Lary C. Walker

Publications

• Nonhuman Primate Models of Alzheimer-Like Cerebral Proteopathy
  Current Pharmaceutical Design. Jan, 2012  |   Pubmed ID: 22288403
• The Presence of Aβ Seeds, and Not Age Per Se, is Critical to the Initiation of Aβ Deposition in the Brain
  Acta Neuropathologica. Jan, 2012  |   Pubmed ID: 22101366
• Exogenous Seeding of Cerebral β-amyloid Deposition in βAPP-transgenic Rats
  Journal of Neurochemistry. Mar, 2012  |   Pubmed ID: 22017494
• Pathogenic Protein Seeding in Alzheimer Disease and Other Neurodegenerative Disorders
  Annals of Neurology. Oct, 2011  |   Pubmed ID: 22028219
• Soluble Aβ Seeds Are Potent Inducers of Cerebral β-amyloid Deposition
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2011  |   Pubmed ID: 21994365
• Cerebral Amyloid-β Proteostasis is Regulated by the Membrane Transport Protein ABCC1 in Mice
  The Journal of Clinical Investigation. Oct, 2011  |   Pubmed ID: 21881209
• The Role of the ATP-binding Cassette Transporter P-glycoprotein in the Transport of β-amyloid Across the Blood-brain Barrier
  Current Pharmaceutical Design. 2011  |   Pubmed ID: 21827406
• Amyloid by Default
  Nature Neuroscience. Jun, 2011  |   Pubmed ID: 21613991
• Automated Detection of Amyloid-β-related Cortical and Subcortical Signal Changes in a Transgenic Model of Alzheimer's Disease Using High-field MRI
  Journal of Alzheimer's Disease : JAD. 2011  |   Pubmed ID: 20966552
• PIB Binding in Aged Primate Brain: Enrichment of High-affinity Sites in Humans with Alzheimer's Disease
  Neurobiology of Aging. Feb, 2011  |   Pubmed ID: 19329226
• Peripherally Applied Abeta-containing Inoculates Induce Cerebral Beta-amyloidosis
  Science (New York, N.Y.). Nov, 2010  |   Pubmed ID: 20966215
• Days to Criterion As an Indicator of Toxicity Associated with Human Alzheimer Amyloid-beta Oligomers
  Annals of Neurology. Aug, 2010  |   Pubmed ID: 20641005
• Mosaic Aging
  Medical Hypotheses. Jun, 2010  |   Pubmed ID: 20110150
• The Grandmother Effect and the Uniqueness of the Human Aging Phenotype
  Gerontology. 2010  |   Pubmed ID: 19864883
• Deficient High-affinity Binding of Pittsburgh Compound B in a Case of Alzheimer's Disease
  Acta Neuropathologica. Feb, 2010  |   Pubmed ID: 19690877
• Molecular Polymorphism of Abeta in Alzheimer's Disease
  Neurobiology of Aging. Apr, 2010  |   Pubmed ID: 18619711
• Ovarian Aging in Squirrel Monkeys (Saimiri Sciureus)
  Reproduction (Cambridge, England). Nov, 2009  |   Pubmed ID: 19656956
• Induction of Cerebral Beta-amyloidosis: Intracerebral Versus Systemic Abeta Inoculation
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2009  |   Pubmed ID: 19622727
• Alzheimer's Disease and Blood-brain Barrier Function-Why Have Anti-beta-amyloid Therapies Failed to Prevent Dementia Progression?
  Neuroscience and Biobehavioral Reviews. Jul, 2009  |   Pubmed ID: 19481107
• The Synthesis and Structure-activity Relationship of Substituted N-phenyl Anthranilic Acid Analogs As Amyloid Aggregation Inhibitors
  Bioorganic & Medicinal Chemistry Letters. Feb, 2009  |   Pubmed ID: 19121939
• Clinico-pathologic Function of Cerebral ABC Transporters - Implications for the Pathogenesis of Alzheimer's Disease
  Current Alzheimer Research. Aug, 2008  |   Pubmed ID: 18690837
• Tauopathy with Paired Helical Filaments in an Aged Chimpanzee
  The Journal of Comparative Neurology. Jul, 2008  |   Pubmed ID: 18481275
• Long-term Hypothermia Reduces Infarct Volume in Aged Rats After Focal Ischemia
  Neuroscience Letters. Jun, 2008  |   Pubmed ID: 18456407
• Development of Transgenic Rats Producing Human Beta-amyloid Precursor Protein As a Model for Alzheimer's Disease: Transgene and Endogenous APP Genes Are Regulated Tissue-specifically
  BMC Neuroscience. 2008  |   Pubmed ID: 18302776
• The Response of the Aged Brain to Stroke: Too Much, Too Soon?
  Current Neurovascular Research. Aug, 2007  |   Pubmed ID: 17691975
• MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer's Amyloid-beta Peptides--implications for the Mechanisms of Abeta Clearance at the Blood-brain Barrier
  Brain Pathology (Zurich, Switzerland). Oct, 2007  |   Pubmed ID: 17610523
• Exogenous Induction of Cerebral Beta-amyloidogenesis is Governed by Agent and Host
  Science (New York, N.Y.). Sep, 2006  |   Pubmed ID: 16990547
• Inducible Proteopathies
  Trends in Neurosciences. Aug, 2006  |   Pubmed ID: 16806508
• Alzheimer Therapeutics-what After the Cholinesterase Inhibitors?
  Age and Ageing. Jul, 2006  |   Pubmed ID: 16644763
• Cerebrovascular P-glycoprotein Expression is Decreased in Creutzfeldt-Jakob Disease
  Acta Neuropathologica. May, 2006  |   Pubmed ID: 16523342
• Calcium Channel Alpha2-delta Type 1 Subunit is the Major Binding Protein for Pregabalin in Neocortex, Hippocampus, Amygdala, and Spinal Cord: an Ex Vivo Autoradiographic Study in Alpha2-delta Type 1 Genetically Modified Mice
  Brain Research. Feb, 2006  |   Pubmed ID: 16460711
• Emerging Prospects for the Disease-modifying Treatment of Alzheimer's Disease
  Biochemical Pharmacology. Apr, 2005  |   Pubmed ID: 15763538
• Proteomic Identification of the Involvement of the Mitochondrial Rieske Protein in Epilepsy
  Epilepsia. Mar, 2005  |   Pubmed ID: 15730530
• The Role of P-glycoprotein in Cerebral Amyloid Angiopathy; Implications for the Early Pathogenesis of Alzheimer's Disease
  Current Alzheimer Research. May, 2004  |   Pubmed ID: 15975076
• Aging, Gender and APOE Isotype Modulate Metabolism of Alzheimer's Abeta Peptides and F-isoprostanes in the Absence of Detectable Amyloid Deposits
  Journal of Neurochemistry. Aug, 2004  |   Pubmed ID: 15287908
• Alzheimer A Beta Vaccination of Rhesus Monkeys (Macaca Mulatta)
  Alzheimer Disease and Associated Disorders. Jan-Mar, 2004  |   Pubmed ID: 15195463
• Alzheimer's Abeta Vaccination of Rhesus Monkeys (Macaca Mulatta)
  Mechanisms of Ageing and Development. Feb, 2004  |   Pubmed ID: 15037022
• Xanthomatosis
  Journal of Neurosurgery. Oct, 2002  |   Pubmed ID: 12405396
• Deposition of Alzheimer's Beta-amyloid is Inversely Correlated with P-glycoprotein Expression in the Brains of Elderly Non-demented Humans
  Pharmacogenetics. Oct, 2002  |   Pubmed ID: 12360104
• Exogenous Induction of Cerebral Beta-amyloidosis in BetaAPP-transgenic Mice
  Peptides. Jul, 2002  |   Pubmed ID: 12128081
• Proteopathy: the Next Therapeutic Frontier?
  Current Opinion in Investigational Drugs (London, England : 2000). May, 2002  |   Pubmed ID: 12090553
• Axonopathy, Tau Abnormalities, and Dyskinesia, but No Neurofibrillary Tangles in P25-transgenic Mice
  The Journal of Comparative Neurology. May, 2002  |   Pubmed ID: 11932941