Khaled Barakat Li Ka Shing Institute for Virology University of Alberta Biography Publications Institution JoVE Articles Khaled Barakat has not added a biography. If you are Khaled Barakat and would like to personalize this page please email our Author Liaison for assistance. Publications New Design of Nucleotide Excision Repair (NER) Inhibitors for Combination Cancer Therapy Journal of Molecular Graphics & Modelling. Feb, 2016 | Pubmed ID: 26939044 Entropy in Bimolecular Simulations: A Comprehensive Review of Atomic Fluctuations-based Methods Journal of Molecular Graphics & Modelling. Nov, 2015 | Pubmed ID: 26407139 Discovery of Novel Peptidomimetics As Irreversible CHIKV NsP2 Protease Inhibitors Using Quantum Mechanical-Based Ligand Descriptors Chemical Biology & Drug Design. Dec, 2015 | Pubmed ID: 26212366 Human PD-1 Binds Differently to Its Human Ligands: a Comprehensive Modeling Study Journal of Molecular Graphics & Modelling. Apr, 2015 | Pubmed ID: 25723350 Targeting the Achilles Heel of the Hepatitis B Virus: a Review of Current Treatments Against Covalently Closed Circular DNA Drug Discovery Today. May, 2015 | Pubmed ID: 25622780 A Refined Model of the HCV NS5A Protein Bound to Daclatasvir Explains Drug-resistant Mutations and Activity Against Divergent Genotypes Journal of Chemical Information and Modeling. Feb, 2015 | Pubmed ID: 24730573 IL-28B is a Key Regulator of B- and T-cell Vaccine Responses Against Influenza PLoS Pathogens. Dec, 2014 | Pubmed ID: 25503988 Thermoplastic Vestibuloplasty: a Novel Technique for Treatment of Lip and Cheek Adhesion Craniomaxillofacial Trauma & Reconstruction. Dec, 2014 | Pubmed ID: 25383145 Human Structural Proteome-wide Characterization of Cyclosporine A Targets Bioinformatics (Oxford, England). Dec, 2014 | Pubmed ID: 25172926 A Human Ether-á-go-go-related (hERG) Ion Channel Atomistic Model Generated by Long Supercomputer Molecular Dynamics Simulations and Its Use in Predicting Drug Cardiotoxicity Toxicology Letters. Nov, 2014 | Pubmed ID: 25127758 Vaccine Adjuvants--understanding Molecular Mechanisms to Improve Vaccines Swiss Medical Weekly. 2014 | Pubmed ID: 24844935 Immunomodulatory Function of Interleukin 28B During Primary Infection with Cytomegalovirus The Journal of Infectious Diseases. Sep, 2014 | Pubmed ID: 24620020 Detailed Computational Study of the Active Site of the Hepatitis C Viral RNA Polymerase to Aid Novel Drug Design Journal of Chemical Information and Modeling. Nov, 2013 | Pubmed ID: 24116674 A Computational Model for Overcoming Drug Resistance Using Selective Dual-inhibitors for Aurora Kinase A and Its T217D Variant Molecular Pharmaceutics. Dec, 2013 | Pubmed ID: 24094068 Small Molecule Inhibitors of ERCC1-XPF Protein-protein Interaction Synergize Alkylating Agents in Cancer Cells Molecular Pharmacology. Jul, 2013 | Pubmed ID: 23580445 Virtual Screening and Biological Evaluation of Inhibitors Targeting the XPA-ERCC1 Interaction PloS One. 2012 | Pubmed ID: 23272099 Modeling the Yew Tree Tubulin and a Comparison of Its Interaction with Paclitaxel to Human Tubulin Pharmaceutical Research. Nov, 2012 | Pubmed ID: 22833053 DNA Repair Inhibitors: the Next Major Step to Improve Cancer Therapy Current Topics in Medicinal Chemistry. 2012 | Pubmed ID: 22794314 Computational Predictions of Volatile Anesthetic Interactions with the Microtubule Cytoskeleton: Implications for Side Effects of General Anesthesia PloS One. 2012 | Pubmed ID: 22761654 DNA Repair Inhibitors: Our Last Disposal to Improve Cancer Therapy Current Topics in Medicinal Chemistry. Jun, 2012 | Pubmed ID: 22690684 DNA Polymerase Beta (pol β) Inhibitors: a Comprehensive Overview Drug Discovery Today. Aug, 2012 | Pubmed ID: 22561893 Discovery of Small Molecule Inhibitors That Interact with γ-tubulin Chemical Biology & Drug Design. May, 2012 | Pubmed ID: 22268380 Effects of Temperature on the P53-DNA Binding Interactions and Their Dynamical Behavior: Comparing the Wild Type to the R248Q Mutant PloS One. 2011 | Pubmed ID: 22110706 Relaxed Complex Scheme Suggests Novel Inhibitors for the Lyase Activity of DNA Polymerase Beta Journal of Molecular Graphics & Modelling. Feb, 2011 | Pubmed ID: 21194999 Discovery and Characterization of the Laulimalide-microtubule Binding Mode by Mass Shift Perturbation Mapping Chemistry & Biology. Jul, 2010 | Pubmed ID: 20659685 Ensemble-based Virtual Screening Reveals Dual-inhibitors for the P53-MDM2/MDMX Interactions Journal of Molecular Graphics & Modelling. Feb, 2010 | Pubmed ID: 20056466 Electrostatic Contributions to Colchicine Binding Within Tubulin Isotypes Electromagnetic Biology and Medicine. 2009 | Pubmed ID: 20017626 Characterization of an Inhibitory Dynamic Pharmacophore for the ERCC1-XPA Interaction Using a Combined Molecular Dynamics and Virtual Screening Approach Journal of Molecular Graphics & Modelling. Sep, 2009 | Pubmed ID: 19473860 Melanotic Neuroectodermal Tumor of Infancy: Review of Literature and Case Report Journal of Pediatric Surgery. Jun, 2008 | Pubmed ID: 18558161 Melanocortin Subtype 4 Receptor Agonists: Structure-activity Relationships About the 4-alkyl Piperidine Core Bioorganic & Medicinal Chemistry Letters. Oct, 2007 | Pubmed ID: 17768046 Discovery and Activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a Potent and Selective Melanocortin Subtype-4 Receptor Agonist Bioorganic & Medicinal Chemistry Letters. Aug, 2005 | Pubmed ID: 15982875 Hypertelorism: the Importance of Three-dimensional Imaging and Trends in the Surgical Correction by Facial Bipartition Plastic and Reconstructive Surgery. May, 2005 | Pubmed ID: 15861056 Evaluation of 45S5 Bioactive Glass Combined As a Bone Substitute in the Reconstruction of Critical Size Calvarial Defects in Rabbits The Journal of Craniofacial Surgery. Jan, 2005 | Pubmed ID: 15699647 Clinical Outcome in Cranioplasty: Critical Review in Long-term Follow-up The Journal of Craniofacial Surgery. Mar, 2003 | Pubmed ID: 12621283 Design and Pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a Potent, Selective, Melanocortin Subtype-4 Receptor Agonist Journal of Medicinal Chemistry. Oct, 2002 | Pubmed ID: 12361385 The Effect of Low-molecular-weight Heparin in the Survival of a Rabbit Congested Skin Flap Plastic and Reconstructive Surgery. May, 2002 | Pubmed ID: 11994604 Easy Tissue Expansion of Prelaminated Mucosa-lined Flaps for Cheek Reconstruction in a Canine Model Plastic and Reconstructive Surgery. May, 2002 | Pubmed ID: 11994602 ELISAベースの結合と競争法は急速にリガンド - 受容体相互作用を決定するために、 Mohameedyaseen Syedbasha1, Janina Linnik1,2,3, Deanna Santer4, Daire O'Shea5, Khaled Barakat4,6, Michael Joyce4, Nina Khanna7, D. Lorne Tyrrell4, Michael Houghton4, Adrian Egli1,8 1Applied Microbiology Research, Department of Biomedicine, University of Basel, 2Department of Biosystems Science and Engineering, ETH Zurich, and Swiss Institute of Bioinformatics, 3Swiss Institute of Bioinformatics, 4Li Ka Shing Institute for Virology, University of Alberta, 5Regional Infectious Diseases Unit, University of Edinburgh, 6Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 7Infection Biology, Department of Biomedicine, University of Basel, 8Clinical Microbiology, University Hospital Basel Chemistry
ELISAベースの結合と競争法は急速にリガンド - 受容体相互作用を決定するために、 Mohameedyaseen Syedbasha1, Janina Linnik1,2,3, Deanna Santer4, Daire O'Shea5, Khaled Barakat4,6, Michael Joyce4, Nina Khanna7, D. Lorne Tyrrell4, Michael Houghton4, Adrian Egli1,8 1Applied Microbiology Research, Department of Biomedicine, University of Basel, 2Department of Biosystems Science and Engineering, ETH Zurich, and Swiss Institute of Bioinformatics, 3Swiss Institute of Bioinformatics, 4Li Ka Shing Institute for Virology, University of Alberta, 5Regional Infectious Diseases Unit, University of Edinburgh, 6Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 7Infection Biology, Department of Biomedicine, University of Basel, 8Clinical Microbiology, University Hospital Basel Chemistry
