glycolysis by Pdk Functions As a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells Cell Stem Cell. Jan, 2013 | Pubmed ID: 23290136 Roles of the Hypoxia Response System in Hematopoietic and Leukemic Stem Cells International Journal of Hematology. May, 2012 | Pubmed ID: 22539363 Regulation of the HIF-1alpha Level is Essential for Hematopoietic Stem Cells Cell Stem Cell. Sep, 2010 | Pubmed ID: 20804974 Stem Cell Defects in ATM-deficient Undifferentiated Spermatogonia Through DNA Damage-induced Cell-cycle Arrest Cell Stem Cell. Feb, 2008 | Pubmed ID: 18371438 Premeiotic Germ Cell Defect in Seminiferous Tubules of Atm-null Testis Biochemical and Biophysical Research Communications. Dec, 2006 | Pubmed ID: 17097049 A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells Hiroshi Kobayashi1, Keiyo Takubo1 1Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine JoVE 61938 Bioengineering
A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells Hiroshi Kobayashi1, Keiyo Takubo1 1Department of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine JoVE 61938 Bioengineering