Kevin W. Plaxco Interdepartmental Program in Biomedical Science and Engineering University of California at Santa Barbara Biography Publications Institution JoVE Articles Kevin W. Plaxco has not added a biography. If you are Kevin W. Plaxco and would like to personalize this page please email our Author Liaison for assistance. Publications A Tight Squeeze: Geometric Effects on the Performance of Three-electrode Electrochemical-aptamer Based Sensors in Constrained, Placements The Analyst. Mar, 2023 | Pubmed ID: 36891771 Efforts Toward the Continuous Monitoring of Molecular Markers of Performance Journal of Science and Medicine in Sport. Jun, 2023 | Pubmed ID: 36841706 On the Rational Design of Cooperative Receptors Annual Review of Biophysics. May, 2023 | Pubmed ID: 36737603 Conformational-switch Biosensors As Novel Tools to Support Continuous, Real-time Molecular Monitoring in Lab-on-a-chip Devices Lab on a Chip. Mar, 2023 | Pubmed ID: 36655710 On the Disinfection of Electrochemical Aptamer-Based Sensors ECS Sensors Plus. Mar, 2022 | Pubmed ID: 36452064 Improved Calibration of Electrochemical Aptamer-based Sensors Scientific Reports. Apr, 2022 | Pubmed ID: 35365672 Electrochemical Aptamer-Based Sensors: A Platform Approach to High-Frequency Molecular Monitoring In Situ in the Living Body Methods in Molecular Biology (Clifton, N.J.). 2022 | Pubmed ID: 34837195 Catalytic Interruption Mitigates Edge Effects in the Characterization of Heterogeneous, Insulating Nanoparticles Journal of the American Chemical Society. Nov, 2021 | Pubmed ID: 34735140 Seconds-resolved Pharmacokinetic Measurements of the Chemotherapeutic Irinotecan in the Living Body Chemical Science. Sep, 2019 | Pubmed ID: 31673321 An Electrochemical Aptamer-based Sensor for the Rapid and Convenient Measurement of L-tryptophan Analytical and Bioanalytical Chemistry. Jul, 2019 | Pubmed ID: 30796485 Exploiting the Conformational-selection Mechanism to Control the Response Kinetics of a "smart" DNA Hydrogel The Analyst. May, 2018 | Pubmed ID: 29713702 Effects of Crowding on the Stability of a Surface-tethered Biopolymer: an Experimental Study of Folding in a Highly Crowded Regime Journal of the American Chemical Society. Jun, 2014 | Pubmed ID: 24919057 Quantification of Transcription Factor Binding in Cell Extracts Using an Electrochemical, Structure-Switching Biosensor Journal of the American Chemical Society. Feb, 2012 | Pubmed ID: 22313286 Engineering Biosensors with Extended, Narrowed, or Arbitrarily Edited Dynamic Range Journal of the American Chemical Society. Feb, 2012 | Pubmed ID: 22239688 Entropic and Electrostatic Effects on the Folding Free Energy of a Surface-attached Biomolecule: an Experimental and Theoretical Study Journal of the American Chemical Society. Feb, 2012 | Pubmed ID: 22239220 Wash-free, Electrochemical Platform for the Quantitative, Multiplexed Detection of Specific Antibodies Analytical Chemistry. Jan, 2012 | Pubmed ID: 22145706 Probe Accessibility Effects on the Performance of Electrochemical Biosensors Employing DNA Monolayers Analytical and Bioanalytical Chemistry. Jan, 2012 | Pubmed ID: 21928081 Two-step, PCR-free Telomerase Detection by Using Exonuclease III-aided Target Recycling Chembiochem : a European Journal of Chemical Biology. Dec, 2011 | Pubmed ID: 22125097 High-precision, in Vitro Validation of the Sequestration Mechanism for Generating Ultrasensitive Dose-response Curves in Regulatory Networks PLoS Computational Biology. Oct, 2011 | Pubmed ID: 21998566 Polarity-switching Electrochemical Sensor for Specific Detection of Single-nucleotide Mismatches Angewandte Chemie (International Ed. in English). Nov, 2011 | Pubmed ID: 21976312 Electrochemical Biosensors Employing an Internal Electrode Attachment Site and Achieving Reversible, High Gain Detection of Specific Nucleic Acid Sequences Analytical Chemistry. Dec, 2011 | Pubmed ID: 21975121 CheapStat: an Open-source, "do-it-yourself" Potentiostat for Analytical and Educational Applications PloS One. 2011 | Pubmed ID: 21931613 Transcription Factor Beacons for the Quantitative Detection of DNA Binding Activity Journal of the American Chemical Society. Sep, 2011 | Pubmed ID: 21815647 Dielectric Spectroscopy of Proteins As a Quantitative Experimental Test of Computational Models of Their Low-frequency Harmonic Motions Journal of the American Chemical Society. Jun, 2011 | Pubmed ID: 21542634 Switch-based Biosensors: a New Approach Towards Real-time, in Vivo Molecular Detection Trends in Biotechnology. Jan, 2011 | Pubmed ID: 21106266 Universality in the Timescales of Internal Loop Formation in Unfolded Proteins and Single-stranded Oligonucleotides Biophysical Journal. Dec, 2010 | Pubmed ID: 21156138 A Mechanistic Study of Electron Transfer from the Distal Termini of Electrode-bound, Single-stranded DNAs Journal of the American Chemical Society. Nov, 2010 | Pubmed ID: 20964337 The Art of Writing Science Protein Science : a Publication of the Protein Society. Dec, 2010 | Pubmed ID: 20954234 Using Triplex-Forming Oligonucleotide Probes for the Reagentless, Electrochemical Detection of Double-Stranded DNA Analytical Chemistry. Oct, 2010 | Pubmed ID: 20936782 Detection of Telomerase Activity in High Concentration of Cell Lysates Using Primer-modified Gold Nanoparticles Journal of the American Chemical Society. Nov, 2010 | Pubmed ID: 20932008 An Electrochemical Supersandwich Assay for Sensitive and Selective DNA Detection in Complex Matrices Journal of the American Chemical Society. Oct, 2010 | Pubmed ID: 20873767 Biomimetic Glass Nanopores Employing Aptamer Gates Responsive to a Small Molecule Chemical Communications (Cambridge, England). Nov, 2010 | Pubmed ID: 20865192 Investigation of an Anomalously Accelerating Substitution in the Folding of a Prototypical Two-state Protein Journal of Molecular Biology. Oct, 2010 | Pubmed ID: 20816985 Reagentless Measurement of Aminoglycoside Antibiotics in Blood Serum Via an Electrochemical, Ribonucleic Acid Aptamer-based Biosensor Analytical Chemistry. Sep, 2010 | Pubmed ID: 20687587 Structure-switching Biosensors: Inspired by Nature Current Opinion in Structural Biology. Aug, 2010 | Pubmed ID: 20627702 Colorimetric Detection of DNA, Small Molecules, Proteins, and Ions Using Unmodified Gold Nanoparticles and Conjugated Polyelectrolytes Proceedings of the National Academy of Sciences of the United States of America. Jun, 2010 | Pubmed ID: 20534499 Label-free, Dual-analyte Electrochemical Biosensors: a New Class of Molecular-electronic Logic Gates Journal of the American Chemical Society. Jun, 2010 | Pubmed ID: 20527878 Folding-based Electrochemical Biosensors: the Case for Responsive Nucleic Acid Architectures Accounts of Chemical Research. Apr, 2010 | Pubmed ID: 20201486 Quantitative, Reagentless, Single-step Electrochemical Detection of Anti-DNA Antibodies Directly in Blood Serum Chemical Communications (Cambridge, England). Mar, 2010 | Pubmed ID: 20177635 Re-engineering Aptamers to Support Reagentless, Self-reporting Electrochemical Sensors The Analyst. Mar, 2010 | Pubmed ID: 20174715 Tracking a Molecular Motor with a Nanoscale Optical Encoder Nano Letters. Mar, 2010 | Pubmed ID: 20121107 Sensitive and Selective Amplified Fluorescence DNA Detection Based on Exonuclease III-aided Target Recycling Journal of the American Chemical Society. Feb, 2010 | Pubmed ID: 20092337 On the Binding of Cationic, Water-soluble Conjugated Polymers to DNA: Electrostatic and Hydrophobic Interactions Journal of the American Chemical Society. Feb, 2010 | Pubmed ID: 20058862 Exploiting Binding-induced Changes in Probe Flexibility for the Optimization of Electrochemical Biosensors Analytical Chemistry. Jan, 2010 | Pubmed ID: 20000457 Engineering New Aptamer Geometries for Electrochemical Aptamer-Based Sensors Proceedings - Society of Photo-Optical Instrumentation Engineers. 2009 | Pubmed ID: 20436792 On the Signaling of Electrochemical Aptamer-Based Sensors: Collision- and Folding-Based Mechanisms Electroanalysis. Jun, 2009 | Pubmed ID: 20436787 A General Electrochemical Method for Label-free Screening of Protein-small Molecule Interactions Chemical Communications (Cambridge, England). Nov, 2009 | Pubmed ID: 19826675 Comparing the Properties of Electrochemical-based DNA Sensors Employing Different Redox Tags Analytical Chemistry. Nov, 2009 | Pubmed ID: 19810694 An Electrochemical Sensor for Single Nucleotide Polymorphism Detection in Serum Based on a Triple-stem DNA Probe Journal of the American Chemical Society. Oct, 2009 | Pubmed ID: 19807078 The Rate of Intramolecular Loop Formation in DNA and Polypeptides: the Absence of the Diffusion-controlled Limit and Fractional Power-law Viscosity Dependence The Journal of Physical Chemistry. B. Oct, 2009 | Pubmed ID: 19780594 Non-sequence-specific Interactions Can Account for the Compaction of Proteins Unfolded Under "native" Conditions Journal of Molecular Biology. Nov, 2009 | Pubmed ID: 19751743 Measuring Distances Within Unfolded Biopolymers Using Fluorescence Resonance Energy Transfer: The Effect of Polymer Chain Dynamics on the Observed Fluorescence Resonance Energy Transfer Efficiency The Journal of Chemical Physics. Aug, 2009 | Pubmed ID: 19725638 Thermodynamic Basis for the Optimization of Binding-induced Biomolecular Switches and Structure-switching Biosensors Proceedings of the National Academy of Sciences of the United States of America. Aug, 2009 | Pubmed ID: 19666496 The Length and Viscosity Dependence of End-to-end Collision Rates in Single-stranded DNA Biophysical Journal. Jul, 2009 | Pubmed ID: 19580758 Fluorescence Detection of Single-nucleotide Polymorphisms with a Single, Self-complementary, Triple-stem DNA Probe Angewandte Chemie (International Ed. in English). 2009 | Pubmed ID: 19431180 High Specificity, Electrochemical Sandwich Assays Based on Single Aptamer Sequences and Suitable for the Direct Detection of Small-molecule Targets in Blood and Other Complex Matrices Journal of the American Chemical Society. May, 2009 | Pubmed ID: 19419171 An Electrochemical Sensor for the Detection of Protein-small Molecule Interactions Directly in Serum and Other Complex Matrices Journal of the American Chemical Society. May, 2009 | Pubmed ID: 19413316 Surface Chemistry Effects on the Performance of an Electrochemical DNA Sensor Bioelectrochemistry (Amsterdam, Netherlands). Sep, 2009 | Pubmed ID: 19362061 Continuous, Real-time Monitoring of Cocaine in Undiluted Blood Serum Via a Microfluidic, Electrochemical Aptamer-based Sensor Journal of the American Chemical Society. Apr, 2009 | Pubmed ID: 19271708 Effects of Probe Length, Probe Geometry, and Redox-tag Placement on the Performance of the Electrochemical E-DNA Sensor Analytical Chemistry. Mar, 2009 | Pubmed ID: 19215066 Reagentless, Electrochemical Approach for the Specific Detection of Double- and Single-stranded DNA Binding Proteins Analytical Chemistry. Feb, 2009 | Pubmed ID: 19199570 Beyond Molecular Beacons: Optical Sensors Based on the Binding-induced Folding of Proteins and Polypeptides Chemistry (Weinheim an Der Bergstrasse, Germany). 2009 | Pubmed ID: 19191230 Protein Complexes: the Evolution of Symmetry Current Biology : CB. Jan, 2009 | Pubmed ID: 19138586 Improving the Stability and Sensing of Electrochemical Biosensors by Employing Trithiol-anchoring Groups in a Six-carbon Self-assembled Monolayer Analytical Chemistry. Feb, 2009 | Pubmed ID: 19133790 Optimization of a Reusable, DNA Pseudoknot-based Electrochemical Sensor for Sequence-specific DNA Detection in Blood Serum Analytical Chemistry. Jan, 2009 | Pubmed ID: 19093760 Some Recommendations for the Practitioner to Improve the Precision of Experimentally Determined Protein Folding Rates and Phi Values Proteins. Feb, 2009 | Pubmed ID: 18655053 Optimization of Electrochemical Aptamer-based Sensors Via Optimization of Probe Packing Density and Surface Chemistry Langmuir : the ACS Journal of Surfaces and Colloids. Sep, 2008 | Pubmed ID: 18690727 Microfluidic Device Architecture for Electrochemical Patterning and Detection of Multiple DNA Sequences Langmuir : the ACS Journal of Surfaces and Colloids. Feb, 2008 | Pubmed ID: 18181654 Chimeric Peptide Beacons: a Direct Polypeptide Analog of DNA Molecular Beacons Chemical Communications (Cambridge, England). Dec, 2007 | Pubmed ID: 18361352 Preparation of Electrode-immobilized, Redox-modified Oligonucleotides for Electrochemical DNA and Aptamer-based Sensing Nature Protocols. 2007 | Pubmed ID: 18007622 Linear, Redox Modified DNA Probes As Electrochemical DNA Sensors Chemical Communications (Cambridge, England). Sep, 2007 | Pubmed ID: 17851622 Label-free Electrochemical Detection of DNA in Blood Serum Via Target-induced Resolution of an Electrode-bound DNA Pseudoknot Journal of the American Chemical Society. Oct, 2007 | Pubmed ID: 17850085 Effect of Molecular Crowding on the Response of an Electrochemical DNA Sensor Langmuir : the ACS Journal of Surfaces and Colloids. Jun, 2007 | Pubmed ID: 17488132 Peptide Beacons: a New Design for Polypeptide-based Optical Biosensors Bioconjugate Chemistry. May-Jun, 2007 | Pubmed ID: 17461545 Influence of Local and Residual Structures on the Scaling Behavior and Dimensions of Unfolded Proteins Biopolymers. Jul, 2007 | Pubmed ID: 17450572 Increasing the Resolution of Single Pair Fluorescence Resonance Energy Transfer Measurements in Solution Via Molecular Cytometry Analytical Chemistry. May, 2007 | Pubmed ID: 17385843 Electrochemical Detection of Parts-per-billion Lead Via an Electrode-bound DNAzyme Assembly Journal of the American Chemical Society. Jan, 2007 | Pubmed ID: 17212391 Aptamer-based Electrochemical Detection of Picomolar Platelet-derived Growth Factor Directly in Blood Serum Analytical Chemistry. Jan, 2007 | Pubmed ID: 17194144 Comparison of the Signaling and Stability of Electrochemical DNA Sensors Fabricated from 6- or 11-carbon Self-assembled Monolayers Langmuir : the ACS Journal of Surfaces and Colloids. Dec, 2006 | Pubmed ID: 17129062 Collective Dynamics of Lysozyme in Water: Terahertz Absorption Spectroscopy and Comparison with Theory The Journal of Physical Chemistry. B. Nov, 2006 | Pubmed ID: 17125398 Single-step Electronic Detection of Femtomolar DNA by Target-induced Strand Displacement in an Electrode-bound Duplex Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17065320 Excimer-based Peptide Beacons: a Convenient Experimental Approach for Monitoring Polypeptide-protein and Polypeptide-oligonucleotide Interactions Journal of the American Chemical Society. Nov, 2006 | Pubmed ID: 17061871 Methods for the Accurate Estimation of Confidence Intervals on Protein Folding Phi-values Protein Science : a Publication of the Protein Society. Oct, 2006 | Pubmed ID: 17008714 Sequence-specific, Electronic Detection of Oligonucleotides in Blood, Soil, and Foodstuffs with the Reagentless, Reusable E-DNA Sensor Analytical Chemistry. Aug, 2006 | Pubmed ID: 16906710 Cooperativity and the Origins of Rapid, Single-exponential Kinetics in Protein Folding Protein Science : a Publication of the Protein Society. Jul, 2006 | Pubmed ID: 16815915 Probing the Collective Vibrational Dynamics of a Protein in Liquid Water by Terahertz Absorption Spectroscopy Protein Science : a Publication of the Protein Society. May, 2006 | Pubmed ID: 16641490 Rapid, Sequence-specific Detection of Unpurified PCR Amplicons Via a Reusable, Electrochemical Sensor Proceedings of the National Academy of Sciences of the United States of America. Mar, 2006 | Pubmed ID: 16537478 An Electronic, Aptamer-based Small-molecule Sensor for the Rapid, Label-free Detection of Cocaine in Adulterated Samples and Biological Fluids Journal of the American Chemical Society. Mar, 2006 | Pubmed ID: 16522082 On the Precision of Experimentally Determined Protein Folding Rates and Phi-values Protein Science : a Publication of the Protein Society. Mar, 2006 | Pubmed ID: 16501226 Differential Labeling of Closely Spaced Biosensor Electrodes Via Electrochemical Lithography Langmuir : the ACS Journal of Surfaces and Colloids. Feb, 2006 | Pubmed ID: 16460130 Absorption Spectra of Liquid Water and Aqueous Buffers Between 0.3 and 3.72 THz The Journal of Chemical Physics. Jan, 2006 | Pubmed ID: 16438614 A Reagentless Signal-on Architecture for Electronic, Aptamer-based Sensors Via Target-induced Strand Displacement Journal of the American Chemical Society. Dec, 2005 | Pubmed ID: 16366535 Experimental Investigation of the Frequency and Substitution Dependence of Negative Phi-values in Two-state Proteins Biochemistry. Sep, 2005 | Pubmed ID: 16142914 Is There or Isn't There? The Case for (and Against) Residual Structure in Chemically Denatured Proteins Critical Reviews in Biochemistry and Molecular Biology. Jul-Aug, 2005 | Pubmed ID: 16126485 Site-specific Dimensions Across a Highly Denatured Protein; a Single Molecule Study Journal of Molecular Biology. Sep, 2005 | Pubmed ID: 16095607 Engineering a Signal Transduction Mechanism for Protein-based Biosensors Proceedings of the National Academy of Sciences of the United States of America. Aug, 2005 | Pubmed ID: 16046542 Label-free Electronic Detection of Thrombin in Blood Serum by Using an Aptamer-based Sensor Angewandte Chemie (International Ed. in English). Aug, 2005 | Pubmed ID: 16044476 Biosensors Based on Binding-modulated Donor-acceptor Distances Trends in Biotechnology. Apr, 2005 | Pubmed ID: 15780710 The Protein Folding Transition State: What Are Phi-values Really Telling Us? Protein and Peptide Letters. Feb, 2005 | Pubmed ID: 15723637 Protein Folding: Defining a "standard" Set of Experimental Conditions and a Preliminary Kinetic Data Set of Two-state Proteins Protein Science : a Publication of the Protein Society. Mar, 2005 | Pubmed ID: 15689503 Apparent Debye-Huckel Electrostatic Effects in the Folding of a Simple, Single Domain Protein Biochemistry. Feb, 2005 | Pubmed ID: 15667218 Random-coil Behavior and the Dimensions of Chemically Unfolded Proteins Proceedings of the National Academy of Sciences of the United States of America. Aug, 2004 | Pubmed ID: 15314214 Using Protein Folding Rates to Test Protein Folding Theories Annual Review of Biochemistry. 2004 | Pubmed ID: 15189160 Terahertz Circular Dichroism Spectroscopy: a Potential Approach to the in Situ Detection of Life's Metabolic and Genetic Machinery Astrobiology. 2003 | Pubmed ID: 14678660 Contact Order Revisited: Influence of Protein Size on the Folding Rate Protein Science : a Publication of the Protein Society. Sep, 2003 | Pubmed ID: 12931003 Electrochemical Interrogation of Conformational Changes As a Reagentless Method for the Sequence-specific Detection of DNA Proceedings of the National Academy of Sciences of the United States of America. Aug, 2003 | Pubmed ID: 12867594 NMR and Temperature-jump Measurements of De Novo Designed Proteins Demonstrate Rapid Folding in the Absence of Explicit Selection for Kinetics Journal of Molecular Biology. Jul, 2003 | Pubmed ID: 12850149 Comparison of the Folding Processes of Distantly Related Proteins. Importance of Hydrophobic Content in Folding Journal of Molecular Biology. Jul, 2003 | Pubmed ID: 12842473 Beyond Superquenching: Hyper-efficient Energy Transfer from Conjugated Polymers to Gold Nanoparticles Proceedings of the National Academy of Sciences of the United States of America. May, 2003 | Pubmed ID: 12750470 Cooperativity, Smooth Energy Landscapes and the Origins of Topology-dependent Protein Folding Rates Journal of Molecular Biology. Feb, 2003 | Pubmed ID: 12547206 The Topomer Search Model: A Simple, Quantitative Theory of Two-state Protein Folding Kinetics Protein Science : a Publication of the Protein Society. Jan, 2003 | Pubmed ID: 12493824 Toward a Taxonomy of the Denatured State: Small Angle Scattering Studies of Unfolded Proteins Advances in Protein Chemistry. 2002 | Pubmed ID: 12418105 The Backbone Conformational Entropy of Protein Folding: Experimental Measures from Atomic Force Microscopy Journal of Molecular Biology. Sep, 2002 | Pubmed ID: 12225756 High-efficiency Fluorescence Quenching of Conjugated Polymers by Proteins Journal of the American Chemical Society. May, 2002 | Pubmed ID: 12010029 How the Folding Rate Constant of Simple, Single-domain Proteins Depends on the Number of Native Contacts Proceedings of the National Academy of Sciences of the United States of America. Mar, 2002 | Pubmed ID: 11904417 Residues Participating in the Protein Folding Nucleus Do Not Exhibit Preferential Evolutionary Conservation Journal of Molecular Biology. Feb, 2002 | Pubmed ID: 11851333 Equilibrium Collapse and the Kinetic 'foldability' of Proteins Biochemistry. Jan, 2002 | Pubmed ID: 11772031 Прецизионный электрохимический определение размеров отдельных электронеактивных частиц Julia Chung1, Kevin W. Plaxco1,2, Lior Sepunaru2 1Interdepartmental Program in Biomedical Science and Engineering, University of California at Santa Barbara, 2Department of Chemistry and Biochemistry, University of California at Santa Barbara JoVE 65116 Chemistry Изготовление Электрохимические ДНК-биосенсоры для Безреагентная Обнаружение нуклеиновых кислот, белков и малых молекул Aaron A. Rowe1, Ryan J. White1, Andrew J. Bonham1, Kevin W. Plaxco2 1Department of Chemistry and Biochemistry, University Of California Santa Barbara, 2Department of Chemistry and Biochemistry, Program in BioMolecular Science and Engineering, University Of California Santa Barbara JoVE 2922 Bioengineering
Прецизионный электрохимический определение размеров отдельных электронеактивных частиц Julia Chung1, Kevin W. Plaxco1,2, Lior Sepunaru2 1Interdepartmental Program in Biomedical Science and Engineering, University of California at Santa Barbara, 2Department of Chemistry and Biochemistry, University of California at Santa Barbara JoVE 65116 Chemistry
Изготовление Электрохимические ДНК-биосенсоры для Безреагентная Обнаружение нуклеиновых кислот, белков и малых молекул Aaron A. Rowe1, Ryan J. White1, Andrew J. Bonham1, Kevin W. Plaxco2 1Department of Chemistry and Biochemistry, University Of California Santa Barbara, 2Department of Chemistry and Biochemistry, Program in BioMolecular Science and Engineering, University Of California Santa Barbara JoVE 2922 Bioengineering
