Lawrence E. Heisler Donnelly Centre for Cellular and Biomolecular Research University of Toronto Biography Publications Institution JoVE Articles Lawrence E. Heisler has not added a biography. If you are Lawrence E. Heisler and would like to personalize this page please email our Author Liaison for assistance. Publications The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression Cell. May, 2018 | Pubmed ID: 29681457 Mitochondrial Mutations Drive Prostate Cancer Aggression Nature Communications. 09, 2017 | Pubmed ID: 28939825 Genomic Hallmarks of Localized, Non-indolent Prostate Cancer Nature. 01, 2017 | Pubmed ID: 28068672 Germline BRCA2 Mutations Drive Prostate Cancers with Distinct Evolutionary Trajectories Nature Communications. Jan, 2017 | Pubmed ID: 28067867 A Comprehensive Assessment of Somatic Mutation Detection in Cancer Using Whole-genome Sequencing Nature Communications. Dec, 2015 | Pubmed ID: 26647970 A Genome Scale Overexpression Screen to Reveal Drug Activity in Human Cells Genome Medicine. 2014 | Pubmed ID: 24944581 Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures Science (New York, N.Y.). Apr, 2014 | Pubmed ID: 24723613 CHIP-MYTH: a Novel Interactive Proteomics Method for the Assessment of Agonist-dependent Interactions of the Human β₂-adrenergic Receptor Biochemical and Biophysical Research Communications. Mar, 2014 | Pubmed ID: 24561123 Miniature Short Hairpin RNA Screens to Characterize Antiproliferative Drugs G3 (Bethesda, Md.). Aug, 2013 | Pubmed ID: 23797109 Effects of the Paf1 Complex and Histone Modifications on SnoRNA 3'-end Formation Reveal Broad and Locus-specific Regulation Molecular and Cellular Biology. Jan, 2013 | Pubmed ID: 23109428 Functional Analysis with a Barcoder Yeast Gene Overexpression System G3 (Bethesda, Md.). Oct, 2012 | Pubmed ID: 23050238 Comparative Chemogenomics to Examine the Mechanism of Action of Dna-targeted Platinum-acridine Anticancer Agents ACS Chemical Biology. Nov, 2012 | Pubmed ID: 22928710 Identification of Yeast Genes That Confer Resistance to Chitosan Oligosaccharide (COS) Using Chemogenomics BMC Genomics. Jun, 2012 | Pubmed ID: 22727066 Moyens Multiples Pour Le Même But: La Base Génétique De Résistance Au Stress Acquise Dans La Levure PLoS Genetics. Nov, 2011 | Pubmed ID: 22102822 Méthodes D'établissement Des Priorités Composés à Augmenter Les Taux De Produits Chimiques De La Sonde De Découverte Dans Des Organismes Modèles Chemistry & Biology. Oct, 2011 | Pubmed ID: 22035796 Posologie Réseaux De Suppression D'interaction Génétiques Améliorer Schémas De Câblage Fonctionnelles De La Cellule Nature Biotechnology. Jun, 2011 | Pubmed ID: 21572441 Une Plate-forme Complète Pour Hautement Multiplexés Mammifères Fonctionnels Cribles Génétiques BMC Genomics. 2011 | Pubmed ID: 21548937 Séquençage De Code à Barres Hautement Multiplexée: Une Méthode Efficace Pour L'analyse Parallèle Des échantillons Groupés Nucleic Acids Research. Jul, 2010 | Pubmed ID: 20460461 Génotype Au Phénotype: Un Problème Complexe Science (New York, N.Y.). Apr, 2010 | Pubmed ID: 20413493 Une Analyse Comparative Des Codes-barres D'ADN Microarray Feature Taille BMC Genomics. 2009 | Pubmed ID: 19825181 Phénotypage Quantitatif Via Séquençage Barcode Profonde Genome Research. Oct, 2009 | Pubmed ID: 19622793 Chimique Et Génétique Du Profil Des Imidazo [1,2-a] Pyridines Et-pyrimidines Révèle Pathways Cibles Conservées Entre Cellules De Levure Et De L'homme PLoS Genetics. Nov, 2008 | Pubmed ID: 19043571 Effets Hors-cible De Drogues Psychoactives Révélé Par échelle Du Génome Entier Essais Chez La Levure PLoS Genetics. 2008 | Pubmed ID: 18688276 Barcoders Levure: Une Application Universelle Chemogénomique D'un Donateur-souche Collection De Transport De Code à Barres Identificateurs Nature Methods. Aug, 2008 | Pubmed ID: 18622398 L'ADN Génomique Fonctionne Comme Une Norme Universelle Externe En Quantitative PCR En Temps Réel Nucleic Acids Research. 2006 | Pubmed ID: 16840529 Les îlots CpG Microarray Séquences Sonde Dérivée à Partir D'une Bibliothèque Physique Sont-ils Représentatifs Des îlots CpG Annotées Sur Le Génome Humain Nucleic Acids Research. 2005 | Pubmed ID: 15911630 Écrans concurrentiel des bibliothèques génomiques de levure Barcoded Andrew M. Smith*1,2, Tanja Durbic*2,3, Julia Oh*4, Malene Urbanus1,2, Michael Proctor5, Lawrence E. Heisler2,3, Guri Giaever2,6, Corey Nislow1,2,3 1Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto, 2Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 3Donnelly Sequencing Centre, University of Toronto, 4Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, 5Stanford Genome Technology Center, Stanford School of Medicine, Stanford University, 6Department of Pharmaceutical Sciences, University of Toronto JoVE 2864 Biology
Écrans concurrentiel des bibliothèques génomiques de levure Barcoded Andrew M. Smith*1,2, Tanja Durbic*2,3, Julia Oh*4, Malene Urbanus1,2, Michael Proctor5, Lawrence E. Heisler2,3, Guri Giaever2,6, Corey Nislow1,2,3 1Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto, 2Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 3Donnelly Sequencing Centre, University of Toronto, 4Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, 5Stanford Genome Technology Center, Stanford School of Medicine, Stanford University, 6Department of Pharmaceutical Sciences, University of Toronto JoVE 2864 Biology