Other Publications (1)
Articles by Li Sha Wei in JoVE
Isometric Contractility Measurement of the Mouse Mesenteric Artery Using Wire Myography Jie Sun1, Guang Ming Yang2, Tao Tao1, Li Sha Wei1, Yang Pan2, Min Sheng Zhu1 1Model Animal Research Center and MOE Key Laboratory of Model Animal and Disease Study, Nanjing University, 2School of Pharmacy, Nanjing University of Chinese Medicine The wire myograph technique is used to investigate vascular smooth muscle functions and screen new drugs. We report a detailed protocol for measuring the isometric contractility of the mouse mesenteric artery and for screening new relaxants of vascular smooth muscle.
Other articles by Li Sha Wei on PubMed
Inflammatory Mediators Mediate Airway Smooth Muscle Contraction Through a G Protein-coupled Receptor-transmembrane Protein 16A-voltage-dependent Ca Channel Axis and Contribute to Bronchial Hyperresponsiveness in Asthma The Journal of Allergy and Clinical Immunology. Apr, 2018 | Pubmed ID: 28754608 Allergic inflammation has long been implicated in asthmatic hyperresponsiveness of airway smooth muscle (ASM), but its underlying mechanism remains incompletely understood. Serving as G protein-coupled receptor agonists, several inflammatory mediators can induce membrane depolarization, contract ASM, and augment cholinergic contractile response. We hypothesized that the signal cascade integrating on membrane depolarization by the mediators might involve asthmatic hyperresponsiveness.