Kevin D. Costa

Publications

• Single-cell RNA Sequencing Reveals Maturation Trajectory in Human Pluripotent Stem Cell-derived Cardiomyocytes in Engineered Tissues
  IScience. Apr, 2023  |   Pubmed ID: 36950112
• Computational Design of Custom Therapeutic Cells to Correct Failing Human Cardiomyocytes
  Frontiers in Systems Biology. 2023  |   Pubmed ID: 36743445
• Age and Blood Pressure Contribute to Aortic Cell and Tissue Stiffness Through Distinct Mechanisms
  Hypertension (Dallas, Tex. : 1979). Aug, 2022  |   Pubmed ID: 35766034
• Generation of Human Induced Pluripotent Stem Cell (iPSC) Lines Derived from Five Patients Carrying the Pathogenic Phospholamban-R14del (PLN-R14del) Variant and Three Non-carrier Family Members
  Stem Cell Research. Apr, 2022  |   Pubmed ID: 35247838
• Gene Editing Reverses Arrhythmia Susceptibility in Humanized PLN-R14del Mice: Modelling a European Cardiomyopathy with Global Impact
  Cardiovascular Research. Dec, 2022  |   Pubmed ID: 35191471
• Cell Therapy Model Restores Failing Human Myocyte Electrophysiology and Calcium Cycling in Fibrotic Myocardium
  Frontiers in Physiology. 2021  |   Pubmed ID: 35046835
• Adverse Effects of Hydroxychloroquine and Azithromycin on Contractility and Arrhythmogenicity Revealed by Human Engineered Cardiac Tissues
  Journal of Molecular and Cellular Cardiology. Apr, 2021  |   Pubmed ID: 33373642
• High-resolution Integrated Piezoresistive Sensors for Microfluidic Monitoring
  Lab on a Chip. Jan, 2021  |   Pubmed ID: 33300516
• Combinatorial Treatment of Human Cardiac Engineered Tissues With Biomimetic Cues Induces Functional Maturation As Revealed by Optical Mapping of Action Potentials and Calcium Transients
  Frontiers in Physiology. 2020  |   Pubmed ID: 32226389
• Adult Human Cardiac Stem Cell Supplementation Effectively Increases Contractile Function and Maturation in Human Engineered Cardiac Tissues
  Stem Cell Research & Therapy. Dec, 2019  |   Pubmed ID: 31801634
• Sarco/endoplasmic Reticulum Ca-ATPase is a More Effective Calcium Remover Than Sodium-calcium Exchanger in Human Embryonic Stem Cell-derived Cardiomyocytes
  American Journal of Physiology. Heart and Circulatory Physiology. Nov, 2019  |   Pubmed ID: 31347915
• Modulation of Chromatin Remodeling Proteins SMYD1 and SMARCD1 Promotes Contractile Function of Human Pluripotent Stem Cell-derived Ventricular Cardiomyocyte in 3D-engineered Cardiac Tissues
  Scientific Reports. May, 2019  |   Pubmed ID: 31097748
• Human Cardiac Ventricular-Like Organoid Chambers and Tissue Strips From Pluripotent Stem Cells As a Two-Tiered Assay for Inotropic Responses
  Clinical Pharmacology and Therapeutics. Aug, 2019  |   Pubmed ID: 30723889
• 3D Printing a Mechanically-Tunable Acrylate Resin on a Commercial DLP-SLA Printer
  Additive Manufacturing. Oct, 2018  |   Pubmed ID: 31106119
• Cardiac Tissue Engineering Models of Inherited and Acquired Cardiomyopathies
  Methods in Molecular Biology (Clifton, N.J.). 2018  |   Pubmed ID: 29987817
• An Introduction to Computational Modeling of Cardiac Electrophysiology and Arrhythmogenicity
  Methods in Molecular Biology (Clifton, N.J.). 2018  |   Pubmed ID: 29987808
• Dehomogenized Elastic Properties of Heterogeneous Layered Materials in AFM Indentation Experiments
  Biophysical Journal. Jun, 2018  |   Pubmed ID: 29874620
• Functional and Transcriptomic Insights into Pathogenesis of R9C Phospholamban Mutation Using Human Induced Pluripotent Stem Cell-derived Cardiomyocytes
  Journal of Molecular and Cellular Cardiology. Jun, 2018  |   Pubmed ID: 29752948
• Bioengineering an Electro-mechanically Functional Miniature Ventricular Heart Chamber from Human Pluripotent Stem Cells
  Biomaterials. May, 2018  |   Pubmed ID: 29459321
• Exosomal MicroRNA-21-5p Mediates Mesenchymal Stem Cell Paracrine Effects on Human Cardiac Tissue Contractility
  Circulation Research. 03, 2018  |   Pubmed ID: 29449318
• Physiologic, Pathologic, and Therapeutic Paracrine Modulation of Cardiac Excitation-Contraction Coupling
  Circulation Research. Jan, 2018  |   Pubmed ID: 29301848
• Coronary Capillary Blood Flow in a Rat Model of Congestive Heart Failure
  Journal of Applied Physiology (Bethesda, Md. : 1985). Mar, 2018  |   Pubmed ID: 29051335
• Rho Kinase Regulates Aortic Vascular Smooth Muscle Cell Stiffness Via Actin/SRF/Myocardin in Hypertension
  Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2017  |   Pubmed ID: 29169155
• Machine Learning of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissue Contractility for Automated Drug Classification
  Stem Cell Reports. Nov, 2017  |   Pubmed ID: 29033305
• CXCR4 and CXCR7 Play Distinct Roles in Cardiac Lineage Specification and Pharmacologic β-adrenergic Response
  Stem Cell Research. 08, 2017  |   Pubmed ID: 28711757
• Experimental and Computational Insight Into Human Mesenchymal Stem Cell Paracrine Signaling and Heterocellular Coupling Effects on Cardiac Contractility and Arrhythmogenicity
  Circulation Research. Aug, 2017  |   Pubmed ID: 28642329
• Inhibition of SRF/myocardin Reduces Aortic Stiffness by Targeting Vascular Smooth Muscle Cell Stiffening in Hypertension
  Cardiovascular Research. Feb, 2017  |   Pubmed ID: 28003268
• Lipidoid MRNA Nanoparticles for Myocardial Delivery in Rodents
  Methods in Molecular Biology (Clifton, N.J.). 2017  |   Pubmed ID: 27910047
• Modeling Electrophysiological Coupling and Fusion Between Human Mesenchymal Stem Cells and Cardiomyocytes
  PLoS Computational Biology. Jul, 2016  |   Pubmed ID: 27454812
• Genomic Correction of Familial Cardiomyopathy in Human Engineered Cardiac Tissues
  European Heart Journal. Nov, 2016  |   Pubmed ID: 27450564
• Losartan Attenuates Degradation of Aorta and Lung Tissue Micromechanics in a Mouse Model of Severe Marfan Syndrome
  Annals of Biomedical Engineering. Oct, 2016  |   Pubmed ID: 27090893
• Decellularized Scaffold Hydrogel Materials for MI Treatment: Could "The Matrix" Really Be the Future?
  Journal of the American College of Cardiology. Mar, 2016  |   Pubmed ID: 26940930
• Direct Hydrogel Encapsulation of Pluripotent Stem Cells Enables Ontomimetic Differentiation and Growth of Engineered Human Heart Tissues
  Biomaterials. Mar, 2016  |   Pubmed ID: 26826618
• Mechanostimulation Promotes Nuclear and Epigenetic Changes in Oligodendrocytes
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2016  |   Pubmed ID: 26791211
• Human Engineered Cardiac Tissues Created Using Induced Pluripotent Stem Cells Reveal Functional Characteristics of BRAF-Mediated Hypertrophic Cardiomyopathy
  PloS One. 2016  |   Pubmed ID: 26784941
• Myocardial Delivery of Lipidoid Nanoparticle Carrying ModRNA Induces Rapid and Transient Expression
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2016  |   Pubmed ID: 26471463
• An Update on the Etiology of Abdominal Aortic Aneurysms: Implications for Future Diagnostic Testing
  Expert Review of Cardiovascular Therapy. Oct, 2015  |   Pubmed ID: 26401919
• An Evolving Understanding of the Genetic Causes of Abdominal Aortic Aneurysm Disease
  Surgical Technology International. May, 2015  |   Pubmed ID: 26055010
• Phospholamban As a Crucial Determinant of the Inotropic Response of Human Pluripotent Stem Cell-derived Ventricular Cardiomyocytes and Engineered 3-dimensional Tissue Constructs
  Circulation. Arrhythmia and Electrophysiology. Feb, 2015  |   Pubmed ID: 25504561
• Stem Cell Factor Gene Transfer Improves Cardiac Function After Myocardial Infarction in Swine
  Circulation. Heart Failure. Jan, 2015  |   Pubmed ID: 25342737
• Physical Developmental Cues for the Maturation of Human Pluripotent Stem Cell-derived Cardiomyocytes
  Stem Cell Research & Therapy. Oct, 2014  |   Pubmed ID: 25688759
• Abnormal Muscle Mechanosignaling Triggers Cardiomyopathy in Mice with Marfan Syndrome
  The Journal of Clinical Investigation. Mar, 2014  |   Pubmed ID: 24531548
• Advancing Functional Engineered Cardiac Tissues Toward a Preclinical Model of Human Myocardium
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2014  |   Pubmed ID: 24174427
• Shear Stress Triggers Insertion of Voltage-gated Potassium Channels from Intracellular Compartments in Atrial Myocytes
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2013  |   Pubmed ID: 24065831
• Synthesis and in Vitro Evaluation of a Multifunctional and Surface-switchable Nanoemulsion Platform
  Chemical Communications (Cambridge, England). Oct, 2013  |   Pubmed ID: 23877789
• Myocyte-depleted Engineered Cardiac Tissues Support Therapeutic Potential of Mesenchymal Stem Cells
  Tissue Engineering. Part A. Jul, 2012  |   Pubmed ID: 22500611
• Biomedical Model Fitting and Error Analysis
  Science Signaling. Sep, 2011  |   Pubmed ID: 21954296