Kostas Pantopoulos Lady Davis Institute for Medical Research Jewish General Hospital Biography Publications Institution JoVE Articles Kostas Pantopoulos has not added a biography. If you are Kostas Pantopoulos and would like to personalize this page please email our Author Liaison for assistance. Publications NTBI Unveiled by Chelatable Fluorescent Beads The Biochemical Journal. Nov, 2014 | Pubmed ID: 25301074 Chronic Hepatitis C and Liver Fibrosis World Journal of Gastroenterology : WJG. Aug, 2014 | Pubmed ID: 25170193 The IRP/IRE System in Vivo: Insights from Mouse Models Frontiers in Pharmacology. 2014 | Pubmed ID: 25120486 Iron-dependent Regulation of Hepcidin in Hjv-/- Mice: Evidence That Hemojuvelin is Dispensable for Sensing Body Iron Levels PloS One. 2014 | Pubmed ID: 24409331 Hepatitis C Virus Infection Causes Iron Deficiency in Huh7.5.1 Cells PloS One. 2013 | Pubmed ID: 24349485 IRP1 Regulates Erythropoiesis and Systemic Iron Homeostasis by Controlling HIF2α MRNA Translation Blood. Aug, 2013 | Pubmed ID: 23777768 Oxygen-dependent Secretion of a Bioactive Hepcidin-GFP Chimera Biochemical and Biophysical Research Communications. Jun, 2013 | Pubmed ID: 23665013 Differences in Activation of Mouse Hepcidin by Dietary Iron and Parenterally Administered Iron Dextran: Compartmentalization is Critical for Iron Sensing Journal of Molecular Medicine (Berlin, Germany). Jan, 2013 | Pubmed ID: 22847740 Unregulated Brain Iron Deposition in Transgenic Mice Over-expressing HMOX1 in the Astrocytic Compartment Journal of Neurochemistry. Oct, 2012 | Pubmed ID: 22881289 Mechanisms of Mammalian Iron Homeostasis Biochemistry. Jul, 2012 | Pubmed ID: 22703180 Alternative Ferritin MRNA Translation Via Internal Initiation RNA (New York, N.Y.). Mar, 2012 | Pubmed ID: 22271759 Regulation of Iron Transport and the Role of Transferrin Biochimica Et Biophysica Acta. Mar, 2012 | Pubmed ID: 22085723 Synthesis of Biocompatible Poly(ɛ-caprolactone)- Block-poly(propylene Adipate) Copolymers Appropriate for Drug Nanoencapsulation in the Form of Core-shell Nanoparticles International Journal of Nanomedicine. 2011 | Pubmed ID: 22162656 Accelerated CCl4-induced Liver Fibrosis in Hjv-/- Mice, Associated with an Oxidative Burst and Precocious Profibrogenic Gene Expression PloS One. 2011 | Pubmed ID: 21966437 Disorders Associated with Systemic or Local Iron Overload: from Pathophysiology to Clinical Practice Metallomics : Integrated Biometal Science. Oct, 2011 | Pubmed ID: 21901209 Conditional Disruption of Mouse HFE2 Gene: Maintenance of Systemic Iron Homeostasis Requires Hepatic but Not Skeletal Muscle Hemojuvelin Hepatology (Baltimore, Md.). Nov, 2011 | Pubmed ID: 21748766 Regulation of Cellular Iron Metabolism The Biochemical Journal. Mar, 2011 | Pubmed ID: 21348856 Redox Control of Iron Regulatory Protein 2 Stability FEBS Letters. Feb, 2011 | Pubmed ID: 21281640 EIF2{alpha} Kinase PKR Modulates the Hypoxic Response by Stat3-dependent Transcriptional Suppression of HIF-1{alpha} Cancer Research. Oct, 2010 | Pubmed ID: 20924113 Iron Inhibits Replication of Infectious Hepatitis C Virus in Permissive Huh7.5.1 Cells Journal of Hepatology. Dec, 2010 | Pubmed ID: 20813419 Tumorigenic Properties of Iron Regulatory Protein 2 (IRP2) Mediated by Its Specific 73-amino Acids Insert PloS One. 2010 | Pubmed ID: 20405006 Iron Absorption and Distribution in TNF(DeltaARE/+) Mice, a Model of Chronic Inflammation Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS). Jan, 2010 | Pubmed ID: 20122582 HO-1-mediated Macroautophagy: a Mechanism for Unregulated Iron Deposition in Aging and Degenerating Neural Tissues Journal of Neurochemistry. May, 2009 | Pubmed ID: 19250338 Small-molecule Inhibitors of HIF-2a Translation Link Its 5'UTR Iron-responsive Element to Oxygen Sensing Molecular Cell. Dec, 2008 | Pubmed ID: 19111663 Function of the Hemochromatosis Protein HFE: Lessons from Animal Models World Journal of Gastroenterology : WJG. Dec, 2008 | Pubmed ID: 19058322 A Role for Lysosomes in the Turnover of Human Iron Regulatory Protein 2 The International Journal of Biochemistry & Cell Biology. 2008 | Pubmed ID: 18582596 Iron Regulatory and Bactericidal Properties of Human Recombinant Hepcidin Expressed in Pichia Pastoris Biochimie. May, 2008 | Pubmed ID: 18295606 Oxidative Stress and Iron Homeostasis: Mechanistic and Health Aspects Critical Reviews in Clinical Laboratory Sciences. 2008 | Pubmed ID: 18293179 Insights on Regulation and Function of the Iron Regulatory Protein 1 (IRP1) Hemoglobin. 2008 | Pubmed ID: 18274988 Iron-dependent Degradation of IRP2 Requires Its C-terminal Region and IRP Structural Integrity BMC Molecular Biology. 2008 | Pubmed ID: 18226225 Human Iron Regulatory Protein 2 is Easily Cleaved in Its Specific Domain: Consequences for the Haem Binding Properties of the Protein The Biochemical Journal. Dec, 2007 | Pubmed ID: 17760563 Sustained Hydrogen Peroxide Induces Iron Uptake by Transferrin Receptor-1 Independent of the Iron Regulatory Protein/iron-responsive Element Network The Journal of Biological Chemistry. Jul, 2007 | Pubmed ID: 17517884 Expression of the Subgenomic Hepatitis C Virus Replicon Alters Iron Homeostasis in Huh7 Cells Journal of Hepatology. Jul, 2007 | Pubmed ID: 17399844 Iron-dependent Degradation of Apo-IRP1 by the Ubiquitin-proteasome Pathway Molecular and Cellular Biology. Apr, 2007 | Pubmed ID: 17242182 Overexpression of Iron Regulatory Protein 1 Suppresses Growth of Tumor Xenografts Carcinogenesis. Apr, 2007 | Pubmed ID: 17127713 In Vivo Tumor Growth is Inhibited by Cytosolic Iron Deprivation Caused by the Expression of Mitochondrial Ferritin Blood. Oct, 2006 | Pubmed ID: 16757684 Alcohol Metabolism-mediated Oxidative Stress Down-regulates Hepcidin Transcription and Leads to Increased Duodenal Iron Transporter Expression The Journal of Biological Chemistry. Aug, 2006 | Pubmed ID: 16737972 Sodium Nitroprusside Promotes IRP2 Degradation Via an Increase in Intracellular Iron and in the Absence of S Nitrosylation at C178 Molecular and Cellular Biology. Mar, 2006 | Pubmed ID: 16479012 Hepcidin Generated by Hepatoma Cells Inhibits Iron Export from Co-cultured THP1 Monocytes Journal of Hepatology. Jun, 2006 | Pubmed ID: 16460831 Inhibition of Transferrin Receptor 1 Transcription by a Cell Density Response Element The Biochemical Journal. Dec, 2005 | Pubmed ID: 16092918 The Pathway for IRP2 Degradation Involving 2-oxoglutarate-dependent Oxygenase(s) Does Not Require the E3 Ubiquitin Ligase Activity of PVHL Biochimica Et Biophysica Acta. Mar, 2005 | Pubmed ID: 15777842 Nitric Oxide Inhibits the Degradation of IRP2 Molecular and Cellular Biology. Feb, 2005 | Pubmed ID: 15684386 Iron Inactivates the RNA Polymerase NS5B and Suppresses Subgenomic Replication of Hepatitis C Virus The Journal of Biological Chemistry. Mar, 2005 | Pubmed ID: 15637067 IRP1 Ser-711 is a Phosphorylation Site, Critical for Regulation of RNA-binding and Aconitase Activities The Biochemical Journal. May, 2005 | Pubmed ID: 15636585 Oxidation-induced Ferritin Turnover in Microglial Cells: Role of Proteasome Free Radical Biology & Medicine. Jan, 2005 | Pubmed ID: 15607911 Iron Metabolism and the IRE/IRP Regulatory System: an Update Annals of the New York Academy of Sciences. Mar, 2004 | Pubmed ID: 15105251 ANP-induced Decrease of Iron Regulatory Protein Activity is Independent of HO-1 Induction American Journal of Physiology. Gastrointestinal and Liver Physiology. Sep, 2004 | Pubmed ID: 15087280 Iron-mediated Degradation of IRP2, an Unexpected Pathway Involving a 2-oxoglutarate-dependent Oxygenase Activity Molecular and Cellular Biology. Feb, 2004 | Pubmed ID: 14729944 A Phosphomimetic Mutation at Ser-138 Renders Iron Regulatory Protein 1 Sensitive to Iron-dependent Degradation Molecular and Cellular Biology. Oct, 2003 | Pubmed ID: 12972614 Myeloperoxidase-derived Hypochlorous Acid Antagonizes the Oxidative Stress-mediated Activation of Iron Regulatory Protein 1 The Journal of Biological Chemistry. Oct, 2003 | Pubmed ID: 12888561 The Haemochromatosis Protein HFE Induces an Apparent Iron-deficient Phenotype in H1299 Cells That is Not Corrected by Co-expression of Beta 2-microglobulin The Biochemical Journal. Mar, 2003 | Pubmed ID: 12464008 The Prolyl 4-hydroxylase Inhibitor Ethyl-3,4-dihydroxybenzoate Generates Effective Iron Deficiency in Cultured Cells FEBS Letters. Oct, 2002 | Pubmed ID: 12372619 Conditional Derepression of Ferritin Synthesis in Cells Expressing a Constitutive IRP1 Mutant Molecular and Cellular Biology. Jul, 2002 | Pubmed ID: 12052872 Redox Control of Iron Regulatory Proteins Redox Report : Communications in Free Radical Research. 2002 | Pubmed ID: 11981450 Activation of Iron Regulatory Protein-1 by Oxidative Stress Methods in Enzymology. 2002 | Pubmed ID: 11885287 Electrophoretic Mobility Shift Assay (EMSA) for the Study of RNA-Protein Interactions: The IRE/IRP Example Carine Fillebeen1,2, Nicole Wilkinson1,2, Kostas Pantopoulos1,2 1Lady Davis Institute for Medical Research, Jewish General Hospital, 2Department of Medicine, McGill University JoVE 52230 Biology
Electrophoretic Mobility Shift Assay (EMSA) for the Study of RNA-Protein Interactions: The IRE/IRP Example Carine Fillebeen1,2, Nicole Wilkinson1,2, Kostas Pantopoulos1,2 1Lady Davis Institute for Medical Research, Jewish General Hospital, 2Department of Medicine, McGill University JoVE 52230 Biology