Kinya Hotta School of Biosciences The University of Nottingham Malaysia Campus Biography Publications Institution JoVE Articles Kinya Hotta has not added a biography. If you are Kinya Hotta and would like to personalize this page please email our Author Liaison for assistance. Publications Oxidative Trans to Cis Isomerization of Olefins in Polyketide Biosynthesis Angewandte Chemie (International Ed. in English). May, 2016 | Pubmed ID: 27072782 Elucidation of Pyranonigrin Biosynthetic Pathway Reveals a Mode of Tetramic Acid, Fused γ-Pyrone, and Exo-Methylene Formation Organic Letters. Oct, 2015 | Pubmed ID: 26414728 Involvement of Lipocalin-like CghA in Decalin-Forming Stereoselective Intramolecular [4+2] Cycloaddition Chembiochem : a European Journal of Chemical Biology. Nov, 2015 | Pubmed ID: 26360642 Epoxide Hydrolase-lasalocid a Structure Provides Mechanistic Insight into Polyether Natural Product Biosynthesis Journal of the American Chemical Society. Jan, 2015 | Pubmed ID: 25535803 Non-heme Dioxygenase Catalyzes Atypical Oxidations of 6,7-bicyclic Systems to Form the 6,6-quinolone Core of Viridicatin-type Fungal Alkaloids Angewandte Chemie (International Ed. in English). Nov, 2014 | Pubmed ID: 25251934 Elucidation of Pseurotin Biosynthetic Pathway Points to Trans-acting C-methyltransferase: Generation of Chemical Diversity Angewandte Chemie (International Ed. in English). Aug, 2014 | Pubmed ID: 24939566 Biophysical Properties of Intrinsically Disordered P130Cas Substrate Domain--implication in Mechanosensing PLoS Computational Biology. Apr, 2014 | Pubmed ID: 24722239 Cytochrome P450 As Dimerization Catalyst in Diketopiperazine Alkaloid Biosynthesis Chembiochem : a European Journal of Chemical Biology. Mar, 2014 | Pubmed ID: 24677498 Conversion of a Disulfide Bond into a Thioacetal Group During Echinomycin Biosynthesis Angewandte Chemie (International Ed. in English). Jan, 2014 | Pubmed ID: 24302672 Distinct Mechanisms for Spiro-carbon Formation Reveal Biosynthetic Pathway Crosstalk Nature Chemical Biology. Dec, 2013 | Pubmed ID: 24121553 Engineering the Polyproline II Propensity of a Class II Major Histocompatibility Complex Ligand Peptide ACS Chemical Biology. Nov, 2013 | Pubmed ID: 24001370 Targeted Disruption of Transcriptional Regulators in Chaetomium Globosum Activates Biosynthetic Pathways and Reveals Transcriptional Regulator-like Behavior of Aureonitol Journal of the American Chemical Society. Sep, 2013 | Pubmed ID: 23941144 Echinomycin Biosynthesis Current Opinion in Chemical Biology. Aug, 2013 | Pubmed ID: 23856054 Yeast-based Genome Mining, Production and Mechanistic Studies of the Biosynthesis of Fungal Polyketide and Peptide Natural Products Natural Product Reports. Aug, 2013 | Pubmed ID: 23824111 Combinatorial Generation of Complexity by Redox Enzymes in the Chaetoglobosin A Biosynthesis Journal of the American Chemical Society. May, 2013 | Pubmed ID: 23611317 Overexpressing Transcriptional Regulator in Chaetomium Globosum Activates a Silent Biosynthetic Pathway: Evaluation of Shanorellin Biosynthesis The Journal of Antibiotics. Jul, 2012 | Pubmed ID: 22569160 Overexpressing Transcriptional Regulator in Aspergillus Oryzae Activates a Silent Biosynthetic Pathway to Produce a Novel Polyketide Chembiochem : a European Journal of Chemical Biology. Apr, 2012 | Pubmed ID: 22447538 Establishing a New Methodology for Genome Mining and Biosynthesis of Polyketides and Peptides Through Yeast Molecular Genetics Chembiochem : a European Journal of Chemical Biology. Apr, 2012 | Pubmed ID: 22447505 Enzymatic Catalysis of Anti-Baldwin Ring Closure in Polyether Biosynthesis Nature. Mar, 2012 | Pubmed ID: 22388816 Structural and Functional Studies of Trans-encoded HLA-DQ2.3 (DQA1*03:01/DQB1*02:01) Protein Molecule The Journal of Biological Chemistry. Apr, 2012 | Pubmed ID: 22362761 Enzymatic Epoxide-opening Cascades Catalyzed by a Pair of Epoxide Hydrolases in the Ionophore Polyether Biosynthesis Organic Letters. Apr, 2011 | Pubmed ID: 21375229 Siderophore-mediated Iron Acquisition in Bacillus Anthracis and Related Strains Microbiology (Reading, England). Jul, 2010 | Pubmed ID: 20466767 Differences in the Risk of Celiac Disease Associated with HLA-DQ2.5 or HLA-DQ2.2 Are Related to Sustained Gluten Antigen Presentation Nature Immunology. Oct, 2009 | Pubmed ID: 19718029 Rationally Engineered Total Biosynthesis of a Synthetic Analogue of a Natural Quinomycin Depsipeptide in Escherichia Coli Chembiochem : a European Journal of Chemical Biology. Aug, 2009 | Pubmed ID: 19588480 Escherichia Coli Allows Efficient Modular Incorporation of Newly Isolated Quinomycin Biosynthetic Enzyme into Echinomycin Biosynthetic Pathway for Rational Design and Synthesis of Potent Antibiotic Unnatural Natural Product Journal of the American Chemical Society. Jul, 2009 | Pubmed ID: 19514719 Chapter 15. Plasmid-borne Gene Cluster Assemblage and Heterologous Biosynthesis of Nonribosomal Peptides in Escherichia Coli Methods in Enzymology. 2009 | Pubmed ID: 19374991 Complete Sequence of Biosynthetic Gene Cluster Responsible for Producing Triostin A and Evaluation of Quinomycin-type Antibiotics from Streptomyces Triostinicus Biotechnology Progress. Nov-Dec, 2008 | Pubmed ID: 19194935 The Missing Link in Petrobactin Biosynthesis: AsbF Encodes a (-)-3-dehydroshikimate Dehydratase Biochemistry. Nov, 2008 | Pubmed ID: 18975921 Biosynthesis of the 3,4-dihydroxybenzoate Moieties of Petrobactin by Bacillus Anthracis The Journal of Organic Chemistry. Aug, 2008 | Pubmed ID: 18582113 Total Biosynthesis of Antitumor Nonribosomal Peptides in Escherichia Coli Nature Chemical Biology. Aug, 2006 | Pubmed ID: 16799553 Nonspecific Medium Effects Versus Specific Group Positioning in the Antibody and Albumin Catalysis of the Base-promoted Ring-opening Reactions of Benzisoxazoles Journal of the American Chemical Society. Jul, 2004 | Pubmed ID: 15225061 Precursor-directed Biosynthesis of Epothilone in Escherichia Coli Journal of the American Chemical Society. Jun, 2004 | Pubmed ID: 15198579 Epothilone C Macrolactonization and Hydrolysis Are Catalyzed by the Isolated Thioesterase Domain of Epothilone Polyketide Synthase Journal of the American Chemical Society. Mar, 2003 | Pubmed ID: 12643694 Catalysis on the Coastline: Theozyme, Molecular Dynamics, and Free Energy Perturbation Analysis of Antibody 21D8 Catalysis of the Decarboxylation of 5-nitro-3-carboxybenzisoxazole Journal of Computational Chemistry. Jan, 2003 | Pubmed ID: 12483679 Probing Ligand Recognition in the Decarboxylase Antibody 21D8: Implications for the Catalytic Mechanism Biochemistry. Jan, 2002 | Pubmed ID: 11790098 Inducible T7 RNA Polymerase-mediated Multigene Expression System, pMGX Mohamed I. Hassan*1, Fern R. McSorley*1, Kinya Hotta2, Christopher N. Boddy1 1Department of Chemistry and Biomolecular Sciences, University of Ottawa, 2School of Biosciences, The University of Nottingham Malaysia Campus JoVE 55187 Genetics
Inducible T7 RNA Polymerase-mediated Multigene Expression System, pMGX Mohamed I. Hassan*1, Fern R. McSorley*1, Kinya Hotta2, Christopher N. Boddy1 1Department of Chemistry and Biomolecular Sciences, University of Ottawa, 2School of Biosciences, The University of Nottingham Malaysia Campus JoVE 55187 Genetics
