Laura J. Niedernhofer Department of Molecular Medicine and the Center on Aging The Scripps Research Institute Biography Publications Institution JoVE Articles Laura J. Niedernhofer has not added a biography. If you are Laura J. Niedernhofer and would like to personalize this page please email our Author Liaison for assistance. Publications Adenoviral Gene Transfer of a Single-chain IL-23 Induces Psoriatic Arthritis-like Symptoms in NOD Mice FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2019 | Pubmed ID: 31170010 Measuring Biological Age in Mice Using Differential Mass Spectrometry Aging. Feb, 2019 | Pubmed ID: 30745468 Methods to Quantify the NF-κB Pathway During Senescence Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30474851 Mouse Models of Accelerated Cellular Senescence Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 30474850 Fisetin is a Senotherapeutic That Extends Health and Lifespan EBioMedicine. Oct, 2018 | Pubmed ID: 30279143 Dysregulation of DAF-16/FOXO3A-mediated Stress Responses Accelerates Oxidative DNA Damage Induced Aging Redox Biology. 09, 2018 | Pubmed ID: 30031267 Senolytics Improve Physical Function and Increase Lifespan in Old Age Nature Medicine. 08, 2018 | Pubmed ID: 29988130 Nuclear Genomic Instability and Aging Annual Review of Biochemistry. 06, 2018 | Pubmed ID: 29925262 Neurodegeneration As the Presenting Symptom in 2 Adults with Xeroderma Pigmentosum Complementation Group F Neurology. Genetics. Jun, 2018 | Pubmed ID: 29892709 Development of Novel NEMO-binding Domain Mimetics for Inhibiting IKK/NF-κB Activation PLoS Biology. 06, 2018 | Pubmed ID: 29889904 Hsp90 Inhibitors As Senolytic Drugs to Extend Healthy Aging Cell Cycle (Georgetown, Tex.). 2018 | Pubmed ID: 29886783 ERCC1-deficient Cells and Mice Are Hypersensitive to Lipid Peroxidation Free Radical Biology & Medicine. 08, 2018 | Pubmed ID: 29860127 Spontaneous DNA Damage to the Nuclear Genome Promotes Senescence, Redox Imbalance and Aging Redox Biology. 07, 2018 | Pubmed ID: 29747066 Senotherapeutics for Healthy Ageing Nature Reviews. Drug Discovery. May, 2018 | Pubmed ID: 29651106 Oxidation Products of 5-Methylcytosine Are Decreased in Senescent Cells and Tissues of Progeroid Mice The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Jul, 2018 | Pubmed ID: 29415265 Circulating Levels of Monocyte Chemoattractant Protein-1 As a Potential Measure of Biological Age in Mice and Frailty in Humans Aging Cell. 04, 2018 | Pubmed ID: 29290100 ERCC4 Variants Identified in a Cohort of Patients with Segmental Progeroid Syndromes Human Mutation. 02, 2018 | Pubmed ID: 29105242 Identification of HSP90 Inhibitors As a Novel Class of Senolytics Nature Communications. 09, 2017 | Pubmed ID: 28871086 The Clinical Potential of Senolytic Drugs Journal of the American Geriatrics Society. Oct, 2017 | Pubmed ID: 28869295 Senescent Intervertebral Disc Cells Exhibit Perturbed Matrix Homeostasis Phenotype Mechanisms of Ageing and Development. 09, 2017 | Pubmed ID: 28830687 Inhibition of NF-κB Improves the Stress Resistance and Myogenic Differentiation of MDSPCs Isolated from Naturally Aged Mice PloS One. 2017 | Pubmed ID: 28640861 Advances in Therapeutic Approaches to Extend Healthspan: a Perspective from the 2 Scripps Symposium on the Biology of Aging Aging Cell. 08, 2017 | Pubmed ID: 28585366 ADAMTS5 Deficiency Protects Mice From Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration Spine. Oct, 2017 | Pubmed ID: 28570296 Systems Biology Guided by XCMS Online Metabolomics Nature Methods. 04, 2017 | Pubmed ID: 28448069 New Agents That Target Senescent Cells: the Flavone, Fisetin, and the BCL-X Inhibitors, A1331852 and A1155463 Aging. 03, 2017 | Pubmed ID: 28273655 Expansion of Myeloid-derived Suppressor Cells with Aging in the Bone Marrow of Mice Through a NF-κB-dependent Mechanism Aging Cell. 06, 2017 | Pubmed ID: 28229533 Quantitative Analysis of Cellular Senescence in Culture and In Vivo Current Protocols in Cytometry. 01, 2017 | Pubmed ID: 28055114 Molecular Pathology Endpoints Useful for Aging Studies Ageing Research Reviews. May, 2017 | Pubmed ID: 27721062 Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage Chemical Research in Toxicology. 12, 2016 | Pubmed ID: 27989142 MTOR Signaling Plays a Critical Role in the Defects Observed in Muscle-derived Stem/progenitor Cells Isolated from a Murine Model of Accelerated Aging Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Aug, 2016 | Pubmed ID: 27572850 Smartphone Analytics: Mobilizing the Lab into the Cloud for Omic-Scale Analyses Analytical Chemistry. Oct, 2016 | Pubmed ID: 27560777 Barriers to the Preclinical Development of Therapeutics That Target Aging Mechanisms The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 11, 2016 | Pubmed ID: 27535964 Identification of a Novel Senolytic Agent, Navitoclax, Targeting the Bcl-2 Family of Anti-apoptotic Factors Aging Cell. 06, 2016 | Pubmed ID: 26711051 In Vivo Detection and Replication Studies of α-anomeric Lesions of 2'-deoxyribonucleosides Nucleic Acids Research. Sep, 2015 | Pubmed ID: 26202973 The Achilles' Heel of Senescent Cells: from Transcriptome to Senolytic Drugs Aging Cell. Aug, 2015 | Pubmed ID: 25754370 NF-κB Activation with Aging: Characterization and Therapeutic Inhibition Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 25736771 Comparison of Mice with Accelerated Aging Caused by Distinct Mechanisms Experimental Gerontology. Aug, 2015 | Pubmed ID: 25617508 Pharmacologic IKK/NF-κB Inhibition Causes Antigen Presenting Cells to Undergo TNFα Dependent ROS-mediated Programmed Cell Death Scientific Reports. Jan, 2014 | Pubmed ID: 24406986 Investigating the Role of DNA Damage in Tobacco Smoking-induced Spine Degeneration The Spine Journal : Official Journal of the North American Spine Society. Mar, 2014 | Pubmed ID: 24211096 DNA Damage Triggers a Chronic Autoinflammatory Response, Leading to Fat Depletion in NER Progeria Cell Metabolism. Sep, 2013 | Pubmed ID: 24011075 NF-κB Inhibition Delays DNA Damage-induced Senescence and Aging in Mice The Journal of Clinical Investigation. Jul, 2012 | Pubmed ID: 22706308 SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs Heike Fuhrmann-Stroissnigg*1, Fernando E. Santiago*1,2,3, Diego Grassi1, YuanYuan Ling1, Laura J. Niedernhofer1,2,3, Paul D. Robbins1,2,3 1Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 2Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 3Institute on the Biology of Aging and Metabolism, University of Minnesota JoVE 58133 Biology
SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs Heike Fuhrmann-Stroissnigg*1, Fernando E. Santiago*1,2,3, Diego Grassi1, YuanYuan Ling1, Laura J. Niedernhofer1,2,3, Paul D. Robbins1,2,3 1Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 2Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 3Institute on the Biology of Aging and Metabolism, University of Minnesota JoVE 58133 Biology
