Lawrence E. Heisler Donnelly Centre for Cellular and Biomolecular Research University of Toronto Biography Publications Institution JoVE Articles Lawrence E. Heisler has not added a biography. If you are Lawrence E. Heisler and would like to personalize this page please email our Author Liaison for assistance. Publications The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression Cell. May, 2018 | Pubmed ID: 29681457 Mitochondrial Mutations Drive Prostate Cancer Aggression Nature Communications. 09, 2017 | Pubmed ID: 28939825 Genomic Hallmarks of Localized, Non-indolent Prostate Cancer Nature. 01, 2017 | Pubmed ID: 28068672 Germline BRCA2 Mutations Drive Prostate Cancers with Distinct Evolutionary Trajectories Nature Communications. Jan, 2017 | Pubmed ID: 28067867 A Comprehensive Assessment of Somatic Mutation Detection in Cancer Using Whole-genome Sequencing Nature Communications. Dec, 2015 | Pubmed ID: 26647970 A Genome Scale Overexpression Screen to Reveal Drug Activity in Human Cells Genome Medicine. 2014 | Pubmed ID: 24944581 Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures Science (New York, N.Y.). Apr, 2014 | Pubmed ID: 24723613 CHIP-MYTH: a Novel Interactive Proteomics Method for the Assessment of Agonist-dependent Interactions of the Human β₂-adrenergic Receptor Biochemical and Biophysical Research Communications. Mar, 2014 | Pubmed ID: 24561123 Miniature Short Hairpin RNA Screens to Characterize Antiproliferative Drugs G3 (Bethesda, Md.). Aug, 2013 | Pubmed ID: 23797109 Effects of the Paf1 Complex and Histone Modifications on SnoRNA 3'-end Formation Reveal Broad and Locus-specific Regulation Molecular and Cellular Biology. Jan, 2013 | Pubmed ID: 23109428 Functional Analysis with a Barcoder Yeast Gene Overexpression System G3 (Bethesda, Md.). Oct, 2012 | Pubmed ID: 23050238 Comparative Chemogenomics to Examine the Mechanism of Action of Dna-targeted Platinum-acridine Anticancer Agents ACS Chemical Biology. Nov, 2012 | Pubmed ID: 22928710 Identification of Yeast Genes That Confer Resistance to Chitosan Oligosaccharide (COS) Using Chemogenomics BMC Genomics. Jun, 2012 | Pubmed ID: 22727066 Múltiples Medios Para El Mismo Fin: La Base Genética De La Resistencia Al Estrés Adquirido En La Levadura PLoS Genetics. Nov, 2011 | Pubmed ID: 22102822 Métodos Compuestos Priorización Aumentar Las Tasas De Química De Sondas De Descubrimiento En Organismos Modelo Chemistry & Biology. Oct, 2011 | Pubmed ID: 22035796 Las Redes De Interacción De Dosis De Supresión Genética Mejorar Diagramas De Cableado Funcionales De La Célula Nature Biotechnology. Jun, 2011 | Pubmed ID: 21572441 Una Plataforma Completa Para Los Mamíferos Altamente Multiplexado Pantallas Genética Funcional BMC Genomics. 2011 | Pubmed ID: 21548937 Código De Barras Altamente Multiplexado Secuenciación: Un Método Eficaz Para El Análisis Paralelo De Muestras Combinadas Nucleic Acids Research. Jul, 2010 | Pubmed ID: 20460461 Genotipo Al Fenotipo: Un Problema Complejo Science (New York, N.Y.). Apr, 2010 | Pubmed ID: 20413493 Un Análisis Comparativo De ADN De Tamaño De Código De Barras De Funciones Microarray BMC Genomics. 2009 | Pubmed ID: 19825181 Fenotipificación Cuantitativa Via Secuenciación De Código De Barras Profundo Genome Research. Oct, 2009 | Pubmed ID: 19622793 Química-genética De Generación De Perfiles De Imidazo [1,2-a] Piridinas Y Pirimidinas, Revela Rutas De Destino Conservados Entre Levaduras Y Células Humanas PLoS Genetics. Nov, 2008 | Pubmed ID: 19043571 Fuera De Objetivo Efectos De Las Drogas Psicoactivas Revelado Por Todo El Genoma De Levadura En Ensayos PLoS Genetics. 2008 | Pubmed ID: 18688276 Barcoders Levadura: Una Aplicación Quimiogenómicos De Un Donante Universal-cepa De Colección De Transporte De Códigos De Barras Identificadores Nature Methods. Aug, 2008 | Pubmed ID: 18622398 ADN Genómico Funciona Como Una Norma Externa Universal En PCR Cuantitativa En Tiempo Real Nucleic Acids Research. 2006 | Pubmed ID: 16840529 CpG Island Microarray Secuencias Sonda Derivada De Una Biblioteca Física Son Representativos De Las Islas CpG Anotados Sobre El Genoma Humano Nucleic Acids Research. 2005 | Pubmed ID: 15911630 Pantallas competitiva Genómica de Bibliotecas de levadura con código de barras Andrew M. Smith*1,2, Tanja Durbic*2,3, Julia Oh*4, Malene Urbanus1,2, Michael Proctor5, Lawrence E. Heisler2,3, Guri Giaever2,6, Corey Nislow1,2,3 1Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto, 2Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 3Donnelly Sequencing Centre, University of Toronto, 4Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, 5Stanford Genome Technology Center, Stanford School of Medicine, Stanford University, 6Department of Pharmaceutical Sciences, University of Toronto JoVE 2864 Biology
Pantallas competitiva Genómica de Bibliotecas de levadura con código de barras Andrew M. Smith*1,2, Tanja Durbic*2,3, Julia Oh*4, Malene Urbanus1,2, Michael Proctor5, Lawrence E. Heisler2,3, Guri Giaever2,6, Corey Nislow1,2,3 1Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto, 2Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 3Donnelly Sequencing Centre, University of Toronto, 4Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, 5Stanford Genome Technology Center, Stanford School of Medicine, Stanford University, 6Department of Pharmaceutical Sciences, University of Toronto JoVE 2864 Biology