Lawrence E. Heisler Donnelly Centre for Cellular and Biomolecular Research University of Toronto Biography Publications Institution JoVE Articles Lawrence E. Heisler has not added a biography. If you are Lawrence E. Heisler and would like to personalize this page please email our Author Liaison for assistance. Publications The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression Cell. May, 2018 | Pubmed ID: 29681457 Mitochondrial Mutations Drive Prostate Cancer Aggression Nature Communications. 09, 2017 | Pubmed ID: 28939825 Genomic Hallmarks of Localized, Non-indolent Prostate Cancer Nature. 01, 2017 | Pubmed ID: 28068672 Germline BRCA2 Mutations Drive Prostate Cancers with Distinct Evolutionary Trajectories Nature Communications. Jan, 2017 | Pubmed ID: 28067867 A Comprehensive Assessment of Somatic Mutation Detection in Cancer Using Whole-genome Sequencing Nature Communications. Dec, 2015 | Pubmed ID: 26647970 A Genome Scale Overexpression Screen to Reveal Drug Activity in Human Cells Genome Medicine. 2014 | Pubmed ID: 24944581 Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures Science (New York, N.Y.). Apr, 2014 | Pubmed ID: 24723613 CHIP-MYTH: a Novel Interactive Proteomics Method for the Assessment of Agonist-dependent Interactions of the Human β₂-adrenergic Receptor Biochemical and Biophysical Research Communications. Mar, 2014 | Pubmed ID: 24561123 Miniature Short Hairpin RNA Screens to Characterize Antiproliferative Drugs G3 (Bethesda, Md.). Aug, 2013 | Pubmed ID: 23797109 Effects of the Paf1 Complex and Histone Modifications on SnoRNA 3'-end Formation Reveal Broad and Locus-specific Regulation Molecular and Cellular Biology. Jan, 2013 | Pubmed ID: 23109428 Functional Analysis with a Barcoder Yeast Gene Overexpression System G3 (Bethesda, Md.). Oct, 2012 | Pubmed ID: 23050238 Comparative Chemogenomics to Examine the Mechanism of Action of Dna-targeted Platinum-acridine Anticancer Agents ACS Chemical Biology. Nov, 2012 | Pubmed ID: 22928710 Identification of Yeast Genes That Confer Resistance to Chitosan Oligosaccharide (COS) Using Chemogenomics BMC Genomics. Jun, 2012 | Pubmed ID: 22727066 Mezzi Multipli Allo Stesso Fine: La Base Genetica Della Resistenza Acquisita in Lievito PLoS Genetics. Nov, 2011 | Pubmed ID: 22102822 Metodi Di Definizione Delle Priorità Dei Composti Aumentano I Tassi Di Scoperta Della Sonda Chimica in Organismi Modello Chemistry & Biology. Oct, 2011 | Pubmed ID: 22035796 Reti Di Interazione Genetica Soppressione Dosaggio Migliorano Gli Schemi Elettrici Funzionali Della Cellula Nature Biotechnology. Jun, 2011 | Pubmed ID: 21572441 Una Piattaforma Completa Per Multiplexed Altamente Schermi Genetici Funzionali Dei Mammiferi BMC Genomics. 2011 | Pubmed ID: 21548937 Codice a Barre Altamente Multiplexed Sequenziamento: Un Metodo Efficiente Per L'analisi Parallela Di Campioni in Pool Nucleic Acids Research. Jul, 2010 | Pubmed ID: 20460461 Genotipo Fenotipo: Un Problema Complesso Science (New York, N.Y.). Apr, 2010 | Pubmed ID: 20413493 Un'analisi Comparativa Delle Dimensione Della Caratteristica Microarray Del DNA Barcode BMC Genomics. 2009 | Pubmed ID: 19825181 Fenotipi Quantitativo Tramite Barcode Deep Sequencing Genome Research. Oct, 2009 | Pubmed ID: 19622793 Analisi Chimica-genetica Delle Pirimidine E - Imidazo [1,2-a] Piridine Rivela Percorsi Target Conservati Tra Lievito E Cellule Umane PLoS Genetics. Nov, 2008 | Pubmed ID: 19043571 Gli Effetti Delle Droghe Psicoattive Rivelati Da Analisi Genome-wide Nel Lievito Fuori Bersaglio PLoS Genetics. 2008 | Pubmed ID: 18688276 Lievito Barcoders: Un'applicazione Di Chemogenomico Di Una Collezione Di Donatore Universale-ceppo Che Trasportano Gli Identificatori Di Codice a Barre Nature Methods. Aug, 2008 | Pubmed ID: 18622398 Funzioni Del DNA Genomiche Come Standard Universale Esterno Nella PCR Quantitativa in Tempo Reale Nucleic Acids Research. 2006 | Pubmed ID: 16840529 Isola CpG Microarray Sonda Sequenze Derivate Da Una Libreria Fisica Sono Rappresentante Delle Isole Di CpG Annotata Sul Genoma Umano Nucleic Acids Research. 2005 | Pubmed ID: 15911630 Schermi competitivo genomica delle Biblioteche di lievito con codice a barre Andrew M. Smith*1,2, Tanja Durbic*2,3, Julia Oh*4, Malene Urbanus1,2, Michael Proctor5, Lawrence E. Heisler2,3, Guri Giaever2,6, Corey Nislow1,2,3 1Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto, 2Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 3Donnelly Sequencing Centre, University of Toronto, 4Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, 5Stanford Genome Technology Center, Stanford School of Medicine, Stanford University, 6Department of Pharmaceutical Sciences, University of Toronto JoVE 2864 Biology
Schermi competitivo genomica delle Biblioteche di lievito con codice a barre Andrew M. Smith*1,2, Tanja Durbic*2,3, Julia Oh*4, Malene Urbanus1,2, Michael Proctor5, Lawrence E. Heisler2,3, Guri Giaever2,6, Corey Nislow1,2,3 1Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto, 2Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 3Donnelly Sequencing Centre, University of Toronto, 4Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, 5Stanford Genome Technology Center, Stanford School of Medicine, Stanford University, 6Department of Pharmaceutical Sciences, University of Toronto JoVE 2864 Biology