Lee J. Martin

Publications

• The Non-human Primate Striatum Undergoes Marked Prolonged Remodeling During Postnatal Development
  Frontiers in Cellular Neuroscience. 2014  |   Pubmed ID: 25294985
• Oscillating Gradient Diffusion MRI Reveals Unique Microstructural Information in Normal and Hypoxia-ischemia Injured Mouse Brains
  Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Nov, 2014  |   Pubmed ID: 25168861
• Induced Pluripotent Stem Cells from Familial Alzheimer's Disease Patients Differentiate into Mature Neurons with Amyloidogenic Properties
  Stem Cells and Development. Aug, 2014  |   Pubmed ID: 25027006
• Skeletal Muscle DNA Damage Precedes Spinal Motor Neuron DNA Damage in a Mouse Model of Spinal Muscular Atrophy (SMA)
  PloS One. 2014  |   Pubmed ID: 24667816
• Mitochondrial Permeability Transition Pore Regulates Parkinson's Disease Development in Mutant α-synuclein Transgenic Mice
  Neurobiology of Aging. May, 2014  |   Pubmed ID: 24325796
• Imaging Neurodegeneration in the Mouse Hippocampus After Neonatal Hypoxia-ischemia Using Oscillating Gradient Diffusion MRI
  Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Sep, 2014  |   Pubmed ID: 24123409
• Mitochondrial DNMT3A and DNA Methylation in Skeletal Muscle and CNS of Transgenic Mouse Models of ALS
  Frontiers in Cellular Neuroscience. 2013  |   Pubmed ID: 24399935
• The Olfactory Bulb in Newborn Piglet is a Reservoir of Neural Stem and Progenitor Cells
  PloS One. 2013  |   Pubmed ID: 24278384
• Aberrant Regulation of DNA Methylation in Amyotrophic Lateral Sclerosis: a New Target of Disease Mechanisms
  Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Oct, 2013  |   Pubmed ID: 23900692
• Adenosine A2A Receptor Contributes to Ischemic Brain Damage in Newborn Piglet
  Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Oct, 2013  |   Pubmed ID: 23860373
• Early Antioxidant Treatment and Delayed Hypothermia After Hypoxia-ischemia Have No Additive Neuroprotection in Newborn Pigs
  Anesthesia and Analgesia. Sep, 2012  |   Pubmed ID: 22745113
• Programmed Necrosis: A Prominent Mechanism of Cell Death Following Neonatal Brain Injury
  Neurology Research International. 2012  |   Pubmed ID: 22666585
• Biology of Mitochondria in Neurodegenerative Diseases
  Progress in Molecular Biology and Translational Science. 2012  |   Pubmed ID: 22482456
• Attenuation of Neonatal Ischemic Brain Damage Using a 20-HETE Synthesis Inhibitor
  Journal of Neurochemistry. Apr, 2012  |   Pubmed ID: 22251169
• Nuclear Localization of Human SOD1 and Mutant SOD1-specific Disruption of Survival Motor Neuron Protein Complex in Transgenic Amyotrophic Lateral Sclerosis Mice
  Journal of Neuropathology and Experimental Neurology. Feb, 2012  |   Pubmed ID: 22249462
• Inhibitory Synaptic Regulation of Motoneurons: a New Target of Disease Mechanisms in Amyotrophic Lateral Sclerosis
  Molecular Neurobiology. Feb, 2012  |   Pubmed ID: 22072396
• Epigenetic Regulation of Motor Neuron Cell Death Through DNA Methylation
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2011  |   Pubmed ID: 22090490
• Mitochondrial Pathobiology in ALS
  Journal of Bioenergetics and Biomembranes. Dec, 2011  |   Pubmed ID: 22083126
• Generation and Characterization of Transgenic Mice Expressing Mitochondrial Targeted Red Fluorescent Protein Selectively in Neurons: Modeling Mitochondriopathy in Excitotoxicity and Amyotrophic Lateral Sclerosis
  Molecular Neurodegeneration. 2011  |   Pubmed ID: 22047141
• Striatal Neuroprotection from Neonatal Hypoxia-ischemia in Piglets by Antioxidant Treatment with EUK-134 or Edaravone
  Developmental Neuroscience. 2011  |   Pubmed ID: 21701140
• Motoneuron Subtypes Show Specificity in Glycine Receptor Channel Abnormalities in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
  Channels (Austin, Tex.). Jul-Aug, 2011  |   Pubmed ID: 21558795
• Neuroprotective Effect of Acid-sensing Ion Channel Inhibitor Psalmotoxin-1 After Hypoxia-ischemia in Newborn Piglet Striatum
  Neurobiology of Disease. Aug, 2011  |   Pubmed ID: 21558004
• Neuronal Cell Death in Neonatal Hypoxia-ischemia
  Annals of Neurology. May, 2011  |   Pubmed ID: 21520238
• Glycine Receptor Channels in Spinal Motoneurons Are Abnormal in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2011  |   Pubmed ID: 21414903
• An Approach to Experimental Synaptic Pathology Using Green Fluorescent Protein-transgenic Mice and Gene Knockout Mice to Show Mitochondrial Permeability Transition Pore-driven Excitotoxicity in Interneurons and Motoneurons
  Toxicologic Pathology. Jan, 2011  |   Pubmed ID: 21378209
• The Mitochondrial Permeability Transition Pore Regulates Nitric Oxide-mediated Apoptosis of Neurons Induced by Target Deprivation
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2011  |   Pubmed ID: 21209222
• Necrostatin Decreases Oxidative Damage, Inflammation, and Injury After Neonatal HI
  Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Jan, 2011  |   Pubmed ID: 20571523
• Mitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases
  Pharmaceuticals (Basel, Switzerland). 2010  |   Pubmed ID: 21258649
• Olesoxime, a Cholesterol-like Neuroprotectant for the Potential Treatment of Amyotrophic Lateral Sclerosis
  IDrugs : the Investigational Drugs Journal. Aug, 2010  |   Pubmed ID: 20721828
• Mitochondrial Pathobiology in Parkinson's Disease and Amyotrophic Lateral Sclerosis
  Journal of Alzheimer's Disease : JAD. 2010  |   Pubmed ID: 20413846
• Skeletal Muscle-restricted Expression of Human SOD1 Causes Motor Neuron Degeneration in Transgenic Mice
  Human Molecular Genetics. Jun, 2010  |   Pubmed ID: 20223753
• Synphilin-1 Attenuates Neuronal Degeneration in the A53T Alpha-synuclein Transgenic Mouse Model
  Human Molecular Genetics. Jun, 2010  |   Pubmed ID: 20185556
• Inducible Nitric Oxide Synthase is Present in Motor Neuron Mitochondria and Schwann Cells and Contributes to Disease Mechanisms in ALS Mice
  Brain Structure & Function. Mar, 2010  |   Pubmed ID: 19888600
• Sigma Receptor Ligand 4-phenyl-1-(4-phenylbutyl)-piperidine Modulates Neuronal Nitric Oxide Synthase/postsynaptic Density-95 Coupling Mechanisms and Protects Against Neonatal Ischemic Degeneration of Striatal Neurons
  Experimental Neurology. Jan, 2010  |   Pubmed ID: 19883643
• The Mitochondrial Permeability Transition Pore: a Molecular Target for Amyotrophic Lateral Sclerosis Therapy
  Biochimica Et Biophysica Acta. Jan, 2010  |   Pubmed ID: 19651206
• Neuropathologic Studies of the Baltimore Longitudinal Study of Aging (BLSA)
  Journal of Alzheimer's Disease : JAD. 2009  |   Pubmed ID: 19661626
• The Mitochondrial Permeability Transition Pore in Motor Neurons: Involvement in the Pathobiology of ALS Mice
  Experimental Neurology. Aug, 2009  |   Pubmed ID: 19272377
• Glycinergic Innervation of Motoneurons is Deficient in Amyotrophic Lateral Sclerosis Mice: a Quantitative Confocal Analysis
  The American Journal of Pathology. Feb, 2009  |   Pubmed ID: 19116365
• Molecular Regulation of DNA Damage-induced Apoptosis in Neurons of Cerebral Cortex
  Cerebral Cortex (New York, N.Y. : 1991). Jun, 2009  |   Pubmed ID: 18820287
• Delayed Neural Network Degeneration After Neonatal Hypoxia-ischemia
  Annals of Neurology. Nov, 2008  |   Pubmed ID: 19067347
• DNA Damage and Repair: Relevance to Mechanisms of Neurodegeneration
  Journal of Neuropathology and Experimental Neurology. May, 2008  |   Pubmed ID: 18431258
• Motoneuron-Krankheit Auftreten in Einem Mausmodell Mutant DCTN3 Zeichnet Sich Durch Defekte Vesikulären Handel
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2008  |   Pubmed ID: 18305234
• Rapid NMDA Receptor Phosphorylation and Oxidative Stress Precede Striatal Neurodegeneration After Hypoxic Ischemia in Newborn Piglets and Are Attenuated with Hypothermia
  International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience. Feb, 2008  |   Pubmed ID: 17950559
• Adult Olfactory Bulb Neural Precursor Cell Grafts Provide Temporary Protection from Motor Neuron Degeneration, Improve Motor Function, and Extend Survival in Amyotrophic Lateral Sclerosis Mice
  Journal of Neuropathology and Experimental Neurology. Nov, 2007  |   Pubmed ID: 17984682
• Resistance to Alzheimer's Pathology is Associated with Nuclear Hypertrophy in Neurons
  Neurobiology of Aging. Oct, 2007  |   Pubmed ID: 17599696
• Transgenic Mice with Human Mutant Genes Causing Parkinson's Disease and Amyotrophic Lateral Sclerosis Provide Common Insight into Mechanisms of Motor Neuron Selective Vulnerability to Degeneration
  Reviews in the Neurosciences. 2007  |   Pubmed ID: 17593875
• Dopamine Receptor Modulation of Hypoxic-ischemic Neuronal Injury in Striatum of Newborn Piglets
  Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Jul, 2007  |   Pubmed ID: 17213860
• Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis Mutant Superoxide Dismutase-1 Transgenic Mice: Mechanisms of Mitochondriopathy and Cell Death
  The Journal of Comparative Neurology. Jan, 2007  |   Pubmed ID: 17099894
• Mitochondriopathy in Parkinson Disease and Amyotrophic Lateral Sclerosis
  Journal of Neuropathology and Experimental Neurology. Dec, 2006  |   Pubmed ID: 17146283
• Amyotrophe Lateralsklerose-2-Mangel Führt Zu Neuronale Degeneration in Amyotrophe Lateralsklerose Durch Veränderte AMPA-Rezeptor-Handel
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2006  |   Pubmed ID: 17093100
• The Adult Neural Stem and Progenitor Cell Niche is Altered in Amyotrophic Lateral Sclerosis Mouse Brain
  The Journal of Comparative Neurology. Jul, 2006  |   Pubmed ID: 16736475
• Parkinson's Disease Alpha-synuclein Transgenic Mice Develop Neuronal Mitochondrial Degeneration and Cell Death
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2006  |   Pubmed ID: 16399671
• Transplanted Human Embryonic Germ Cell-derived Neural Stem Cells Replace Neurons and Oligodendrocytes in the Forebrain of Neonatal Mice with Excitotoxic Brain Damage
  Journal of Neuroscience Research. Dec, 2005  |   Pubmed ID: 16247803
• Apoptosis in Perinatal Hypoxic-ischemic Brain Injury: How Important is It and Should It Be Inhibited?
  Brain Research. Brain Research Reviews. Dec, 2005  |   Pubmed ID: 16216332
• Adult Motor Neuron Apoptosis is Mediated by Nitric Oxide and Fas Death Receptor Linked by DNA Damage and P53 Activation
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2005  |   Pubmed ID: 16000635
• In Situ Immunoradiographic Method for Quantification of Specific Proteins in Normal and Ischemic Brain Regions
  Journal of Neuroscience Methods. Apr, 2005  |   Pubmed ID: 15814155
• Pluripotent Fates and Tissue Regenerative Potential of Adult Olfactory Bulb Neural Stem and Progenitor Cells
  Journal of Neurotrauma. Oct, 2004  |   Pubmed ID: 15672637
• Neonatal Mice Lacking Functional Fas Death Receptors Are Resistant to Hypoxic-ischemic Brain Injury
  Neurobiology of Disease. Oct, 2004  |   Pubmed ID: 15350969
• Histopathologische Und Verhaltensstörungen Charakterisierung Eines Neuen Modells Der Herzstillstand Und Reanimation Bei Mäusen
  Journal of Neuroscience Methods. Jun, 2004  |   Pubmed ID: 15126043
• Nitrierung Des Striatalen Na, K-ATPase Kommt Alpha3 Isoform in Normale Entwicklung Des Gehirns, Ist Aber Nicht Während Der Hypoxie-Ischämie Bei Neugeborenen Ferkeln Erhöht
  Neurochemical Research. Dec, 2003  |   Pubmed ID: 14649731
• Hypothermie Für 24 Stunden Nach Asphyktische Herzstillstand Bei Ferkeln Bietet Striatalen Neuroprotektion, Die 10 Tage Nach Der Wiedererwärmung Aufrechterhalten Wird
  Pediatric Research. Aug, 2003  |   Pubmed ID: 12736390
• Olfactory Bulb Core is a Rich Source of Neural Progenitor and Stem Cells in Adult Rodent and Human
  The Journal of Comparative Neurology. May, 2003  |   Pubmed ID: 12687705
• Early Events of Target Deprivation/axotomy-induced Neuronal Apoptosis in Vivo: Oxidative Stress, DNA Damage, P53 Phosphorylation and Subcellular Redistribution of Death Proteins
  Journal of Neurochemistry. Apr, 2003  |   Pubmed ID: 12641745
• DNA Damage Profiling in Motor Neurons: a Single-cell Analysis by Comet Assay
  Neurochemical Research. Oct, 2002  |   Pubmed ID: 12462407
• DNA Base-excision Repair Enzyme Apurinic/apyrimidinic Endonuclease/redox Factor-1 is Increased and Competent in the Brain and Spinal Cord of Individuals with Amyotrophic Lateral Sclerosis
  Neuromolecular Medicine. 2002  |   Pubmed ID: 12230304
• Rapid Subcellular Redistribution of Bax Precedes Caspase-3 and Endonuclease Activation During Excitotoxic Neuronal Apoptosis in Rat Brain
  Journal of Neurotrauma. Jul, 2002  |   Pubmed ID: 12184852
• Immature and Mature Cortical Neurons Engage Different Apoptotic Mechanisms Involving Caspase-3 and the Mitogen-activated Protein Kinase Pathway
  Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Aug, 2002  |   Pubmed ID: 12172379
• Veränderte Expression Und Phosphorylierung Von N-Methyl-D-Aspartat-Rezeptoren Im Striatum Ferkel Nach Hypoxie-Ischämie
  Brain Research. Molecular Brain Research. Jul, 2002  |   Pubmed ID: 12117552
• Long-term Culture of Mouse Cortical Neurons As a Model for Neuronal Development, Aging, and Death
  Journal of Neurobiology. Apr, 2002  |   Pubmed ID: 11920724
• Axonal Transection in Adult Rat Brain Induces Transsynaptic Apoptosis and Persistent Atrophy of Target Neurons
  Journal of Neurotrauma. Jan, 2002  |   Pubmed ID: 11852982
• Injury-induced Spinal Motor Neuron Apoptosis is Preceded by DNA Single-strand Breaks and is P53- and Bax-dependent
  Journal of Neurobiology. Feb, 2002  |   Pubmed ID: 11810634