Lawrence S.B. Goldstein Department of Cellular and Molecular Medicine University of California San Diego Biography Publications Institution JoVE Articles Lawrence S.B. Goldstein has not added a biography. If you are Lawrence S.B. Goldstein and would like to personalize this page please email our Author Liaison for assistance. Publications Effect of Potent γ-Secretase Modulator in Human Neurons Derived From Multiple Presenilin 1-Induced Pluripotent Stem Cell Mutant Carriers JAMA Neurology. Oct, 2014 | Pubmed ID: 25285942 Long-distance Axonal Growth from Human Induced Pluripotent Stem Cells After Spinal Cord Injury Neuron. Aug, 2014 | Pubmed ID: 25123310 Biophysical Challenges to Axonal Transport: Motor-cargo Deficiencies and Neurodegeneration Annual Review of Biophysics. 2014 | Pubmed ID: 24702007 UV Irradiation Accelerates Amyloid Precursor Protein (APP) Processing and Disrupts APP Axonal Transport The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2014 | Pubmed ID: 24573290 Fast Axonal Transport of the Proteasome Complex Depends on Membrane Interaction and Molecular Motor Function Journal of Cell Science. Apr, 2014 | Pubmed ID: 24522182 The Presenilin-1 ΔE9 Mutation Results in Reduced γ-secretase Activity, but Not Total Loss of PS1 Function, in Isogenic Human Stem Cells Cell Reports. Nov, 2013 | Pubmed ID: 24239350 Presenilins Regulate Neurotrypsin Gene Expression and Neurotrypsin-dependent Agrin Cleavage Via Cyclic AMP Response Element-binding Protein (CREB) Modulation The Journal of Biological Chemistry. Dec, 2013 | Pubmed ID: 24145027 The Microtubule Regulatory Protein Stathmin Is Required to Maintain the Integrity of Axonal Microtubules in Drosophila PloS One. 2013 | Pubmed ID: 23840848 Presenilin Controls Kinesin-1 and Dynein Function During APP-vesicle Transport in Vivo Human Molecular Genetics. Oct, 2013 | Pubmed ID: 23710041 A Pan-BCL2 Inhibitor Renders Bone-marrow-resident Human Leukemia Stem Cells Sensitive to Tyrosine Kinase Inhibition Cell Stem Cell. Mar, 2013 | Pubmed ID: 23333150 Endogenous GSK-3/shaggy Regulates Bidirectional Axonal Transport of the Amyloid Precursor Protein Traffic (Copenhagen, Denmark). Mar, 2013 | Pubmed ID: 23279138 ADAR1 Promotes Malignant Progenitor Reprogramming in Chronic Myeloid Leukemia Proceedings of the National Academy of Sciences of the United States of America. Jan, 2013 | Pubmed ID: 23275297 Using Human-induced Pluripotent Stem Cells to Model Monogenic Metabolic Disorders of the Liver Seminars in Liver Disease. Nov, 2012 | Pubmed ID: 23397530 New Frontiers in Human Cell Biology and Medicine: Can Pluripotent Stem Cells Deliver? The Journal of Cell Biology. Nov, 2012 | Pubmed ID: 23148231 An October Call to Arms: We Are Research! Molecular Biology of the Cell. Sep, 2012 | Pubmed ID: 22936697 Alzheimer's Disease in a Dish: Promises and Challenges of Human Stem Cell Models Human Molecular Genetics. Oct, 2012 | Pubmed ID: 22865875 Enhanced β-secretase Processing Alters APP Axonal Transport and Leads to Axonal Defects Human Molecular Genetics. Nov, 2012 | Pubmed ID: 22843498 Subpixel Colocalization Reveals Amyloid Precursor Protein-dependent Kinesin-1 and Dynein Association with Axonal Vesicles Proceedings of the National Academy of Sciences of the United States of America. May, 2012 | Pubmed ID: 22582169 Axonal Transport and Neurodegenerative Disease: Can We See the Elephant? Progress in Neurobiology. Dec, 2012 | Pubmed ID: 22484448 Disruption and Therapeutic Rescue of Autophagy in a Human Neuronal Model of Niemann Pick Type C1 Human Molecular Genetics. Jun, 2012 | Pubmed ID: 22437840 Molecular Motor Function in Axonal Transport in Vivo Probed by Genetic and Computational Analysis in Drosophila Molecular Biology of the Cell. May, 2012 | Pubmed ID: 22398725 Probing Sporadic and Familial Alzheimer's Disease Using Induced Pluripotent Stem Cells Nature. Feb, 2012 | Pubmed ID: 22278060 Kinesin Light Chain 1 Suppression Impairs Human Embryonic Stem Cell Neural Differentiation and Amyloid Precursor Protein Metabolism PloS One. 2012 | Pubmed ID: 22272245 In the Trenches: Lessons for Scientists from California's Proposition 71 Campaign Molecular Biology of the Cell. Nov, 2011 | Pubmed ID: 22039069 Decellularized Porcine Brain Matrix for Cell Culture and Tissue Engineering Scaffolds Tissue Engineering. Part A. Nov, 2011 | Pubmed ID: 21883047 A Role for Kinesin Heavy Chain in Controlling Vesicle Transport into Dendrites in Drosophila Molecular Biology of the Cell. Nov, 2011 | Pubmed ID: 21880894 Cell-surface Marker Signatures for the Isolation of Neural Stem Cells, Glia and Neurons Derived from Human Pluripotent Stem Cells PloS One. 2011 | Pubmed ID: 21407814 Somatic Coding Mutations in Human Induced Pluripotent Stem Cells Nature. Mar, 2011 | Pubmed ID: 21368825 Stable Kinesin and Dynein Assemblies Drive the Axonal Transport of Mammalian Prion Protein Vesicles Cell. Feb, 2011 | Pubmed ID: 21335237 Investigating Synapse Formation and Function Using Human Pluripotent Stem Cell-derived Neurons Proceedings of the National Academy of Sciences of the United States of America. Feb, 2011 | Pubmed ID: 21278334 Unconventional Allies: Interdisciplinary Approaches to Science Policy and Funding Trends in Cell Biology. Dec, 2010 | Pubmed ID: 21106464 Kinesin-1 Transport Reductions Enhance Human Tau Hyperphosphorylation, Aggregation and Neurodegeneration in Animal Models of Tauopathies Human Molecular Genetics. Nov, 2010 | Pubmed ID: 20817925 Patients Beware: Commercialized Stem Cell Treatments on the Web Cell Stem Cell. Jul, 2010 | Pubmed ID: 20621049 The Role of YAP Transcription Coactivator in Regulating Stem Cell Self-renewal and Differentiation Genes & Development. Jun, 2010 | Pubmed ID: 20516196 Sunday Driver Interacts with Two Distinct Classes of Axonal Organelles The Journal of Biological Chemistry. Dec, 2009 | Pubmed ID: 19801628 Examination of Potential Mechanisms of Amyloid-induced Defects in Neuronal Transport Neurobiology of Disease. Oct, 2009 | Pubmed ID: 19497367 Axonal Stress Kinase Activation and Tau Misbehavior Induced by Kinesin-1 Transport Defects The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2009 | Pubmed ID: 19420244 Enhanced Sensitivity of Striatal Neurons to Axonal Transport Defects Induced by Mutant Huntingtin The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2008 | Pubmed ID: 19074039 Amyloid Precursor Protein-induced Axonopathies Are Independent of Amyloid-beta Peptides Human Molecular Genetics. Nov, 2008 | Pubmed ID: 18694898 Mutant SOD1 in Cell Types Other Than Motor Neurons and Oligodendrocytes Accelerates Onset of Disease in ALS Mice Proceedings of the National Academy of Sciences of the United States of America. May, 2008 | Pubmed ID: 18492803 Dynactin is Required for Coordinated Bidirectional Motility, but Not for Dynein Membrane Attachment Molecular Biology of the Cell. Jun, 2007 | Pubmed ID: 17360970 Analysis of Kinesin-2 Function in Photoreceptor Cells Using Synchronous Cre-loxP Knockout of Kif3a with RHO-Cre Investigative Ophthalmology & Visual Science. Nov, 2006 | Pubmed ID: 17065525 The Genetics of Axonal Transport and Axonal Transport Disorders PLoS Genetics. Sep, 2006 | Pubmed ID: 17009871 Increased App Expression in a Mouse Model of Down's Syndrome Disrupts NGF Transport and Causes Cholinergic Neuron Degeneration Neuron. Jul, 2006 | Pubmed ID: 16815330 Axonal Transport and Alzheimer's Disease Annual Review of Biochemistry. 2006 | Pubmed ID: 16756504 Linking Molecular Motors to Alzheimer's Disease Journal of Physiology, Paris. Mar-May, 2006 | Pubmed ID: 16459060 Kinesin-2 and Photoreceptor Cell Death: Requirement of Motor Subunits Experimental Eye Research. Feb, 2006 | Pubmed ID: 16337628 Sunday Driver Links Axonal Transport to Damage Signaling The Journal of Cell Biology. Feb, 2005 | Pubmed ID: 15738268 Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer's Disease Science (New York, N.Y.). Feb, 2005 | Pubmed ID: 15731448 Polyglutamine Diseases and Transport Problems: Deadly Traffic Jams on Neuronal Highways Archives of Neurology. Jan, 2005 | Pubmed ID: 15642849 A Standardized Kinesin Nomenclature The Journal of Cell Biology. Oct, 2004 | Pubmed ID: 15479732 Microtubule-dependent Transport in Neurons: Steps Towards an Understanding of Regulation, Function and Dysfunction Current Opinion in Cell Biology. Aug, 2004 | Pubmed ID: 15261678 Cargo-carrying Motor Vehicles on the Neuronal Highway: Transport Pathways and Neurodegenerative Disease Journal of Neurobiology. Feb, 2004 | Pubmed ID: 14704957 Do Disorders of Movement Cause Movement Disorders and Dementia? Neuron. Oct, 2003 | Pubmed ID: 14556718 Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila Neuron. Sep, 2003 | Pubmed ID: 14527431 JNK1 is Required for Maintenance of Neuronal Microtubules and Controls Phosphorylation of Microtubule-associated Proteins Developmental Cell. Apr, 2003 | Pubmed ID: 12689591 Abnormal Neurofilament Transport Caused by Targeted Disruption of Neuronal Kinesin Heavy Chain KIF5A The Journal of Cell Biology. Apr, 2003 | Pubmed ID: 12682084 Kidney-specific Inactivation of the KIF3A Subunit of Kinesin-II Inhibits Renal Ciliogenesis and Produces Polycystic Kidney Disease Proceedings of the National Academy of Sciences of the United States of America. Apr, 2003 | Pubmed ID: 12672950 A Genetic Screen for Suppressors and Enhancers of the Drosophila Cdk1-cyclin B Identifies Maternal Factors That Regulate Microtubule and Microfilament Stability Genetics. Nov, 2002 | Pubmed ID: 12454065 Principles of Cargo Attachment to Cytoplasmic Motor Proteins Current Opinion in Cell Biology. Feb, 2002 | Pubmed ID: 11792546 Adociasulfates 1-6, Inhibitors of Kinesin Motor Proteins from the Sponge Haliclona (aka Adocia) Sp The Journal of Organic Chemistry. Jul, 1999 | Pubmed ID: 11674622 Karakterisere sammensætningen af Molecular Motors på Moving axonal Cargo Brug af "Cargo Mapping" Analyse Sylvia Neumann1, George E. Campbell*1, Lukasz Szpankowski*2,3, Lawrence S.B. Goldstein2,4, Sandra E. Encalada1 1Department of Molecular and Experimental Medicine, Dorris Neuroscience Center, The Scripps Research Institute, 2Department of Cellular and Molecular Medicine, University of California San Diego, 3Department of Bioengineering, University of California San Diego, 4Department of Neurosciences, University of California San Diego School of Medicine Neuroscience
Karakterisere sammensætningen af Molecular Motors på Moving axonal Cargo Brug af "Cargo Mapping" Analyse Sylvia Neumann1, George E. Campbell*1, Lukasz Szpankowski*2,3, Lawrence S.B. Goldstein2,4, Sandra E. Encalada1 1Department of Molecular and Experimental Medicine, Dorris Neuroscience Center, The Scripps Research Institute, 2Department of Cellular and Molecular Medicine, University of California San Diego, 3Department of Bioengineering, University of California San Diego, 4Department of Neurosciences, University of California San Diego School of Medicine Neuroscience
