Lawrence Lum Department of Cell Biology UT Southwestern Medical Center Biography Publications Institution JoVE Articles Lawrence Lum has not added a biography. If you are Lawrence Lum and would like to personalize this page please email our Author Liaison for assistance. Publications Evaluating the Effects of Lenalidomide Induction Therapy on Peripheral Stem Cells Collection in Patients Undergoing Autologous Stem Cell Transplant for Multiple Myeloma Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer. Apr, 2013 | Pubmed ID: 23591714 CD20-Targeted T Cells After Stem Cell Transplantation for High Risk and Refractory Non-Hodgkin's Lymphoma Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. Jun, 2013 | Pubmed ID: 23529012 Signaling: Making a Leaner Hedgehog Nature Chemical Biology. Apr, 2013 | Pubmed ID: 23508185 A Targeted RNAi Screen of the Breast Cancer Genome Identifies KIF14 and TLN1 As Genes That Modulate Docetaxel Chemosensitivity in Triple-negative Breast Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2013 | Pubmed ID: 23479679 The Development of Highly Potent Inhibitors for Porcupine Journal of Medicinal Chemistry. Mar, 2013 | Pubmed ID: 23477365 Targeting and Killing of Glioblastoma with Activated T Cells Armed with Bispecific Antibodies BMC Cancer. 2013 | Pubmed ID: 23433400 Microenvironment Generated During EGFR Targeted Killing of Pancreatic Tumor Cells by ATC Inhibits Myeloid-derived Suppressor Cells Through COX2 and PGE2 Dependent Pathway Journal of Translational Medicine. 2013 | Pubmed ID: 23394575 A Phase I Dose-escalation Trial of High-dose Melphalan with Palifermin for Cytoprotection Followed by Autologous Stem Cell Transplantation for Patients with Multiple Myeloma with Normal Renal Function Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. Jan, 2013 | Pubmed ID: 22892551 The Chemistry and Biology of Nakiterpiosin - C-nor-D-Homosteroids Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. Oct, 2012 | Pubmed ID: 23226922 Pan-Bcl-2 Inhibitor AT-101 Enhances Tumor Cell Killing by EGFR Targeted T Cells PloS One. 2012 | Pubmed ID: 23185240 Cell Biology. The Unusual Case of Porcupine Science (New York, N.Y.). Aug, 2012 | Pubmed ID: 22923569 Phase I Trial of Bortezomib During Maintenance Phase After High Dose Melphalan and Autologous Stem Cell Transplantation in Patients with Multiple Myeloma Journal of Chemotherapy (Florence, Italy). Jun, 2012 | Pubmed ID: 22759762 Generation and Immunologic Functions of Th17 Cells in Malignant Gliomas Cancer Immunology, Immunotherapy : CII. Jul, 2012 | Pubmed ID: 22752645 Anti-thymocyte Globulin (thymoglobulin), Tacrolimus, and Sirolimus As Acute Graft-versus-host Disease Prophylaxis for Unrelated Hematopoietic Stem Cell Transplantation Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. Nov, 2012 | Pubmed ID: 22710143 Anti-CD3 × anti-GD2 Bispecific Antibody Redirects T-cell Cytolytic Activity to Neuroblastoma Targets Pediatric Blood & Cancer. Dec, 2012 | Pubmed ID: 22707078 Diverse Chemical Scaffolds Support Direct Inhibition of the Membrane-bound O-acyltransferase Porcupine The Journal of Biological Chemistry. Jun, 2012 | Pubmed ID: 22593577 In Vivo Wnt Signaling Tracing Through a Transgenic Biosensor Fish Reveals Novel Activity Domains Developmental Biology. Jun, 2012 | Pubmed ID: 22546689 Melphalan 180 Mg/m2 Can Be Safely Administered As Conditioning Regimen Before an Autologous Stem Cell Transplantation (ASCT) in Multiple Myeloma Patients with Creatinine Clearance 60 ML/min/1.73 M2 or Lower with Use of Palifermin for Cytoprotection: Results of a Phase I Trial Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. Sep, 2012 | Pubmed ID: 22453252 Targeting Cytomegalovirus-infected Cells Using T Cells Armed with Anti-CD3 × Anti-CMV Bispecific Antibody Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. Jul, 2012 | Pubmed ID: 22313635 Aprepitant for Prevention of Nausea and Vomiting Secondary to High-dose Cyclophosphamide Administered to Patients Undergoing Autologous Peripheral Blood Stem Cells Mobilization: a Phase II Trial Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer. Oct, 2012 | Pubmed ID: 22193771 The Immunological Contribution of NF-κB Within the Tumor Microenvironment: a Potential Protective Role of Zinc As an Anti-tumor Agent Biochimica Et Biophysica Acta. Apr, 2012 | Pubmed ID: 22155217 Scutellaria Extract and Wogonin Inhibit Tumor-mediated Induction of T(reg) Cells Via Inhibition of TGF-β1 Activity Cancer Immunology, Immunotherapy : CII. May, 2012 | Pubmed ID: 22057676 A Th1 Cytokine-enriched Microenvironment Enhances Tumor Killing by Activated T Cells Armed with Bispecific Antibodies and Inhibits the Development of Myeloid-derived Suppressor Cells Cancer Immunology, Immunotherapy : CII. Apr, 2012 | Pubmed ID: 21971587 Mechanistic Insight into Myc Stabilization in Breast Cancer Involving Aberrant Axin1 Expression Proceedings of the National Academy of Sciences of the United States of America. Feb, 2012 | Pubmed ID: 21808024 Activated T Cells from Umbilical Cord Blood Armed with Anti-CD3 × Anti-CD20 Bispecific Antibody Mediate Specific Cytotoxicity Against CD20+ Targets with Minimal Allogeneic Reactivity: a Strategy for Providing Antitumor Effects After Cord Blood Transplants Transfusion. Jan, 2012 | Pubmed ID: 21745212 Targeting T Cells with Bispecific Antibodies for Cancer Therapy BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. Dec, 2011 | Pubmed ID: 22050339 In Vitro Synthesis of Primary Specific Anti-breast Cancer Antibodies by Normal Human Peripheral Blood Mononuclear Cells Cancer Immunology, Immunotherapy : CII. Dec, 2011 | Pubmed ID: 21713642 Induction of Specific Cellular and Humoral Responses Against Renal Cell Carcinoma After Combination Therapy with Cryoablation and Granulocyte-macrophage Colony Stimulating Factor: a Pilot Study Journal of Immunotherapy (Hagerstown, Md. : 1997). Jun, 2011 | Pubmed ID: 21577139 Small Molecule Wnt Inhibitors Enhance the Efficiency of BMP-4-directed Cardiac Differentiation of Human Pluripotent Stem Cells Journal of Molecular and Cellular Cardiology. Sep, 2011 | Pubmed ID: 21569778 Canonical Wnt9b Signaling Balances Progenitor Cell Expansion and Differentiation During Kidney Development Development (Cambridge, England). Apr, 2011 | Pubmed ID: 21350016 Genome-wide RNAi Screen Reveals Disease-associated Genes That Are Common to Hedgehog and Wnt Signaling Science Signaling. 2011 | Pubmed ID: 21266715 Drugging the Cancer Stem Cell Compartment: Lessons Learned from the Hedgehog and Wnt Signal Transduction Pathways Annual Review of Pharmacology and Toxicology. 2011 | Pubmed ID: 20887197 Detección De Resistencia Al Oseltamivir Durante El Tratamiento De La Infección Del Virus De La Influenza H1N1 2009 En Pacientes Inmunocomprometidos: Utilidad De Los Valores De Umbral De Ciclo De La Transcriptasa Inversa En Tiempo Real Cualitativa PCR Journal of Clinical Microbiology. Nov, 2010 | Pubmed ID: 20844229 Tankyrase is Necessary for Canonical Wnt Signaling During Kidney Development Developmental Dynamics : an Official Publication of the American Association of Anatomists. Jul, 2010 | Pubmed ID: 20549720 Cancer Therapy with Bispecific Antibodies: Clinical Experience Current Opinion in Molecular Therapeutics. Jun, 2010 | Pubmed ID: 20521223 Effect of Disruption of Akt-1 of Lin(-)c-kit(+) Stem Cells on Myocardial Performance in Infarcted Heart Cardiovascular Research. Sep, 2010 | Pubmed ID: 20410290 Role of Donor Lymphocyte Infusions in Relapsed Hematological Malignancies After Stem Cell Transplantation Revisited Cancer Treatment Reviews. Nov, 2010 | Pubmed ID: 20381970 Chemical and Biological Studies of Nakiterpiosin and Nakiterpiosinone Journal of the American Chemical Society. Jan, 2010 | Pubmed ID: 20000429 Structure-activity Relationship Studies of Small-molecule Inhibitors of Wnt Response Bioorganic & Medicinal Chemistry Letters. Jul, 2009 | Pubmed ID: 19410457 Nonabsorbable Corticosteroids Use in the Treatment of Gastrointestinal Graft-versus-host Disease Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. Apr, 2009 | Pubmed ID: 19285626 Small Molecule-mediated Disruption of Wnt-dependent Signaling in Tissue Regeneration and Cancer Nature Chemical Biology. Feb, 2009 | Pubmed ID: 19125156 Development and Prospects for Bispecific Antibody-based Therapeutics in Cancer and Other Applications Expert Opinion on Drug Discovery. Sep, 2008 | Pubmed ID: 23506181 A Genome-wide RNAi Screen for Wnt/beta-catenin Pathway Components Identifies Unexpected Roles for TCF Transcription Factors in Cancer Proceedings of the National Academy of Sciences of the United States of America. Jul, 2008 | Pubmed ID: 18621708 Targeting Human CD34+ Hematopoietic Stem Cells with Anti-CD45 X Anti-myosin Light-chain Bispecific Antibody Preserves Cardiac Function in Myocardial Infarction Journal of Applied Physiology (Bethesda, Md. : 1985). Jun, 2008 | Pubmed ID: 18292296 Hedgehog Signaling Pathway in Drosophila Science's STKE : Signal Transduction Knowledge Environment. Oct, 2007 | Pubmed ID: 17925578 Hedgehog Signaling Pathway Science's STKE : Signal Transduction Knowledge Environment. Oct, 2007 | Pubmed ID: 17925577 Deconstructing the Hedgehog Pathway in Development and Disease Science (New York, N.Y.). Oct, 2007 | Pubmed ID: 17916724 Tissue Engineering and Stem Cell Therapy for Myocardial Repair Frontiers in Bioscience : a Journal and Virtual Library. 2007 | Pubmed ID: 17569637 Anticuerpos Dirigidos Contra Células De Miocardio Infartado Stem Cells (Dayton, Ohio). Mar, 2007 | Pubmed ID: 17138964 Reducir Al Mínimo El Riesgo De Denunciar Los Falsos Positivos En Gran Escala Las Pantallas De RNAi Nature Methods. Oct, 2006 | Pubmed ID: 16990807 Prevalence of Off-target Effects in Drosophila RNA Interference Screens Nature. Sep, 2006 | Pubmed ID: 16964239 A Genomewide Screen for Components of the RNAi Pathway in Drosophila Cultured Cells Proceedings of the National Academy of Sciences of the United States of America. Aug, 2006 | Pubmed ID: 16882716 The Ihog Cell-surface Proteins Bind Hedgehog and Mediate Pathway Activation Cell. Apr, 2006 | Pubmed ID: 16630821 Enhanced Killing of Primary Ovarian Cancer by Retargeting Autologous Cytokine-induced Killer Cells with Bispecific Antibodies: a Preclinical Study Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2006 | Pubmed ID: 16551871 Human T Cells Armed with Her2/neu Bispecific Antibodies Divide, Are Cytotoxic, and Secrete Cytokines with Repeated Stimulation Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2006 | Pubmed ID: 16428502 The New Face of Bispecific Antibodies: Targeting Cancer and Much More Experimental Hematology. Jan, 2006 | Pubmed ID: 16413384 Anti-CD3 X Anti-epidermal Growth Factor Receptor (EGFR) Bispecific Antibody Redirects T-cell Cytolytic Activity to EGFR-positive Cancers in Vitro and in an Animal Model Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2006 | Pubmed ID: 16397041 Retargeting T Cells and Immune Effector Cells with Bispecific Antibodies Cancer Chemotherapy and Biological Response Modifiers. 2005 | Pubmed ID: 16110617 Virtual Reality of Stem Cell Transplantation to Repair Injured Myocardium Journal of Cellular Biochemistry. Aug, 2005 | Pubmed ID: 15962306 Preclinical Studies Comparing Different Bispecific Antibodies for Redirecting T Cell Cytotoxicity to Extracellular Antigens on Prostate Carcinomas Anticancer Research. Jan-Feb, 2005 | Pubmed ID: 15816517 T Cells Armed with Anti-CD3 X Anti-CD20 Bispecific Antibody Enhance Killing of CD20+ Malignant B Cells and Bypass Complement-mediated Rituximab Resistance in Vitro Experimental Hematology. Apr, 2005 | Pubmed ID: 15781336 Extensive Phosphorylation of Smoothened in Hedgehog Pathway Activation Proceedings of the National Academy of Sciences of the United States of America. Dec, 2004 | Pubmed ID: 15598741 Anti-CD3 X Anti-HER2 Bispecific Antibody Effectively Redirects Armed T Cells to Inhibit Tumor Development and Growth in Hormone-refractory Prostate Cancer-bearing Severe Combined Immunodeficient Beige Mice Clinical Prostate Cancer. Sep, 2004 | Pubmed ID: 15479495 The Hedgehog Response Network: Sensors, Switches, and Routers Science (New York, N.Y.). Jun, 2004 | Pubmed ID: 15205520 How Important is HER2/neu Amplification and Expression when Selecting Patients for HER2/neu-targeted Therapies? Clinical Breast Cancer. Apr, 2004 | Pubmed ID: 15140288 Redirected T-cell Cytotoxicity to Epithelial Cell Adhesion Molecule-overexpressing Adenocarcinomas by a Novel Recombinant Antibody, E3Bi, in Vitro and in an Animal Model Cancer. Mar, 2004 | Pubmed ID: 14983507 Targeting of Lin-Sca+ Hematopoietic Stem Cells with Bispecific Antibodies to Injured Myocardium Blood Cells, Molecules & Diseases. Jan-Feb, 2004 | Pubmed ID: 14757418 Differentiation Hotspots: the Deterioration of Hierarchy and Stochasm Blood Cells, Molecules & Diseases. Jan-Feb, 2004 | Pubmed ID: 14757410 Evidence for a Critical Role of the Tumor Necrosis Factor Alpha Convertase (TACE) in Ectodomain Shedding of the P75 Neurotrophin Receptor (p75NTR) The Journal of Biological Chemistry. Feb, 2004 | Pubmed ID: 14638693 Hedgehog Signal Transduction Via Smoothened Association with a Cytoplasmic Complex Scaffolded by the Atypical Kinesin, Costal-2 Molecular Cell. Nov, 2003 | Pubmed ID: 14636583 Future Prospects for Patient Care Utilizing Autologous Lymphoid and Hematopoietic Stem Cells Medicine and Health, Rhode Island. Aug, 2003 | Pubmed ID: 14582220 Phase I/II Study of Treatment of Stage IV Breast Cancer with OKT3 X Trastuzumab-armed Activated T Cells Clinical Breast Cancer. Aug, 2003 | Pubmed ID: 14499016 Potential Role for ADAM15 in Pathological Neovascularization in Mice Molecular and Cellular Biology. Aug, 2003 | Pubmed ID: 12897135 Identification of Hedgehog Pathway Components by RNAi in Drosophila Cultured Cells Science (New York, N.Y.). Mar, 2003 | Pubmed ID: 12663920 The New Stem Cell Biology Transactions of the American Clinical and Climatological Association. 2002 | Pubmed ID: 12053709 Immune Modulation in Cancer Patients After Adoptive Transfer of Anti-CD3/Anti-CD28-Costimulated T Cells-Phase I Clinical Trial Journal of Immunotherapy : Official Journal of the Society for Biological Therapy. Sep-Oct, 2001 | Pubmed ID: 11685083 Una plataforma de detección de luciferasa basado multiplexado para interrogar cáncer asociado transducción de señales en las células cultivadas Ozlem Kulak1, Lawrence Lum1 1Department of Cell Biology, UT Southwestern Medical Center JoVE 50369 Medicine
Una plataforma de detección de luciferasa basado multiplexado para interrogar cáncer asociado transducción de señales en las células cultivadas Ozlem Kulak1, Lawrence Lum1 1Department of Cell Biology, UT Southwestern Medical Center JoVE 50369 Medicine