In JoVE (1)

Other Publications (8)

Articles by Lars Eichhorn in JoVE

 JoVE Medicine

A Model to Simulate Clinically Relevant Hypoxia in Humans

1Department of Anaesthesiology and Intensive Care Medicine, University Hospital of Bonn, 2Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, 3Institute for Terrestrial and Aquatic Wildlife Research, University of Veterinary Medicine Hannover, 4Institute of Physiology 2, University of Bonn

JoVE 54933

Other articles by Lars Eichhorn on PubMed

Monitoring of Cerebral Oxygen Saturation During Resuscitation in Out-of-hospital Cardiac Arrest: a Feasibility Study in a Physician Staffed Emergency Medical System

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. Oct, 2014  |  Pubmed ID: 25286829

Despite recent advances in resuscitation algorithms, neurological injury after cardiac arrest due to cerebral ischemia and reperfusion is one of the reasons for poor neurological outcome. There is currently no adequate means of measuring cerebral perfusion during cardiac arrest. It was the aim of this study to investigate the feasibility of measuring near infrared spectroscopy (NIRS) as a potential surrogate parameter for cerebral perfusion in patients with out-of-hospital resuscitations in a physician-staffed emergency medical service.

Postconditioning with a CpG Containing Oligodeoxynucleotide Ameliorates Myocardial Infarction in a Murine Closed-chest Model

Life Sciences. Oct, 2014  |  Pubmed ID: 25445440

Toll-like receptor (TLR)9 ligand CpG-oligodeoxynucleotide (CpG-ODN) exerts preconditioning in myocardial ischemia/reperfusion. We hypothesized a postconditioning effect of CpG-ODN in a murine closed-chest model of myocardial infarction.

Evaluation of Near-infrared Spectroscopy Under Apnea-dependent Hypoxia in Humans

Journal of Clinical Monitoring and Computing. Dec, 2015  |  Pubmed ID: 25649718

In this study we investigated the responsiveness of near-infrared spectroscopy (NIRS) recordings measuring regional cerebral tissue oxygenation (rSO2) during hypoxia in apneic divers. The goal was to mimic dynamic hypoxia as present during cardiopulmonary resuscitation, laryngospasm, airway obstruction, or the "cannot ventilate cannot intubate" situation. Ten experienced apneic divers performed maximal breath hold maneuvers under dry conditions. SpO2 was measured by Masimo™ pulse oximetry on the forefinger of the left hand. NIRS was measured by NONIN Medical's EQUANOX™ on the forehead or above the musculus quadriceps femoris. Following apnea median cerebral rSO2 and SpO2 values decreased significantly from 71 to 54 and from 100 to 65%, respectively. As soon as cerebral rSO2 and SpO2 values decreased monotonically the correlation between normalized cerebral rSO2 and SpO2 values was highly significant (Pearson correlation coefficient = 0.893). Prior to correlation analyses, the values were normalized by dividing them by the individual means of stable pre-apneic measurements. Cerebral rSO2 measured re-saturation after termination of apnea significantly earlier (10 s, SD = 3.6 s) compared to SpO2 monitoring (21 s, SD = 4.4 s) [t(9) = 7.703, p < 0.001, r(2) = 0.868]. Our data demonstrate that NIRS monitoring reliably measures dynamic changes in cerebral tissue oxygen saturation, and identifies successful re-saturation faster than SpO2. Measuring cerebral rSO2 may prove beneficial in case of respiratory emergencies and during pulseless situations where SpO2 monitoring is impossible.

Impact of Carbamylation on Three Different Methods, HPLC, Capillary Electrophoresis and TINIA of Measuring HbA1c Levels in Patients with Kidney Disease

Diabetes Research and Clinical Practice. Apr, 2015  |  Pubmed ID: 25684605

Aim of this study was to investigate whether established IFCC traceable routine measurements of HbA1c levels in patients with kidney diseases result in comparable and valid results. Additionally, the influence of carbamylation as a marker of uremia on the measurement methods was assessed.

IgG Subclass Distribution in Patients with Monoclonal Gammopathy

Clinica Chimica Acta; International Journal of Clinical Chemistry. Apr, 2015  |  Pubmed ID: 25704301

Diving Medicine in Clinical Practice

Deutsches Arzteblatt International. Feb, 2015  |  Pubmed ID: 25797514

Diving is a popular sport, and some recreational divers have medical risk factors. Their health can be endangered by high extracorporeal (ambient) pressure and its many systemic effects.

In Reply

Deutsches Arzteblatt International. Sep, 2015  |  Pubmed ID: 26396052

Commentaries on Viewpoint: Why Predominantly Neurological DCS in Breath-hold Divers?

Journal of Applied Physiology (Bethesda, Md. : 1985). Jun, 2016  |  Pubmed ID: 27306840

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