Kwok-Fai Lau

Publications

• CAG RNAs Induce DNA Damage and Apoptosis by Silencing Expression in Polyglutamine Degeneration
  Proceedings of the National Academy of Sciences of the United States of America. May, 2021  |   Pubmed ID: 33947817
• ARF6-Rac1 Signaling-mediated Neurite Outgrowth is Potentiated by the Neuronal Adaptor FE65 Through Orchestrating ARF6 and ELMO1
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 12, 2020  |   Pubmed ID: 33047393
• Micro-RNA Clusters Integrate Evolutionary Constraints on Expression and Target Affinities: The MiR-6/5/4/286/3/309 Cluster in Drosophila
  Molecular Biology and Evolution. 10, 2020  |   Pubmed ID: 32521021
• The Roles of Atypical Protein Kinase Cs (aPKCs) in the Nervous System: Targets for Neuroregeneration?
  Neural Regeneration Research. Aug, 2020  |   Pubmed ID: 31997808
• Proximity Ligation Assay for the Investigation of the Intramolecular Interaction of ELMO1
  Bio-protocol. Dec, 2019  |   Pubmed ID: 33654944
• Attenuation of Amyloid-β Generation by Atypical Protein Kinase C-mediated Phosphorylation of Engulfment Adaptor PTB Domain Containing 1 Threonine 35
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 11, 2019  |   Pubmed ID: 31373844
• A Peptidylic Inhibitor for Neutralizing (GGGGCC)-Associated Neurodegeneration in C9ALS-FTD
  Molecular Therapy. Nucleic Acids. Jun, 2019  |   Pubmed ID: 30889483
• Familial Ataxia, Tremor, and Dementia in a Polish Family with a Novel Mutation in the CCDC88C Gene
  Movement Disorders : Official Journal of the Movement Disorder Society. 01, 2019  |   Pubmed ID: 30398676
• Proteolytic Cleavage of Amyloid Precursor Protein by ADAM10 Mediates Proliferation and Migration in Breast Cancer
  EBioMedicine. Dec, 2018  |   Pubmed ID: 30470613
• Exo70 Is Essential for Neurite Extension and Survival Under Thermal Stress
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 09, 2018  |   Pubmed ID: 30209205
• Amyloid Precursor Protein Is Associated with Aggressive Behavior in Nonluminal Breast Cancers
  The Oncologist. 11, 2018  |   Pubmed ID: 30108157
• Planar Cell Polarity Gene Triggers Apoptosis in Neurodegenerative Disease Models
  EMBO Reports. 09, 2018  |   Pubmed ID: 30026307
• Three SpoA-domain Proteins Interact in the Creation of the Flagellar Type III Secretion System in
  The Journal of Biological Chemistry. 09, 2018  |   Pubmed ID: 29991595
• Neuronal Adaptor FE65 Stimulates Rac1-mediated Neurite Outgrowth by Recruiting and Activating ELMO1
  The Journal of Biological Chemistry. 05, 2018  |   Pubmed ID: 29615491
• A Peptidylic Inhibitor for Neutralizing Expanded RNA-induced Nucleolar Stress in Polyglutamine Diseases
  RNA (New York, N.Y.). 04, 2018  |   Pubmed ID: 29295891
• GULP1/CED-6 Ameliorates Amyloid-β Toxicity in a Drosophila Model of Alzheimer's Disease
  Oncotarget. Nov, 2017  |   Pubmed ID: 29245900
• Phosphorylation of FE65 at Threonine 579 by GSK3β Stimulates Amyloid Precursor Protein Processing
  Scientific Reports. 09, 2017  |   Pubmed ID: 28963516
• The Lysosomal Protein Cathepsin L is a Progranulin Protease
  Molecular Neurodegeneration. 07, 2017  |   Pubmed ID: 28743268
• Nucleophosmin Interacts with PIN2/TERF1-interacting Telomerase Inhibitor 1 (PinX1) and Attenuates the PinX1 Inhibition on Telomerase Activity
  Scientific Reports. 03, 2017  |   Pubmed ID: 28255170
• Assessing a Peptidylic Inhibitor-based Therapeutic Approach That Simultaneously Suppresses Polyglutamine RNA- and Protein-mediated Toxicities in Patient Cells and Drosophila
  Disease Models & Mechanisms. Mar, 2016  |   Pubmed ID: 26839389
• Phosphorylation of FE65 Ser610 by Serum- and Glucocorticoid-induced Kinase 1 Modulates Alzheimer's Disease Amyloid Precursor Protein Processing
  The Biochemical Journal. Sep, 2015  |   Pubmed ID: 26188042
• The SARS-coronavirus Membrane Protein Induces Apoptosis Via Interfering with PDK1-PKB/Akt Signalling
  The Biochemical Journal. Dec, 2014  |   Pubmed ID: 25271362
• A Novel Missense Mutation in CCDC88C Activates the JNK Pathway and Causes a Dominant Form of Spinocerebellar Ataxia
  Journal of Medical Genetics. Sep, 2014  |   Pubmed ID: 25062847
• FE65 Interacts with ADP-ribosylation Factor 6 to Promote Neurite Outgrowth
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jan, 2014  |   Pubmed ID: 24056087
• CAG Expansion Induces Nucleolar Stress in Polyglutamine Diseases
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2012  |   Pubmed ID: 22847428
• Influenza Polymerase Activity Correlates with the Strength of Interaction Between Nucleoprotein and PB2 Through the Host-specific Residue K/E627
  PloS One. 2012  |   Pubmed ID: 22570712
• DNA Microarray Expression Analysis of Baicalin-induced Differentiation of C17.2 Neural Stem Cells
  Chembiochem : a European Journal of Chemical Biology. Jun, 2012  |   Pubmed ID: 22556041
• Degradation of Mutant Huntingtin Via the Ubiquitin/proteasome System is Modulated by FE65
  The Biochemical Journal. May, 2012  |   Pubmed ID: 22352297
• Promoter Characterization and Genomic Organization of the Human X11β Gene APBA2
  Neuroreport. Feb, 2012  |   Pubmed ID: 22222501
• Genomic Organization and Promoter Cloning of the Human X11α Gene APBA1
  DNA and Cell Biology. May, 2012  |   Pubmed ID: 22136355
• VAPB Interacts with the Mitochondrial Protein PTPIP51 to Regulate Calcium Homeostasis
  Human Molecular Genetics. Mar, 2012  |   Pubmed ID: 22131369
• Lemur Tyrosine Kinase-2 Signalling Regulates Kinesin-1 Light Chain-2 Phosphorylation and Binding of Smad2 Cargo
  Oncogene. May, 2012  |   Pubmed ID: 21996745
• Perturbation of U2AF65/NXF1-mediated RNA Nuclear Export Enhances RNA Toxicity in PolyQ Diseases
  Human Molecular Genetics. Oct, 2011  |   Pubmed ID: 21725067
• GULP1 is a Novel APP-interacting Protein That Alters APP Processing
  The Biochemical Journal. Jun, 2011  |   Pubmed ID: 21486224
• Expanded Polyglutamine Domain Possesses Nuclear Export Activity Which Modulates Subcellular Localization and Toxicity of PolyQ Disease Protein Via Exportin-1
  Human Molecular Genetics. May, 2011  |   Pubmed ID: 21300695
• Neuronal Differentiation of C17.2 Neural Stem Cells Induced by a Natural Flavonoid, Baicalin
  Chembiochem : a European Journal of Chemical Biology. Feb, 2011  |   Pubmed ID: 21290546
• An X11alpha/FSBP Complex Represses Transcription of the GSK3beta Gene Promoter
  Neuroreport. Aug, 2010  |   Pubmed ID: 20531236
• Expression of the Neuronal Adaptor Protein X11alpha Protects Against Memory Dysfunction in a Transgenic Mouse Model of Alzheimer's Disease
  Journal of Alzheimer's Disease : JAD. 2010  |   Pubmed ID: 20378958
• Transcriptional Regulation of Human FE65, a Ligand of Alzheimer's Disease Amyloid Precursor Protein, by Sp1
  Journal of Cellular Biochemistry. Mar, 2010  |   Pubmed ID: 20091743
• Cryptotanshinone, an Acetylcholinesterase Inhibitor from Salvia Miltiorrhiza, Ameliorates Scopolamine-induced Amnesia in Morris Water Maze Task
  Planta Medica. Feb, 2010  |   Pubmed ID: 19774505
• X11beta Rescues Memory and Long-term Potentiation Deficits in Alzheimer's Disease APPswe Tg2576 Mice
  Human Molecular Genetics. Dec, 2009  |   Pubmed ID: 19744962
• Dexras1 Interacts with FE65 to Regulate FE65-amyloid Precursor Protein-dependent Transcription
  The Journal of Biological Chemistry. Dec, 2008  |   Pubmed ID: 18922798
• Familial Amyotrophic Lateral Sclerosis-linked SOD1 Mutants Perturb Fast Axonal Transport to Reduce Axonal Mitochondria Content
  Human Molecular Genetics. Nov, 2007  |   Pubmed ID: 17725983
• Glycogen Synthase Kinase-3 Beta-mediated Tau Phosphorylation in Cultured Cell Lines
  Neuroreport. Feb, 2003  |   Pubmed ID: 12598741