Lieping Chen Yale Cancer Center Yale School of Medicine Biography Publications Institution JoVE Articles Lieping Chen has not added a biography. If you are Lieping Chen and would like to personalize this page please email our Author Liaison for assistance. Publications Endogenous Expression of B7-H4 Improves Long-term Murine Islet Allograft Survival Transplantation. Jan, 2013 | Pubmed ID: 23192157 Durable Cancer Regression Off-treatment and Effective Re-induction Therapy with an Anti-PD-1 Antibody Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2012 | Pubmed ID: 23169436 Lymphatic Endothelial Cells Induce Tolerance Via PD-L1 and Lack of Costimulation Leading to High-level PD-1 Expression on CD8 T Cells Blood. Dec, 2012 | Pubmed ID: 22993390 Blockade of Both B7-H4 and CTLA-4 Co-signaling Pathways Enhances Mouse Islet Allograft Survival Islets. Jul, 2012 | Pubmed ID: 22878670 PD-1 Blockage Reverses Immune Dysfunction and Hepatitis B Viral Persistence in a Mouse Animal Model PloS One. 2012 | Pubmed ID: 22761734 Safety, Activity, and Immune Correlates of Anti-PD-1 Antibody in Cancer The New England Journal of Medicine. Jun, 2012 | Pubmed ID: 22658127 Colocalization of Inflammatory Response with B7-h1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape Science Translational Medicine. Mar, 2012 | Pubmed ID: 22461641 Cancer-induced Immunosuppression: IL-18-elicited Immunoablative NK Cells Cancer Research. Jun, 2012 | Pubmed ID: 22427351 The B7 Homologues and Their Receptors in Hematologic Malignancies European Journal of Haematology. Jun, 2012 | Pubmed ID: 22372959 Stimulation of Natural Killer Cells with a CD137-specific Antibody Enhances Trastuzumab Efficacy in Xenotransplant Models of Breast Cancer The Journal of Clinical Investigation. Feb, 2012 | Pubmed ID: 22326955 B7-H4 Treatment of T Cells Inhibits ERK, JNK, P38, and AKT Activation PloS One. 2012 | Pubmed ID: 22238573 Loss of B7-H1 Expression by Recipient Parenchymal Cells Leads to Expansion of Infiltrating Donor CD8+ T Cells and Persistence of Graft-versus-host Disease Journal of Immunology (Baltimore, Md. : 1950). Jan, 2012 | Pubmed ID: 22156590 B7-H4 Induces Donor-specific Tolerance in Mouse Islet Allografts Cell Transplantation. 2012 | Pubmed ID: 21929869 Expression of Anti-HVEM Single-chain Antibody on Tumor Cells Induces Tumor-specific Immunity with Long-term Memory Cancer Immunology, Immunotherapy : CII. Feb, 2012 | Pubmed ID: 21877247 Blockade of the B7-H1/PD-1 Pathway for Cancer Immunotherapy The Yale Journal of Biology and Medicine. Dec, 2011 | Pubmed ID: 22180678 Herpesvirus Entry Mediator Regulates Hypoxia-inducible Factor-1α and Erythropoiesis in Mice The Journal of Clinical Investigation. Dec, 2011 | Pubmed ID: 22080867 B7-H4 Pathway in Islet Transplantation and β-Cell Replacement Therapies Journal of Transplantation. 2011 | Pubmed ID: 22028949 Early Treatment of NOD Mice with B7-H4 Reduces the Incidence of Autoimmune Diabetes Diabetes. Dec, 2011 | Pubmed ID: 21984581 Ex Vivo Expanded Hematopoietic Stem Cells Overcome the MHC Barrier in Allogeneic Transplantation Cell Stem Cell. Aug, 2011 | Pubmed ID: 21816363 Cutting Edge: A Monoclonal Antibody Specific for the Programmed Death-1 Homolog Prevents Graft-versus-host Disease in Mouse Models Journal of Immunology (Baltimore, Md. : 1950). Aug, 2011 | Pubmed ID: 21768399 The Development and Functions of CD4(+) T Cells Expressing a Transgenic TCR Specific for an MHC-I-restricted Tumor Antigenic Epitope Cellular & Molecular Immunology. Jul, 2011 | Pubmed ID: 21643003 B7-h2 is a Costimulatory Ligand for CD28 in Human Immunity. May, 2011 | Pubmed ID: 21530327 Cell Surface Signaling Molecules in the Control of Immune Responses: a Tide Model Immunity. Apr, 2011 | Pubmed ID: 21511182 Blockade of B7-H1 (programmed Death Ligand 1) Enhances Humoral Immunity by Positively Regulating the Generation of T Follicular Helper Cells Journal of Immunology (Baltimore, Md. : 1950). May, 2011 | Pubmed ID: 21490158 Lymphotoxin Signal Promotes Thymic Organogenesis by Eliciting RANK Expression in the Embryonic Thymic Stroma Journal of Immunology (Baltimore, Md. : 1950). May, 2011 | Pubmed ID: 21441458 Host APCs Augment in Vivo Expansion of Donor Natural Regulatory T Cells Via B7H1/B7.1 in Allogeneic Recipients Journal of Immunology (Baltimore, Md. : 1950). Mar, 2011 | Pubmed ID: 21263067 CD137 Stimulation Enhances the Antilymphoma Activity of Anti-CD20 Antibodies Blood. Feb, 2011 | Pubmed ID: 21193697 Immunobiology of Cancer Therapies Targeting CD137 and B7-H1/PD-1 Cosignal Pathways Current Topics in Microbiology and Immunology. 2011 | Pubmed ID: 20582531 B7-H1 Expression on Non-B and Non-T Cells Promotes Distinct Effects on T- and B-cell Responses in Autoimmune Arthritis European Journal of Immunology. Nov, 2010 | Pubmed ID: 21061440 CD137-mediated Pathogenesis from Chronic Hepatitis to Hepatocellular Carcinoma in Hepatitis B Virus-transgenic Mice Journal of Immunology (Baltimore, Md. : 1950). Dec, 2010 | Pubmed ID: 21059892 Retraction: Immunotherapeutic Potential of B7-DC (PD-L2) Cross-linking Antibody in Conferring Antitumor Immunity Cancer Research. Nov, 2010 | Pubmed ID: 21045150 B7-H1-dependent Sex-related Differences in Tumor Immunity and Immunotherapy Responses Journal of Immunology (Baltimore, Md. : 1950). Sep, 2010 | Pubmed ID: 20686128 Structural Immunology of Costimualtory and Coinhibitory Molecules Science China. Life Sciences. Feb, 2010 | Pubmed ID: 20596825 Crucial Roles of B7-H1 and B7-DC Expressed on Mesenteric Lymph Node Dendritic Cells in the Generation of Antigen-specific CD4+Foxp3+ Regulatory T Cells in the Establishment of Oral Tolerance Blood. Sep, 2010 | Pubmed ID: 20574047 Phase I Study of Single-agent Anti-programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jul, 2010 | Pubmed ID: 20516446 Deficiency in B7-H1 (PD-L1)/PD-1 Coinhibition Triggers Pancreatic Beta-cell Destruction by Insulin-specific, Murine CD8 T-cells Diabetes. Aug, 2010 | Pubmed ID: 20484136 Retraction: Naturally Occurring Human IgM Antibody That Binds B7-DC and Potentiates T Cell Stimulation by Dendritic Cells Journal of Immunology (Baltimore, Md. : 1950). Jun, 2010 | Pubmed ID: 20483792 Interferon-gamma and Tumor Necrosis Factor-alpha Induce an Immunoinhibitory Molecule, B7-H1, Via Nuclear Factor-kappaB Activation in Blasts in Myelodysplastic Syndromes Blood. Aug, 2010 | Pubmed ID: 20472834 B7-H1/CD80 Interaction is Required for the Induction and Maintenance of Peripheral T-cell Tolerance Blood. Aug, 2010 | Pubmed ID: 20472828 PD-1 Regulates Germinal Center B Cell Survival and the Formation and Affinity of Long-lived Plasma Cells Nature Immunology. Jun, 2010 | Pubmed ID: 20453843 Treatment with Anti-CD137 MAbs Causes Intense Accumulations of Liver T Cells Without Selective Antitumor Immunotherapeutic Effects in This Organ Cancer Immunology, Immunotherapy : CII. Aug, 2010 | Pubmed ID: 20336294 CD137 Agonist Antibody Prevents Cancer Recurrence: Contribution of CD137 on Both Hematopoietic and Nonhematopoietic Cells Blood. Mar, 2010 | Pubmed ID: 20068221 Costimulator B7-DC Attenuates Strong Th2 Responses Induced by Nippostrongylus Brasiliensis Journal of Immunology (Baltimore, Md. : 1950). Feb, 2010 | Pubmed ID: 20065112 Leucocyte-associated Immunoglobulin-like Receptor-1 is an Inhibitory Regulator of Contact Hypersensitivity Immunology. Dec, 2009 | Pubmed ID: 19930044 NOD2 Ligation Subverts IFN-alpha Production by Liver Plasmacytoid Dendritic Cells and Inhibits Their T Cell Allostimulatory Activity Via B7-H1 Up-regulation Journal of Immunology (Baltimore, Md. : 1950). Dec, 2009 | Pubmed ID: 19890047 Potential Role of Decoy B7-H4 in the Pathogenesis of Rheumatoid Arthritis: a Mouse Model Informed by Clinical Data PLoS Medicine. Oct, 2009 | Pubmed ID: 19841745 Kupffer Cell Suppression of CD8+ T Cells in Human Hepatocellular Carcinoma is Mediated by B7-H1/programmed Death-1 Interactions Cancer Research. Oct, 2009 | Pubmed ID: 19826049 Tumor-expressed B7-H1 and B7-DC in Relation to PD-1+ T-cell Infiltration and Survival of Patients with Cervical Carcinoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2009 | Pubmed ID: 19825956 Therapeutic Effect of CD137 Immunomodulation in Lymphoma and Its Enhancement by Treg Depletion Blood. Oct, 2009 | Pubmed ID: 19641184 Reciprocal Differentiation and Tissue-specific Pathogenesis of Th1, Th2, and Th17 Cells in Graft-versus-host Disease Blood. Oct, 2009 | Pubmed ID: 19602708 B and T Lymphocyte Attenuator Tempers Early Infection Immunity Journal of Immunology (Baltimore, Md. : 1950). Aug, 2009 | Pubmed ID: 19587015 Fine Tuning the Immune Response Through B7-H3 and B7-H4 Immunological Reviews. May, 2009 | Pubmed ID: 19426220 Target-dependent B7-H1 Regulation Contributes to Clearance of Central Nervous System Infection and Dampens Morbidity Journal of Immunology (Baltimore, Md. : 1950). May, 2009 | Pubmed ID: 19380790 PD-1 on Dendritic Cells Impedes Innate Immunity Against Bacterial Infection Blood. Jun, 2009 | Pubmed ID: 19339692 Local Expression of B7-H4 by Recombinant Adenovirus Transduction in Mouse Islets Prolongs Allograft Survival Transplantation. Feb, 2009 | Pubmed ID: 19307783 Palettes of Vaccines and Immunostimulatory Monoclonal Antibodies for Combination Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2009 | Pubmed ID: 19240168 Turning the Tide of Lymphocyte Costimulation Journal of Immunology (Baltimore, Md. : 1950). Mar, 2009 | Pubmed ID: 19234146 B7-H1 (PD-L1) on T Cells is Required for T-cell-mediated Conditioning of Dendritic Cell Maturation Proceedings of the National Academy of Sciences of the United States of America. Feb, 2009 | Pubmed ID: 19202065 Functional B7.2 and B7-H2 Molecules on Myeloma Cells Are Associated with a Growth Advantage Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2009 | Pubmed ID: 19188146 B7-H4-deficient Mice Display Augmented Neutrophil-mediated Innate Immunity Blood. Feb, 2009 | Pubmed ID: 19109567 Neurological and Behavioral Abnormalities, Ventricular Dilatation, Altered Cellular Functions, Inflammation, and Neuronal Injury in Brains of Mice Due to Common, Persistent, Parasitic Infection Journal of Neuroinflammation. 2008 | Pubmed ID: 18947414 Cutting Edge: IFN-gamma Enables APC to Promote Memory Th17 and Abate Th1 Cell Development Journal of Immunology (Baltimore, Md. : 1950). Nov, 2008 | Pubmed ID: 18941172 PD-1 Ligands Expressed on Myeloid-derived APC in the CNS Regulate T-cell Responses in EAE European Journal of Immunology. Oct, 2008 | Pubmed ID: 18825752 B7-H1 on Hepatocytes Facilitates Priming of Specific CD8 T Cells but Limits the Specific Recall of Primed Responses Gastroenterology. Sep, 2008 | Pubmed ID: 18621049 Tumor-induced Immune Suppression of in Vivo Effector T-cell Priming is Mediated by the B7-H1/PD-1 Axis and Transforming Growth Factor Beta Cancer Research. Jul, 2008 | Pubmed ID: 18593946 Fc-dependent Expression of CD137 on Human NK Cells: Insights into "agonistic" Effects of Anti-CD137 Monoclonal Antibodies Blood. Aug, 2008 | Pubmed ID: 18519814 Inhibitory B7-family Molecules in the Tumour Microenvironment Nature Reviews. Immunology. Jun, 2008 | Pubmed ID: 18500231 Detrimental Contribution of the Immuno-inhibitor B7-H1 to Rabies Virus Encephalitis Journal of Immunology (Baltimore, Md. : 1950). Jun, 2008 | Pubmed ID: 18490751 B7-H1 Restricts Neuroantigen-specific T Cell Responses and Confines Inflammatory CNS Damage: Implications for the Lesion Pathogenesis of Multiple Sclerosis European Journal of Immunology. Jun, 2008 | Pubmed ID: 18421793 CD137 is Expressed in Human Atherosclerosis and Promotes Development of Plaque Inflammation in Hypercholesterolemic Mice Circulation. Mar, 2008 | Pubmed ID: 18285570 B7-H1 is a Ubiquitous Antiapoptotic Receptor on Cancer Cells Blood. Apr, 2008 | Pubmed ID: 18223165 Blocking of Monocyte-associated B7-H1 (CD274) Enhances HCV-specific T Cell Immunity in Chronic Hepatitis C Infection Journal of Leukocyte Biology. Mar, 2008 | Pubmed ID: 18086898 Multivalent 4-1BB Binding Aptamers Costimulate CD8+ T Cells and Inhibit Tumor Growth in Mice The Journal of Clinical Investigation. Jan, 2008 | Pubmed ID: 18060045 Tolerogenic Maturation of Liver Sinusoidal Endothelial Cells Promotes B7-homolog 1-dependent CD8+ T Cell Tolerance Hepatology (Baltimore, Md.). Jan, 2008 | Pubmed ID: 17975811 Blockade of Endogenous B7-H1 Suppresses Antibacterial Protection After Primary Listeria Monocytogenes Infection Immunology. Jan, 2008 | Pubmed ID: 17971153 Programmed Death-1 Concentration at the Immunological Synapse is Determined by Ligand Affinity and Availability Proceedings of the National Academy of Sciences of the United States of America. Nov, 2007 | Pubmed ID: 17968013 Relationship Between B7-H4, Regulatory T Cells, and Patient Outcome in Human Ovarian Carcinoma Cancer Research. Sep, 2007 | Pubmed ID: 17875732 How Ebola and Marburg Viruses Battle the Immune System Nature Reviews. Immunology. Jul, 2007 | Pubmed ID: 17589545 LIGHT-related Molecular Network in the Regulation of Innate and Adaptive Immunity Immunologic Research. 2007 | Pubmed ID: 17496344 B7-H1 Up-regulation on Myeloid Dendritic Cells Significantly Suppresses T Cell Immune Function in Patients with Chronic Hepatitis B Journal of Immunology (Baltimore, Md. : 1950). May, 2007 | Pubmed ID: 17475895 The New B7s: Playing a Pivotal Role in Tumor Immunity Journal of Immunotherapy (Hagerstown, Md. : 1997). Apr, 2007 | Pubmed ID: 17414316 Role of PD-1 and Its Ligand, B7-H1, in Early Fate Decisions of CD8 T Cells Blood. Jul, 2007 | Pubmed ID: 17392506 Cytokine-mediated Disruption of Lymphocyte Trafficking, Hemopoiesis, and Induction of Lymphopenia, Anemia, and Thrombocytopenia in Anti-CD137-treated Mice Journal of Immunology (Baltimore, Md. : 1950). Apr, 2007 | Pubmed ID: 17371976 Interaction Between B7-H1 and PD-1 Determines Initiation and Reversal of T-cell Anergy Blood. Jul, 2007 | Pubmed ID: 17289811 Immunostimulatory Monoclonal Antibodies for Cancer Therapy Nature Reviews. Cancer. Feb, 2007 | Pubmed ID: 17251916 CD137 Stimulation Delivers an Antigen-independent Growth Signal for T Lymphocytes with Memory Phenotype Blood. Jun, 2007 | Pubmed ID: 17244673 Effects of Specific Immunotherapy on the B7 Family of Costimulatory Molecules in Allergic Inflammation Journal of Immunology (Baltimore, Md. : 1950). Feb, 2007 | Pubmed ID: 17237444 Selective Targeting of the LIGHT-HVEM Costimulatory System for the Treatment of Graft-versus-host Disease Blood. May, 2007 | Pubmed ID: 17179227 Filoviruses and the Balance of Innate, Adaptive, and Inflammatory Responses Viral Immunology. 2006 | Pubmed ID: 17201655 Human Bone Marrow: a Reservoir for "enhanced Effector Memory" CD8+ T Cells with Potent Recall Function Journal of Immunology (Baltimore, Md. : 1950). Nov, 2006 | Pubmed ID: 17082586 Suppression of Human T-cell Responses to Beta-cells by Activation of B7-H4 Pathway Cell Transplantation. 2006 | Pubmed ID: 16970282 Modulation of Immune Response by B7 Family Molecules in Tumor Microenvironments Immunological Investigations. 2006 | Pubmed ID: 16916759 Inhibition of Th2-mediated Allergic Airway Inflammatory Disease by CD137 Costimulation Journal of Immunology (Baltimore, Md. : 1950). Jul, 2006 | Pubmed ID: 16818735 Does Decentralisation Improve Human Resource Management in the Health Sector? A Case Study from China Social Science & Medicine (1982). Oct, 2006 | Pubmed ID: 16808993 The Role of Leukemia-derived B7-H1 (PD-L1) in Tumor-T-cell Interactions in Humans Experimental Hematology. Jul, 2006 | Pubmed ID: 16797416 Cutting Edge: Induction of B7-H4 on APCs Through IL-10: Novel Suppressive Mode for Regulatory T Cells Journal of Immunology (Baltimore, Md. : 1950). Jul, 2006 | Pubmed ID: 16785496 Reviving Exhausted T Lymphocytes During Chronic Virus Infection by B7-H1 Blockade Trends in Molecular Medicine. Jun, 2006 | Pubmed ID: 16650803 B7-H4 Expression Identifies a Novel Suppressive Macrophage Population in Human Ovarian Carcinoma The Journal of Experimental Medicine. Apr, 2006 | Pubmed ID: 16606666 Essential Role of TNF Family Molecule LIGHT As a Cytokine in the Pathogenesis of Hepatitis The Journal of Clinical Investigation. Apr, 2006 | Pubmed ID: 16557300 Low Surface Expression of B7-1 (CD80) is an Immunoescape Mechanism of Colon Carcinoma Cancer Research. Feb, 2006 | Pubmed ID: 16489051 Interferon Regulatory Factor-1 is Prerequisite to the Constitutive Expression and IFN-gamma-induced Upregulation of B7-H1 (CD274) FEBS Letters. Feb, 2006 | Pubmed ID: 16413538 Renewed Interest in Cancer Immunotherapy with the Tumor Necrosis Factor Superfamily Molecules Cancer Immunology, Immunotherapy : CII. Apr, 2006 | Pubmed ID: 16187084 B7-H1 (CD274) Inhibits the Development of Herpetic Stromal Keratitis (HSK) FEBS Letters. Nov, 2005 | Pubmed ID: 16253242 The Many Sounds of T Lymphocyte Silence Immunologic Research. 2005 | Pubmed ID: 16234580 Renal Tubular Epithelial Cells Modulate T-cell Responses Via ICOS-L and B7-H1 Kidney International. Nov, 2005 | Pubmed ID: 16221208 Costimulatory Molecule B7-H1 in Primary and Metastatic Clear Cell Renal Cell Carcinoma Cancer. Nov, 2005 | Pubmed ID: 16208700 Expression of Functional B7-H2 and B7.2 Costimulatory Molecules and Their Prognostic Implications in De Novo Acute Myeloid Leukemia Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2005 | Pubmed ID: 16115907 Cigarette Smoke Extract Suppresses Human Dendritic Cell Function Leading to Preferential Induction of Th-2 Priming Journal of Immunology (Baltimore, Md. : 1950). Aug, 2005 | Pubmed ID: 16081845 Role of B7-H1 and B7-H4 Molecules in Down-regulating Effector Phase of T-cell Immunity: Novel Cancer Escaping Mechanisms Frontiers in Bioscience : a Journal and Virtual Library. 2005 | Pubmed ID: 15970540 Constitutive and Inducible Expression of B7 Family of Ligands by Human Airway Epithelial Cells American Journal of Respiratory Cell and Molecular Biology. Sep, 2005 | Pubmed ID: 15961727 In Vivo Costimulatory Role of B7-DC in Tuning T Helper Cell 1 and Cytotoxic T Lymphocyte Responses The Journal of Experimental Medicine. May, 2005 | Pubmed ID: 15897272 Enhancement of CD4 and CD8 Immunity by Anti-CD137 (4-1BB) Monoclonal Antibodies During Hepatitis C Vaccination with Recombinant Adenovirus Vaccine. May, 2005 | Pubmed ID: 15855007 Microglial Expression of the B7 Family Member B7 Homolog 1 Confers Strong Immune Inhibition: Implications for Immune Responses and Autoimmunity in the CNS The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2005 | Pubmed ID: 15758163 Blockade of B7-H1 and PD-1 by Monoclonal Antibodies Potentiates Cancer Therapeutic Immunity Cancer Research. Feb, 2005 | Pubmed ID: 15705911 B7-H3 Promotes Acute and Chronic Allograft Rejection European Journal of Immunology. Feb, 2005 | Pubmed ID: 15682454 Anti-CD137 MAb Treatment Inhibits Experimental Autoimmune Uveitis by Limiting Expansion and Increasing Apoptotic Death of Uveitogenic T Cells Investigative Ophthalmology & Visual Science. Feb, 2005 | Pubmed ID: 15671287 T Lymphocyte Co-signaling Pathways of the B7-CD28 Family Cellular & Molecular Immunology. Feb, 2004 | Pubmed ID: 16212919 Therapeutic Efficacy of MUC1-specific Cytotoxic T Lymphocytes and CD137 Co-stimulation in a Spontaneous Breast Cancer Model Breast Disease. 2004 | Pubmed ID: 15687707 Cutting Edge: Cbl-b: One of the Key Molecules Tuning CD28- and CTLA-4-mediated T Cell Costimulation Journal of Immunology (Baltimore, Md. : 1950). Dec, 2004 | Pubmed ID: 15585834 Costimulatory B7-H1 in Renal Cell Carcinoma Patients: Indicator of Tumor Aggressiveness and Potential Therapeutic Target Proceedings of the National Academy of Sciences of the United States of America. Dec, 2004 | Pubmed ID: 15569934 B7-H3 Enhances Tumor Immunity in Vivo by Costimulating Rapid Clonal Expansion of Antigen-specific CD8+ Cytolytic T Cells Journal of Immunology (Baltimore, Md. : 1950). Nov, 2004 | Pubmed ID: 15494491 Interferon-beta Enhances Monocyte and Dendritic Cell Expression of B7-H1 (PD-L1), a Strong Inhibitor of Autologous T-cell Activation: Relevance for the Immune Modulatory Effect in Multiple Sclerosis Journal of Neuroimmunology. Oct, 2004 | Pubmed ID: 15342209 Specific Recruitment of Regulatory T Cells in Ovarian Carcinoma Fosters Immune Privilege and Predicts Reduced Survival Nature Medicine. Sep, 2004 | Pubmed ID: 15322536 Immunotherapeutic Potential of B7-DC (PD-L2) Cross-linking Antibody in Conferring Antitumor Immunity Cancer Research. Jul, 2004 | Pubmed ID: 15256470 Co-signaling Molecules of the B7-CD28 Family in Positive and Negative Regulation of T Lymphocyte Responses Microbes and Infection / Institut Pasteur. Jul, 2004 | Pubmed ID: 15207823 53BP1 is Required for Class Switch Recombination The Journal of Cell Biology. May, 2004 | Pubmed ID: 15159415 Selective Suppression of Dendritic Cell Functions by Cigarette Smoke Extract Chest. May, 2004 | Pubmed ID: 15136445 Co-inhibitory Molecules of the B7-CD28 Family in the Control of T-cell Immunity Nature Reviews. Immunology. May, 2004 | Pubmed ID: 15122199 Strong Synergy Between Mutant Ras and HPV16 E6/E7 in the Development of Primary Tumors Oncogene. May, 2004 | Pubmed ID: 15077191 Improving Efficacy of Interleukin-12-transfected Dendritic Cells Injected into Murine Colon Cancer with Anti-CD137 Monoclonal Antibodies and Alloantigens International Journal of Cancer. Journal International Du Cancer. May, 2004 | Pubmed ID: 15054868 Structural and Functional Analysis of the Costimulatory Receptor Programmed Death-1 Immunity. Mar, 2004 | Pubmed ID: 15030777 B7-H1 Determines Accumulation and Deletion of Intrahepatic CD8(+) T Lymphocytes Immunity. Mar, 2004 | Pubmed ID: 15030776 Local Expression of B7-H1 Promotes Organ-specific Autoimmunity and Transplant Rejection The Journal of Clinical Investigation. Mar, 2004 | Pubmed ID: 14991067 Control of Autoimmune Diseases by the B7-CD28 Family Molecules Current Pharmaceutical Design. 2004 | Pubmed ID: 14754392 Costimulation-based Immunotherapy for Head and Neck Cancer Current Treatment Options in Oncology. Feb, 2004 | Pubmed ID: 14697154 New B7 Family Members with Positive and Negative Costimulatory Function American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Jan, 2004 | Pubmed ID: 14678029 Ligation of CD137 Receptor Prevents and Reverses Established Anergy of CD8+ Cytolytic T Lymphocytes in Vivo Blood. Jan, 2004 | Pubmed ID: 12969968 CD137 Signaling Interferes with Activation and Function of CD4+CD25+ Regulatory T Cells in Induced Tolerance to Experimental Autoimmune Thyroiditis Cellular Immunology. Nov, 2003 | Pubmed ID: 14746804 Immunology of B7-H1 and Its Roles in Human Diseases International Journal of Hematology. Nov, 2003 | Pubmed ID: 14686489 Blocking the Monocyte Chemoattractant Protein-1/CCR2 Chemokine Pathway Induces Permanent Survival of Islet Allografts Through a Programmed Death-1 Ligand-1-dependent Mechanism Journal of Immunology (Baltimore, Md. : 1950). Dec, 2003 | Pubmed ID: 14662900 Expression of the B7-related Molecule B7-H1 by Glioma Cells: a Potential Mechanism of Immune Paralysis Cancer Research. Nov, 2003 | Pubmed ID: 14612546 Genomic Organization and Expression Analysis of B7-H4, an Immune Inhibitory Molecule of the B7 Family Journal of Immunology (Baltimore, Md. : 1950). Nov, 2003 | Pubmed ID: 14568939 B7-H1 Blockade Augments Adoptive T-cell Immunotherapy for Squamous Cell Carcinoma Cancer Research. Oct, 2003 | Pubmed ID: 14559843 Blockade of B7-H1 Suppresses the Development of Chronic Intestinal Inflammation Journal of Immunology (Baltimore, Md. : 1950). Oct, 2003 | Pubmed ID: 14530338 Human Muscle Cells Express a B7-related Molecule, B7-H1, with Strong Negative Immune Regulatory Potential: a Novel Mechanism of Counterbalancing the Immune Attack in Idiopathic Inflammatory Myopathies FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Oct, 2003 | Pubmed ID: 12923066 Autoimmune Diabetes in HLA-DR3/DQ8 Transgenic Mice Expressing the Co-stimulatory Molecule B7-1 in the Beta Cells of Islets of Langerhans International Immunology. Sep, 2003 | Pubmed ID: 12917255 Cancer Therapeutic Monoclonal Antibodies Targeting Lymphocyte Co-stimulatory Pathways Current Opinion in Investigational Drugs (London, England : 2000). Jun, 2003 | Pubmed ID: 12901227 Differential Binding Properties of B7-H1 and B7-DC to Programmed Death-1 Biochemical and Biophysical Research Communications. Aug, 2003 | Pubmed ID: 12893276 Cooperative B7-1/2 (CD80/CD86) and B7-DC Costimulation of CD4+ T Cells Independent of the PD-1 Receptor The Journal of Experimental Medicine. Jul, 2003 | Pubmed ID: 12847135 B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity Immunity. Jun, 2003 | Pubmed ID: 12818165 A Simple and Rapid Vortex Method for Preparing Antigen/adjuvant Emulsions for Immunization Journal of Immunological Methods. May, 2003 | Pubmed ID: 12738377 B7-H1 Pathway and Its Role in the Evasion of Tumor Immunity Journal of Molecular Medicine (Berlin, Germany). May, 2003 | Pubmed ID: 12721664 Molecular Modeling and Functional Mapping of B7-H1 and B7-DC Uncouple Costimulatory Function from PD-1 Interaction The Journal of Experimental Medicine. May, 2003 | Pubmed ID: 12719480 Characterization of Antigen Processing Machinery and Survivin Expression in Tonsillar Squamous Cell Carcinoma Cancer. May, 2003 | Pubmed ID: 12712472 Expression of the Costimulatory Molecule B7-H2 (inducible Costimulator Ligand) by Human Airway Epithelial Cells American Journal of Respiratory Cell and Molecular Biology. May, 2003 | Pubmed ID: 12707012 Blockade of B7-H1 Improves Myeloid Dendritic Cell-mediated Antitumor Immunity Nature Medicine. May, 2003 | Pubmed ID: 12704383 B7 Family Molecules Are Favorably Positioned at the Human Maternal-fetal Interface Biology of Reproduction. May, 2003 | Pubmed ID: 12606489 Naturally Occurring Human IgM Antibody That Binds B7-DC and Potentiates T Cell Stimulation by Dendritic Cells Journal of Immunology (Baltimore, Md. : 1950). Feb, 2003 | Pubmed ID: 12574348 Costimulating Aberrant T Cell Responses by B7-H1 Autoantibodies in Rheumatoid Arthritis The Journal of Clinical Investigation. Feb, 2003 | Pubmed ID: 12569162 B7-H1 is Up-regulated in HIV Infection and is a Novel Surrogate Marker of Disease Progression Blood. Apr, 2003 | Pubmed ID: 12468426 [Antitumor Immunity Elicited by 4-1BBL Gene Transfected Hepa1-6 in Vivo] Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology. Dec, 2002 | Pubmed ID: 12502438 Cross-linking the B7 Family Molecule B7-DC Directly Activates Immune Functions of Dendritic Cells The Journal of Experimental Medicine. Nov, 2002 | Pubmed ID: 12438431 Costimulatory Molecule-targeted Antibody Therapy of a Spontaneous Autoimmune Disease Nature Medicine. Dec, 2002 | Pubmed ID: 12426559 Signaling Through NK Cell-associated CD137 Promotes Both Helper Function for CD8+ Cytolytic T Cells and Responsiveness to IL-2 but Not Cytolytic Activity Journal of Immunology (Baltimore, Md. : 1950). Oct, 2002 | Pubmed ID: 12370353 Impaired Infiltration of Tumor-specific Cytolytic T Cells in the Absence of Interferon-gamma Despite Their Normal Maturation in Lymphoid Organs During CD137 Monoclonal Antibody Therapy Cancer Research. Aug, 2002 | Pubmed ID: 12154048 Immunoglobulin Fusion Proteins As a Tool for Evaluation of T-cell Costimulatory Molecules Molecular Biotechnology. Jul, 2002 | Pubmed ID: 12102550 Tumor-associated B7-H1 Promotes T-cell Apoptosis: a Potential Mechanism of Immune Evasion Nature Medicine. Aug, 2002 | Pubmed ID: 12091876 Anti-4-1BB Monoclonal Antibody Enhances Rejection of Large Tumor Burden by Promoting Survival but Not Clonal Expansion of Tumor-specific CD8+ T Cells Cancer Research. Jun, 2002 | Pubmed ID: 12067989 Modulation of Dendritic Cell Differentiation and Maturation by Decoy Receptor 3 Journal of Immunology (Baltimore, Md. : 1950). May, 2002 | Pubmed ID: 11994433 Cutting Edge: Selective Impairment of CD8+ T Cell Function in Mice Lacking the TNF Superfamily Member LIGHT Journal of Immunology (Baltimore, Md. : 1950). May, 2002 | Pubmed ID: 11994431 Cutting Edge: Expression of Functional CD137 Receptor by Dendritic Cells Journal of Immunology (Baltimore, Md. : 1950). May, 2002 | Pubmed ID: 11970964 Ligand Binding Sites of Inducible Costimulator and High Avidity Mutants with Improved Function The Journal of Experimental Medicine. Apr, 2002 | Pubmed ID: 11956294 Antibody Gene Therapy: Old Wine in a New Bottle Nature Medicine. Apr, 2002 | Pubmed ID: 11927934 Strategies for Antigen Loading of Dendritic Cells to Enhance the Antitumor Immune Response Cancer Research. Mar, 2002 | Pubmed ID: 11912169 Immunotherapy of Human Papillomavirus-associated Malignancies and the Challenges Posed by T-cell Tolerance Frontiers in Bioscience : a Journal and Virtual Library. Apr, 2002 | Pubmed ID: 11897572 Provision of Antigen and CD137 Signaling Breaks Immunological Ignorance, Promoting Regression of Poorly Immunogenic Tumors The Journal of Clinical Investigation. Mar, 2002 | Pubmed ID: 11877473 Reassessment of CD62L As a Marker of Pre-effector T Cells in the Tumor Draining Lymph Nodes of Head and Neck Cancer Patients Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. Feb, 2002 | Pubmed ID: 11870350 Blockade of LIGHT/LTbeta and CD40 Signaling Induces Allospecific T Cell Anergy, Preventing Graft-versus-host Disease The Journal of Clinical Investigation. Feb, 2002 | Pubmed ID: 11854328 Administration of Agonistic Anti-4-1BB Monoclonal Antibody Leads to the Amelioration of Experimental Autoimmune Encephalomyelitis Journal of Immunology (Baltimore, Md. : 1950). Feb, 2002 | Pubmed ID: 11801689 Interleukin 4 Receptor-directed Cytotoxin Therapy for Human Head and Neck Squamous Cell Carcinoma in Animal Models Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2002 | Pubmed ID: 11801570 Иммуногистохимического окрашивания B7-H1 (PD-L1) на Парафиновые Слайды из ткани поджелудочной железы аденокарцинома Elaine Bigelow1,2, Katherine M. Bever1,2, Haiying Xu1,2,3, Allison Yager1, Annie Wu1,2,4, Janis Taube3,5, Lieping Chen6, Elizabeth M. Jaffee1,2,5,7,8, Robert A. Anders1,2,5,8, Lei Zheng1,2,4,5,7 1The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 2Department of Oncology, The Johns Hopkins University School of Medicine, 3Department of Dermatology, The Johns Hopkins University School of Medicine, 4Department of Surgery, Johns Hopkins University School of Medicine, 5The Sol Goldman Pancreatic Cancer Center, The Johns Hopkins University School of Medicine, 6Yale Cancer Center, Yale School of Medicine, 7The Skip Viragh Center for Pancreatic Cancer, The Johns Hopkins University School of Medicine, 8Department of Pathology, The Johns Hopkins University School of Medicine JoVE 4059 Medicine
Иммуногистохимического окрашивания B7-H1 (PD-L1) на Парафиновые Слайды из ткани поджелудочной железы аденокарцинома Elaine Bigelow1,2, Katherine M. Bever1,2, Haiying Xu1,2,3, Allison Yager1, Annie Wu1,2,4, Janis Taube3,5, Lieping Chen6, Elizabeth M. Jaffee1,2,5,7,8, Robert A. Anders1,2,5,8, Lei Zheng1,2,4,5,7 1The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 2Department of Oncology, The Johns Hopkins University School of Medicine, 3Department of Dermatology, The Johns Hopkins University School of Medicine, 4Department of Surgery, Johns Hopkins University School of Medicine, 5The Sol Goldman Pancreatic Cancer Center, The Johns Hopkins University School of Medicine, 6Yale Cancer Center, Yale School of Medicine, 7The Skip Viragh Center for Pancreatic Cancer, The Johns Hopkins University School of Medicine, 8Department of Pathology, The Johns Hopkins University School of Medicine JoVE 4059 Medicine
