Koji Okamoto Devision of Cancer Differentiation National Cancer Center Research Institute Biography Publications Institution JoVE Articles Koji Okamoto has not added a biography. If you are Koji Okamoto and would like to personalize this page please email our Author Liaison for assistance. Publications Slow-Cycling Cancer Stem Cells Regulate Progression and Chemoresistance in Colon Cancer Cancer Research. Oct, 2020 | Pubmed ID: 32816913 ALDH-Dependent Glycolytic Activation Mediates Stemness and Paclitaxel Resistance in Patient-Derived Spheroid Models of Uterine Endometrial Cancer Stem Cell Reports. 10, 2019 | Pubmed ID: 31564647 N822K- or V560G-mutated KIT Activation Preferentially Occurs in Lipid Rafts of the Golgi Apparatus in Leukemia Cells Cell Communication and Signaling : CCS. 09, 2019 | Pubmed ID: 31484543 NOX1-Dependent MTORC1 Activation Via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression Cell Reports. 07, 2019 | Pubmed ID: 31365870 Hormonal Regulation of Patient-Derived Endometrial Cancer Stem-like Cells Generated by Three-Dimensional Culture Endocrinology. 08, 2019 | Pubmed ID: 31265065 Semaphorin Signaling Via MICAL3 Induces Symmetric Cell Division to Expand Breast Cancer Stem-like Cells Proceedings of the National Academy of Sciences of the United States of America. 01, 2019 | Pubmed ID: 30587593 Proteasome 26S Subunit PSMD1 Regulates Breast Cancer Cell Growth Through P53 Protein Degradation Journal of Biochemistry. Jan, 2018 | Pubmed ID: 28992264 Heterogeneity Among -positive Colon Stem Cells Molecular & Cellular Oncology. 2017 | Pubmed ID: 28868346 The Induction of Selected Wnt Target Genes by Tcf1 Mediates Generation of Tumorigenic Colon Stem Cells Cell Reports. 05, 2017 | Pubmed ID: 28467911 Sox2-dependent Inhibition of P21 is Associated with Poor Prognosis of Endometrial Cancer Cancer Science. Apr, 2017 | Pubmed ID: 28188685 Investigations in the Possibility of Early Detection of Colorectal Cancer by Gas Chromatography/triple-quadrupole Mass Spectrometry Oncotarget. Mar, 2017 | Pubmed ID: 28179577 Tumor-derived Spheroids: Relevance to Cancer Stem Cells and Clinical Applications Cancer Science. Mar, 2017 | Pubmed ID: 28064442 Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype PloS One. 2016 | Pubmed ID: 27902773 TNIK Inhibition Abrogates Colorectal Cancer Stemness Nature Communications. 08, 2016 | Pubmed ID: 27562646 Establishment and Characterization of an In Vitro Model of Ovarian Cancer Stem-like Cells with an Enhanced Proliferative Capacity Cancer Research. Jan, 2016 | Pubmed ID: 26669863 MicroRNA Library-Based Functional Screening Identified Androgen-Sensitive MiR-216a As a Player in Bicalutamide Resistance in Prostate Cancer Journal of Clinical Medicine. Oct, 2015 | Pubmed ID: 26506397 Short Hairpin RNA Library-based Functional Screening Identified Ribosomal Protein L31 That Modulates Prostate Cancer Cell Growth Via P53 Pathway PloS One. 2014 | Pubmed ID: 25285958 Senescence-inducing Stress Promotes Proteolysis of Phosphoglycerate Mutase Via Ubiquitin Ligase Mdm2 The Journal of Cell Biology. Mar, 2014 | Pubmed ID: 24567357 MKK7 Mediates MiR-493-dependent Suppression of Liver Metastasis of Colon Cancer Cells Cancer Science. Apr, 2014 | Pubmed ID: 24533778 Genome Engineering of Mammalian Haploid Embryonic Stem Cells Using the Cas9/RNA System PeerJ. Dec, 2013 | Pubmed ID: 24432195 Induction of the Stem-like Cell Regulator CD44 by Rho Kinase Inhibition Contributes to the Maintenance of Colon Cancer-initiating Cells Cancer Research. Oct, 2012 | Pubmed ID: 23002207 MiR-493 Induction During Carcinogenesis Blocks Metastatic Settlement of Colon Cancer Cells in Liver The EMBO Journal. Apr, 2012 | Pubmed ID: 22373578 Differential Expression of Nanog1 and Nanogp8 in Colon Cancer Cells Biochemical and Biophysical Research Communications. Feb, 2012 | Pubmed ID: 22079639 Systematic Exploration of Cancer-associated MicroRNA Through Functional Screening Assays Cancer Science. Sep, 2011 | Pubmed ID: 21668585 Tumor Suppressor MiR-22 Determines P53-dependent Cellular Fate Through Post-transcriptional Regulation of P21 Cancer Research. Jul, 2011 | Pubmed ID: 21565979 Cancer Susceptibility Polymorphism of P53 at Codon 72 Affects Phosphorylation and Degradation of P53 Protein The Journal of Biological Chemistry. May, 2011 | Pubmed ID: 21454683 Functional Screening Using a MicroRNA Virus Library and Microarrays: a New High-throughput Assay to Identify Tumor-suppressive MicroRNAs Carcinogenesis. Aug, 2010 | Pubmed ID: 20525881 Mdmx Enhances P53 Ubiquitination by Altering the Substrate Preference of the Mdm2 Ubiquitin Ligase FEBS Letters. Sep, 2009 | Pubmed ID: 19619542 Cytoplasmic Tethering is Involved in Synergistic Inhibition of P53 by Mdmx and Mdm2 Cancer Science. Jul, 2009 | Pubmed ID: 19432880 Hedgehog Signaling Overrides P53-mediated Tumor Suppression by Activating Mdm2 Proceedings of the National Academy of Sciences of the United States of America. Mar, 2008 | Pubmed ID: 18359851 KAP1 Dictates P53 Response Induced by Chemotherapeutic Agents Via Mdm2 Interaction Biochemical and Biophysical Research Communications. Dec, 2006 | Pubmed ID: 17056014 Differential Roles of ATM- and Chk2-mediated Phosphorylations of Hdmx in Response to DNA Damage Molecular and Cellular Biology. Sep, 2006 | Pubmed ID: 16943424 DNA Damage-induced Phosphorylation of MdmX at Serine 367 Activates P53 by Targeting MdmX for Mdm2-dependent Degradation Molecular and Cellular Biology. Nov, 2005 | Pubmed ID: 16227609 Functional Role of Mdm2 Phosphorylation by ATR in Attenuation of P53 Nuclear Export Oncogene. Dec, 2003 | Pubmed ID: 14654783 Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1 Yuko Miyagawa1, Kazunori Nagasaka1, Kaoru Yamawaki2,3, Yutaro Mori2,3, Tatsuya Ishiguro2, Kei Hashimoto1, Ryoko Koike1, Siho Fukui1, Takeru Sugihara1, Takayuki Ichinose1, Haruko Hiraike1, Koichiro Kido1, Koji Okamoto3, Takayuki Enomoto2, Takuya Ayabe1 1Department of Obstetrics and Gynecology, Teikyo University School of Medicine, 2Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, 3Devision of Cancer Differentiation, National Cancer Center Research Institute JoVE 61751 Biology
Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1 Yuko Miyagawa1, Kazunori Nagasaka1, Kaoru Yamawaki2,3, Yutaro Mori2,3, Tatsuya Ishiguro2, Kei Hashimoto1, Ryoko Koike1, Siho Fukui1, Takeru Sugihara1, Takayuki Ichinose1, Haruko Hiraike1, Koichiro Kido1, Koji Okamoto3, Takayuki Enomoto2, Takuya Ayabe1 1Department of Obstetrics and Gynecology, Teikyo University School of Medicine, 2Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, 3Devision of Cancer Differentiation, National Cancer Center Research Institute JoVE 61751 Biology
