Articles by Khaled M. Arafeh in JoVE
A 'Plug and Play' Method to Create Water-dispersible Nanoassemblies Containing an Amphiphilic Polymer, Organic Dyes and Upconverting Nanoparticles Khaled M. Arafeh*1, Amir M. Asadirad*1, Jason Woodson Li1, Danielle Wilson*1, Tuoqi Wu*1, Neil R. Branda1 14D LABS and Department of Chemistry, Simon Fraser University Organic dye molecules and oleic acid coated upconverting nanoparticles are not water-soluble. This protocol describes a ‘plug and play’ method that enables the transfer of organic dye molecules and upconverting particles from their initial hydrophobic solvent to water.
Other articles by Khaled M. Arafeh on PubMed
Synthesis of Neolamellarin A, an Inhibitor of Hypoxia-inducible Factor-1 Natural Product Communications. Jul, 2009 | Pubmed ID: 19731594 Neolamellarin A, a metabolite isolated from the sponge Dendrilla nigra, was found to inhibit hypoxia-inducible factor-1 (HIF-1) activation by 26% at 10 microM concentration and inhibition of HIF-1 has become a major antitumor molecular target. Herein the first synthesis of neolamellarin A is described. The synthetic strategy features the condensation of vinylogous amide with aminomalonate to construct the 3,4-bis(4-methoxyphenyl)-1H-pyrrole core and the subsequent acylation and deprotection rendered the target compound in 18% over all yield.
A UV-blocking Polymer Shell Prevents One-photon Photoreactions While Allowing Multi-photon Processes in Encapsulated Upconverting Nanoparticles Angewandte Chemie (International Ed. in English). Oct, 2013 | Pubmed ID: 24038865 Sun block for nanoparticles: Unintentional photorelease triggered by UV light is a problem in photodynamic therapy. Encapsulating upconverting nanoparticles containing photoswitches in a UV-blocking amphiphilic polymer shuts down the one-photon process and only allows two-photon-driven photochemistry. Thus, UV light is blocked while NIR light can reach the nanoparticle core and trigger photorelease.