Lan Kluwe Department of Maxillofacial Surgery University Medical Center Hamburg-Eppendorf Biography Publications Institution JoVE Articles Lan Kluwe has not added a biography. If you are Lan Kluwe and would like to personalize this page please email our Author Liaison for assistance. Publications A Novel Genetic- and Cell-based Tool for Assessing the Efficacy and Toxicity of Anticancer Drugs in Vitro Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. Nov, 2015 | Pubmed ID: 26558359 Postoperative Bleeding Risk for Oral Surgery Under Continued Rivaroxaban Anticoagulant Therapy Clinical Oral Investigations. Oct, 2015 | Pubmed ID: 26498769 Increased Postoperative Bleeding Risk Among Patients with Local Flap Surgery Under Continued Clopidogrel Therapy BioMed Research International. 2015 | Pubmed ID: 26345612 Optimized in Vitro Procedure for Assessing the Cytocompatibility of Magnesium-based Biomaterials Acta Biomaterialia. Sep, 2015 | Pubmed ID: 26073090 Quantitative Associations of Scalp and Body Subcutaneous Neurofibromas with Internal Plexiform Tumors in Neurofibromatosis 1 American Journal of Medical Genetics. Part A. Jul, 2015 | Pubmed ID: 25900062 Preclinical Assessment of the Anticancer Drug Response of Plexiform Neurofibroma Tissue Using Primary Cultures Journal of Clinical Neurology (Seoul, Korea). Apr, 2015 | Pubmed ID: 25851896 Is Immediate Bony Microsurgical Reconstruction After Head and Neck Tumor Ablation Associated with a Higher Rate of Local Recurrence? Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery. Apr, 2015 | Pubmed ID: 25701393 Postoperative Bleeding Risk for Oral Surgery Under Continued Clopidogrel Antiplatelet Therapy BioMed Research International. 2015 | Pubmed ID: 25632402 Efficacy and Side-effects of a Semi-individualized Chinese Herb Mixture "Tiáo Gēng Tāng" for Menopausal Syndrome in China In Vivo (Athens, Greece). Jan-Feb, 2015 | Pubmed ID: 25600538 Lack of Evidence for Increased Postoperative Bleeding Risk for Dental Osteotomy with Continued Aspirin Therapy Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. Jan, 2015 | Pubmed ID: 25442244 Nilotinib is More Potent Than Imatinib for Treating Plexiform Neurofibroma in Vitro and in Vivo PloS One. 2014 | Pubmed ID: 25340526 Lack of Evidence for Increased Risk of Postoperative Bleeding After Cutaneous Surgery in the Head and Neck in Patients Taking Aspirin The British Journal of Oral & Maxillofacial Surgery. Jul, 2014 | Pubmed ID: 24703383 Differences of 25-hydroxyvitamin D3 Concentrations in Children and Adults with Neurofibromatosis Type 1 Clinical Biochemistry. May, 2014 | Pubmed ID: 24613576 Fractal Dimension of Time-resolved Autofluorescence Discriminates Tumour from Healthy Tissues in the Oral Cavity Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery. Sep, 2014 | Pubmed ID: 24444757 Lack of Evidence for Predictive and Prognostic Value of Cyclin D1 Gene Polymorphism CCND1 G870A for Oral Squamous Cell Carcinoma Anticancer Research. Jan, 2014 | Pubmed ID: 24403468 Prognostic Relevance of Circulating Tumor Cells in Blood and Disseminated Tumor Cells in Bone Marrow of Patients with Squamous Cell Carcinoma of the Oral Cavity Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2014 | Pubmed ID: 24218516 Efficacy and Selectivity of Nilotinib on NF1-associated Tumors in Vitro Journal of Neuro-oncology. Jan, 2014 | Pubmed ID: 24173684 Postoperative Bleeding Risk for Cutaneous Surgery in the Head and Neck Region with Continued Phenprocoumon Therapy Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery. Jul, 2014 | Pubmed ID: 24103463 Immunohistochemical and FISH Analysis of EGFR and Its Prognostic Value in Patients with Oral Squamous Cell Carcinoma Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. Mar, 2014 | Pubmed ID: 24020871 P53 Immunohistochemical Expression Does Not Correlate with Clinical Features in 207 Carcinomas of the Oral Cavity and in the Head and Neck Region Clinical Oral Investigations. Jan, 2014 | Pubmed ID: 23404560 B-scan Ultrasonographic Monitoring of Orthotopic Xenografted Plexiform Neurofibroma in Mice In Vivo (Athens, Greece). Nov-Dec, 2013 | Pubmed ID: 24292574 Immunohistochemical Analysis of P16 Expression, HPV Infection and Its Prognostic Utility in Oral Squamous Cell Carcinoma Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. Oct, 2013 | Pubmed ID: 23721566 Serum Biomarkers for Neurofibromatosis Type 1 and Early Detection of Malignant Peripheral Nerve-sheath Tumors BMC Medicine. 2013 | Pubmed ID: 23618374 Amplification of the PPFIA1 Gene Region on 11q13 in Oral Squamous Cell Carcinomas (OSCC) Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery. Dec, 2013 | Pubmed ID: 23453270 Sensitivity of Malignant Peripheral Nerve Sheath Tumor Cells to TRAIL is Augmented by Loss of NF1 Through Modulation of MYC/MAD and is Potentiated by Curcumin Through Induction of ROS PloS One. 2013 | Pubmed ID: 23437333 Genomic Imbalance of HMMR/RHAMM Regulates the Sensitivity and Response of Malignant Peripheral Nerve Sheath Tumour Cells to Aurora Kinase Inhibition Oncotarget. Jan, 2013 | Pubmed ID: 23328114 Efficacy and Side Effects of Chinese Herbal Medicine for Menopausal Symptoms: a Critical Review Evidence-based Complementary and Alternative Medicine : ECAM. 2012 | Pubmed ID: 23365599 Non-coding RNA ANRIL and the Number of Plexiform Neurofibromas in Patients with NF1 Microdeletions BMC Medical Genetics. 2012 | Pubmed ID: 23101500 Growth Dynamics of Plexiform Neurofibromas: a Retrospective Cohort Study of 201 Patients with Neurofibromatosis 1 Orphanet Journal of Rare Diseases. 2012 | Pubmed ID: 23035791 Dissecting the Clinical Phenotype Associated with Mosaic Type-2 NF1 Microdeletions Neurogenetics. Aug, 2012 | Pubmed ID: 22581253 Clinical Presentation, Immunohistochemistry and Electron Microscopy Indicate Neurofibromatosis Type 2-associated Gliomas to Be Spinal Ependymomas Neuropathology : Official Journal of the Japanese Society of Neuropathology. Dec, 2012 | Pubmed ID: 22394059 Ferritin Light Chain and Squamous Cell Carcinoma Antigen 1 Are Coreceptors for Cellular Attachment and Entry of Hepatitis B Virus International Journal of Nanomedicine. 2012 | Pubmed ID: 22359459 Internal Tumor Burden in Neurofibromatosis Type I Patients with Large NF1 Deletions Genes, Chromosomes & Cancer. May, 2012 | Pubmed ID: 22294457 Allelic Drop-out, Allele Imbalance, or Loss of Heterozygosity? Genes, Chromosomes & Cancer. May, 2012 | Pubmed ID: 22294435 Tissue-specific Differences in the Proportion of Mosaic Large NF1 Deletions Are Suggestive of a Selective Growth Advantage of Hematopoietic Del(+/-) Stem Cells Human Mutation. Mar, 2012 | Pubmed ID: 22190464 Characterization of the Nonallelic Homologous Recombination Hotspot PRS3 Associated with Type-3 NF1 Deletions Human Mutation. Feb, 2012 | Pubmed ID: 22045503 Chinese Herb Mix Tiáo-Gēng-Tāng Possesses Antiaging and Antioxidative Effects and Upregulates Expression of Estrogen Receptors Alpha and Beta in Ovariectomized Rats BMC Complementary and Alternative Medicine. 2011 | Pubmed ID: 22206438 Delineation of the Clinical Phenotype Associated with Non-mosaic Type-2 NF1 Deletions: Two Case Reports Journal of Medical Case Reports. 2011 | Pubmed ID: 22151963 Atypical Neurofibromas in Neurofibromatosis Type 1 Are Premalignant Tumors Genes, Chromosomes & Cancer. Dec, 2011 | Pubmed ID: 21987445 MIA is a Potential Biomarker for Tumour Load in Neurofibromatosis Type 1 BMC Medicine. 2011 | Pubmed ID: 21726432 Cancer Stem Cell-like Cells Derived from Malignant Peripheral Nerve Sheath Tumors PloS One. 2011 | Pubmed ID: 21695156 Plexiform Neurofibromas in Children with Neurofibromatosis Type 1: Frequency and Associated Clinical Deficits The Journal of Pediatrics. Oct, 2011 | Pubmed ID: 21621223 Monozygotic Twins Discordant for Neurofibromatosis Type 1 Due to a Postzygotic NF1 Gene Mutation Human Mutation. Jun, 2011 | Pubmed ID: 21618341 Effects of Splicing Mutations on NF2-transcripts: Transcript Analysis and Information Theoretic Predictions Genes, Chromosomes & Cancer. Aug, 2011 | Pubmed ID: 21563229 基因表达分析识别潜在生物标志物的神经纤维瘤病键入 1 包括肾上腺髓质素。 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2010 | Pubmed ID: 20739432 Intrachromosomal Mitotic Nonallelic Homologous Recombination is the Major Molecular Mechanism Underlying Type-2 NF1 Deletions Human Mutation. Oct, 2010 | Pubmed ID: 20725927 A Novel Third Type of Recurrent NF1 Microdeletion Mediated by Nonallelic Homologous Recombination Between LRRC37B-containing Low-copy Repeats in 17q11.2 Human Mutation. Jun, 2010 | Pubmed ID: 20506354 Analysis of NF1 Somatic Mutations in Cutaneous Neurofibromas from Patients with High Tumor Burden Neurogenetics. Oct, 2010 | Pubmed ID: 20358387 Extended Runs of Homozygosity at 17q11.2: an Association with Type-2 NF1 Deletions? Human Mutation. Mar, 2010 | Pubmed ID: 20052761 Large Intragenic Deletions of the NF2 Gene: Breakpoints and Associated Phenotypes Genes, Chromosomes & Cancer. Feb, 2010 | Pubmed ID: 19924781 Imatinib Mesylate (Glivec) Inhibits Schwann Cell Viability and Reduces the Size of Human Plexiform Neurofibroma in a Xenograft Model Journal of Neuro-oncology. May, 2010 | Pubmed ID: 19921098 Genome-wide High-resolution Analysis of DNA Copy Number Alterations in NF1-associated Malignant Peripheral Nerve Sheath Tumors Using 32K BAC Array Genes, Chromosomes & Cancer. Oct, 2009 | Pubmed ID: 19603524 Ral Overactivation in Malignant Peripheral Nerve Sheath Tumors Molecular and Cellular Biology. Jul, 2009 | Pubmed ID: 19414599 The Spectrum of Somatic and Germline NF1 Mutations in NF1 Patients with Spinal Neurofibromas Neurogenetics. Jul, 2009 | Pubmed ID: 19221814 Mechanisms of Loss of Heterozygosity in Neurofibromatosis Type 1-associated Plexiform Neurofibromas The Journal of Investigative Dermatology. Mar, 2009 | Pubmed ID: 18800150 Correlation of Nonsense and Frameshift Mutations with Severity of Retinal Abnormalities in Neurofibromatosis 2 Archives of Ophthalmology (Chicago, Ill. : 1960). Oct, 2008 | Pubmed ID: 18852415 Assessment of Benign Tumor Burden by Whole-body MRI in Patients with Neurofibromatosis 1 Neuro-oncology. Aug, 2008 | Pubmed ID: 18559970 Germline and Somatic NF1 Gene Mutations in Plexiform Neurofibromas Human Mutation. Aug, 2008 | Pubmed ID: 18484666 High-resolution DNA Copy Number Profiling of Malignant Peripheral Nerve Sheath Tumors Using Targeted Microarray-based Comparative Genomic Hybridization Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2008 | Pubmed ID: 18281533 Absence of Cutaneous Neurofibromas in an NF1 Patient with an Atypical Deletion Partially Overlapping the Common 1.4 Mb Microdeleted Region American Journal of Medical Genetics. Part A. Mar, 2008 | Pubmed ID: 18265407 Copy Number Variations in the NF1 Gene Region Are Infrequent and Do Not Predispose to Recurrent Type-1 Deletions European Journal of Human Genetics : EJHG. May, 2008 | Pubmed ID: 18212816 Telomerase Activity is a Biomarker for High Grade Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1 Individuals Genes, Chromosomes & Cancer. Mar, 2008 | Pubmed ID: 18069666 Germline and Somatic NF1 Gene Mutation Spectrum in NF1-associated Malignant Peripheral Nerve Sheath Tumors (MPNSTs) Human Mutation. Jan, 2008 | Pubmed ID: 17960768 Type 2 NF1 Deletions Are Highly Unusual by Virtue of the Absence of Nonallelic Homologous Recombination Hotspots and an Apparent Preference for Female Mitotic Recombination American Journal of Human Genetics. Dec, 2007 | Pubmed ID: 17999360 Histopathology and Clinical Outcome of NF1-associated Vs. Sporadic Malignant Peripheral Nerve Sheath Tumors Journal of Neuro-oncology. Apr, 2007 | Pubmed ID: 17111191 Conservation of Hotspots for Recombination in Low-copy Repeats Associated with the NF1 Microdeletion Nature Genetics. Dec, 2006 | Pubmed ID: 17115058 Large-scale Molecular Comparison of Human Schwann Cells to Malignant Peripheral Nerve Sheath Tumor Cell Lines and Tissues Cancer Research. Mar, 2006 | Pubmed ID: 16510576 Unilateral Vestibular Schwannoma with Other Neurofibromatosis Type 2-related Tumors: Clinical and Molecular Study of a Unique Phenotype Journal of Neurosurgery. Feb, 2006 | Pubmed ID: 16509493 Malignant Peripheral Nerve Sheath Tumors (MPNST) in Neurofibromatosis Type 1 (NF1): Diagnostic Findings on Magnetic Resonance Images and Mutation Analysis of the NF1 Gene Anticancer Research. May-Jun, 2005 | Pubmed ID: 16033085 Extensively High Load of Internal Tumors Determined by Whole Body MRI Scanning in a Patient with Neurofibromatosis Type 1 and a Non-LCR-mediated 2-Mb Deletion in 17q11.2 Human Genetics. May, 2005 | Pubmed ID: 15776250 Do Hormonal Contraceptives Stimulate Growth of Neurofibromas? A Survey on 59 NF1 Patients BMC Cancer. Feb, 2005 | Pubmed ID: 15703081 Prevalence of Neurofibromatosis 1 in German Children at Elementary School Enrollment Archives of Dermatology. Jan, 2005 | Pubmed ID: 15655144 Screening for Large Mutations of the NF2 Gene Genes, Chromosomes & Cancer. Apr, 2005 | Pubmed ID: 15645494 Somatic Mitochondrial DNA Mutations in Neurofibromatosis Type 1-associated Tumors Molecular Cancer Research : MCR. Aug, 2004 | Pubmed ID: 15328370 Genetic and Phenotypic Characterization of Tumor Cells Derived from Malignant Peripheral Nerve Sheath Tumors of Neurofibromatosis Type 1 Patients Neurobiology of Disease. Jun, 2004 | Pubmed ID: 15207265 Sulindac Derivatives Inhibit Cell Growth and Induce Apoptosis in Primary Cells from Malignant Peripheral Nerve Sheath Tumors of NF1-patients Cancer Cell International. May, 2004 | Pubmed ID: 15147581 Screening 500 Unselected Neurofibromatosis 1 Patients for Deletions of the NF1 Gene Human Mutation. Feb, 2004 | Pubmed ID: 14722914 Constitutional NF1 Mutations in Neurofibromatosis 1 Patients with Malignant Peripheral Nerve Sheath Tumors Human Mutation. Nov, 2003 | Pubmed ID: 14517963 Polyneuropathy in Neurofibromatosis 2: Clinical Findings, Molecular Genetics and Neuropathological Alterations in Sural Nerve Biopsy Specimens Acta Neuropathologica. Aug, 2002 | Pubmed ID: 12111361 Treatment of ADHD in Neurofibromatosis Type 1 Developmental Medicine and Child Neurology. Mar, 2002 | Pubmed ID: 12005317 Mutations in the LGI1/Epitempin Gene on 10q24 Cause Autosomal Dominant Lateral Temporal Epilepsy Human Molecular Genetics. May, 2002 | Pubmed ID: 11978770 NF1 Mutations in Neurofibromatosis 1 Patients with Plexiform Neurofibromas Human Mutation. Mar, 2002 | Pubmed ID: 11857752 Presymptomatic Diagnosis for Children of Sporadic Neurofibromatosis 2 Patients: a Method Based on Tumor Analysis Genetics in Medicine : Official Journal of the American College of Medical Genetics. Jan-Feb, 2002 | Pubmed ID: 11839955 Vestibular Schwannoma Growth in Patients with Neurofibromatosis Type 2: a Longitudinal Study Journal of Neurosurgery. Feb, 2002 | Pubmed ID: 11838794 Establishment and Characterization of a Schwannoma Cell Line from a Patient with Neurofibromatosis 2 International Journal of Oncology. Mar, 2002 | Pubmed ID: 11836557 评估抗癌药物的特异性 Lan Kluwe1,2,3 1Department of Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, 2Department of Neurology, University Medical Center Hamburg-Eppendorf, 3Laboratory for Tumor Biology and Regenerative Medicine, University Medical Center Hamburg-Eppendorf JoVE 53752 Medicine
评估抗癌药物的特异性 Lan Kluwe1,2,3 1Department of Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, 2Department of Neurology, University Medical Center Hamburg-Eppendorf, 3Laboratory for Tumor Biology and Regenerative Medicine, University Medical Center Hamburg-Eppendorf JoVE 53752 Medicine