Leslie Tung Department of Biomedical Engineering Johns Hopkins University Biography Publications Institution JoVE Articles Leslie Tung has not added a biography. If you are Leslie Tung and would like to personalize this page please email our Author Liaison for assistance. Publications Adipose-derived Perivascular Mesenchymal Stromal/stem Cells Promote Functional Vascular Tissue Engineering for Cardiac Regenerative Purposes Journal of Tissue Engineering and Regenerative Medicine. Jan, 2017 | Pubmed ID: 28103423 Functional Coupling with Cardiac Muscle Promotes Maturation of HPSC-Derived Sympathetic Neurons Cell Stem Cell. Jul, 2016 | Pubmed ID: 27320040 Precisely Parameterized Experimental and Computational Models of Tissue Organization Integrative Biology : Quantitative Biosciences from Nano to Macro. Feb, 2016 | Pubmed ID: 26822672 Tetanizing Prepulse: A Novel Strategy to Mitigate Implantable Cardioverter-defibrillator Shock-related Pain Heart Rhythm. May, 2016 | Pubmed ID: 26767423 Variability of Action Potentials Within and Among Cardiac Cell Clusters Derived from Human Embryonic Stem Cells Scientific Reports. Jan, 2016 | Pubmed ID: 26729331 Engineered Heart Slices for Electrophysiological and Contractile Studies Biomaterials. Jul, 2015 | Pubmed ID: 25934457 Physical Developmental Cues for the Maturation of Human Pluripotent Stem Cell-derived Cardiomyocytes Stem Cell Research & Therapy. Oct, 2014 | Pubmed ID: 25688759 Automated Grouping of Action Potentials of Human Embryonic Stem Cell-derived Cardiomyocytes IEEE Transactions on Bio-medical Engineering. Sep, 2014 | Pubmed ID: 25148658 Optical Mapping of Optogenetically Shaped Cardiac Action Potentials Scientific Reports. Aug, 2014 | Pubmed ID: 25135113 A Mutation Causing Brugada Syndrome Identifies a Mechanism for Altered Autonomic and Oxidant Regulation of Cardiac Sodium Currents Circulation. Cardiovascular Genetics. Jun, 2014 | Pubmed ID: 24795344 Acute Slowing of Cardiac Conduction in Response to Myofibroblast Coupling to Cardiomyocytes Through N-cadherin Journal of Molecular and Cellular Cardiology. Mar, 2014 | Pubmed ID: 24412534 A Metamorphosis Distance for Embryonic Cardiac Action Potential Interpolation and Classification Medical Image Computing and Computer-assisted Intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. 2013 | Pubmed ID: 24505700 Structural and Functional Plasticity in Long-term Cultures of Adult Ventricular Myocytes Journal of Molecular and Cellular Cardiology. Dec, 2013 | Pubmed ID: 24076394 Defibrillation Success with High Frequency Electric Fields is Related to Degree and Location of Conduction Block Heart Rhythm : the Official Journal of the Heart Rhythm Society. Jan, 2013 | Pubmed ID: 23354078 Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells As Models for Normal and Diseased Cardiac Electrophysiology and Contractility Progress in Biophysics and Molecular Biology. Oct-Nov, 2012 | Pubmed ID: 22971665 Electrophysiological and Contractile Function of Cardiomyocytes Derived from Human Embryonic Stem Cells Progress in Biophysics and Molecular Biology. Oct-Nov, 2012 | Pubmed ID: 22958937 Oscillation in Cycle Length Induces Transient Discordant and Steady-state Concordant Alternans in the Heart PloS One. 2012 | Pubmed ID: 22792346 Dynamics of Early Afterdepolarization-mediated Triggered Activity in Cardiac Monolayers Biophysical Journal. Jun, 2012 | Pubmed ID: 22735520 Engraftment of Human Embryonic Stem Cell Derived Cardiomyocytes Improves Conduction in an Arrhythmogenic in Vitro Model Journal of Molecular and Cellular Cardiology. Jul, 2012 | Pubmed ID: 22713758 Reversible Cardiac Conduction Block and Defibrillation with High-frequency Electric Field Science Translational Medicine. Sep, 2011 | Pubmed ID: 21957174 Mechanical Coupling Between Myofibroblasts and Cardiomyocytes Slows Electric Conduction in Fibrotic Cell Monolayers Circulation. May, 2011 | Pubmed ID: 21537003 Expanding on Forty Years of Reflection The Journal of Physiology. May, 2011 | Pubmed ID: 21532028 A Universal System for Highly Efficient Cardiac Differentiation of Human Induced Pluripotent Stem Cells That Eliminates Interline Variability PloS One. 2011 | Pubmed ID: 21494607 In Vitro Electrophysiological Mapping of Stem Cells Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20680822 Vulnerable Windows Define Susceptibility to Alternans and Spatial Discordance American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2010 | Pubmed ID: 20363894 Nanoscale Cues Regulate the Structure and Function of Macroscopic Cardiac Tissue Constructs Proceedings of the National Academy of Sciences of the United States of America. Jan, 2010 | Pubmed ID: 20018748 Spiral Waves and Reentry Dynamics in an in Vitro Model of the Healed Infarct Border Zone Circulation Research. Nov, 2009 | Pubmed ID: 19815825 IK1 Heterogeneity Affects Genesis and Stability of Spiral Waves in Cardiac Myocyte Monolayers Circulation Research. Feb, 2009 | Pubmed ID: 19122180 Myofibrillar Architecture in Engineered Cardiac Myocytes Circulation Research. Aug, 2008 | Pubmed ID: 18635822 Representation of Collective Electrical Behavior of Cardiac Cell Sheets Biophysical Journal. Aug, 2008 | Pubmed ID: 18469085 Cell Cultures As Models of Cardiac Mechanoelectric Feedback Progress in Biophysics and Molecular Biology. Jun-Jul, 2008 | Pubmed ID: 18384846 Region [corrected] of Slowed Conduction Acts As Core for Spiral Wave Reentry in Cardiac Cell Monolayers American Journal of Physiology. Heart and Circulatory Physiology. Jan, 2008 | Pubmed ID: 17965287 Electric Field Perturbations of Spiral Waves Attached to Millimeter-size Obstacles Biophysical Journal. Feb, 2008 | Pubmed ID: 17921205 Imaging Fibrillation/defibrillation in a Dish Journal of Electrocardiology. Nov-Dec, 2007 | Pubmed ID: 17993331 Novel Anisotropic Engineered Cardiac Tissues: Studies of Electrical Propagation Biochemical and Biophysical Research Communications. Oct, 2007 | Pubmed ID: 17689494 Lentiviral Vector-mediated Expression of GFP or Kir2.1 Alters the Electrophysiology of Neonatal Rat Ventricular Myocytes Without Inducing Cytotoxicity American Journal of Physiology. Heart and Circulatory Physiology. Nov, 2007 | Pubmed ID: 17675572 Gene Transfer of Connexin43 Mutants Attenuates Coupling in Cardiomyocytes: Novel Basis for Modulation of Cardiac Conduction by Gene Therapy Circulation Research. Jun, 2007 | Pubmed ID: 17495226 Spiral Wave Attachment to Millimeter-sized Obstacles Circulation. Nov, 2006 | Pubmed ID: 17088465 Optical Imaging of Arrhythmias in Tissue Culture Journal of Electrocardiology. Oct, 2006 | Pubmed ID: 17015066 Electrical Pacing Counteracts Intrinsic Shortening of Action Potential Duration of Neonatal Rat Ventricular Cells in Culture Journal of Molecular and Cellular Cardiology. Oct, 2006 | Pubmed ID: 16950369 Proarrhythmic Potential of Mesenchymal Stem Cell Transplantation Revealed in an in Vitro Coculture Model Circulation. Apr, 2006 | Pubmed ID: 16606790 Structure-related Initiation of Reentry by Rapid Pacing in Monolayers of Cardiac Cells Circulation Research. Mar, 2006 | Pubmed ID: 16469953 Acceleration of Functional Reentry by Rapid Pacing in Anisotropic Cardiac Monolayers: Formation of Multi-wave Functional Reentries Cardiovascular Research. Feb, 2006 | Pubmed ID: 16274682 Antiarrhythmic Engineering of Skeletal Myoblasts for Cardiac Transplantation Circulation Research. Jul, 2005 | Pubmed ID: 15976318 Mechanoelectrical Excitation by Fluid Jets in Monolayers of Cultured Cardiac Myocytes Journal of Applied Physiology (Bethesda, Md. : 1985). Jun, 2005 | Pubmed ID: 15731396 Paradoxical Loss of Excitation with High Intensity Pulses During Electric Field Stimulation of Single Cardiac Cells Biophysical Journal. Apr, 2005 | Pubmed ID: 15665123 Multiarm Spirals in a Two-dimensional Cardiac Substrate Proceedings of the National Academy of Sciences of the United States of America. Oct, 2004 | Pubmed ID: 15492227 Ionic Currents Involved in Shock-induced Nonlinear Changes in Transmembrane Potential Responses of Single Cardiac Cells Pflugers Archiv : European Journal of Physiology. Dec, 2004 | Pubmed ID: 15480751 Fluorescence Imaging of Electrical Activity in Cardiac Cells Using an All-solid-state System IEEE Transactions on Bio-medical Engineering. Feb, 2004 | Pubmed ID: 14765706 Stretch-induced Excitation and Action Potential Changes of Single Cardiac Cells Progress in Biophysics and Molecular Biology. May-Jul, 2003 | Pubmed ID: 12732271 Functional Reentry in Cultured Monolayers of Neonatal Rat Cardiac Cells American Journal of Physiology. Heart and Circulatory Physiology. Jul, 2003 | Pubmed ID: 12623789 Inter-pulse Interval Between Rectangular Voltage Pulses Affects Electroporation Threshold of Artificial Lipid Bilayers IEEE Transactions on Nanobioscience. Sep, 2002 | Pubmed ID: 16696301 A Novel Algorithm for Cardiac Biosignal Filtering Based on Filtered Residue Method IEEE Transactions on Bio-medical Engineering. Nov, 2002 | Pubmed ID: 12450361 Decomposition of Field-induced Transmembrane Potential Responses of Single Cardiac Cells IEEE Transactions on Bio-medical Engineering. Sep, 2002 | Pubmed ID: 12214875 Spatial Heterogeneity of Transmembrane Potential Responses of Single Guinea-pig Cardiac Cells During Electric Field Stimulation The Journal of Physiology. Jul, 2002 | Pubmed ID: 12122146 Effects of Uniform Electric Fields on Intracellular Calcium Transients in Single Cardiac Cells American Journal of Physiology. Heart and Circulatory Physiology. Jan, 2002 | Pubmed ID: 11748049 Effects of Strong Electrical Shock on Cardiac Muscle Tissuea Annals of the New York Academy of Sciences. May, 1994 | Pubmed ID: 28621858 Skapande av hjärtvävnad som visar mekanisk integration av sfäroider med 3D bioprinting Chin Siang Ong1,2, Takuma Fukunishi1, Andrew Nashed1, Adriana Blazeski3, Huaitao Zhang1, Samantha Hardy1, Deborah DiSilvestre2, Luca Vricella1, John Conte1, Leslie Tung3, Gordon Tomaselli2, Narutoshi Hibino1 1Division of Cardiac Surgery, Johns Hopkins Hospital, 2Division of Cardiology, Johns Hopkins Hospital, 3Department of Biomedical Engineering, Johns Hopkins University JoVE 55438 Bioengineering
Skapande av hjärtvävnad som visar mekanisk integration av sfäroider med 3D bioprinting Chin Siang Ong1,2, Takuma Fukunishi1, Andrew Nashed1, Adriana Blazeski3, Huaitao Zhang1, Samantha Hardy1, Deborah DiSilvestre2, Luca Vricella1, John Conte1, Leslie Tung3, Gordon Tomaselli2, Narutoshi Hibino1 1Division of Cardiac Surgery, Johns Hopkins Hospital, 2Division of Cardiology, Johns Hopkins Hospital, 3Department of Biomedical Engineering, Johns Hopkins University JoVE 55438 Bioengineering
